Reviewed, UniProtKB/Swiss-Prot P92504 (CYC1_ASCSU)

Names and origin

Protein names	Recommended name:     Cytochrome c type-1
Organism	Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Taxonomic identifier	6253 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Nematoda › Chromadorea › Ascaridida › Ascaridoidea › Ascarididae › Ascaris

Protein attributes

Sequence length	112 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Electron carrier between complex III (ubiquinol-cytochrome c oxireductase) and complex IV (cytochrome c oxidase).
Subcellular location	Mitochondrion matrix.
Developmental stage	Found in the mitochondria from unembryonated eggs, and in second-, third-, and fourth-stage larvae. Highest expression found in second-stage larvae. Reaches undetectable levels in the adult.
Post-translational modification	Binds 1 heme group per subunit.
Sequence similarities	Belongs to the cytochrome c family.
Biophysicochemical properties	Redox potential: E0 is +248 mV.
Mass spectrometry	Molecular mass is 13119 Da from positions 2 - 112. Determined by ESI. Ref.2

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Mitochondrion
Ligand	Heme Iron Metal-binding
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.2
	Chain	2 – 112	111	Cytochrome c type-1		PRO_0000108268
Sites
	Metal binding	24	1	Iron (heme axial ligand) By similarity
	Metal binding	85	1	Iron (heme axial ligand) By similarity
	Binding site	20	1	Heme (covalent) By similarity
	Binding site	23	1	Heme (covalent) By similarity
Experimental info
	Sequence conflict	11	1	S → R AA sequence Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P92504-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: C216ED197637E4B1	FASTA	112	12,565
	10 20 30 40 50 60 MPEIPEGDYE SGKKVFKQRC LQCHVVDSKA TKTGPTLHGI IGRKSGAVPG FDYSTANKNK 70 80 90 100 110 GVVWTRETLF EYLLNPKKYI PGTKMVFAGL KKADERADLI KYIEEECKKP IS

References

[1]	"cDNA cloning for mitochondrial cytochrome c and its adult-specific isoform from Ascaris suum." Takamiya S., Hirawake H., Kuramochi T., Aoki T., Kojima S., Kita K. Mol. Biochem. Parasitol. 76:293-297(1996) [PubMed: 8920015] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Muscle.
[2]	"Molecular and functional properties of cytochrome c from adult Ascaris suum muscle." Takamiya S., Yu Y., Cavaleante M.E., Murayama K., Taka H., Tateno S., Takeuchi T., Aoki T. Mol. Biochem. Parasitol. 79:61-70(1996) [PubMed: 8844672] [Abstract] Cited for: CHARACTERIZATION, PROTEIN SEQUENCE OF 2-34, MASS SPECTROMETRY.

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases
EMBLGenBankDDBJ	D73391 mRNA. Translation: BAA11131.1. Different termination.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR002327. Cyt_c_1A/1B. IPR003088. Cyt_c_I. IPR009056. Cyt_c_monohaem. [Graphical view]
Gene3D	G3DSA:1.10.760.10. Cytochrome_c_R. 1 hit.
PANTHER	PTHR11961. Cyt_CIAB. 1 hit.
Pfam	PF00034. Cytochrom_C. 1 hit. [Graphical view]
PRINTS	PR00604. CYTCHRMECIAB.
PROSITE	PS51007. CYTC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYC1_ASCSU

Accession

Primary (citable) accession number: P92504

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 23, 2007
Last modified:	November 24, 2009
This is version 72 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)