Reviewed, UniProtKB/Swiss-Prot P92119 (TPIS_AEDTO)

Names and origin

Protein names

Recommended name:
    Triosephosphate isomerase
      Short name=TIM
    EC=5.3.1.1
Alternative name(s):
    Triose-phosphate isomerase

Gene names

Name:

Tpi

Organism

Aedes togoi (Mosquito) (Ochlerotatus togoi)

Taxonomic identifier

55967 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Culicini › Aedes › Finlaya

Protein attributes

Sequence length	206 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glyceraldehyde 3-phosphate = glycerone phosphate.
Pathway	Carbohydrate biosynthesis; gluconeogenesis. Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the triosephosphate isomerase family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Gluconeogenesis Glycolysis Lipid synthesis Pentose shunt
Molecular function	Isomerase
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	triose-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›206	›206	Triosephosphate isomerase		PRO_0000090124
Sites
	Active site	76	1	Electrophile By similarity
	Active site	146	1	Proton acceptor By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	206	1

Sequences

	Sequence		Length	Mass (Da)
	P92119-1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: AD89BBA000FF8B69	FASTA	206	21,925
	10 20 30 40 50 60 SIAELCKVLT TGPLNADTEV VVGCPAPYLT LARSQLPDSV GVAAQNCYKV AKGAFTGEIS 70 80 90 100 110 120 PAMLKDLNIG WVILGHSERR AIFGESDELI ADKVAHALAE GLKVIACIGE TLQEREAGQT 130 140 150 160 170 180 EAVCFRQTKA IADKVKDWSN VVVAYEPVWA IGTGKTATPE QAQEVHVALR KWFTDNVSAD 190 200 VSASIRIQYG GSVTAANCRE LAAKPD

References

[1]	"Towards a reconciliation of the introns early or late views: triosephosphate isomerase genes from insects." Tyshenko M.G., Walker V.K. Biochim. Biophys. Acta 1353:131-136(1997) [PubMed: 9294007] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U82708 Genomic DNA. Translation: AAB48449.1.
3D structure databases
HSSP	HSSP built from PDB template 1TPH based on UniProtKB P00940.
SMR	P92119. Positions 2-206.
ModBase	Search...
Enzyme and pathway databases
BRENDA	5.3.1.1. 282.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR000652. Triosephosphate_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR21139. Triophos_ismrse. 1 hit.
Pfam	PF00121. TIM. 1 hit. [Graphical view]
ProDom	PD001005. Triophos_ismrse. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00419. tim. 1 hit.
PROSITE	PS00171. TIM_1. 1 hit. PS51440. TIM_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPIS_AEDTO

Accession

Primary (citable) accession number: P92119

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)