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Protein

Cytochrome c oxidase subunit 3

Gene

COX3

more
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Miscellaneous

A stretch of 270 kb of the mitochondrial genome is duplicated within the centromere of chromosome 2 resulting in the duplication of the gene. The expression of this duplicated gene (At2g07687) is not demonstrated. It is also probably not RNA edited and therefore differs in all the positions known to be edited.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciARA:AT2G07687-MONOMER
ARA:ATMG00730-MONOMER
MetaCyc:ATMG00730-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:COX3
Ordered Locus Names:AtMg00730Imported
AND
Ordered Locus Names:At2g07687Imported
Encoded oniMitochondrion
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componentsi: Chromosome 2, Mitochondrion

Organism-specific databases

AraportiAT2G07687
ATMG00730

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001837371 – 265Cytochrome c oxidase subunit 3Add BLAST265

Proteomic databases

PaxDbiP92514

Expressioni

Gene expression databases

ExpressionAtlasiP92514 baseline and differential
GenevisibleiP92514 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.ATMG00730.1

Structurei

3D structure databases

ProteinModelPortaliP92514
SMRiP92514
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4664 Eukaryota
COG1845 LUCA
HOGENOMiHOG000264954
InParanoidiP92514
KOiK02262
OrthoDBiEOG0936099W
PhylomeDBiP92514

Family and domain databases

CDDicd01665 Cyt_c_Oxidase_III, 1 hit
Gene3Di1.20.120.80, 1 hit
InterProiView protein in InterPro
IPR024791 Cyt_c/ubiquinol_Oxase_su3
IPR033945 Cyt_c_oxase_su3_dom
IPR000298 Cyt_c_oxidase-like_su3
IPR035973 Cyt_c_oxidase_su3-like_sf
IPR013833 Cyt_c_oxidase_su3_a-hlx
PANTHERiPTHR11403 PTHR11403, 1 hit
PfamiView protein in Pfam
PF00510 COX3, 1 hit
SUPFAMiSSF81452 SSF81452, 1 hit
PROSITEiView protein in PROSITE
PS50253 COX3, 1 hit

Sequencei

Sequence statusi: Complete.

P92514-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIESQRHSYH LVDPSPWPIS GSLGALATTV GGVMYMHSFQ GGARLLSLGL
60 70 80 90 100
IFILYTMFVW WRDVLRESTL EGHHTKVVQL GLRYGFILFI VSEVMFFFAF
110 120 130 140 150
FWAFFHSSLA PAVEIGGIWP PKGIEVLDPW EIPFLNTLIL LSSGAAVTWA
160 170 180 190 200
HHAILAGKEK RAVYALVATV LLALVFTGFQ GMEYYQAPFT ISDSIYGSTF
210 220 230 240 250
FLATGFHGFH VIIGTLFLII CGIRQYLGHL TKEHHVGFEA AAWYWHFVDV
260
VWLFLFVSIY WWGGI
Length:265
Mass (Da):29,961
Last modified:May 4, 2001 - v2
Checksum:i753978DE1CAA13F1
GO

RNA editingi

Edited at positions 38, 82, 86, 104, 105, 138 and 141.2 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08501 Genomic DNA Translation: CAA69818.3 Sequence problems.
JF729200 Genomic DNA Translation: AEK01262.1 Sequence problems.
JF729201 Genomic DNA Translation: AEK01298.1 Sequence problems.
JF729202 Genomic DNA Translation: AEK01326.1 Sequence problems.
AC007143 Genomic DNA Translation: AAM15412.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC06078.1 Sequence problems.
EF488906 mRNA Translation: ABS50618.1
EF488907 mRNA Translation: ABS50619.1
RefSeqiNP_085532.2, NC_001284.2
NP_178782.1, NM_126741.2
UniGeneiAt.47771

Genome annotation databases

GeneIDi814601
815364
KEGGiath:ArthMp065
ath:AT2G07687

Keywords - Coding sequence diversityi

RNA editing

Similar proteinsi

Entry informationi

Entry nameiCOX3_ARATH
AccessioniPrimary (citable) accession number: P92514
Secondary accession number(s): A7KNG3, F4IMA5, Q8S8B5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 4, 2001
Last modified: April 25, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health