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Protein

Protein STRICTOSIDINE SYNTHASE-LIKE 11

Gene

SSL11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.By similarity

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Catalytic activityi

3-alpha-(S)-strictosidine + H2O = tryptamine + secologanin.

Pathwayi: 3alpha(S)-strictosidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 3alpha(S)-strictosidine from secologanin and tryptamine.
Proteins known to be involved in this subpathway in this organism are:
  1. Protein STRICTOSIDINE SYNTHASE-LIKE 11 (SSL11), Protein STRICTOSIDINE SYNTHASE-LIKE 12 (SSL12)
This subpathway is part of the pathway 3alpha(S)-strictosidine biosynthesis, which is itself part of Alkaloid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 3alpha(S)-strictosidine from secologanin and tryptamine, the pathway 3alpha(S)-strictosidine biosynthesis and in Alkaloid biosynthesis.

GO - Molecular functioni

  • hydrolase activity, acting on ester bonds Source: GO_Central
  • strictosidine synthase activity Source: TAIR

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAlkaloid metabolism

Enzyme and pathway databases

BioCyciARA:AT1G74000-MONOMER
UniPathwayiUPA00311; UER00447

Names & Taxonomyi

Protein namesi
Recommended name:
Protein STRICTOSIDINE SYNTHASE-LIKE 111 Publication (EC:4.3.3.2)
Short name:
AtSSL111 Publication
Alternative name(s):
Strictosidine synthase 121 Publication
Short name:
AtSS121 Publication
Strictosidine synthase 3
Short name:
SS-3
Gene namesi
Name:SSL111 Publication
Synonyms:SS121 Publication, SS3
Ordered Locus Names:At1g74000Imported
ORF Names:F2P9.13Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G74000
TAIRilocus:2031511 AT1G74000

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000003333124 – 329Protein STRICTOSIDINE SYNTHASE-LIKE 11Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi79N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP92976

Expressioni

Gene expression databases

ExpressionAtlasiP92976 baseline and differential
GenevisibleiP92976 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G74000.1

Structurei

3D structure databases

ProteinModelPortaliP92976
SMRiP92976
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the strictosidine synthase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1520 Eukaryota
COG3386 LUCA
HOGENOMiHOG000223915
KOiK01757
OMAiWVAISNT
OrthoDBiEOG09360F65
PhylomeDBiP92976

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR018119 Strictosidine_synth_cons-reg
IPR004141 Strictosidine_synthase
PANTHERiPTHR10426 PTHR10426, 1 hit
PfamiView protein in Pfam
PF03088 Str_synth, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P92976-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRSFVSLIS LLLLLSFSSS VLSTKKSSFQ KLPVPGNRTG PEAFAFDSTG
60 70 80 90 100
KGFYTGVTGG KILKYLPKKG YVDFAQITNS SKSSLCDGAL GTTNVEKCGR
110 120 130 140 150
PAGIAFNTKT GDLYVADAAL GLHVIPRRGG LAKKIADSVG GKPFLFLDGL
160 170 180 190 200
DVDPTTGVVY FTSFSSTFGP RDVLKAVATK DSTGKFFKYD PSKKVVTVLM
210 220 230 240 250
EGLSGSAGCA VSSDGSFVLV GQFTKSNIKR YWIKGSKAGT SEDFTNSVSN
260 270 280 290 300
PDNIKRIGST GNFWVASVVN SATGPTNPSA VKVSSAGKVL QTIPLKDKFG
310 320
DTLVSEVNEY KGQLYIGALF GPFAGILKL
Length:329
Mass (Da):34,667
Last modified:June 6, 2002 - v2
Checksum:iC549547884B6E1C1
GO

Sequence cautioni

The sequence AAB40595 differs from that shown. Reason: Frameshift at positions 309 and 327.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54 – 55YT → LP in AAB40595 (Ref. 1) Curated2
Sequence conflicti155T → N in AAB40595 (Ref. 1) Curated1
Sequence conflicti201E → D in AAB40595 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43946 mRNA Translation: AAB40595.1 Frameshift.
AC016662 Genomic DNA Translation: AAG52519.1
CP002684 Genomic DNA Translation: AEE35536.1
AK230236 mRNA Translation: BAF02041.1
PIRiG96767
RefSeqiNP_177540.3, NM_106059.5
UniGeneiAt.18213

Genome annotation databases

EnsemblPlantsiAT1G74000.1; AT1G74000.1; AT1G74000
GeneIDi843738
GrameneiAT1G74000.1; AT1G74000.1; AT1G74000
KEGGiath:AT1G74000

Similar proteinsi

Entry informationi

Entry nameiSSL11_ARATH
AccessioniPrimary (citable) accession number: P92976
Secondary accession number(s): Q0WLG6, Q9C9C1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 6, 2002
Last modified: April 25, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health