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Protein

Chloride channel protein CLC-b

Gene

CLC-B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Voltage-gated chloride channel.

GO - Molecular functioni

  • nitrate:proton symporter activity Source: TAIR
  • voltage-gated chloride channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiR-ATH-2672351. Stimuli-sensing channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride channel protein CLC-b
Short name:
AtCLC-b
Alternative name(s):
CBS domain-containing protein CBSCLC7
Gene namesi
Name:CLC-B
Synonyms:CBSCLC7
Ordered Locus Names:At3g27170
ORF Names:MYF5.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G27170.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei87 – 10721Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei130 – 15021Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei177 – 19721Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei205 – 22521Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei247 – 26721Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=6Sequence analysisAdd
BLAST
Transmembranei327 – 34721Helical; Name=7Sequence analysisAdd
BLAST
Transmembranei370 – 39021Helical; Name=8Sequence analysisAdd
BLAST
Transmembranei452 – 47221Helical; Name=9Sequence analysisAdd
BLAST
Transmembranei477 – 49721Helical; Name=10Sequence analysisAdd
BLAST
Transmembranei509 – 52921Helical; Name=11Sequence analysisAdd
BLAST
Transmembranei530 – 55021Helical; Name=12Sequence analysisAdd
BLAST
Transmembranei735 – 75521Helical; Name=13Sequence analysisAdd
BLAST

GO - Cellular componenti

  • chloride channel complex Source: UniProtKB-KW
  • plant-type vacuole membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 780780Chloride channel protein CLC-bPRO_0000094466Add
BLAST

Proteomic databases

PaxDbiP92942.
PRIDEiP92942.

PTM databases

iPTMnetiP92942.

Expressioni

Tissue specificityi

Broadly expressed in the plant.

Gene expression databases

GenevisibleiP92942. AT.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi7666. 18 interactions.
STRINGi3702.AT3G27170.1.

Structurei

3D structure databases

ProteinModelPortaliP92942.
SMRiP92942. Positions 79-626.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini594 – 66370CBS 1PROSITE-ProRule annotationAdd
BLAST
Domaini708 – 77063CBS 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 CBS domains.PROSITE-ProRule annotation

Keywords - Domaini

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0474. Eukaryota.
COG0038. LUCA.
HOGENOMiHOG000231081.
InParanoidiP92942.
KOiK05016.
OMAiYTSIDQG.
OrthoDBiEOG093602TR.
PhylomeDBiP92942.

Family and domain databases

Gene3Di1.10.3080.10. 2 hits.
InterProiIPR000644. CBS_dom.
IPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
IPR002251. Cl_channel_pln.
[Graphical view]
PfamiPF00571. CBS. 1 hit.
PF00654. Voltage_CLC. 1 hit.
[Graphical view]
PRINTSiPR00762. CLCHANNEL.
PR01120. CLCHANNELPLT.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
SUPFAMiSSF81340. SSF81340. 2 hits.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P92942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEEDLNQIG GNSNYNGEGG DPESNTLNQP LVKANRTLSS TPLALVGAKV
60 70 80 90 100
SHIESLDYEI NENDLFKHDW RKRSKAQVLQ YVFLKWTLAC LVGLFTGLIA
110 120 130 140 150
TLINLAVENI AGYKLLAVGH FLTQERYVTG LMVLVGANLG LTLVASVLCV
160 170 180 190 200
CFAPTAAGPG IPEIKAYLNG VDTPNMFGAT TMIVKIVGSI GAVAAGLDLG
210 220 230 240 250
KEGPLVHIGS CIASLLGQGG TDNHRIKWRW LRYFNNDRDR RDLITCGSAA
260 270 280 290 300
GVCAAFRSPV GGVLFALEEV ATWWRSALLW RTFFSTAVVV VVLREFIEIC
310 320 330 340 350
NSGKCGLFGK GGLIMFDVSH VTYTYHVTDI IPVMLIGVIG GILGSLYNHL
360 370 380 390 400
LHKVLRLYNL INEKGKIHKV LLSLTVSLFT SVCLYGLPFL AKCKPCDPSI
410 420 430 440 450
DEICPTNGRS GNFKQFHCPK GYYNDLATLL LTTNDDAVRN LFSSNTPNEF
460 470 480 490 500
GMGSLWIFFV LYCILGLFTF GIATPSGLFL PIILMGAAYG RMLGAAMGSY
510 520 530 540 550
TSIDQGLYAV LGAAALMAGS MRMTVSLCVI FLELTNNLLL LPITMIVLLI
560 570 580 590 600
AKTVGDSFNP SIYDIILHLK GLPFLEANPE PWMRNLTVGE LGDAKPPVVT
610 620 630 640 650
LQGVEKVSNI VDVLKNTTHN AFPVLDEAEV PQVGLATGAT ELHGLILRAH
660 670 680 690 700
LVKVLKKRWF LTEKRRTEEW EVREKFPWDE LAEREDNFDD VAITSAEMEM
710 720 730 740 750
YVDLHPLTNT TPYTVMENMS VAKALVLFRQ VGLRHLLIVP KIQASGMCPV
760 770 780
VGILTRQDLR AYNILQAFPL LEKSKGGKTH
Length:780
Mass (Da):85,458
Last modified:May 1, 1997 - v1
Checksum:i0E9FB0FBF52AEAA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71446 mRNA. Translation: CAA96058.1.
AP001312 Genomic DNA. Translation: BAB01934.1.
CP002686 Genomic DNA. Translation: AEE77275.1.
AY062518 mRNA. Translation: AAL32596.1.
RefSeqiNP_189353.1. NM_113631.3.
UniGeneiAt.15.
At.37101.

Genome annotation databases

EnsemblPlantsiAT3G27170.1; AT3G27170.1; AT3G27170.
GeneIDi822336.
GrameneiAT3G27170.1; AT3G27170.1; AT3G27170.
KEGGiath:AT3G27170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71446 mRNA. Translation: CAA96058.1.
AP001312 Genomic DNA. Translation: BAB01934.1.
CP002686 Genomic DNA. Translation: AEE77275.1.
AY062518 mRNA. Translation: AAL32596.1.
RefSeqiNP_189353.1. NM_113631.3.
UniGeneiAt.15.
At.37101.

3D structure databases

ProteinModelPortaliP92942.
SMRiP92942. Positions 79-626.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi7666. 18 interactions.
STRINGi3702.AT3G27170.1.

PTM databases

iPTMnetiP92942.

Proteomic databases

PaxDbiP92942.
PRIDEiP92942.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G27170.1; AT3G27170.1; AT3G27170.
GeneIDi822336.
GrameneiAT3G27170.1; AT3G27170.1; AT3G27170.
KEGGiath:AT3G27170.

Organism-specific databases

TAIRiAT3G27170.

Phylogenomic databases

eggNOGiKOG0474. Eukaryota.
COG0038. LUCA.
HOGENOMiHOG000231081.
InParanoidiP92942.
KOiK05016.
OMAiYTSIDQG.
OrthoDBiEOG093602TR.
PhylomeDBiP92942.

Enzyme and pathway databases

ReactomeiR-ATH-2672351. Stimuli-sensing channels.

Miscellaneous databases

PROiP92942.

Gene expression databases

GenevisibleiP92942. AT.

Family and domain databases

Gene3Di1.10.3080.10. 2 hits.
InterProiIPR000644. CBS_dom.
IPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
IPR002251. Cl_channel_pln.
[Graphical view]
PfamiPF00571. CBS. 1 hit.
PF00654. Voltage_CLC. 1 hit.
[Graphical view]
PRINTSiPR00762. CLCHANNEL.
PR01120. CLCHANNELPLT.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
SUPFAMiSSF81340. SSF81340. 2 hits.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLCB_ARATH
AccessioniPrimary (citable) accession number: P92942
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.