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Protein

Chloride channel protein CLC-d

Gene

CLC-D

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Voltage-gated chloride channel.

GO - Molecular functioni

GO - Biological processi

  • unidimensional cell growth Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiR-ATH-2672351. Stimuli-sensing channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride channel protein CLC-d
Short name:
AtCLC-d
Alternative name(s):
CBS domain-containing protein CBSCLC2
Gene namesi
Name:CLC-D
Synonyms:CBSCLC2
Ordered Locus Names:At5g26240
ORF Names:F9D12.10, T19G15.90
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G26240.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei78 – 98Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei119 – 139Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei170 – 190Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei195 – 215Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei237 – 257Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei267 – 287Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei320 – 340Helical; Name=7Sequence analysisAdd BLAST21
Transmembranei361 – 381Helical; Name=8Sequence analysisAdd BLAST21
Transmembranei451 – 471Helical; Name=9Sequence analysisAdd BLAST21
Transmembranei474 – 494Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei508 – 528Helical; Name=11Sequence analysisAdd BLAST21
Transmembranei529 – 549Helical; Name=12Sequence analysisAdd BLAST21
Transmembranei731 – 751Helical; Name=13Sequence analysisAdd BLAST21

GO - Cellular componenti

  • chloride channel complex Source: UniProtKB-KW
  • trans-Golgi network Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi180I → R: Abolishes the activity. 1 Publication1
Mutagenesisi187L → R: Abolishes the activity. 1 Publication1
Mutagenesisi471P → L: Abolishes the activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000944681 – 792Chloride channel protein CLC-dAdd BLAST792

Proteomic databases

PaxDbiP92943.
PRIDEiP92943.

PTM databases

iPTMnetiP92943.

Expressioni

Tissue specificityi

Broadly expressed in the plant, but predominantly in the silique.

Gene expression databases

GenevisibleiP92943. AT.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi17968. 1 interactor.
STRINGi3702.AT5G26240.1.

Structurei

3D structure databases

ProteinModelPortaliP92943.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini592 – 652CBS 1PROSITE-ProRule annotationAdd BLAST61
Domaini704 – 761CBS 2PROSITE-ProRule annotationAdd BLAST58

Sequence similaritiesi

Contains 2 CBS domains.PROSITE-ProRule annotation

Keywords - Domaini

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0474. Eukaryota.
COG0038. LUCA.
HOGENOMiHOG000231081.
InParanoidiP92943.
KOiK05016.
OMAiTNSGIEC.
OrthoDBiEOG093602TR.
PhylomeDBiP92943.

Family and domain databases

Gene3Di1.10.3080.10. 2 hits.
InterProiIPR000644. CBS_dom.
IPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
IPR002251. Cl_channel_pln.
[Graphical view]
PfamiPF00571. CBS. 1 hit.
PF00654. Voltage_CLC. 1 hit.
[Graphical view]
PRINTSiPR00762. CLCHANNEL.
PR01120. CLCHANNELPLT.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
SUPFAMiSSF81340. SSF81340. 2 hits.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P92943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSNHLQNGI ESDNLLWSRV PESDDTSTDD ITLLNSHRDG DGGVNSLDYE
60 70 80 90 100
VIENYAYREE QAHRGKLYVG YYVAVKWFFS LLIGIGTGLA AVFINLSVEN
110 120 130 140 150
FAGWKFALTF AIIQKSYFAG FIVYLLINLV LVFSSAYIIT QFAPAAAGSG
160 170 180 190 200
IPEIKGYLNG IDIPGTLLFR TLIGKIFGSI GSVGGGLALG KEGPLVHTGA
210 220 230 240 250
CIASLLGQGG STKYHLNSRW PQLFKSDRDR RDLVTCGCAA GVAAAFRAPV
260 270 280 290 300
GGVLFALEEV TSWWRSQLMW RVFFTSAIVA VVVRTAMGWC KSGICGHFGG
310 320 330 340 350
GGFIIWDVSD GQDDYYFKEL LPMAVIGVIG GLLGALFNQL TLYMTSWRRN
360 370 380 390 400
SLHKKGNRVK IIEACIISCI TSAISFGLPL LRKCSPCPES VPDSGIECPR
410 420 430 440 450
PPGMYGNYVN FFCKTDNEYN DLATIFFNTQ DDAIRNLFSA KTMREFSAQS
460 470 480 490 500
LLTFLAMFYT LAVVTFGTAV PAGQFVPGIM IGSTYGRLVG MFVVRFYKKL
510 520 530 540 550
NIEEGTYALL GAASFLGGSM RMTVSLCVIM VEITNNLKLL PLIMLVLLIS
560 570 580 590 600
KAVGDAFNEG LYEVQARLKG IPLLESRPKY HMRQMIAKEA CQSQKVISLP
610 620 630 640 650
RVIRVADVAS ILGSNKHNGF PVIDHTRSGE TLVIGLVLRS HLLVLLQSKV
660 670 680 690 700
DFQHSPLPCD PSARNIRHSF SEFAKPVSSK GLCIEDIHLT SDDLEMYIDL
710 720 730 740 750
APFLNPSPYV VPEDMSLTKV YNLFRQLGLR HLFVVPRPSR VIGLITRKDL
760 770 780 790
LIEENGESSA VELQQSTSVR GRYSETATRM DAARPLLDDL LG
Length:792
Mass (Da):87,062
Last modified:February 2, 2004 - v2
Checksum:i45B136A2A8CCE85A
GO

Sequence cautioni

The sequence AAC26247 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti775E → D in CAA96065 (PubMed:8969232).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71450 mRNA. Translation: CAA96065.1.
AC005965 Genomic DNA. No translation available.
AF077407 Genomic DNA. Translation: AAC26247.2. Sequence problems.
CP002688 Genomic DNA. Translation: AED93540.1.
PIRiT01843.
RefSeqiNP_197996.1. NM_122525.3.
UniGeneiAt.25560.

Genome annotation databases

EnsemblPlantsiAT5G26240.1; AT5G26240.1; AT5G26240.
GeneIDi832693.
GrameneiAT5G26240.1; AT5G26240.1; AT5G26240.
KEGGiath:AT5G26240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71450 mRNA. Translation: CAA96065.1.
AC005965 Genomic DNA. No translation available.
AF077407 Genomic DNA. Translation: AAC26247.2. Sequence problems.
CP002688 Genomic DNA. Translation: AED93540.1.
PIRiT01843.
RefSeqiNP_197996.1. NM_122525.3.
UniGeneiAt.25560.

3D structure databases

ProteinModelPortaliP92943.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi17968. 1 interactor.
STRINGi3702.AT5G26240.1.

PTM databases

iPTMnetiP92943.

Proteomic databases

PaxDbiP92943.
PRIDEiP92943.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G26240.1; AT5G26240.1; AT5G26240.
GeneIDi832693.
GrameneiAT5G26240.1; AT5G26240.1; AT5G26240.
KEGGiath:AT5G26240.

Organism-specific databases

TAIRiAT5G26240.

Phylogenomic databases

eggNOGiKOG0474. Eukaryota.
COG0038. LUCA.
HOGENOMiHOG000231081.
InParanoidiP92943.
KOiK05016.
OMAiTNSGIEC.
OrthoDBiEOG093602TR.
PhylomeDBiP92943.

Enzyme and pathway databases

ReactomeiR-ATH-2672351. Stimuli-sensing channels.

Miscellaneous databases

PROiP92943.

Gene expression databases

GenevisibleiP92943. AT.

Family and domain databases

Gene3Di1.10.3080.10. 2 hits.
InterProiIPR000644. CBS_dom.
IPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
IPR002251. Cl_channel_pln.
[Graphical view]
PfamiPF00571. CBS. 1 hit.
PF00654. Voltage_CLC. 1 hit.
[Graphical view]
PRINTSiPR00762. CLCHANNEL.
PR01120. CLCHANNELPLT.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
SUPFAMiSSF81340. SSF81340. 2 hits.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLCD_ARATH
AccessioniPrimary (citable) accession number: P92943
Secondary accession number(s): O81491
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 2, 2004
Last modified: November 30, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.