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P92514

- COX3_ARATH

UniProt

P92514 - COX3_ARATH

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Protein

Cytochrome c oxidase subunit 3

Gene

COX3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciARA:AT2G07687-MONOMER.
ARA:ATMG00730-MONOMER.
MetaCyc:ATMG00730-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:COX3
Ordered Locus Names:AtMg00730
Encoded oniMitochondrion
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2, UP000006548: Mitochondrion

Organism-specific databases

TAIRiATMG00730.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Cytochrome c oxidase subunit 3PRO_0000183737Add
BLAST

Proteomic databases

PaxDbiP92514.
PRIDEiP92514.

Expressioni

Gene expression databases

GenevestigatoriP92514.

Interactioni

Protein-protein interaction databases

STRINGi3702.ATMG00730.1-P.

Structurei

3D structure databases

ProteinModelPortaliP92514.
SMRiP92514. Positions 5-263.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei41 – 6121HelicalSequence AnalysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence AnalysisAdd
BLAST
Transmembranei137 – 15721HelicalSequence AnalysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence AnalysisAdd
BLAST
Transmembranei200 – 22021HelicalSequence AnalysisAdd
BLAST
Transmembranei245 – 26521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
HOGENOMiHOG000264954.
InParanoidiP92514.
KOiK02262.
PhylomeDBiP92514.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P92514-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIESQRHSYH LVDPSPWPIS GSLGALATTV GGVMYMHSFQ GGARLLSLGL
60 70 80 90 100
IFILYTMFVW WRDVLRESTL EGHHTKVVQL GLRYGFILFI VSEVMFFFAF
110 120 130 140 150
FWAFFHSSLA PAVEIGGIWP PKGIEVLDPW EIPFLNTLIL LSSGAAVTWA
160 170 180 190 200
HHAILAGKEK RAVYALVATV LLALVFTGFQ GMEYYQAPFT ISDSIYGSTF
210 220 230 240 250
FLATGFHGFH VIIGTLFLII CGIRQYLGHL TKEHHVGFEA AAWYWHFVDV
260
VWLFLFVSIY WWGGI
Length:265
Mass (Da):29,961
Last modified:May 4, 2001 - v2
Checksum:i753978DE1CAA13F1
GO

RNA editingi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08501 Genomic DNA. Translation: CAA69818.3. Sequence problems.
JF729200 Genomic DNA. Translation: AEK01262.1. Sequence problems.
JF729201 Genomic DNA. Translation: AEK01298.1. Sequence problems.
JF729202 Genomic DNA. Translation: AEK01326.1. Sequence problems.
AC007143 Genomic DNA. Translation: AAM15412.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC06078.1. Sequence problems.
EF488906 mRNA. Translation: ABS50618.1.
EF488907 mRNA. Translation: ABS50619.1.
RefSeqiNP_085532.2. NC_001284.2.
NP_178782.1. NM_126741.2.
UniGeneiAt.47771.

Genome annotation databases

EnsemblPlantsiAT2G07687.1; AT2G07687.1; AT2G07687.
ATMG00730.1; ATMG00730.1; ATMG00730.
GeneIDi814601.
815364.
KEGGiath:ArthMp065.
ath:AT2G07687.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08501 Genomic DNA. Translation: CAA69818.3 . Sequence problems.
JF729200 Genomic DNA. Translation: AEK01262.1 . Sequence problems.
JF729201 Genomic DNA. Translation: AEK01298.1 . Sequence problems.
JF729202 Genomic DNA. Translation: AEK01326.1 . Sequence problems.
AC007143 Genomic DNA. Translation: AAM15412.1 . Sequence problems.
CP002685 Genomic DNA. Translation: AEC06078.1 . Sequence problems.
EF488906 mRNA. Translation: ABS50618.1 .
EF488907 mRNA. Translation: ABS50619.1 .
RefSeqi NP_085532.2. NC_001284.2.
NP_178782.1. NM_126741.2.
UniGenei At.47771.

3D structure databases

ProteinModelPortali P92514.
SMRi P92514. Positions 5-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.ATMG00730.1-P.

Proteomic databases

PaxDbi P92514.
PRIDEi P92514.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G07687.1 ; AT2G07687.1 ; AT2G07687 .
ATMG00730.1 ; ATMG00730.1 ; ATMG00730 .
GeneIDi 814601.
815364.
KEGGi ath:ArthMp065.
ath:AT2G07687.

Organism-specific databases

TAIRi ATMG00730.

Phylogenomic databases

eggNOGi COG1845.
HOGENOMi HOG000264954.
InParanoidi P92514.
KOi K02262.
PhylomeDBi P92514.

Enzyme and pathway databases

BioCyci ARA:AT2G07687-MONOMER.
ARA:ATMG00730-MONOMER.
MetaCyc:ATMG00730-MONOMER.

Gene expression databases

Genevestigatori P92514.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mitochondrial genome of Arabidopsis thaliana contains 57 genes in 366,924 nucleotides."
    Unseld M., Marienfeld J.R., Brandt P., Brennicke A.
    Nat. Genet. 15:57-61(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. "Double-strand break repair processes drive evolution of the mitochondrial genome in Arabidopsis."
    Davila J.I., Arrieta-Montiel M.P., Wamboldt Y., Cao J., Hagmann J., Shedge V., Xu Y.Z., Weigel D., Mackenzie S.A.
    BMC Biol. 9:64-64(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. C24, cv. Columbia and cv. Landsberg erecta.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (AT2G07687).
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION (AT2G07687).
    Strain: cv. Columbia.
  5. "Genetic architecture of mitochondrial editing in Arabidopsis thaliana."
    Bentolila S., Elliott L.E., Hanson M.R.
    Genetics 178:1693-1708(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-258, RNA EDITING.
    Strain: cv. Columbia and cv. Landsberg erecta.
    Tissue: Rosette leaf.
  6. "RNA editing in Arabidopsis mitochondria effects 441 C to U changes in ORFs."
    Giege P., Brennicke A.
    Proc. Natl. Acad. Sci. U.S.A. 96:15324-15329(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA EDITING.

Entry informationi

Entry nameiCOX3_ARATH
AccessioniPrimary (citable) accession number: P92514
Secondary accession number(s): A7KNG3, F4IMA5, Q8S8B5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 4, 2001
Last modified: October 29, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

A stretch of 270 kb of the mitochondrial genome is duplicated within the centromere of chromosome 2 resulting in the duplication of the gene. The expression of this duplicated gene (At2g07687) is not demonstrated. It is also probably not RNA edited and therefore differs in all the positions known to be edited.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3