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Protein
Submitted name:

Cysteine proteinase LmCPB1

Gene

lmcpb1

Organism
Leishmania mexicana
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Cysteine proteinase LmCPB1Imported
Gene namesi
Name:lmcpb1Imported
OrganismiLeishmania mexicanaImported
Taxonomic identifieri5665 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27UniRule annotationAdd BLAST27
ChainiPRO_500416194728 – 359UniRule annotationAdd BLAST332

Structurei

3D structure databases

ProteinModelPortaliP92185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 94Inhibitor_I29InterPro annotationAdd BLAST57
Domaini126 – 339Pept_C1InterPro annotationAdd BLAST214

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili45 – 72Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the peptidase C1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG1542. Eukaryota.
COG4870. LUCA.

Family and domain databases

InterProiIPR033163. CPB_peptidase.
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PTHR12411:SF363. PTHR12411:SF363. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P92185-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSRAALCA VAVVCVVLAA ACAPARAIHV GTPAAALFEE FKRTYGRAYE
60 70 80 90 100
TLAEEQQRLA NFERNLELMR EHQARNPHAQ FGITKFFDLS EAEFCARYLN
110 120 130 140 150
GAAYFAAAKR HTPQHYPKAR ADLSAVPDAV DWREKGAVTP VKDQGACGSC
160 170 180 190 200
WAFSAVGNIE GQWYLAGHEL VSLSEQQLVS CDDMNDGCDG GLMLQAFDWL
210 220 230 240 250
LQNTNGHLYT EDSYPYVSGN GYLPECSNSS KLVVGAQIDG HVLIGSSEKA
260 270 280 290 300
MAAWLAKNGP IAIALDASSF MSYKSGVLTA CIGKQVNHAV LLVGYDMTGE
310 320 330 340 350
VPYWVIKNSW GGDWGEQGYV RVVMGVNACL LSEYPVSAHV RESAAPGTST

SSETPAQNG
Length:359
Mass (Da):38,663
Last modified:July 5, 2004 - v3
Checksum:i0F075C1EC00F94A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49963 Genomic DNA. Translation: CAA90237.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49963 Genomic DNA. Translation: CAA90237.1.

3D structure databases

ProteinModelPortaliP92185.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1542. Eukaryota.
COG4870. LUCA.

Family and domain databases

InterProiIPR033163. CPB_peptidase.
IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PTHR12411:SF363. PTHR12411:SF363. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP92185_LEIME
AccessioniPrimary (citable) accession number: P92185
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: July 5, 2004
Last modified: October 5, 2016
This is version 67 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.