SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P92658

- CYB_MAMPR

UniProt

P92658 - CYB_MAMPR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cytochrome b
Gene
MT-CYB, COB, CYTB, MTCYB
Organism
Mammuthus primigenius (Siberian woolly mammoth)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis By similarity.

Cofactori

Binds 2 heme groups non-covalently By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831Iron 1 (heme b562 axial ligand)
Metal bindingi97 – 971Iron 2 (heme b566 axial ligand)
Metal bindingi182 – 1821Iron 1 (heme b562 axial ligand)
Metal bindingi196 – 1961Iron 2 (heme b566 axial ligand)

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
  3. oxidoreductase activity Source: InterPro

GO - Biological processi

  1. respiratory electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b
Alternative name(s):
Complex III subunit 3
Complex III subunit III
Cytochrome b-c1 complex subunit 3
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Gene namesi
Name:MT-CYB
Synonyms:COB, CYTB, MTCYB
Encoded oniMitochondrion
OrganismiMammuthus primigenius (Siberian woolly mammoth)
Taxonomic identifieri37349 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaProboscideaElephantidaeMammuthus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321Helical; Reviewed prediction
Add
BLAST
Transmembranei76 – 9823Helical; Reviewed prediction
Add
BLAST
Transmembranei116 – 13621Helical; Reviewed prediction
Add
BLAST
Transmembranei140 – 15819Helical; Reviewed prediction
Add
BLAST
Transmembranei178 – 19821Helical; Reviewed prediction
Add
BLAST
Transmembranei229 – 24921Helical; Reviewed prediction
Add
BLAST
Transmembranei288 – 30821Helical; Reviewed prediction
Add
BLAST
Transmembranei323 – 34321Helical; Reviewed prediction
Add
BLAST
Transmembranei348 – 36821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Cytochrome b
PRO_0000061150Add
BLAST

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1) By similarity.

Structurei

3D structure databases

ProteinModelPortaliP92658.
SMRiP92658. Positions 1-378.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome b family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017694.

Family and domain databases

Gene3Di1.20.810.10. 1 hit.
InterProiIPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR016174. Di-haem_cyt_TM.
[Graphical view]
PfamiPF00032. Cytochrom_B_C. 1 hit.
PF13631. Cytochrom_B_N_2. 1 hit.
[Graphical view]
SUPFAMiSSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEiPS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P92658-1 [UniParc]FASTAAdd to Basket

« Hide

MTHIRKSHPL LKILNKSFID LPTPSNISTW WNFGSLLGAC LITQILTGLF    50
LAMHYTPDTM TAFSSMSHIC RDVNYGWIIR QLHSNGASIF FLCLYTHIGR 100
NIYYGSYLYS ETWNTGIMLL LITMATAFMG YVLPWGQMSF WGATVITNLF 150
SAIPYIGTDL VEWIWGGFSV DKATLNRFFA LHFILPFTMI ALAGVHLTFL 200
HETGSNNPLG LTSDSDKIPF HPYYTIKDFL GLLILILFLL LLALLSPDML 250
GDPDNYMPAD PLNTPLHIKP EWYFLFAYAI LRSVPNKLGG VLALLLSILI 300
LGIMPLLHTS KHRSMMLRPL SQVLFWTLAT DLLMLTWIGS QPVEYPYIII 350
GQMASILYFS IILAFLPIAG MIENYLIK 378
Length:378
Mass (Da):42,777
Last modified:January 27, 2003 - v3
Checksum:i786EDA681CDB0958
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 962Missing in AAD14109. 1 Publication
Sequence conflicti218 – 2181I → V in BAA20277. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50842 Genomic DNA. Translation: BAA25008.1.
DQ188829 Genomic DNA. Translation: ABA29796.1.
DQ316067 Genomic DNA. Translation: ABC17890.1.
D83047 Genomic DNA. Translation: BAA20277.1.
U79411 Genomic DNA. Translation: AAB38284.1.
U23738 Genomic DNA. Translation: AAA73786.1.
U23739 Genomic DNA. Translation: AAA73787.1.
S72502 Genomic DNA. Translation: AAD14109.1.
RefSeqiYP_398766.1. NC_007596.2.

Genome annotation databases

GeneIDi3773153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50842 Genomic DNA. Translation: BAA25008.1 .
DQ188829 Genomic DNA. Translation: ABA29796.1 .
DQ316067 Genomic DNA. Translation: ABC17890.1 .
D83047 Genomic DNA. Translation: BAA20277.1 .
U79411 Genomic DNA. Translation: AAB38284.1 .
U23738 Genomic DNA. Translation: AAA73786.1 .
U23739 Genomic DNA. Translation: AAA73787.1 .
S72502 Genomic DNA. Translation: AAD14109.1 .
RefSeqi YP_398766.1. NC_007596.2.

3D structure databases

ProteinModelPortali P92658.
SMRi P92658. Positions 1-378.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3773153.

Organism-specific databases

CTDi 4519.

Phylogenomic databases

HOVERGENi HBG017694.

Family and domain databases

Gene3Di 1.20.810.10. 1 hit.
InterProi IPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR016174. Di-haem_cyt_TM.
[Graphical view ]
Pfami PF00032. Cytochrom_B_C. 1 hit.
PF13631. Cytochrom_B_N_2. 1 hit.
[Graphical view ]
SUPFAMi SSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEi PS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular phylogenetic inference of the woolly mammoth Mammuthus primigenius, based on complete sequences of mitochondrial cytochrome b and 12S ribosomal RNA genes."
    Noro M., Masuda R., Dubrovo I.A., Yoshida M.C., Kato M.
    J. Mol. Evol. 46:314-326(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Muscle.
  2. "Multiplex amplification of the mammoth mitochondrial genome and the evolution of Elephantidae."
    Krause J., Dear P.H., Pollack J.L., Slatkin M., Spriggs H., Barnes I., Lister A.M., Ebersberger I., Paeaebo S., Hofreiter M.
    Nature 439:724-727(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete mitochondrial genome and phylogeny of Pleistocene mammoth Mammuthus primigenius."
    Rogaev E.I., Moliaka Y.K., Malyarchuk B.A., Kondrashov F.A., Derenko M.V., Chumakov I., Grigorenko A.P.
    PLoS Biol. 4:403-410(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Muscle.
  4. "Phylogenetic position of mammoth and Steller's sea cow within Tethytheria demonstrated by mitochondrial DNA sequences."
    Ozawa T., Hayashi S., Mikhelson V.M.
    J. Mol. Evol. 44:406-413(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-335.
    Tissue: Muscle.
  5. Derenko M., Malyarchuk B., Shields G.F.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-143.
  6. Yang H., Golenberg E.M., Shoshani J.
    Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-106.
    Strain: Isolate allele Fairbank and Isolate allele Lyakhovskiy.
  7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-114.
    Tissue: Bone.

Entry informationi

Entry nameiCYB_MAMPR
AccessioniPrimary (citable) accession number: P92658
Secondary accession number(s): Q35052
, Q35053, Q36723, Q38PR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 27, 2003
Last modified: June 11, 2014
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm By similarity.

Keywords - Technical termi

Extinct organism protein

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi