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P93101 (CDC2_OXYRB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division control protein 2 homolog

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
p34cdc2
Gene names
Name:CDC2
Synonyms:CDK34
OrganismOxybasis rubra (Red goosefoot) (Chenopodium rubrum)
Taxonomic identifier3560 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesAmaranthaceaeChenopodioideaeAtripliceaeOxybasis

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a key role in the control of the eukaryotic cell cycle. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Enzyme regulation

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 294294Cell division control protein 2 homolog
PRO_0000085751

Regions

Domain4 – 287284Protein kinase
Nucleotide binding10 – 189ATP By similarity

Sites

Active site1271Proton acceptor By similarity
Binding site331ATP By similarity

Amino acid modifications

Modified residue141Phosphothreonine By similarity
Modified residue151Phosphotyrosine By similarity
Modified residue1611Phosphothreonine; by CAK By similarity

Sequences

Sequence LengthMass (Da)Tools
P93101 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: B82748F8E4B600E6

FASTA29433,832
        10         20         30         40         50         60 
MDQYEKVEKI GEGTYGVVYK ARDKVTNETI ALKKIRLEQE DEGVPSTAIR EISLLKEMQH 

        70         80         90        100        110        120 
GNIVRLQDVV HSEKRLYLVF EYLDLDLKKH MDSCPDFAKD PRMIKRFLYQ ILRGIAYCHS 

       130        140        150        160        170        180 
HRVLHRDLKP QNLLIDRQTN ALKLADFGLA RAFGIPVRTF THEVVTLWYR APEILLGSRH 

       190        200        210        220        230        240 
YSTPVDVWSV GCIFAEMVNQ KPLFPGDSEI DELFKIFRTL GTPNEETWPG VTSLPDFKSS 

       250        260        270        280        290 
FPKWISKDLS AVVPNLDPAG IDLLNKMLCL DPSKRITARN ALEHEYFKDI GFVP 

« Hide

References

[1]"Nucleotide sequence of a cDNA encoding a CDK34-protein kinase from a photoautotrophic cell suspension culture of Chenopodium rubrum L."
Renz A., Schmelzl B., Beck E.
Plant Gene Register PGR97-045
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y10160 mRNA. Translation: CAA71242.1.

3D structure databases

ProteinModelPortalP93101.
SMRP93101. Positions 1-290.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP93101.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDC2_OXYRB
AccessionPrimary (citable) accession number: P93101
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: May 1, 1997
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families