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Protein

Rac-like GTP-binding protein ARAC11

Gene

ARAC11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in cell polarity control during the actin-dependent tip growth of pollen tubes. May regulate callose synthase 1 (CALS1) activity through the interaction with UGT1.1 Publication
Inactive GDP-bound Rho GTPases reside in the cytosol, are found in a complex with Rho GDP-dissociation inhibitors (Rho GDIs), and are released from the GDI protein in order to translocate to membranes upon activation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20GTPBy similarity8
Nucleotide bindingi60 – 64GTPBy similarity5
Nucleotide bindingi118 – 121GTPBy similarity4

GO - Molecular functioni

  • GTPase activating protein binding Source: TAIR
  • GTPase activity Source: TAIR
  • GTP binding Source: TAIR

GO - Biological processi

  • establishment of vesicle localization Source: TAIR
  • pollen tube growth Source: TAIR
  • regulation of actin filament depolymerization Source: TAIR
  • regulation of actin filament polymerization Source: TAIR
  • regulation of exocytosis Source: TAIR
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-194840. Rho GTPase cycle.
R-ATH-198203. PI3K/AKT activation.
R-ATH-392451. G beta:gamma signalling through PI3Kgamma.
R-ATH-5666185. RHO GTPases Activate Rhotekin and Rhophilins.
R-ATH-5689896. Ovarian tumor domain proteases.
R-ATH-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Rac-like GTP-binding protein ARAC11
Alternative name(s):
GTPase protein ROP1
Gene namesi
Name:ARAC11
Synonyms:RAC11, ROP1
Ordered Locus Names:At3g51300
ORF Names:F24M12.340
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G51300.

Subcellular locationi

GO - Cellular componenti

  • apical part of cell Source: TAIR
  • cytoplasm Source: TAIR
  • nucleolus Source: TAIR
  • nucleus Source: TAIR
  • phragmoplast Source: TAIR
  • plasma membrane Source: TAIR
  • spindle Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001989251 – 194Rac-like GTP-binding protein ARAC11Add BLAST194
PropeptideiPRO_0000227587195 – 197Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194Cysteine methyl esterSequence analysis1
Lipidationi194S-geranylgeranyl cysteineSequence analysis1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP92978.

Expressioni

Tissue specificityi

Exclusively expressed in mature pollen and pollen tubes.1 Publication

Gene expression databases

GenevisibleiP92978. AT.

Interactioni

Subunit structurei

Part of a complex containing ROPGEF1 and PRK2 (PubMed:23024212). Interacts with UGT1, ICR1, ICR2, ICR3, ICR4 and ICR5.4 Publications

GO - Molecular functioni

  • GTPase activating protein binding Source: TAIR

Protein-protein interaction databases

BioGridi9611. 22 interactors.
IntActiP92978. 3 interactors.
STRINGi3702.AT3G51300.1.

Structurei

3D structure databases

ProteinModelPortaliP92978.
SMRiP92978.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 43Effector regionSequence analysis9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi182 – 189Poly-Lys8

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000233974.
InParanoidiP92978.
KOiK04392.
OMAiACAKEIK.
OrthoDBiEOG09360LB1.
PhylomeDBiP92978.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P92978-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASRFVKCV TVGDGAVGKT CLLISYTSNT FPTDYVPTVF DNFSANVVVN
60 70 80 90 100
GSTVNLGLWD TAGQEDYNRL RPLSYRGADV FILAFSLISK ASYENVSKKW
110 120 130 140 150
IPELKHYAPG VPIVLVGTKL DLRDDKQFFI DHPGAVPITT AQGEELRKQI
160 170 180 190
GAPTYIECSS KTQENVKAVF DAAIRVVLQP PKQKKKKSKA QKACSIL
Length:197
Mass (Da):21,619
Last modified:January 1, 1998 - v2
Checksum:iDAF48ED8D3051AC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49971 Genomic DNA. Translation: AAC78390.1.
AF085480 Genomic DNA. Translation: AAC35850.1.
AL132980 Genomic DNA. Translation: CAB62652.1.
CP002686 Genomic DNA. Translation: AEE78776.1.
AF375412 mRNA. Translation: AAK52996.1.
AY066054 mRNA. Translation: AAL47421.1.
PIRiT45761.
RefSeqiNP_190698.1. NM_114989.4.
UniGeneiAt.28445.

Genome annotation databases

EnsemblPlantsiAT3G51300.1; AT3G51300.1; AT3G51300.
GeneIDi824293.
GrameneiAT3G51300.1; AT3G51300.1; AT3G51300.
KEGGiath:AT3G51300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49971 Genomic DNA. Translation: AAC78390.1.
AF085480 Genomic DNA. Translation: AAC35850.1.
AL132980 Genomic DNA. Translation: CAB62652.1.
CP002686 Genomic DNA. Translation: AEE78776.1.
AF375412 mRNA. Translation: AAK52996.1.
AY066054 mRNA. Translation: AAL47421.1.
PIRiT45761.
RefSeqiNP_190698.1. NM_114989.4.
UniGeneiAt.28445.

3D structure databases

ProteinModelPortaliP92978.
SMRiP92978.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi9611. 22 interactors.
IntActiP92978. 3 interactors.
STRINGi3702.AT3G51300.1.

Proteomic databases

PaxDbiP92978.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G51300.1; AT3G51300.1; AT3G51300.
GeneIDi824293.
GrameneiAT3G51300.1; AT3G51300.1; AT3G51300.
KEGGiath:AT3G51300.

Organism-specific databases

TAIRiAT3G51300.

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
HOGENOMiHOG000233974.
InParanoidiP92978.
KOiK04392.
OMAiACAKEIK.
OrthoDBiEOG09360LB1.
PhylomeDBiP92978.

Enzyme and pathway databases

ReactomeiR-ATH-194840. Rho GTPase cycle.
R-ATH-198203. PI3K/AKT activation.
R-ATH-392451. G beta:gamma signalling through PI3Kgamma.
R-ATH-5666185. RHO GTPases Activate Rhotekin and Rhophilins.
R-ATH-5689896. Ovarian tumor domain proteases.
R-ATH-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiP92978.

Gene expression databases

GenevisibleiP92978. AT.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAC11_ARATH
AccessioniPrimary (citable) accession number: P92978
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.