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P92658

- CYB_MAMPR

UniProt

P92658 - CYB_MAMPR

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Protein

Cytochrome b

Gene

MT-CYB

Organism
Mammuthus primigenius (Siberian woolly mammoth)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.By similarity

Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831Iron 1 (heme b562 axial ligand)
Metal bindingi97 – 971Iron 2 (heme b566 axial ligand)
Metal bindingi182 – 1821Iron 1 (heme b562 axial ligand)
Metal bindingi196 – 1961Iron 2 (heme b566 axial ligand)

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
  3. oxidoreductase activity Source: InterPro

GO - Biological processi

  1. respiratory electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b
Alternative name(s):
Complex III subunit 3
Complex III subunit III
Cytochrome b-c1 complex subunit 3
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Gene namesi
Name:MT-CYB
Synonyms:COB, CYTB, MTCYB
Encoded oniMitochondrion
OrganismiMammuthus primigenius (Siberian woolly mammoth)
Taxonomic identifieri37349 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaProboscideaElephantidaeMammuthus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5321HelicalSequence AnalysisAdd
BLAST
Transmembranei76 – 9823HelicalSequence AnalysisAdd
BLAST
Transmembranei116 – 13621HelicalSequence AnalysisAdd
BLAST
Transmembranei140 – 15819HelicalSequence AnalysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence AnalysisAdd
BLAST
Transmembranei229 – 24921HelicalSequence AnalysisAdd
BLAST
Transmembranei288 – 30821HelicalSequence AnalysisAdd
BLAST
Transmembranei323 – 34321HelicalSequence AnalysisAdd
BLAST
Transmembranei348 – 36821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Cytochrome bPRO_0000061150Add
BLAST

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).By similarity

Structurei

3D structure databases

ProteinModelPortaliP92658.
SMRiP92658. Positions 1-378.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome b family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017694.

Family and domain databases

Gene3Di1.20.810.10. 1 hit.
InterProiIPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR016174. Di-haem_cyt_TM.
[Graphical view]
PfamiPF00032. Cytochrom_B_C. 1 hit.
PF13631. Cytochrom_B_N_2. 1 hit.
[Graphical view]
SUPFAMiSSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEiPS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P92658-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTHIRKSHPL LKILNKSFID LPTPSNISTW WNFGSLLGAC LITQILTGLF
60 70 80 90 100
LAMHYTPDTM TAFSSMSHIC RDVNYGWIIR QLHSNGASIF FLCLYTHIGR
110 120 130 140 150
NIYYGSYLYS ETWNTGIMLL LITMATAFMG YVLPWGQMSF WGATVITNLF
160 170 180 190 200
SAIPYIGTDL VEWIWGGFSV DKATLNRFFA LHFILPFTMI ALAGVHLTFL
210 220 230 240 250
HETGSNNPLG LTSDSDKIPF HPYYTIKDFL GLLILILFLL LLALLSPDML
260 270 280 290 300
GDPDNYMPAD PLNTPLHIKP EWYFLFAYAI LRSVPNKLGG VLALLLSILI
310 320 330 340 350
LGIMPLLHTS KHRSMMLRPL SQVLFWTLAT DLLMLTWIGS QPVEYPYIII
360 370
GQMASILYFS IILAFLPIAG MIENYLIK
Length:378
Mass (Da):42,777
Last modified:January 27, 2003 - v3
Checksum:i786EDA681CDB0958
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 962Missing in AAD14109. (PubMed:8047136)Curated
Sequence conflicti218 – 2181I → V in BAA20277. (PubMed:9089080)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50842 Genomic DNA. Translation: BAA25008.1.
DQ188829 Genomic DNA. Translation: ABA29796.1.
DQ316067 Genomic DNA. Translation: ABC17890.1.
D83047 Genomic DNA. Translation: BAA20277.1.
U79411 Genomic DNA. Translation: AAB38284.1.
U23738 Genomic DNA. Translation: AAA73786.1.
U23739 Genomic DNA. Translation: AAA73787.1.
S72502 Genomic DNA. Translation: AAD14109.1.
RefSeqiYP_398766.1. NC_007596.2.

Genome annotation databases

GeneIDi3773153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50842 Genomic DNA. Translation: BAA25008.1 .
DQ188829 Genomic DNA. Translation: ABA29796.1 .
DQ316067 Genomic DNA. Translation: ABC17890.1 .
D83047 Genomic DNA. Translation: BAA20277.1 .
U79411 Genomic DNA. Translation: AAB38284.1 .
U23738 Genomic DNA. Translation: AAA73786.1 .
U23739 Genomic DNA. Translation: AAA73787.1 .
S72502 Genomic DNA. Translation: AAD14109.1 .
RefSeqi YP_398766.1. NC_007596.2.

3D structure databases

ProteinModelPortali P92658.
SMRi P92658. Positions 1-378.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3773153.

Organism-specific databases

CTDi 4519.

Phylogenomic databases

HOVERGENi HBG017694.

Family and domain databases

Gene3Di 1.20.810.10. 1 hit.
InterProi IPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR016174. Di-haem_cyt_TM.
[Graphical view ]
Pfami PF00032. Cytochrom_B_C. 1 hit.
PF13631. Cytochrom_B_N_2. 1 hit.
[Graphical view ]
SUPFAMi SSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEi PS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular phylogenetic inference of the woolly mammoth Mammuthus primigenius, based on complete sequences of mitochondrial cytochrome b and 12S ribosomal RNA genes."
    Noro M., Masuda R., Dubrovo I.A., Yoshida M.C., Kato M.
    J. Mol. Evol. 46:314-326(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Muscle.
  2. "Multiplex amplification of the mammoth mitochondrial genome and the evolution of Elephantidae."
    Krause J., Dear P.H., Pollack J.L., Slatkin M., Spriggs H., Barnes I., Lister A.M., Ebersberger I., Paeaebo S., Hofreiter M.
    Nature 439:724-727(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete mitochondrial genome and phylogeny of Pleistocene mammoth Mammuthus primigenius."
    Rogaev E.I., Moliaka Y.K., Malyarchuk B.A., Kondrashov F.A., Derenko M.V., Chumakov I., Grigorenko A.P.
    PLoS Biol. 4:403-410(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Muscle.
  4. "Phylogenetic position of mammoth and Steller's sea cow within Tethytheria demonstrated by mitochondrial DNA sequences."
    Ozawa T., Hayashi S., Mikhelson V.M.
    J. Mol. Evol. 44:406-413(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-335.
    Tissue: Muscle.
  5. Derenko M., Malyarchuk B., Shields G.F.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-143.
  6. Yang H., Golenberg E.M., Shoshani J.
    Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-106.
    Strain: Isolate allele Fairbank and Isolate allele Lyakhovskiy.
  7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-114.
    Tissue: Bone.

Entry informationi

Entry nameiCYB_MAMPR
AccessioniPrimary (citable) accession number: P92658
Secondary accession number(s): Q35052
, Q35053, Q36723, Q38PR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 27, 2003
Last modified: November 26, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.By similarity

Keywords - Technical termi

Extinct organism protein

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3