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Protein

Cytochrome b

Gene

MT-CYB

Organism
Mammuthus primigenius (Siberian woolly mammoth)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.By similarity

Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83Iron 1 (heme b562 axial ligand)By similarity1
Metal bindingi97Iron 2 (heme b566 axial ligand)By similarity1
Metal bindingi182Iron 1 (heme b562 axial ligand)By similarity1
Metal bindingi196Iron 2 (heme b566 axial ligand)By similarity1
Binding sitei201UbiquinoneBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b
Alternative name(s):
Complex III subunit 3
Complex III subunit III
Cytochrome b-c1 complex subunit 3
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Gene namesi
Name:MT-CYB
Synonyms:COB, CYTB, MTCYB
Encoded oniMitochondrion
OrganismiMammuthus primigenius (Siberian woolly mammoth)
Taxonomic identifieri37349 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaProboscideaElephantidaeMammuthus

Subcellular locationi

  • Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53HelicalBy similarityAdd BLAST21
Transmembranei77 – 98HelicalBy similarityAdd BLAST22
Transmembranei113 – 133HelicalBy similarityAdd BLAST21
Transmembranei178 – 198HelicalBy similarityAdd BLAST21
Transmembranei226 – 246HelicalBy similarityAdd BLAST21
Transmembranei288 – 308HelicalBy similarityAdd BLAST21
Transmembranei320 – 340HelicalBy similarityAdd BLAST21
Transmembranei347 – 367HelicalBy similarityAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000611501 – 378Cytochrome bAdd BLAST378

Interactioni

Subunit structurei

The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP92658.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome b family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017694.

Family and domain databases

CDDicd00284. Cytochrome_b_N. 1 hit.
Gene3Di1.20.810.10. 1 hit.
InterProiIPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR030689. Cytochrome_b.
IPR016174. Di-haem_cyt_TM.
[Graphical view]
PfamiPF00032. Cytochrom_B_C. 1 hit.
PF00033. Cytochrome_B. 1 hit.
[Graphical view]
PIRSFiPIRSF038885. COB. 1 hit.
SUPFAMiSSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEiPS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P92658-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHIRKSHPL LKILNKSFID LPTPSNISTW WNFGSLLGAC LITQILTGLF
60 70 80 90 100
LAMHYTPDTM TAFSSMSHIC RDVNYGWIIR QLHSNGASIF FLCLYTHIGR
110 120 130 140 150
NIYYGSYLYS ETWNTGIMLL LITMATAFMG YVLPWGQMSF WGATVITNLF
160 170 180 190 200
SAIPYIGTDL VEWIWGGFSV DKATLNRFFA LHFILPFTMI ALAGVHLTFL
210 220 230 240 250
HETGSNNPLG LTSDSDKIPF HPYYTIKDFL GLLILILFLL LLALLSPDML
260 270 280 290 300
GDPDNYMPAD PLNTPLHIKP EWYFLFAYAI LRSVPNKLGG VLALLLSILI
310 320 330 340 350
LGIMPLLHTS KHRSMMLRPL SQVLFWTLAT DLLMLTWIGS QPVEYPYIII
360 370
GQMASILYFS IILAFLPIAG MIENYLIK
Length:378
Mass (Da):42,777
Last modified:January 27, 2003 - v3
Checksum:i786EDA681CDB0958
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95 – 96Missing in AAD14109 (PubMed:8047136).Curated2
Sequence conflicti218I → V in BAA20277 (PubMed:9089080).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50842 Genomic DNA. Translation: BAA25008.1.
DQ188829 Genomic DNA. Translation: ABA29796.1.
DQ316067 Genomic DNA. Translation: ABC17890.1.
D83047 Genomic DNA. Translation: BAA20277.1.
U79411 Genomic DNA. Translation: AAB38284.1.
U23738 Genomic DNA. Translation: AAA73786.1.
U23739 Genomic DNA. Translation: AAA73787.1.
S72502 Genomic DNA. Translation: AAD14109.1.
RefSeqiYP_398766.1. NC_007596.2.

Genome annotation databases

GeneIDi3773153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50842 Genomic DNA. Translation: BAA25008.1.
DQ188829 Genomic DNA. Translation: ABA29796.1.
DQ316067 Genomic DNA. Translation: ABC17890.1.
D83047 Genomic DNA. Translation: BAA20277.1.
U79411 Genomic DNA. Translation: AAB38284.1.
U23738 Genomic DNA. Translation: AAA73786.1.
U23739 Genomic DNA. Translation: AAA73787.1.
S72502 Genomic DNA. Translation: AAD14109.1.
RefSeqiYP_398766.1. NC_007596.2.

3D structure databases

ProteinModelPortaliP92658.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3773153.

Organism-specific databases

CTDi4519.

Phylogenomic databases

HOVERGENiHBG017694.

Family and domain databases

CDDicd00284. Cytochrome_b_N. 1 hit.
Gene3Di1.20.810.10. 1 hit.
InterProiIPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR030689. Cytochrome_b.
IPR016174. Di-haem_cyt_TM.
[Graphical view]
PfamiPF00032. Cytochrom_B_C. 1 hit.
PF00033. Cytochrome_B. 1 hit.
[Graphical view]
PIRSFiPIRSF038885. COB. 1 hit.
SUPFAMiSSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEiPS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYB_MAMPR
AccessioniPrimary (citable) accession number: P92658
Secondary accession number(s): Q35052
, Q35053, Q36723, Q38PR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 27, 2003
Last modified: November 2, 2016
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.By similarity

Caution

The full-length protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools.By similarity

Keywords - Technical termi

Extinct organism protein

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.