Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP synthase subunit a-2

Gene

ATP6-2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane (By similarity).By similarity

Miscellaneous

The atp6 gene is located on the border of one of the mitochondrial DNA repeats resulting in two identical copies of the mature protein with different propeptide extensions.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit a-2
Alternative name(s):
F-ATPase protein 6
P6-2
Gene namesi
Name:ATP6-2
Ordered Locus Names:AtMg01170
Encoded oniMitochondrion
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componentsi: Chromosome 2, Mitochondrion

Organism-specific databases

AraportiATMG01170

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei280 – 300HelicalSequence analysisAdd BLAST21
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000026041 – 97Add BLAST97
ChainiPRO_000000260598 – 349ATP synthase subunit a-2Add BLAST252

Proteomic databases

PaxDbiP92547

Expressioni

Gene expression databases

ExpressionAtlasiP92547 baseline and differential

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Protein-protein interaction databases

STRINGi3702.ATMG01170.1

Structurei

3D structure databases

ProteinModelPortaliP92547
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase A chain family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4665 Eukaryota
COG0356 LUCA
HOGENOMiHOG000253874
InParanoidiP92547
KOiK02126

Family and domain databases

Gene3Di1.20.120.220, 1 hit
HAMAPiMF_01393 ATP_synth_a_bact, 1 hit
InterProiView protein in InterPro
IPR000568 ATP_synth_F0_asu
IPR023011 ATP_synth_F0_asu_AS
IPR035908 F0_ATP_A_sf
PfamiView protein in Pfam
PF00119 ATP-synt_A, 1 hit
PRINTSiPR00123 ATPASEA
SUPFAMiSSF81336 SSF81336, 1 hit
TIGRFAMsiTIGR01131 ATP_synt_6_or_A, 1 hit
PROSITEiView protein in PROSITE
PS00449 ATPASE_A, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P92547-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERLTRLNHF LVNMRWDFYE GVIQAGYIRN LQRELDHTPA ELLGSKLDLI
60 70 80 90 100
FFRESLNLST YVNNWYMQNL GVPGPVNFIE KYHDACFSNY MKLMEIPSPL
110 120 130 140 150
DQFEIVPLIP MHIGNFYFSF TNSSLFMLLT LSFFLLLIHF VTKKGGGNLV
160 170 180 190 200
PNAWQSLVEL LYDFVLNLVK EQIGGLSGNV KQMFFPCILV TFLFLLFCNL
210 220 230 240 250
QGMIPYSFTV TSHFLITLAL SFSIFIGITI VGFQRHGLHF FSFLLPAGVP
260 270 280 290 300
LPLAPFLVLL ELISYCFRAL SLGIRLFANM MAGHSLVKIL SGFAWTMLCM
310 320 330 340
NDIFYFIGAL GPLFIVLALT GLELGVAILQ AYVFTILICI YLNDAINLH
Length:349
Mass (Da):39,729
Last modified:March 1, 2004 - v2
Checksum:i092504C68791ECA6
GO

RNA editingi

Edited at position 123.2 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08501 Genomic DNA Translation: CAA69800.1 Sequence problems.
CP002685 Genomic DNA No translation available.
RefSeqiNP_085569.1, NC_001284.2

Genome annotation databases

GeneIDi3890461
KEGGiath:ArthMp098

Keywords - Coding sequence diversityi

RNA editing

Similar proteinsi

Entry informationi

Entry nameiATP62_ARATH
AccessioniPrimary (citable) accession number: P92547
Secondary accession number(s): Q1ZXW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: April 25, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health