Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P92976

- STS3_ARATH

UniProt

P92976 - STS3_ARATH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Strictosidine synthase 3

Gene

SS3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.By similarity

Catalytic activityi

3-alpha-(S)-strictosidine + H2O = tryptamine + secologanin.

Pathwayi

GO - Molecular functioni

  1. strictosidine synthase activity Source: TAIR

GO - Biological processi

  1. alkaloid metabolic process Source: UniProtKB-KW
  2. biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Alkaloid metabolism

Enzyme and pathway databases

BioCyciARA:AT1G74000-MONOMER.
UniPathwayiUPA00311; UER00447.

Names & Taxonomyi

Protein namesi
Recommended name:
Strictosidine synthase 3 (EC:4.3.3.2)
Short name:
SS-3
Gene namesi
Name:SS3
Ordered Locus Names:At1g74000
ORF Names:F2P9.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G74000.

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. cell wall Source: TAIR
  2. plant-type cell wall Source: TAIR
  3. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 329306Strictosidine synthase 3PRO_0000033331Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP92976.
PRIDEiP92976.

Expressioni

Gene expression databases

ExpressionAtlasiP92976. baseline and differential.
GenevestigatoriP92976.

Structurei

3D structure databases

ProteinModelPortaliP92976.
SMRiP92976. Positions 40-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the strictosidine synthase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3386.
HOGENOMiHOG000223915.
KOiK01757.
OMAiDFAQITN.
PhylomeDBiP92976.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR018119. Strictosidine_synth_cons-reg.
IPR004141. Strictosidine_synthase.
[Graphical view]
PANTHERiPTHR10426:SF22. PTHR10426:SF22. 1 hit.
PfamiPF03088. Str_synth. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P92976-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMRSFVSLIS LLLLLSFSSS VLSTKKSSFQ KLPVPGNRTG PEAFAFDSTG
60 70 80 90 100
KGFYTGVTGG KILKYLPKKG YVDFAQITNS SKSSLCDGAL GTTNVEKCGR
110 120 130 140 150
PAGIAFNTKT GDLYVADAAL GLHVIPRRGG LAKKIADSVG GKPFLFLDGL
160 170 180 190 200
DVDPTTGVVY FTSFSSTFGP RDVLKAVATK DSTGKFFKYD PSKKVVTVLM
210 220 230 240 250
EGLSGSAGCA VSSDGSFVLV GQFTKSNIKR YWIKGSKAGT SEDFTNSVSN
260 270 280 290 300
PDNIKRIGST GNFWVASVVN SATGPTNPSA VKVSSAGKVL QTIPLKDKFG
310 320
DTLVSEVNEY KGQLYIGALF GPFAGILKL
Length:329
Mass (Da):34,667
Last modified:June 6, 2002 - v2
Checksum:iC549547884B6E1C1
GO

Sequence cautioni

The sequence AAB40595.1 differs from that shown. Reason: Frameshift at positions 309 and 327. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 552YT → LP in AAB40595. 1 PublicationCurated
Sequence conflicti155 – 1551T → N in AAB40595. 1 PublicationCurated
Sequence conflicti201 – 2011E → D in AAB40595. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43946 mRNA. Translation: AAB40595.1. Frameshift.
AC016662 Genomic DNA. Translation: AAG52519.1.
CP002684 Genomic DNA. Translation: AEE35536.1.
PIRiG96767.
RefSeqiNP_177540.3. NM_106059.4.
UniGeneiAt.18213.

Genome annotation databases

EnsemblPlantsiAT1G74000.1; AT1G74000.1; AT1G74000.
GeneIDi843738.
KEGGiath:AT1G74000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43946 mRNA. Translation: AAB40595.1 . Frameshift.
AC016662 Genomic DNA. Translation: AAG52519.1 .
CP002684 Genomic DNA. Translation: AEE35536.1 .
PIRi G96767.
RefSeqi NP_177540.3. NM_106059.4.
UniGenei At.18213.

3D structure databases

ProteinModelPortali P92976.
SMRi P92976. Positions 40-327.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P92976.
PRIDEi P92976.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G74000.1 ; AT1G74000.1 ; AT1G74000 .
GeneIDi 843738.
KEGGi ath:AT1G74000.

Organism-specific databases

TAIRi AT1G74000.

Phylogenomic databases

eggNOGi COG3386.
HOGENOMi HOG000223915.
KOi K01757.
OMAi DFAQITN.
PhylomeDBi P92976.

Enzyme and pathway databases

UniPathwayi UPA00311 ; UER00447 .
BioCyci ARA:AT1G74000-MONOMER.

Gene expression databases

ExpressionAtlasi P92976. baseline and differential.
Genevestigatori P92976.

Family and domain databases

Gene3Di 2.120.10.30. 1 hit.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR018119. Strictosidine_synth_cons-reg.
IPR004141. Strictosidine_synthase.
[Graphical view ]
PANTHERi PTHR10426:SF22. PTHR10426:SF22. 1 hit.
Pfami PF03088. Str_synth. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Jain A.K., Nessler C.L.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Landsberg erecta.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.

Entry informationi

Entry nameiSTS3_ARATH
AccessioniPrimary (citable) accession number: P92976
Secondary accession number(s): Q9C9C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 6, 2002
Last modified: October 29, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3