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P92976

- STS3_ARATH

UniProt

P92976 - STS3_ARATH

Protein

Strictosidine synthase 3

Gene

SS3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (06 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.By similarity

    Catalytic activityi

    3-alpha-(S)-strictosidine + H2O = tryptamine + secologanin.

    Pathwayi

    GO - Molecular functioni

    1. strictosidine synthase activity Source: TAIR

    GO - Biological processi

    1. alkaloid metabolic process Source: UniProtKB-KW
    2. biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Alkaloid metabolism

    Enzyme and pathway databases

    BioCyciARA:AT1G74000-MONOMER.
    UniPathwayiUPA00311; UER00447.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Strictosidine synthase 3 (EC:4.3.3.2)
    Short name:
    SS-3
    Gene namesi
    Name:SS3
    Ordered Locus Names:At1g74000
    ORF Names:F2P9.13
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G74000.

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. cell wall Source: TAIR
    2. plant-type cell wall Source: TAIR
    3. vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 329306Strictosidine synthase 3PRO_0000033331Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP92976.
    PRIDEiP92976.

    Expressioni

    Gene expression databases

    ArrayExpressiP92976.
    GenevestigatoriP92976.

    Structurei

    3D structure databases

    ProteinModelPortaliP92976.
    SMRiP92976. Positions 40-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the strictosidine synthase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3386.
    HOGENOMiHOG000223915.
    InParanoidiP92976.
    KOiK01757.
    OMAiDFAQITN.
    PhylomeDBiP92976.

    Family and domain databases

    Gene3Di2.120.10.30. 1 hit.
    InterProiIPR011042. 6-blade_b-propeller_TolB-like.
    IPR018119. Strictosidine_synth_cons-reg.
    IPR004141. Strictosidine_synthase.
    [Graphical view]
    PANTHERiPTHR10426:SF22. PTHR10426:SF22. 1 hit.
    PfamiPF03088. Str_synth. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P92976-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMRSFVSLIS LLLLLSFSSS VLSTKKSSFQ KLPVPGNRTG PEAFAFDSTG    50
    KGFYTGVTGG KILKYLPKKG YVDFAQITNS SKSSLCDGAL GTTNVEKCGR 100
    PAGIAFNTKT GDLYVADAAL GLHVIPRRGG LAKKIADSVG GKPFLFLDGL 150
    DVDPTTGVVY FTSFSSTFGP RDVLKAVATK DSTGKFFKYD PSKKVVTVLM 200
    EGLSGSAGCA VSSDGSFVLV GQFTKSNIKR YWIKGSKAGT SEDFTNSVSN 250
    PDNIKRIGST GNFWVASVVN SATGPTNPSA VKVSSAGKVL QTIPLKDKFG 300
    DTLVSEVNEY KGQLYIGALF GPFAGILKL 329
    Length:329
    Mass (Da):34,667
    Last modified:June 6, 2002 - v2
    Checksum:iC549547884B6E1C1
    GO

    Sequence cautioni

    The sequence AAB40595.1 differs from that shown. Reason: Frameshift at positions 309 and 327.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti54 – 552YT → LP in AAB40595. 1 PublicationCurated
    Sequence conflicti155 – 1551T → N in AAB40595. 1 PublicationCurated
    Sequence conflicti201 – 2011E → D in AAB40595. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43946 mRNA. Translation: AAB40595.1. Frameshift.
    AC016662 Genomic DNA. Translation: AAG52519.1.
    CP002684 Genomic DNA. Translation: AEE35536.1.
    PIRiG96767.
    RefSeqiNP_177540.3. NM_106059.4.
    UniGeneiAt.18213.

    Genome annotation databases

    EnsemblPlantsiAT1G74000.1; AT1G74000.1; AT1G74000.
    GeneIDi843738.
    KEGGiath:AT1G74000.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43946 mRNA. Translation: AAB40595.1 . Frameshift.
    AC016662 Genomic DNA. Translation: AAG52519.1 .
    CP002684 Genomic DNA. Translation: AEE35536.1 .
    PIRi G96767.
    RefSeqi NP_177540.3. NM_106059.4.
    UniGenei At.18213.

    3D structure databases

    ProteinModelPortali P92976.
    SMRi P92976. Positions 40-327.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P92976.
    PRIDEi P92976.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G74000.1 ; AT1G74000.1 ; AT1G74000 .
    GeneIDi 843738.
    KEGGi ath:AT1G74000.

    Organism-specific databases

    TAIRi AT1G74000.

    Phylogenomic databases

    eggNOGi COG3386.
    HOGENOMi HOG000223915.
    InParanoidi P92976.
    KOi K01757.
    OMAi DFAQITN.
    PhylomeDBi P92976.

    Enzyme and pathway databases

    UniPathwayi UPA00311 ; UER00447 .
    BioCyci ARA:AT1G74000-MONOMER.

    Gene expression databases

    ArrayExpressi P92976.
    Genevestigatori P92976.

    Family and domain databases

    Gene3Di 2.120.10.30. 1 hit.
    InterProi IPR011042. 6-blade_b-propeller_TolB-like.
    IPR018119. Strictosidine_synth_cons-reg.
    IPR004141. Strictosidine_synthase.
    [Graphical view ]
    PANTHERi PTHR10426:SF22. PTHR10426:SF22. 1 hit.
    Pfami PF03088. Str_synth. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Jain A.K., Nessler C.L.
      Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Landsberg erecta.
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiSTS3_ARATH
    AccessioniPrimary (citable) accession number: P92976
    Secondary accession number(s): Q9C9C1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: June 6, 2002
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-2 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3