ID CCMC_ARATH Reviewed; 256 AA. AC P92527; A0A2P2CLG9; A7KNF3; Q6IDC1; Q8S883; Q8S8B9; DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot. DT 13-SEP-2023, sequence version 5. DT 24-JAN-2024, entry version 128. DE RecName: Full=Putative cytochrome c biosynthesis ccmC-like mitochondrial protein; DE AltName: Full=ABC transporter I family member 3; DE Short=ABC transporter ABCI.3; DE Short=AtABCI3; GN Name=CCMC; Synonyms=ABCI3, ABCI4, ABCI5, CCB256, CCB3; GN OrderedLocusNames=AtMg00900; OS Arabidopsis thaliana (Mouse-ear cress). OG Mitochondrion. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. C24; RX PubMed=8988169; DOI=10.1038/ng0197-57; RA Unseld M., Marienfeld J.R., Brandt P., Brennicke A.; RT "The mitochondrial genome of Arabidopsis thaliana contains 57 genes in RT 366,924 nucleotides."; RL Nat. Genet. 15:57-61(1997). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND RNA EDITING. RC STRAIN=cv. Columbia; RX PubMed=29519893; DOI=10.1105/tpc.18.00024; RA Sloan D.B., Wu Z., Sharbrough J.; RT "Correction of persistent errors in Arabidopsis reference mitochondrial RT genomes."; RL Plant Cell 30:525-527(2018). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (AT2G07681 AND AT2G07771). RC STRAIN=cv. Columbia; RX PubMed=10617197; DOI=10.1038/45471; RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.; RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."; RL Nature 402:761-768(1999). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (AT2G07681 AND AT2G07771). RC STRAIN=cv. Columbia; RA Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.; RT "Arabidopsis ORF clones."; RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] OF 33-232, AND RNA EDITING. RC STRAIN=cv. Columbia, and cv. Landsberg erecta; TISSUE=Rosette leaf; RX PubMed=17565941; DOI=10.1534/genetics.107.073585; RA Bentolila S., Elliott L.E., Hanson M.R.; RT "Genetic architecture of mitochondrial editing in Arabidopsis thaliana."; RL Genetics 178:1693-1708(2008). RN [6] RP RNA EDITING. RX PubMed=10611383; DOI=10.1073/pnas.96.26.15324; RA Giege P., Brennicke A.; RT "RNA editing in Arabidopsis mitochondria effects 441 C to U changes in RT ORFs."; RL Proc. Natl. Acad. Sci. U.S.A. 96:15324-15329(1999). RN [7] RP GENE FAMILY, AND NOMENCLATURE. RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001; RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M., RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A., RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.; RT "Plant ABC proteins - a unified nomenclature and updated inventory."; RL Trends Plant Sci. 13:151-159(2008). CC -!- FUNCTION: May be involved in the export of heme to the mitochondrion CC for the biogenesis of c-type cytochromes. CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Multi-pass CC membrane protein {ECO:0000305}. CC -!- RNA EDITING: Modified_positions=35 {ECO:0000269|PubMed:10611383, CC ECO:0000269|PubMed:17565941, ECO:0000269|PubMed:29519893}, 45 CC {ECO:0000269|PubMed:10611383, ECO:0000269|PubMed:17565941, CC ECO:0000269|PubMed:29519893}, 60 {ECO:0000269|PubMed:10611383, CC ECO:0000269|PubMed:17565941, ECO:0000269|PubMed:29519893}, 62 CC {ECO:0000269|PubMed:10611383, ECO:0000269|PubMed:17565941, CC ECO:0000269|PubMed:29519893}, 88 {ECO:0000269|PubMed:10611383, CC ECO:0000269|PubMed:17565941}, 111 {ECO:0000269|PubMed:10611383, CC ECO:0000269|PubMed:17565941, ECO:0000269|PubMed:29519893}, 132 CC {ECO:0000269|PubMed:10611383, ECO:0000269|PubMed:17565941, CC ECO:0000269|PubMed:29519893}, 134 {ECO:0000269|PubMed:10611383, CC ECO:0000269|PubMed:17565941, ECO:0000269|PubMed:29519893}, 141 CC {ECO:0000269|PubMed:10611383, ECO:0000269|PubMed:17565941, CC ECO:0000269|PubMed:29519893}, 149 {ECO:0000269|PubMed:10611383, CC ECO:0000269|PubMed:17565941, ECO:0000269|PubMed:29519893}, 153 CC {ECO:0000269|PubMed:10611383, ECO:0000269|PubMed:17565941, CC ECO:0000269|PubMed:29519893}, 155 {ECO:0000269|PubMed:10611383, CC ECO:0000269|PubMed:17565941, ECO:0000269|PubMed:29519893}, 156 CC {ECO:0000269|PubMed:10611383, ECO:0000269|PubMed:17565941, CC ECO:0000269|PubMed:29519893}, 158 {ECO:0000269|PubMed:10611383, CC ECO:0000269|PubMed:17565941, ECO:0000269|PubMed:29519893}, 166 CC {ECO:0000269|PubMed:10611383, ECO:0000269|PubMed:17565941, CC ECO:0000269|PubMed:29519893}, 174 {ECO:0000269|PubMed:10611383, CC ECO:0000269|PubMed:17565941, ECO:0000269|PubMed:29519893}, 183 CC {ECO:0000269|PubMed:10611383, ECO:0000269|PubMed:17565941, CC ECO:0000269|PubMed:29519893}, 190 {ECO:0000269|PubMed:10611383, CC ECO:0000269|PubMed:17565941, ECO:0000269|PubMed:29519893}, 192 CC {ECO:0000269|PubMed:10611383, ECO:0000269|PubMed:17565941, CC ECO:0000269|PubMed:29519893}, 203 {ECO:0000269|PubMed:10611383, CC ECO:0000269|PubMed:17565941, ECO:0000269|PubMed:29519893}, 205 CC {ECO:0000269|PubMed:10611383, ECO:0000269|PubMed:17565941, CC ECO:0000269|PubMed:29519893}, 207 {ECO:0000269|PubMed:10611383, CC ECO:0000269|PubMed:17565941, ECO:0000269|PubMed:29519893}, 217 CC {ECO:0000269|PubMed:10611383, ECO:0000269|PubMed:17565941, CC ECO:0000269|PubMed:29519893}, 219 {ECO:0000269|PubMed:10611383, CC ECO:0000269|PubMed:17565941, ECO:0000269|PubMed:29519893}, 225 CC {ECO:0000269|PubMed:10611383, ECO:0000269|PubMed:17565941, CC ECO:0000269|PubMed:29519893}; Note=The stop codon at position 257 is CC created by RNA editing. {ECO:0000269|PubMed:10611383, CC ECO:0000269|PubMed:17565941}; CC -!- MISCELLANEOUS: A stretch of 270 kb of the mitochondrial genome is CC duplicated within the centromere of chromosome 2 resulting in the CC duplication of the gene. The expression of the duplicated genes CC (At2g07681 and At2g07771) is demonstrated. CC -!- SIMILARITY: Belongs to the CcmC/CycZ/HelC family. {ECO:0000305}. CC -!- CAUTION: Was originally (PubMed:18299247) thought to belong to the ABC CC transporter family. Lacks the conserved ABC domain, which is one of the CC features of the ABC transporter family. {ECO:0000305|PubMed:18299247}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y08501; CAA69832.3; ALT_SEQ; Genomic_DNA. DR EMBL; BK010421; DAB41520.2; -; Genomic_DNA. DR EMBL; AC007143; AAM15415.1; ALT_SEQ; Genomic_DNA. DR EMBL; AC007730; AAM15509.1; ALT_SEQ; Genomic_DNA. DR EMBL; BT014752; AAT41735.1; ALT_SEQ; mRNA. DR EMBL; BT014995; AAT70446.1; ALT_SEQ; mRNA. DR EMBL; EF488896; ABS50608.1; ALT_SEQ; mRNA. DR EMBL; EF488897; ABS50609.1; ALT_SEQ; mRNA. DR RefSeq; NP_085546.2; NC_001284.2. DR RefSeq; NP_973435.1; NM_201706.1. DR AlphaFoldDB; P92527; -. DR SMR; P92527; -. DR STRING; 3702.A0A2P2CLG9; -. DR GeneID; 815357; -. DR KEGG; ath:AT2G07771; -. DR Araport; ATMG00900; -. DR TAIR; ATMG00900; ABCI3. DR InParanoid; P92527; -. DR OrthoDB; 454670at2759; -. DR PRO; PR:P92527; -. DR Proteomes; UP000006548; Mitochondrion MT. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro. DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW. DR InterPro; IPR002541; Cyt_c_assembly. DR InterPro; IPR003557; Cyt_c_biogenesis_CcmC. DR InterPro; IPR045062; Cyt_c_biogenesis_CcsA/CcmC. DR NCBIfam; TIGR01191; ccmC; 1. DR PANTHER; PTHR30071:SF17; CYTOCHROME C ASSEMBLY PROTEIN-RELATED; 1. DR PANTHER; PTHR30071; HEME EXPORTER PROTEIN C; 1. DR Pfam; PF01578; Cytochrom_C_asm; 1. DR PRINTS; PR01386; CCMCBIOGNSIS. PE 2: Evidence at transcript level; KW Cytochrome c-type biogenesis; Membrane; Mitochondrion; Reference proteome; KW RNA editing; Transmembrane; Transmembrane helix. FT CHAIN 1..256 FT /note="Putative cytochrome c biosynthesis ccmC-like FT mitochondrial protein" FT /id="PRO_0000201561" FT TRANSMEM 21..41 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 60..80 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 91..111 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 129..149 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 151..171 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 192..212 FT /note="Helical" FT /evidence="ECO:0000255" FT CONFLICT 146 FT /note="S -> P (in Ref. 1; CAA69832, 3; AAM15415/AAM15509, FT 4; AAT41735/AAT70446 and 5; ABS50608/ABS50609)" FT /evidence="ECO:0000305" FT CONFLICT 184 FT /note="G -> S (in Ref. 3; AAM15415)" FT /evidence="ECO:0000305" SQ SEQUENCE 256 AA; 28798 MW; 3340020E493C9613 CRC64; MSVSLLQPSF LMSKTRSYAQ ILIGSWLFLT AMAIYLSLGV APLDFQQGGN SRILYVHVPV AWMSIIVYIA TAINTFLFLL TKHPLYLRSS GTGIEMGAFF TLFTLVTGGF WGRPMWGTFW VWDARLTSVF ILFFIYLGAL CFQKLSVELA SILICVGLID IPIIKFSVNW WNTLHQPGSI SRFGTSIHVS MLIPILSNFA NFLFLTCILF VLETRLLILS FLESSITEEI EAREGIPKPS SLALFASMAE WLKRPT //