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P92514

- COX3_ARATH

UniProt

P92514 - COX3_ARATH

Protein

Cytochrome c oxidase subunit 3

Gene

COX3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (04 May 2001)
      Previous versions | rss
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    Functioni

    Subunits I, II and III form the functional core of the enzyme complex.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aerobic electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciARA:AT2G07687-MONOMER.
    ARA:ATMG00730-MONOMER.
    MetaCyc:ATMG00730-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide III
    Gene namesi
    Name:COX3
    Ordered Locus Names:AtMg00730
    Encoded oniMitochondrion
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2, UP000006548: Mitochondrion

    Organism-specific databases

    TAIRiATMG00730.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 265265Cytochrome c oxidase subunit 3PRO_0000183737Add
    BLAST

    Proteomic databases

    PaxDbiP92514.
    PRIDEiP92514.

    Expressioni

    Gene expression databases

    GenevestigatoriP92514.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.ATMG00730.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliP92514.
    SMRiP92514. Positions 5-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei137 – 15721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei162 – 18221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei200 – 22021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei245 – 26521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1845.
    HOGENOMiHOG000264954.
    InParanoidiP92514.
    KOiK02262.
    PhylomeDBiP92514.

    Family and domain databases

    Gene3Di1.20.120.80. 1 hit.
    InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view]
    PANTHERiPTHR11403. PTHR11403. 1 hit.
    PfamiPF00510. COX3. 1 hit.
    [Graphical view]
    SUPFAMiSSF81452. SSF81452. 1 hit.
    PROSITEiPS50253. COX3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P92514-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIESQRHSYH LVDPSPWPIS GSLGALATTV GGVMYMHSFQ GGARLLSLGL    50
    IFILYTMFVW WRDVLRESTL EGHHTKVVQL GLRYGFILFI VSEVMFFFAF 100
    FWAFFHSSLA PAVEIGGIWP PKGIEVLDPW EIPFLNTLIL LSSGAAVTWA 150
    HHAILAGKEK RAVYALVATV LLALVFTGFQ GMEYYQAPFT ISDSIYGSTF 200
    FLATGFHGFH VIIGTLFLII CGIRQYLGHL TKEHHVGFEA AAWYWHFVDV 250
    VWLFLFVSIY WWGGI 265
    Length:265
    Mass (Da):29,961
    Last modified:May 4, 2001 - v2
    Checksum:i753978DE1CAA13F1
    GO

    RNA editingi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08501 Genomic DNA. Translation: CAA69818.3. Sequence problems.
    JF729200 Genomic DNA. Translation: AEK01262.1. Sequence problems.
    JF729201 Genomic DNA. Translation: AEK01298.1. Sequence problems.
    JF729202 Genomic DNA. Translation: AEK01326.1. Sequence problems.
    AC007143 Genomic DNA. Translation: AAM15412.1. Sequence problems.
    CP002685 Genomic DNA. Translation: AEC06078.1. Sequence problems.
    EF488906 mRNA. Translation: ABS50618.1.
    EF488907 mRNA. Translation: ABS50619.1.
    RefSeqiNP_085532.2. NC_001284.2.
    NP_178782.1. NM_126741.2.
    UniGeneiAt.47771.

    Genome annotation databases

    EnsemblPlantsiAT2G07687.1; AT2G07687.1; AT2G07687.
    ATMG00730.1; ATMG00730.1; ATMG00730.
    GeneIDi814601.
    815364.
    KEGGiath:ArthMp065.
    ath:AT2G07687.

    Keywords - Coding sequence diversityi

    RNA editing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08501 Genomic DNA. Translation: CAA69818.3 . Sequence problems.
    JF729200 Genomic DNA. Translation: AEK01262.1 . Sequence problems.
    JF729201 Genomic DNA. Translation: AEK01298.1 . Sequence problems.
    JF729202 Genomic DNA. Translation: AEK01326.1 . Sequence problems.
    AC007143 Genomic DNA. Translation: AAM15412.1 . Sequence problems.
    CP002685 Genomic DNA. Translation: AEC06078.1 . Sequence problems.
    EF488906 mRNA. Translation: ABS50618.1 .
    EF488907 mRNA. Translation: ABS50619.1 .
    RefSeqi NP_085532.2. NC_001284.2.
    NP_178782.1. NM_126741.2.
    UniGenei At.47771.

    3D structure databases

    ProteinModelPortali P92514.
    SMRi P92514. Positions 5-263.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.ATMG00730.1-P.

    Proteomic databases

    PaxDbi P92514.
    PRIDEi P92514.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G07687.1 ; AT2G07687.1 ; AT2G07687 .
    ATMG00730.1 ; ATMG00730.1 ; ATMG00730 .
    GeneIDi 814601.
    815364.
    KEGGi ath:ArthMp065.
    ath:AT2G07687.

    Organism-specific databases

    TAIRi ATMG00730.

    Phylogenomic databases

    eggNOGi COG1845.
    HOGENOMi HOG000264954.
    InParanoidi P92514.
    KOi K02262.
    PhylomeDBi P92514.

    Enzyme and pathway databases

    BioCyci ARA:AT2G07687-MONOMER.
    ARA:ATMG00730-MONOMER.
    MetaCyc:ATMG00730-MONOMER.

    Gene expression databases

    Genevestigatori P92514.

    Family and domain databases

    Gene3Di 1.20.120.80. 1 hit.
    InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
    IPR013833. Cyt_c_oxidase_su3_a-hlx.
    IPR000298. Cyt_c_oxidase_su3_dom.
    [Graphical view ]
    PANTHERi PTHR11403. PTHR11403. 1 hit.
    Pfami PF00510. COX3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81452. SSF81452. 1 hit.
    PROSITEi PS50253. COX3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mitochondrial genome of Arabidopsis thaliana contains 57 genes in 366,924 nucleotides."
      Unseld M., Marienfeld J.R., Brandt P., Brennicke A.
      Nat. Genet. 15:57-61(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. "Double-strand break repair processes drive evolution of the mitochondrial genome in Arabidopsis."
      Davila J.I., Arrieta-Montiel M.P., Wamboldt Y., Cao J., Hagmann J., Shedge V., Xu Y.Z., Weigel D., Mackenzie S.A.
      BMC Biol. 9:64-64(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. C24, cv. Columbia and cv. Landsberg erecta.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (AT2G07687).
      Strain: cv. Columbia.
    4. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION (AT2G07687).
      Strain: cv. Columbia.
    5. "Genetic architecture of mitochondrial editing in Arabidopsis thaliana."
      Bentolila S., Elliott L.E., Hanson M.R.
      Genetics 178:1693-1708(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-258, RNA EDITING.
      Strain: cv. Columbia and cv. Landsberg erecta.
      Tissue: Rosette leaf.
    6. "RNA editing in Arabidopsis mitochondria effects 441 C to U changes in ORFs."
      Giege P., Brennicke A.
      Proc. Natl. Acad. Sci. U.S.A. 96:15324-15329(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: RNA EDITING.

    Entry informationi

    Entry nameiCOX3_ARATH
    AccessioniPrimary (citable) accession number: P92514
    Secondary accession number(s): A7KNG3, F4IMA5, Q8S8B5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 4, 2001
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    A stretch of 270 kb of the mitochondrial genome is duplicated within the centromere of chromosome 2 resulting in the duplication of the gene. The expression of this duplicated gene (At2g07687) is not demonstrated. It is also probably not RNA edited and therefore differs in all the positions known to be edited.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3