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Protein

Putative cytochrome c biosynthesis ccmC-like mitochondrial protein

Gene

CCMC

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the export of heme to the mitochondrion for the biogenesis of c-type cytochromes.

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. heme transporter activity Source: InterPro

GO - Biological processi

  1. cytochrome complex assembly Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cytochrome c-type biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Putative cytochrome c biosynthesis ccmC-like mitochondrial protein
Alternative name(s):
ABC transporter I family member 3
Short name:
ABC transporter ABCI.3
Short name:
AtABCI3
Gene namesi
Name:CCMC
Synonyms:ABCI3, ABCI4, ABCI5, CCB256, CCB3
Ordered Locus Names:AtMg00900
Encoded oniMitochondrion
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Mitochondrion

Organism-specific databases

TAIRiATMG00900.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Transmembranei91 – 11121HelicalSequence AnalysisAdd
BLAST
Transmembranei129 – 14921HelicalSequence AnalysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST
Transmembranei192 – 21221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 232232Putative cytochrome c biosynthesis ccmC-like mitochondrial proteinPRO_0000201561Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP92527.

Interactioni

Protein-protein interaction databases

STRINGi3702.ATMG00900.1-P.

Family & Domainsi

Sequence similaritiesi

Belongs to the CcmC/CycZ/HelC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP92527.

Family and domain databases

InterProiIPR002541. Cyt_c_assembly.
IPR003557. Cyt_c_biogenesis_CcmC.
[Graphical view]
PfamiPF01578. Cytochrom_C_asm. 1 hit.
[Graphical view]
PRINTSiPR01386. CCMCBIOGNSIS.
TIGRFAMsiTIGR01191. ccmC. 1 hit.

Sequencei

Sequence statusi: Complete.

P92527-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSLLQPSF LMSKTRSYAQ ILIGSWLFLT AMAIYLSLGV APLDFQQGGN
60 70 80 90 100
SRILYVHVPV AWMSIIVYIA TAINTFLFLL TKHPLYLCSS GTGIEMGAFF
110 120 130 140 150
TLFTLVTGGF WGRPMWGTFW VWDARLTSVF ILFFIYLGAL CFQKLPVELA
160 170 180 190 200
SILICVGLID IPIIKFSVNW WNTLHQPGSI SRFGTSIHVS MLIPILSNFA
210 220 230
NFLFLTCILF VLETRLLILS FLESSITEEI EA
Length:232
Mass (Da):26,087
Last modified:March 15, 2004 - v4
Checksum:i14B7ECE8A50AFA5D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti184 – 1841G → S in AAM15415 (PubMed:10617197).Curated

RNA editingi

Edited at positions 35, 45, 60, 62, 88, 111, 132, 134, 141, 149, 153, 155, 156, 158, 166, 174, 183, 190, 192, 203, 205, 207, 217, 219 and 225.2 Publications
The stop codon at position 233 is created by RNA editing.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08501 Genomic DNA. Translation: CAA69832.3. Sequence problems.
AC007143 Genomic DNA. Translation: AAM15415.1. Sequence problems.
AC007730 Genomic DNA. Translation: AAM15509.1. Sequence problems.
BT014752 mRNA. Translation: AAT41735.1. Sequence problems.
BT014995 mRNA. Translation: AAT70446.1. Sequence problems.
EF488896 mRNA. Translation: ABS50608.1. Sequence problems.
EF488897 mRNA. Translation: ABS50609.1. Sequence problems.
RefSeqiNP_085546.2. NC_001284.2.
NP_973435.1. NM_201706.1.
UniGeneiAt.66420.

Genome annotation databases

GeneIDi3890473.
815357.
KEGGiath:ArthMp079.
ath:AT2G07771.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08501 Genomic DNA. Translation: CAA69832.3. Sequence problems.
AC007143 Genomic DNA. Translation: AAM15415.1. Sequence problems.
AC007730 Genomic DNA. Translation: AAM15509.1. Sequence problems.
BT014752 mRNA. Translation: AAT41735.1. Sequence problems.
BT014995 mRNA. Translation: AAT70446.1. Sequence problems.
EF488896 mRNA. Translation: ABS50608.1. Sequence problems.
EF488897 mRNA. Translation: ABS50609.1. Sequence problems.
RefSeqiNP_085546.2. NC_001284.2.
NP_973435.1. NM_201706.1.
UniGeneiAt.66420.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.ATMG00900.1-P.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3890473.
815357.
KEGGiath:ArthMp079.
ath:AT2G07771.

Organism-specific databases

TAIRiATMG00900.

Phylogenomic databases

InParanoidiP92527.

Miscellaneous databases

PROiP92527.

Gene expression databases

GenevestigatoriP92527.

Family and domain databases

InterProiIPR002541. Cyt_c_assembly.
IPR003557. Cyt_c_biogenesis_CcmC.
[Graphical view]
PfamiPF01578. Cytochrom_C_asm. 1 hit.
[Graphical view]
PRINTSiPR01386. CCMCBIOGNSIS.
TIGRFAMsiTIGR01191. ccmC. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The mitochondrial genome of Arabidopsis thaliana contains 57 genes in 366,924 nucleotides."
    Unseld M., Marienfeld J.R., Brandt P., Brennicke A.
    Nat. Genet. 15:57-61(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (AT2G07681 AND AT2G07771).
    Strain: cv. Columbia.
  3. "Arabidopsis ORF clones."
    Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (AT2G07681 AND AT2G07771).
    Strain: cv. Columbia.
  4. "Genetic architecture of mitochondrial editing in Arabidopsis thaliana."
    Bentolila S., Elliott L.E., Hanson M.R.
    Genetics 178:1693-1708(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-232, RNA EDITING.
    Strain: cv. Columbia and cv. Landsberg erecta.
    Tissue: Rosette leaf.
  5. "RNA editing in Arabidopsis mitochondria effects 441 C to U changes in ORFs."
    Giege P., Brennicke A.
    Proc. Natl. Acad. Sci. U.S.A. 96:15324-15329(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA EDITING.
  6. Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiCCMC_ARATH
AccessioniPrimary (citable) accession number: P92527
Secondary accession number(s): A7KNF3
, Q6IDC1, Q8S883, Q8S8B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: April 29, 2015
This is version 98 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

A stretch of 270 kb of the mitochondrial genome is duplicated within the centromere of chromosome 2 resulting in the duplication of the gene. The expression of the duplicated genes (At2g07681 and At2g07771) is demonstrated.

Caution

Was originally (PubMed:18299247) thought to belong to the ABC transporter family. Lacks the conserved ABC domain, which is one of the features of the ABC transporter family.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.