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P92527 (CCMC_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative cytochrome c biosynthesis ccmC-like mitochondrial protein
Alternative name(s):
ABC transporter I family member 3
Short name=ABC transporter ABCI.3
Short name=AtABCI3
Gene names
Name:CCMC
Synonyms:ABCI3, ABCI4, ABCI5, CCB256, CCB3
Ordered Locus Names:AtMg00900
Encoded onMitochondrion
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in the export of heme to the mitochondrion for the biogenesis of c-type cytochromes.

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein Potential.

Miscellaneous

A stretch of 270 kb of the mitochondrial genome is duplicated within the centromere of chromosome 2 resulting in the duplication of the gene. The expression of the duplicated genes (At2g07681 and At2g07771) is demonstrated.

Sequence similarities

Belongs to the CcmC/CycZ/HelC family.

Caution

Was originally (Ref.6) thought to belong to the ABC transporter family. Lacks the conserved ABC domain, which is one of the features of the ABC transporter family.

RNA editing

Edited at positions 35, 45, 60, 62, 88, 111, 132, 134, 141, 149, 153, 155, 156, 158, 166, 174, 183, 190, 192, 203, 205, 207, 217, 219 and 225.
The stop codon at position 233 is created by RNA editing. Ref.4 Ref.5

Ontologies

Keywords
   Biological processCytochrome c-type biogenesis
   Cellular componentMembrane
Mitochondrion
   Coding sequence diversityRNA editing
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processrespiratory chain complex IV assembly

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionheme transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 232232Putative cytochrome c biosynthesis ccmC-like mitochondrial protein
PRO_0000201561

Regions

Transmembrane21 – 4121Helical; Potential
Transmembrane60 – 8021Helical; Potential
Transmembrane91 – 11121Helical; Potential
Transmembrane129 – 14921Helical; Potential
Transmembrane151 – 17121Helical; Potential
Transmembrane192 – 21221Helical; Potential

Experimental info

Sequence conflict1841G → S in AAM15415. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P92527 [UniParc].

Last modified March 15, 2004. Version 4.
Checksum: 14B7ECE8A50AFA5D

FASTA23226,087
        10         20         30         40         50         60 
MSVSLLQPSF LMSKTRSYAQ ILIGSWLFLT AMAIYLSLGV APLDFQQGGN SRILYVHVPV 

        70         80         90        100        110        120 
AWMSIIVYIA TAINTFLFLL TKHPLYLCSS GTGIEMGAFF TLFTLVTGGF WGRPMWGTFW 

       130        140        150        160        170        180 
VWDARLTSVF ILFFIYLGAL CFQKLPVELA SILICVGLID IPIIKFSVNW WNTLHQPGSI 

       190        200        210        220        230 
SRFGTSIHVS MLIPILSNFA NFLFLTCILF VLETRLLILS FLESSITEEI EA 

« Hide

References

« Hide 'large scale' references
[1]"The mitochondrial genome of Arabidopsis thaliana contains 57 genes in 366,924 nucleotides."
Unseld M., Marienfeld J.R., Brandt P., Brennicke A.
Nat. Genet. 15:57-61(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (AT2G07681 AND AT2G07771).
Strain: cv. Columbia.
[3]"Arabidopsis ORF clones."
Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (AT2G07681 AND AT2G07771).
Strain: cv. Columbia.
[4]"Genetic architecture of mitochondrial editing in Arabidopsis thaliana."
Bentolila S., Elliott L.E., Hanson M.R.
Genetics 178:1693-1708(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-232, RNA EDITING.
Strain: cv. Columbia and cv. Landsberg erecta.
Tissue: Rosette leaf.
[5]"RNA editing in Arabidopsis mitochondria effects 441 C to U changes in ORFs."
Giege P., Brennicke A.
Proc. Natl. Acad. Sci. U.S.A. 96:15324-15329(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: RNA EDITING.
[6]"Plant ABC proteins - a unified nomenclature and updated inventory."
Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M., Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A., Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.
Trends Plant Sci. 13:151-159(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y08501 Genomic DNA. Translation: CAA69832.3. Sequence problems.
AC007143 Genomic DNA. Translation: AAM15415.1. Sequence problems.
AC007730 Genomic DNA. Translation: AAM15509.1. Sequence problems.
BT014752 mRNA. Translation: AAT41735.1. Sequence problems.
BT014995 mRNA. Translation: AAT70446.1. Sequence problems.
EF488896 mRNA. Translation: ABS50608.1. Sequence problems.
EF488897 mRNA. Translation: ABS50609.1. Sequence problems.
RefSeqNP_085546.2. NC_001284.2.
NP_973435.1. NM_201706.1.
UniGeneAt.66420.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING3702.ATMG00900.1-P.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3890473.
815357.
KEGGath:ArthMp079.
ath:AT2G07771.

Organism-specific databases

TAIRATMG00900.

Gene expression databases

GenevestigatorP92527.

Family and domain databases

InterProIPR002541. Cyt_c_assembly.
IPR003557. Cyt_c_biogenesis_CcmC.
[Graphical view]
PfamPF01578. Cytochrom_C_asm. 1 hit.
[Graphical view]
PRINTSPR01386. CCMCBIOGNSIS.
TIGRFAMsTIGR01191. ccmC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCCMC_ARATH
AccessionPrimary (citable) accession number: P92527
Secondary accession number(s): A7KNF3 expand/collapse secondary AC list , Q6IDC1, Q8S883, Q8S8B9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: May 14, 2014
This is version 94 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names