Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P92188

- PSA1_TRYCR

UniProt

P92188 - PSA1_TRYCR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Proteasome subunit alpha type-1

Gene
N/A
Organism
Trypanosoma cruzi
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Protein family/group databases

MEROPSiT01.976.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-1 (EC:3.4.25.1)
Alternative name(s):
Proteasome 29 kDa subunit
TCPR29
OrganismiTrypanosoma cruzi
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
  3. proteasome core complex, alpha-subunit complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Proteasome subunit alpha type-1PRO_0000124071Add
BLAST

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP92188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P92188-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFKNQYDTNT TTWSPTGRLF QVEYANEAVN NGSAAVGAKN KDFVVLTALK
60 70 80 90 100
RSPVAQFSSY QEKVFKLDDH VGMAIAGLVA DGRMLARFVR TECMNYRYMH
110 120 130 140 150
DSDNPLPLIA EIVGEKYQRH IQFAGKRPFG VGLLIAGYDS TGPHLYHTVP
160 170 180 190 200
SGDVFDFKAT AMGLRSQAAR TYLEKHFESF PDCGLDELIM HALKALAAAT
210 220 230 240 250
SGGAELNIKN TTIAIVGKGT PFMVLTEEAA RKYLDGFKMR PEDIPPAPEA
260
EEEETLQERS LDVEE
Length:265
Mass (Da):29,335
Last modified:May 1, 1997 - v1
Checksum:i730E0EC27994AA2A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381A → T in AAB48403. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73850 Genomic DNA. Translation: AAB48403.1.
U73851 mRNA. Translation: AAB48404.1.
U75302 mRNA. Translation: AAB48405.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73850 Genomic DNA. Translation: AAB48403.1 .
U73851 mRNA. Translation: AAB48404.1 .
U75302 mRNA. Translation: AAB48405.1 .

3D structure databases

ProteinModelPortali P92188.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi T01.976.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view ]
SMARTi SM00948. Proteasome_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "T. cruzi 29 kDa proteasome subunit class II mRNA."
    Lima B.D., Batista J.A.N., Bartholomeu D.C., Vainstein M.H., de Sa C.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Tulahuen.
  2. "The 29 kDa subunit genomic sequence of Trypanosoma cruzi proteasome."
    Bartholomeu D.C., Batista J.A.N., Lima B.D., Vainstein M.H., Sa Martins C.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DM28.

Entry informationi

Entry nameiPSA1_TRYCR
AccessioniPrimary (citable) accession number: P92188
Secondary accession number(s): P90643
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3