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Protein

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Gene
N/A
Organism
Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in the pathway tricarboxylic acid cycle, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi95Iron (heme axial ligand); shared with large subunitBy similarity1
Binding sitei107Ubiquinone; shared with IPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport, Tricarboxylic acid cycle
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18286
BRENDAi1.3.5.4 474
SABIO-RKP92507
UniPathwayiUPA00223

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Short name:
CybS
Alternative name(s):
Cytochrome b558 small subunit
Succinate-ubiquinone reductase membrane anchor subunit
OrganismiAscaris suum (Pig roundworm) (Ascaris lumbricoides)
Taxonomic identifieri6253 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaAscarididaAscaridoideaAscarididaeAscaris

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 57Mitochondrial matrixBy similarityAdd BLAST32
Transmembranei58 – 78HelicalBy similarityAdd BLAST21
Topological domaini79 – 83Mitochondrial intermembraneBy similarity5
Transmembranei84 – 104HelicalBy similarityAdd BLAST21
Topological domaini105 – 117Mitochondrial matrixBy similarityAdd BLAST13
Transmembranei118 – 139HelicalBy similarityAdd BLAST22
Topological domaini140 – 156Mitochondrial intermembraneBy similarityAdd BLAST17

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25Mitochondrion1 PublicationAdd BLAST25
ChainiPRO_000000649026 – 156Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialAdd BLAST131

Interactioni

Subunit structurei

Forms part of complex II containing four subunits: a flavoprotein (FP), an iron-sulfur protein (IP) and a cytochrome b composed of a large and a small subunit.By similarity

Structurei

Secondary structure

1156
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni42 – 48Combined sources7
Helixi56 – 78Combined sources23
Helixi82 – 107Combined sources26
Helixi110 – 113Combined sources4
Helixi115 – 142Combined sources28
Helixi146 – 155Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VR8X-ray2.81D/H1-156[»]
3VR9X-ray3.01D/H1-156[»]
3VRAX-ray3.44D/H1-156[»]
3VRBX-ray2.91D/H1-156[»]
4YSXX-ray2.25D/H1-156[»]
4YSYX-ray3.10D/H1-156[»]
4YSZX-ray3.30D/H1-156[»]
4YT0X-ray3.66D/H1-156[»]
4YTMX-ray3.40D/H1-156[»]
4YTNX-ray3.00D/H1-156[»]
5C2TX-ray2.75D/H1-156[»]
5C3JX-ray2.80D/H1-156[»]
ProteinModelPortaliP92507
SMRiP92507
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CybS family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Family and domain databases

CDDicd03496 SQR_TypeC_CybS, 1 hit
Gene3Di1.20.1300.10, 1 hit
InterProiView protein in InterPro
IPR007992 CybS
IPR034804 SQR/QFR_C/D
PANTHERiPTHR13337 PTHR13337, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P92507-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSAVRRAIP LSARILRTSL IQRCAGATSA AVTGAAPPQF DPIAAEKGFK
60 70 80 90 100
PLHSHGTLFK IERYFAAAMV PLIPAAYFIH GREMDLCLAL ALTLHVHWGV
110 120 130 140 150
WGVVNDYGRP FVLGDTLAAA VRVGAYIFTA CLLAGLLYFN EHDVGLTRAF

EMVWEL
Length:156
Mass (Da):16,996
Last modified:July 1, 1997 - v2
Checksum:i6515299AF6CFA93F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78158 mRNA Translation: BAA11233.1

Similar proteinsi

Entry informationi

Entry nameiDHSD_ASCSU
AccessioniPrimary (citable) accession number: P92507
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: October 25, 2017
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

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