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P92658 (CYB_MAMPR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome b
Alternative name(s):
Complex III subunit 3
Complex III subunit III
Cytochrome b-c1 complex subunit 3
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Gene names
Name:MT-CYB
Synonyms:COB, CYTB, MTCYB
Encoded onMitochondrion
OrganismMammuthus primigenius (Siberian woolly mammoth)
Taxonomic identifier37349 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaProboscideaElephantidaeMammuthus

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis By similarity.

Cofactor

Binds 2 heme groups non-covalently By similarity.

Subunit structure

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1) By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Miscellaneous

Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm By similarity.

Sequence similarities

Belongs to the cytochrome b family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 378378Cytochrome b
PRO_0000061150

Regions

Transmembrane33 – 5321Helical; Potential
Transmembrane76 – 9823Helical; Potential
Transmembrane116 – 13621Helical; Potential
Transmembrane140 – 15819Helical; Potential
Transmembrane178 – 19821Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane288 – 30821Helical; Potential
Transmembrane323 – 34321Helical; Potential
Transmembrane348 – 36821Helical; Potential

Sites

Metal binding831Iron 1 (heme b562 axial ligand)
Metal binding971Iron 2 (heme b566 axial ligand)
Metal binding1821Iron 1 (heme b562 axial ligand)
Metal binding1961Iron 2 (heme b566 axial ligand)

Experimental info

Sequence conflict95 – 962Missing in AAD14109. Ref.7
Sequence conflict2181I → V in BAA20277. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P92658 [UniParc].

Last modified January 27, 2003. Version 3.
Checksum: 786EDA681CDB0958

FASTA37842,777
        10         20         30         40         50         60 
MTHIRKSHPL LKILNKSFID LPTPSNISTW WNFGSLLGAC LITQILTGLF LAMHYTPDTM 

        70         80         90        100        110        120 
TAFSSMSHIC RDVNYGWIIR QLHSNGASIF FLCLYTHIGR NIYYGSYLYS ETWNTGIMLL 

       130        140        150        160        170        180 
LITMATAFMG YVLPWGQMSF WGATVITNLF SAIPYIGTDL VEWIWGGFSV DKATLNRFFA 

       190        200        210        220        230        240 
LHFILPFTMI ALAGVHLTFL HETGSNNPLG LTSDSDKIPF HPYYTIKDFL GLLILILFLL 

       250        260        270        280        290        300 
LLALLSPDML GDPDNYMPAD PLNTPLHIKP EWYFLFAYAI LRSVPNKLGG VLALLLSILI 

       310        320        330        340        350        360 
LGIMPLLHTS KHRSMMLRPL SQVLFWTLAT DLLMLTWIGS QPVEYPYIII GQMASILYFS 

       370 
IILAFLPIAG MIENYLIK 

« Hide

References

[1]"Molecular phylogenetic inference of the woolly mammoth Mammuthus primigenius, based on complete sequences of mitochondrial cytochrome b and 12S ribosomal RNA genes."
Noro M., Masuda R., Dubrovo I.A., Yoshida M.C., Kato M.
J. Mol. Evol. 46:314-326(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Muscle.
[2]"Multiplex amplification of the mammoth mitochondrial genome and the evolution of Elephantidae."
Krause J., Dear P.H., Pollack J.L., Slatkin M., Spriggs H., Barnes I., Lister A.M., Ebersberger I., Paeaebo S., Hofreiter M.
Nature 439:724-727(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete mitochondrial genome and phylogeny of Pleistocene mammoth Mammuthus primigenius."
Rogaev E.I., Moliaka Y.K., Malyarchuk B.A., Kondrashov F.A., Derenko M.V., Chumakov I., Grigorenko A.P.
PLoS Biol. 4:403-410(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Muscle.
[4]"Phylogenetic position of mammoth and Steller's sea cow within Tethytheria demonstrated by mitochondrial DNA sequences."
Ozawa T., Hayashi S., Mikhelson V.M.
J. Mol. Evol. 44:406-413(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-335.
Tissue: Muscle.
[5]Derenko M., Malyarchuk B., Shields G.F.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-143.
[6]Yang H., Golenberg E.M., Shoshani J.
Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-106.
Strain: Isolate allele Fairbank and Isolate allele Lyakhovskiy.
[7]"DNA from ancient mammoth bones."
Hagelberg E., Thomas M.G., Cook C.E. Jr., Sher A.V., Baryshnikov G.F., Lister A.M.
Nature 370:333-334(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-114.
Tissue: Bone.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D50842 Genomic DNA. Translation: BAA25008.1.
DQ188829 Genomic DNA. Translation: ABA29796.1.
DQ316067 Genomic DNA. Translation: ABC17890.1.
D83047 Genomic DNA. Translation: BAA20277.1.
U79411 Genomic DNA. Translation: AAB38284.1.
U23738 Genomic DNA. Translation: AAA73786.1.
U23739 Genomic DNA. Translation: AAA73787.1.
S72502 Genomic DNA. Translation: AAD14109.1.
RefSeqYP_398766.1. NC_007596.2.

3D structure databases

ProteinModelPortalP92658.
SMRP92658. Positions 1-378.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3773153.

Organism-specific databases

CTD4519.

Phylogenomic databases

HOVERGENHBG017694.
ProtClustDBMTH00100.

Family and domain databases

Gene3D1.20.810.10. 1 hit.
InterProIPR016175. Cyt_b/b6.
IPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR016174. Di-haem_cyt_TM.
[Graphical view]
PANTHERPTHR19271:SF0. PTHR19271:SF0. 1 hit.
PfamPF00032. Cytochrom_B_C. 1 hit.
PF13631. Cytochrom_B_N_2. 1 hit.
[Graphical view]
SUPFAMSSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEPS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYB_MAMPR
AccessionPrimary (citable) accession number: P92658
Secondary accession number(s): Q35052 expand/collapse secondary AC list , Q35053, Q36723, Q38PR0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 27, 2003
Last modified: February 19, 2014
This is version 79 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families