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P92658

- CYB_MAMPR

UniProt

P92658 - CYB_MAMPR

Protein

Cytochrome b

Gene

MT-CYB

Organism
Mammuthus primigenius (Siberian woolly mammoth)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 3 (27 Jan 2003)
      Previous versions | rss
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    Functioni

    Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.By similarity

    Cofactori

    Binds 2 heme groups non-covalently.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi83 – 831Iron 1 (heme b562 axial ligand)
    Metal bindingi97 – 971Iron 2 (heme b566 axial ligand)
    Metal bindingi182 – 1821Iron 1 (heme b562 axial ligand)
    Metal bindingi196 – 1961Iron 2 (heme b566 axial ligand)

    GO - Molecular functioni

    1. electron carrier activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW
    3. oxidoreductase activity Source: InterPro

    GO - Biological processi

    1. respiratory electron transport chain Source: InterPro

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome b
    Alternative name(s):
    Complex III subunit 3
    Complex III subunit III
    Cytochrome b-c1 complex subunit 3
    Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
    Gene namesi
    Name:MT-CYB
    Synonyms:COB, CYTB, MTCYB
    Encoded oniMitochondrion
    OrganismiMammuthus primigenius (Siberian woolly mammoth)
    Taxonomic identifieri37349 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaProboscideaElephantidaeMammuthus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 378378Cytochrome bPRO_0000061150Add
    BLAST

    Interactioni

    Subunit structurei

    The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP92658.
    SMRiP92658. Positions 1-378.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei76 – 9823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei116 – 13621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819HelicalSequence AnalysisAdd
    BLAST
    Transmembranei178 – 19821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei229 – 24921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei348 – 36821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome b family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG017694.

    Family and domain databases

    Gene3Di1.20.810.10. 1 hit.
    InterProiIPR005798. Cyt_b/b6_C.
    IPR005797. Cyt_b/b6_N.
    IPR027387. Cytb/b6-like.
    IPR016174. Di-haem_cyt_TM.
    [Graphical view]
    PfamiPF00032. Cytochrom_B_C. 1 hit.
    PF13631. Cytochrom_B_N_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF81342. SSF81342. 1 hit.
    SSF81648. SSF81648. 1 hit.
    PROSITEiPS51003. CYTB_CTER. 1 hit.
    PS51002. CYTB_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P92658-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTHIRKSHPL LKILNKSFID LPTPSNISTW WNFGSLLGAC LITQILTGLF    50
    LAMHYTPDTM TAFSSMSHIC RDVNYGWIIR QLHSNGASIF FLCLYTHIGR 100
    NIYYGSYLYS ETWNTGIMLL LITMATAFMG YVLPWGQMSF WGATVITNLF 150
    SAIPYIGTDL VEWIWGGFSV DKATLNRFFA LHFILPFTMI ALAGVHLTFL 200
    HETGSNNPLG LTSDSDKIPF HPYYTIKDFL GLLILILFLL LLALLSPDML 250
    GDPDNYMPAD PLNTPLHIKP EWYFLFAYAI LRSVPNKLGG VLALLLSILI 300
    LGIMPLLHTS KHRSMMLRPL SQVLFWTLAT DLLMLTWIGS QPVEYPYIII 350
    GQMASILYFS IILAFLPIAG MIENYLIK 378
    Length:378
    Mass (Da):42,777
    Last modified:January 27, 2003 - v3
    Checksum:i786EDA681CDB0958
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti95 – 962Missing in AAD14109. (PubMed:8047136)Curated
    Sequence conflicti218 – 2181I → V in BAA20277. (PubMed:9089080)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50842 Genomic DNA. Translation: BAA25008.1.
    DQ188829 Genomic DNA. Translation: ABA29796.1.
    DQ316067 Genomic DNA. Translation: ABC17890.1.
    D83047 Genomic DNA. Translation: BAA20277.1.
    U79411 Genomic DNA. Translation: AAB38284.1.
    U23738 Genomic DNA. Translation: AAA73786.1.
    U23739 Genomic DNA. Translation: AAA73787.1.
    S72502 Genomic DNA. Translation: AAD14109.1.
    RefSeqiYP_398766.1. NC_007596.2.

    Genome annotation databases

    GeneIDi3773153.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50842 Genomic DNA. Translation: BAA25008.1 .
    DQ188829 Genomic DNA. Translation: ABA29796.1 .
    DQ316067 Genomic DNA. Translation: ABC17890.1 .
    D83047 Genomic DNA. Translation: BAA20277.1 .
    U79411 Genomic DNA. Translation: AAB38284.1 .
    U23738 Genomic DNA. Translation: AAA73786.1 .
    U23739 Genomic DNA. Translation: AAA73787.1 .
    S72502 Genomic DNA. Translation: AAD14109.1 .
    RefSeqi YP_398766.1. NC_007596.2.

    3D structure databases

    ProteinModelPortali P92658.
    SMRi P92658. Positions 1-378.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3773153.

    Organism-specific databases

    CTDi 4519.

    Phylogenomic databases

    HOVERGENi HBG017694.

    Family and domain databases

    Gene3Di 1.20.810.10. 1 hit.
    InterProi IPR005798. Cyt_b/b6_C.
    IPR005797. Cyt_b/b6_N.
    IPR027387. Cytb/b6-like.
    IPR016174. Di-haem_cyt_TM.
    [Graphical view ]
    Pfami PF00032. Cytochrom_B_C. 1 hit.
    PF13631. Cytochrom_B_N_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81342. SSF81342. 1 hit.
    SSF81648. SSF81648. 1 hit.
    PROSITEi PS51003. CYTB_CTER. 1 hit.
    PS51002. CYTB_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular phylogenetic inference of the woolly mammoth Mammuthus primigenius, based on complete sequences of mitochondrial cytochrome b and 12S ribosomal RNA genes."
      Noro M., Masuda R., Dubrovo I.A., Yoshida M.C., Kato M.
      J. Mol. Evol. 46:314-326(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Muscle.
    2. "Multiplex amplification of the mammoth mitochondrial genome and the evolution of Elephantidae."
      Krause J., Dear P.H., Pollack J.L., Slatkin M., Spriggs H., Barnes I., Lister A.M., Ebersberger I., Paeaebo S., Hofreiter M.
      Nature 439:724-727(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete mitochondrial genome and phylogeny of Pleistocene mammoth Mammuthus primigenius."
      Rogaev E.I., Moliaka Y.K., Malyarchuk B.A., Kondrashov F.A., Derenko M.V., Chumakov I., Grigorenko A.P.
      PLoS Biol. 4:403-410(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Muscle.
    4. "Phylogenetic position of mammoth and Steller's sea cow within Tethytheria demonstrated by mitochondrial DNA sequences."
      Ozawa T., Hayashi S., Mikhelson V.M.
      J. Mol. Evol. 44:406-413(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-335.
      Tissue: Muscle.
    5. Derenko M., Malyarchuk B., Shields G.F.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-143.
    6. Yang H., Golenberg E.M., Shoshani J.
      Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-106.
      Strain: Isolate allele Fairbank and Isolate allele Lyakhovskiy.
    7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-114.
      Tissue: Bone.

    Entry informationi

    Entry nameiCYB_MAMPR
    AccessioniPrimary (citable) accession number: P92658
    Secondary accession number(s): Q35052
    , Q35053, Q36723, Q38PR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 27, 2003
    Last modified: October 1, 2014
    This is version 82 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.By similarity

    Keywords - Technical termi

    Extinct organism protein

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3