P92693 (COX2_PONAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:	MT-CO2
Synonyms:	COII, COXII, MTCO2

Encoded on

Mitochondrion

Organism

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) [Reference proteome]

Taxonomic identifier

9601 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Ponginae › Pongo

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from sequence or structural similarity. Source: UniProtKB respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Cytochrome c oxidase subunit 2		PRO_0000183668
Regions
	Topological domain	1 – 26	26	Mitochondrial intermembrane Potential
	Transmembrane	27 – 48	22	Helical; Potential
	Topological domain	49 – 62	14	Mitochondrial matrix Potential
	Transmembrane	63 – 82	20	Helical; Potential
	Topological domain	83 – 227	145	Mitochondrial intermembrane Potential
Sites
	Metal binding	161	1	Copper A By similarity
	Metal binding	196	1	Copper A By similarity
	Metal binding	200	1	Copper A By similarity
	Metal binding	204	1	Copper A By similarity

Sequences

	Sequence		Length	Mass (Da)
	P92693 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 3C27B12B79E83CE2	FASTA	227	25,582
	10 20 30 40 50 60 MAHAAQVGLQ DATSPIMEEL VIFHDHALMI IFLICFLVLY ALFLTLTTKL TNTSISDAQE 70 80 90 100 110 120 METIWTILPA IILILIALPS LRILYLTDEI NDPSFTIKSI GHQWYWTYEY TDYGGLIFNS 130 140 150 160 170 180 YMLPPLFLEP GDLRLLDVDN RVVLPVEAPV RMMITSQDVL HSWTVPSLGL KTDAIPGRLN 190 200 210 220 QTTFTATRPG VYYGQCSEIC GANHSFMPIV LELIPLKIFE MGPVFTL

References

[1]	"The mitochondrial DNA molecule of Sumatran orangutan and a molecular proposal for two (Bornean and Sumatran) species of orangutan." Xu X., Arnason U. J. Mol. Evol. 43:431-437(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Isolate YN93-312.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X97707 Genomic DNA. Translation: CAA66286.1.
RefSeq	NP_007838.1. NC_002083.1.
3D structure databases
ProteinModelPortal	P92693.
SMR	P92693. Positions 1-220.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSPPYT00000024437; ENSPPYP00000023442; ENSPPYG00000020958.
GeneID	808475.
KEGG	pon:808475.
Organism-specific databases
CTD	4513.
Phylogenomic databases
GeneTree	ENSGT00390000017410.
HOVERGEN	HBG012727.
KO	K02261.
OrthoDB	EOG4BZN3N.
ProtClustDB	MTH00098.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR014222. Cyt_c_oxidase_su2. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
TIGRFAMs	TIGR02866. CoxB. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_PONAB

Accession

Primary (citable) accession number: P92693

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program