P92527 (CCMC_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative cytochrome c biosynthesis ccmC-like mitochondrial protein

Alternative name(s):
ABC transporter I family member 3
Short name=ABC transporter ABCI.3
Short name=AtABCI3

Gene names

Name:	CCMC
Synonyms:	ABCI3, ABCI4, ABCI5, CCB256, CCB3
Ordered Locus Names:	AtMg00900

Encoded on

Mitochondrion

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in the export of heme to the mitochondrion for the biogenesis of c-type cytochromes.
Subcellular location	Mitochondrion membrane; Multi-pass membrane protein Potential.
Miscellaneous	A stretch of 270 kb of the mitochondrial genome is duplicated within the centromere of chromosome 2 resulting in the duplication of the gene. The expression of the duplicated genes (At2g07681 and At2g07771) is demonstrated.
Sequence similarities	Belongs to the CcmC/CycZ/HelC family.
Caution	Was originally (Ref.6) thought to belong to the ABC transporter family. Lacks the conserved ABC domain, which is one of the features of the ABC transporter family.
RNA editing	Edited at positions 35, 45, 60, 62, 88, 111, 132, 134, 141, 149, 153, 155, 156, 158, 166, 174, 183, 190, 192, 203, 205, 207, 217, 219 and 225. The stop codon at position 233 is created by RNA editing. Ref.4 Ref.5

Ontologies

Keywords
Biological process	Cytochrome c-type biogenesis
Cellular component	Membrane Mitochondrion
Coding sequence diversity	RNA editing
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cytochrome complex assembly Inferred from electronic annotation. Source: UniProtKB-KW respiratory chain complex IV assembly Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	heme transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 232	232	Putative cytochrome c biosynthesis ccmC-like mitochondrial protein		PRO_0000201561
Regions
	Transmembrane	21 – 41	21	Helical; Potential
	Transmembrane	60 – 80	21	Helical; Potential
	Transmembrane	91 – 111	21	Helical; Potential
	Transmembrane	129 – 149	21	Helical; Potential
	Transmembrane	151 – 171	21	Helical; Potential
	Transmembrane	192 – 212	21	Helical; Potential
Experimental info
	Sequence conflict	184	1	G → S in AAM15415. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P92527 [UniParc]. Last modified March 15, 2004. Version 4. Checksum: 14B7ECE8A50AFA5D	FASTA	232	26,087
	10 20 30 40 50 60 MSVSLLQPSF LMSKTRSYAQ ILIGSWLFLT AMAIYLSLGV APLDFQQGGN SRILYVHVPV 70 80 90 100 110 120 AWMSIIVYIA TAINTFLFLL TKHPLYLCSS GTGIEMGAFF TLFTLVTGGF WGRPMWGTFW 130 140 150 160 170 180 VWDARLTSVF ILFFIYLGAL CFQKLPVELA SILICVGLID IPIIKFSVNW WNTLHQPGSI 190 200 210 220 230 SRFGTSIHVS MLIPILSNFA NFLFLTCILF VLETRLLILS FLESSITEEI EA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The mitochondrial genome of Arabidopsis thaliana contains 57 genes in 366,924 nucleotides." Unseld M., Marienfeld J.R., Brandt P., Brennicke A. Nat. Genet. 15:57-61(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C. Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (AT2G07681 AND AT2G07771). Strain: cv. Columbia.
[3]	"Arabidopsis ORF clones." Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (AT2G07681 AND AT2G07771). Strain: cv. Columbia.
[4]	"Genetic architecture of mitochondrial editing in Arabidopsis thaliana." Bentolila S., Elliott L.E., Hanson M.R. Genetics 178:1693-1708(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-232, RNA EDITING. Strain: cv. Columbia and cv. Landsberg erecta. Tissue: Rosette leaf.
[5]	"RNA editing in Arabidopsis mitochondria effects 441 C to U changes in ORFs." Giege P., Brennicke A. Proc. Natl. Acad. Sci. U.S.A. 96:15324-15329(1999) [PubMed] [Europe PMC] [Abstract] Cited for: RNA EDITING.
[6]	"Plant ABC proteins - a unified nomenclature and updated inventory." Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M., Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A., Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L. Trends Plant Sci. 13:151-159(2008) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y08501 Genomic DNA. Translation: CAA69832.3. Sequence problems. AC007143 Genomic DNA. Translation: AAM15415.1. Sequence problems. AC007730 Genomic DNA. Translation: AAM15509.1. Sequence problems. BT014752 mRNA. Translation: AAT41735.1. Sequence problems. BT014995 mRNA. Translation: AAT70446.1. Sequence problems. EF488896 mRNA. Translation: ABS50608.1. Sequence problems. EF488897 mRNA. Translation: ABS50609.1. Sequence problems.
IPI	IPI00537106.
RefSeq	NP_085546.2. NC_001284.2. NP_973435.1. NM_201706.1.
UniGene	At.66420.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	3702.ATMG00900.1-P.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3890473. 815357.
KEGG	ath:ArthMp079. ath:AT2G07771.
Organism-specific databases
TAIR	AtMg00900.
Phylogenomic databases
ProtClustDB	CLSN2688042.
Gene expression databases
Genevestigator	P92527.
GermOnline	ATMG00900. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR002541. Cyt_c_assembly. IPR003557. Cyt_c_biogenesis_CcmC. [Graphical view]
Pfam	PF01578. Cytochrom_C_asm. 1 hit. [Graphical view]
PRINTS	PR01386. CCMCBIOGNSIS.
TIGRFAMs	TIGR01191. ccmC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CCMC_ARATH

Accession

Primary (citable) accession number: P92527
Secondary accession number(s): A7KNF3 , Q6IDC1, Q8S883, Q8S8B9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	March 15, 2004
Last modified:	May 1, 2013
This is version 87 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program