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Protein

Larval cuticle protein 5

Gene

Lcp65Ab1

more
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the cuticle of the larva.

GO - Molecular functioni

  • structural constituent of chitin-based larval cuticle Source: UniProtKB

GO - Biological processi

  • chitin-based cuticle development Source: FlyBase
  • larval chitin-based cuticle development Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Larval cuticle protein 5
Alternative name(s):
Larval cuticle protein V
Gene namesi
Name:Lcp65Ab1
Synonyms:DCP3-alpha, Lcp5
ORF Names:CG18776
AND
Name:Lcp65Ab2
Synonyms:DCP3-beta, Lcp5
ORF Names:CG18773
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0020644. Lcp65Ab1.
FBgn0020643. Lcp65Ab2.

Subcellular locationi

GO - Cellular componenti

  • extracellular matrix Source: FlyBase
  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cuticle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Chaini19 – 10486Larval cuticle protein 5PRO_0000006394Add
BLAST

Proteomic databases

PaxDbiP92192.
PRIDEiP92192.

Expressioni

Developmental stagei

Expression begins at the end of second larval instar, present throughout third larval instar and is gone by the pupal stages.1 Publication

Gene expression databases

ExpressionAtlasiP92192. differential.
GenevisibleiP92192. DM.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 10271Chitin-binding type R&RPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 chitin-binding type R&R domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00530000064111.
InParanoidiP92192.
OMAiEGNTHTI.
OrthoDBiEOG72JWJ7.
PhylomeDBiP92192.

Family and domain databases

InterProiIPR000618. Insect_cuticle.
[Graphical view]
PfamiPF00379. Chitin_bind_4. 1 hit.
[Graphical view]
PROSITEiPS51155. CHIT_BIND_RR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P92192-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLIVFVAL FAMAVARPNL AEIVRQVSDV EPEKWSSDVE TSDGTSIKQE
60 70 80 90 100
GVLKNAGTDN EAAVVHGSFT WVDEKTGEKF TITYVADENG YQPQGAHLPV

APVA
Length:104
Mass (Da):11,267
Last modified:May 1, 1997 - v1
Checksum:iBA60DD9483DD6992
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 7211AAVVHGSFTWV → CRCRPRILHLG in AAD00301 (Ref. 1) CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81550 mRNA. Translation: AAD00301.1.
U84746 Genomic DNA. Translation: AAB88065.1.
U84747 Genomic DNA. Translation: AAB88066.1.
AE014296 Genomic DNA. Translation: AAG22328.1.
AE014296 Genomic DNA. Translation: AAG22331.1.
AY071366 mRNA. Translation: AAL48988.1.
RefSeqiNP_524814.2. NM_080075.3.
NP_788469.1. NM_176291.3.
UniGeneiDm.20808.
Dm.33352.

Genome annotation databases

EnsemblMetazoaiFBtr0076992; FBpp0076701; FBgn0020643.
FBtr0076994; FBpp0076702; FBgn0020644.
GeneIDi48381.
48382.
KEGGidme:Dmel_CG18773.
dme:Dmel_CG32400.
UCSCiCG18773-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81550 mRNA. Translation: AAD00301.1.
U84746 Genomic DNA. Translation: AAB88065.1.
U84747 Genomic DNA. Translation: AAB88066.1.
AE014296 Genomic DNA. Translation: AAG22328.1.
AE014296 Genomic DNA. Translation: AAG22331.1.
AY071366 mRNA. Translation: AAL48988.1.
RefSeqiNP_524814.2. NM_080075.3.
NP_788469.1. NM_176291.3.
UniGeneiDm.20808.
Dm.33352.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiP92192.
PRIDEiP92192.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0076992; FBpp0076701; FBgn0020643.
FBtr0076994; FBpp0076702; FBgn0020644.
GeneIDi48381.
48382.
KEGGidme:Dmel_CG18773.
dme:Dmel_CG32400.
UCSCiCG18773-RA. d. melanogaster.

Organism-specific databases

CTDi48381.
48382.
FlyBaseiFBgn0020644. Lcp65Ab1.
FBgn0020643. Lcp65Ab2.

Phylogenomic databases

GeneTreeiENSGT00530000064111.
InParanoidiP92192.
OMAiEGNTHTI.
OrthoDBiEOG72JWJ7.
PhylomeDBiP92192.

Miscellaneous databases

PROiP92192.

Gene expression databases

ExpressionAtlasiP92192. differential.
GenevisibleiP92192. DM.

Family and domain databases

InterProiIPR000618. Insect_cuticle.
[Graphical view]
PfamiPF00379. Chitin_bind_4. 1 hit.
[Graphical view]
PROSITEiPS51155. CHIT_BIND_RR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The cuticle proteins of Drosophila melanogaster: sequence of Lcp5 in the third chromosome cluster."
    Mandalaparthy P., Jiang S., Schneider G., Chihara C.
    Dros. Info. Service 77:49-51(1996)
    Cited for: NUCLEOTIDE SEQUENCE (LCP65AB1).
    Strain: Oregon-R.
  2. "A cluster of cuticle genes of Drosophila at 65A: sequence, structure and evolution."
    Charles J.-P., Chihara C., Nejad S., Riddiford L.M.
    Genetics 147:1213-1224(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (LCP65AB1 AND LCP65AB2).
    Strain: Iso-1.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (LCP65AB1 AND LCP65AB2).
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. "A Drosophila full-length cDNA resource."
    Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
    Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (LCP65AB2).
    Strain: Berkeley.
  6. "Identification of proteins and developmental expression of RNAs encoded by the 65A cuticle protein gene cluster in Drosophila melanogaster."
    Charles J.-P., Chihara C., Nejad S., Riddiford L.M.
    Insect Biochem. Mol. Biol. 28:131-138(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-32, DEVELOPMENTAL STAGE.
    Strain: Oregon-R.
    Tissue: Larva.

Entry informationi

Entry nameiLCP5_DROME
AccessioniPrimary (citable) accession number: P92192
Secondary accession number(s): O96905
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 1, 1997
Last modified: June 8, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.