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Protein

Chloride channel protein CLC-b

Gene

CLC-B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Voltage-gated chloride channel.

GO - Molecular functioni

  • nitrate:proton symporter activity Source: TAIR
  • voltage-gated chloride channel activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionChloride channel, Ion channel, Voltage-gated channel
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-ATH-2672351 Stimuli-sensing channels

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride channel protein CLC-b
Short name:
AtCLC-b
Alternative name(s):
CBS domain-containing protein CBSCLC7
Gene namesi
Name:CLC-B
Synonyms:CBSCLC7
Ordered Locus Names:At3g27170
ORF Names:MYF5.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G27170
TAIRilocus:2095123 AT3G27170

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei87 – 107Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei130 – 150Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei177 – 197Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei205 – 225Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei247 – 267Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei277 – 297Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei327 – 347Helical; Name=7Sequence analysisAdd BLAST21
Transmembranei370 – 390Helical; Name=8Sequence analysisAdd BLAST21
Transmembranei452 – 472Helical; Name=9Sequence analysisAdd BLAST21
Transmembranei477 – 497Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei509 – 529Helical; Name=11Sequence analysisAdd BLAST21
Transmembranei530 – 550Helical; Name=12Sequence analysisAdd BLAST21
Transmembranei735 – 755Helical; Name=13Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000944661 – 780Chloride channel protein CLC-bAdd BLAST780

Proteomic databases

PaxDbiP92942

PTM databases

iPTMnetiP92942

Expressioni

Tissue specificityi

Broadly expressed in the plant.

Gene expression databases

ExpressionAtlasiP92942 baseline and differential
GenevisibleiP92942 AT

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with PP2A5 (PubMed:27676158).By similarity1 Publication

Protein-protein interaction databases

BioGridi7666, 18 interactors
IntActiP92942, 1 interactor
STRINGi3702.AT3G27170.1

Structurei

3D structure databases

ProteinModelPortaliP92942
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini594 – 663CBS 1PROSITE-ProRule annotationAdd BLAST70
Domaini708 – 770CBS 2PROSITE-ProRule annotationAdd BLAST63

Sequence similaritiesi

Keywords - Domaini

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0474 Eukaryota
COG0038 LUCA
HOGENOMiHOG000231081
InParanoidiP92942
KOiK05016
OMAiMEERFRP
OrthoDBiEOG093602TR
PhylomeDBiP92942

Family and domain databases

InterProiView protein in InterPro
IPR000644 CBS_dom
IPR014743 Cl-channel_core
IPR001807 Cl-channel_volt-gated
IPR002251 Cl_channel_pln
PfamiView protein in Pfam
PF00571 CBS, 1 hit
PF00654 Voltage_CLC, 1 hit
PRINTSiPR00762 CLCHANNEL
PR01120 CLCHANNELPLT
SMARTiView protein in SMART
SM00116 CBS, 2 hits
SUPFAMiSSF81340 SSF81340, 2 hits
PROSITEiView protein in PROSITE
PS51371 CBS, 2 hits

Sequencei

Sequence statusi: Complete.

P92942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEEDLNQIG GNSNYNGEGG DPESNTLNQP LVKANRTLSS TPLALVGAKV
60 70 80 90 100
SHIESLDYEI NENDLFKHDW RKRSKAQVLQ YVFLKWTLAC LVGLFTGLIA
110 120 130 140 150
TLINLAVENI AGYKLLAVGH FLTQERYVTG LMVLVGANLG LTLVASVLCV
160 170 180 190 200
CFAPTAAGPG IPEIKAYLNG VDTPNMFGAT TMIVKIVGSI GAVAAGLDLG
210 220 230 240 250
KEGPLVHIGS CIASLLGQGG TDNHRIKWRW LRYFNNDRDR RDLITCGSAA
260 270 280 290 300
GVCAAFRSPV GGVLFALEEV ATWWRSALLW RTFFSTAVVV VVLREFIEIC
310 320 330 340 350
NSGKCGLFGK GGLIMFDVSH VTYTYHVTDI IPVMLIGVIG GILGSLYNHL
360 370 380 390 400
LHKVLRLYNL INEKGKIHKV LLSLTVSLFT SVCLYGLPFL AKCKPCDPSI
410 420 430 440 450
DEICPTNGRS GNFKQFHCPK GYYNDLATLL LTTNDDAVRN LFSSNTPNEF
460 470 480 490 500
GMGSLWIFFV LYCILGLFTF GIATPSGLFL PIILMGAAYG RMLGAAMGSY
510 520 530 540 550
TSIDQGLYAV LGAAALMAGS MRMTVSLCVI FLELTNNLLL LPITMIVLLI
560 570 580 590 600
AKTVGDSFNP SIYDIILHLK GLPFLEANPE PWMRNLTVGE LGDAKPPVVT
610 620 630 640 650
LQGVEKVSNI VDVLKNTTHN AFPVLDEAEV PQVGLATGAT ELHGLILRAH
660 670 680 690 700
LVKVLKKRWF LTEKRRTEEW EVREKFPWDE LAEREDNFDD VAITSAEMEM
710 720 730 740 750
YVDLHPLTNT TPYTVMENMS VAKALVLFRQ VGLRHLLIVP KIQASGMCPV
760 770 780
VGILTRQDLR AYNILQAFPL LEKSKGGKTH
Length:780
Mass (Da):85,458
Last modified:May 1, 1997 - v1
Checksum:i0E9FB0FBF52AEAA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71446 mRNA Translation: CAA96058.1
AP001312 Genomic DNA Translation: BAB01934.1
CP002686 Genomic DNA Translation: AEE77275.1
AY062518 mRNA Translation: AAL32596.1
RefSeqiNP_189353.1, NM_113631.4
UniGeneiAt.15
At.37101

Genome annotation databases

EnsemblPlantsiAT3G27170.1; AT3G27170.1; AT3G27170
GeneIDi822336
GrameneiAT3G27170.1; AT3G27170.1; AT3G27170
KEGGiath:AT3G27170

Similar proteinsi

Entry informationi

Entry nameiCLCB_ARATH
AccessioniPrimary (citable) accession number: P92942
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health