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P92188 (PSA1_TRYCR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit alpha type-1

EC=3.4.25.1
Alternative name(s):
Proteasome 29 kDa subunit
TCPR29
OrganismTrypanosoma cruzi
Taxonomic identifier5693 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Proteasome subunit alpha type-1
PRO_0000124071

Experimental info

Sequence conflict381A → T in AAB48403. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P92188 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 730E0EC27994AA2A

FASTA26529,335
        10         20         30         40         50         60 
MFKNQYDTNT TTWSPTGRLF QVEYANEAVN NGSAAVGAKN KDFVVLTALK RSPVAQFSSY 

        70         80         90        100        110        120 
QEKVFKLDDH VGMAIAGLVA DGRMLARFVR TECMNYRYMH DSDNPLPLIA EIVGEKYQRH 

       130        140        150        160        170        180 
IQFAGKRPFG VGLLIAGYDS TGPHLYHTVP SGDVFDFKAT AMGLRSQAAR TYLEKHFESF 

       190        200        210        220        230        240 
PDCGLDELIM HALKALAAAT SGGAELNIKN TTIAIVGKGT PFMVLTEEAA RKYLDGFKMR 

       250        260 
PEDIPPAPEA EEEETLQERS LDVEE 

« Hide

References

[1]"T. cruzi 29 kDa proteasome subunit class II mRNA."
Lima B.D., Batista J.A.N., Bartholomeu D.C., Vainstein M.H., de Sa C.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Tulahuen.
[2]"The 29 kDa subunit genomic sequence of Trypanosoma cruzi proteasome."
Bartholomeu D.C., Batista J.A.N., Lima B.D., Vainstein M.H., Sa Martins C.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: DM28.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U73850 Genomic DNA. Translation: AAB48403.1.
U73851 mRNA. Translation: AAB48404.1.
U75302 mRNA. Translation: AAB48405.1.

3D structure databases

ProteinModelPortalP92188.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPST01.976.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSA1_TRYCR
AccessionPrimary (citable) accession number: P92188
Secondary accession number(s): P90643
Entry history
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: May 1, 1997
Last modified: June 11, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries