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P92514 (COX3_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:COX3
Ordered Locus Names:AtMg00730
Encoded onMitochondrion
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Miscellaneous

A stretch of 270 kb of the mitochondrial genome is duplicated within the centromere of chromosome 2 resulting in the duplication of the gene. The expression of this duplicated gene (At2g07687) is not demonstrated. It is also probably not RNA edited and therefore differs in all the positions known to be edited.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

RNA editing

Edited at positions 38, 82, 86, 104, 105, 138 and 141. Ref.5 Ref.6

Ontologies

Keywords
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   Coding sequence diversityRNA editing
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaerobic electron transport chain

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncytochrome-c oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Cytochrome c oxidase subunit 3
PRO_0000183737

Regions

Transmembrane41 – 6121Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane137 – 15721Helical; Potential
Transmembrane162 – 18221Helical; Potential
Transmembrane200 – 22021Helical; Potential
Transmembrane245 – 26521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P92514 [UniParc].

Last modified May 4, 2001. Version 2.
Checksum: 753978DE1CAA13F1

FASTA26529,961
        10         20         30         40         50         60 
MIESQRHSYH LVDPSPWPIS GSLGALATTV GGVMYMHSFQ GGARLLSLGL IFILYTMFVW 

        70         80         90        100        110        120 
WRDVLRESTL EGHHTKVVQL GLRYGFILFI VSEVMFFFAF FWAFFHSSLA PAVEIGGIWP 

       130        140        150        160        170        180 
PKGIEVLDPW EIPFLNTLIL LSSGAAVTWA HHAILAGKEK RAVYALVATV LLALVFTGFQ 

       190        200        210        220        230        240 
GMEYYQAPFT ISDSIYGSTF FLATGFHGFH VIIGTLFLII CGIRQYLGHL TKEHHVGFEA 

       250        260 
AAWYWHFVDV VWLFLFVSIY WWGGI 

« Hide

References

« Hide 'large scale' references
[1]"The mitochondrial genome of Arabidopsis thaliana contains 57 genes in 366,924 nucleotides."
Unseld M., Marienfeld J.R., Brandt P., Brennicke A.
Nat. Genet. 15:57-61(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]"Double-strand break repair processes drive evolution of the mitochondrial genome in Arabidopsis."
Davila J.I., Arrieta-Montiel M.P., Wamboldt Y., Cao J., Hagmann J., Shedge V., Xu Y.Z., Weigel D., Mackenzie S.A.
BMC Biol. 9:64-64(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. C24, cv. Columbia and cv. Landsberg erecta.
[3]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (AT2G07687).
Strain: cv. Columbia.
[4]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION (AT2G07687).
Strain: cv. Columbia.
[5]"Genetic architecture of mitochondrial editing in Arabidopsis thaliana."
Bentolila S., Elliott L.E., Hanson M.R.
Genetics 178:1693-1708(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-258, RNA EDITING.
Strain: cv. Columbia and cv. Landsberg erecta.
Tissue: Rosette leaf.
[6]"RNA editing in Arabidopsis mitochondria effects 441 C to U changes in ORFs."
Giege P., Brennicke A.
Proc. Natl. Acad. Sci. U.S.A. 96:15324-15329(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: RNA EDITING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y08501 Genomic DNA. Translation: CAA69818.3. Sequence problems.
JF729200 Genomic DNA. Translation: AEK01262.1. Sequence problems.
JF729201 Genomic DNA. Translation: AEK01298.1. Sequence problems.
JF729202 Genomic DNA. Translation: AEK01326.1. Sequence problems.
AC007143 Genomic DNA. Translation: AAM15412.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC06078.1. Sequence problems.
EF488906 mRNA. Translation: ABS50618.1.
EF488907 mRNA. Translation: ABS50619.1.
RefSeqNP_085532.2. NC_001284.2.
NP_178782.1. NM_126741.2.
UniGeneAt.47771.

3D structure databases

ProteinModelPortalP92514.
SMRP92514. Positions 5-263.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING3702.ATMG00730.1-P.

Proteomic databases

PaxDbP92514.
PRIDEP92514.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G07687.1; AT2G07687.1; AT2G07687.
ATMG00730.1; ATMG00730.1; ATMG00730.
GeneID814601.
815364.
KEGGath:ArthMp065.
ath:AT2G07687.

Organism-specific databases

TAIRATMG00730.

Phylogenomic databases

eggNOGCOG1845.
HOGENOMHOG000264954.
InParanoidP92514.
KOK02262.
PhylomeDBP92514.

Enzyme and pathway databases

BioCycARA:AT2G07687-MONOMER.
ARA:ATMG00730-MONOMER.
MetaCyc:ATMG00730-MONOMER.

Gene expression databases

GenevestigatorP92514.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. SSF81452. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_ARATH
AccessionPrimary (citable) accession number: P92514
Secondary accession number(s): A7KNG3, F4IMA5, Q8S8B5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 4, 2001
Last modified: June 11, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names