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P92039

- P92039_HAECO

UniProt

P92039 - P92039_HAECO

Protein
Submitted name:

Acetylcholine receptor alpha subunit

Gene

AChR

Organism
Haemonchus contortus (Barber pole worm)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. acetylcholine-activated cation-selective channel activity Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Acetylcholine receptor alpha subunitImported
    Gene namesi
    Name:AChRImported
    OrganismiHaemonchus contortus (Barber pole worm)Imported
    Taxonomic identifieri6289 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaStrongylidaTrichostrongyloideaHaemonchidaeHaemonchinaeHaemonchus

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919 PotentialImportedAdd
    BLAST
    Chaini20 – 512493acetylcholine receptor alpha subunitImportedPRO_5000145150Add
    BLAST

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliP92039.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotation

    Keywords - Domaini

    SignalImported, Transmembrane, Transmembrane helixSAAS annotation

    Family and domain databases

    Gene3Di1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProiIPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P92039-1 [UniParc]FASTAAdd to Basket

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    MRHLLSFVIS FVSFYYIYAN EDAKRLYDDL MVNYNRHRRP ASGPHEPLTI    50
    KLKLRLSQII DVHEIDQIMT CSVWLKQVWI DKKLSWDPES YGGVSVLYVP 100
    YEMIWVPDIV LYNNADSNYN ITISTKATLH YSGEVTWEPP AIFKSMCQID 150
    VRWFPFDEQQ CHLKFGSWTN SENLLNLELL ENNVRYEEEV NEQGIVDNIT 200
    IADDGIDLSD YYPSVEWDIM SRVARRRSKN YPSCCPQSAY IDIMYYLELR 250
    RKPLFYTVNL VFPCVGISFL TILVFYLPSD SGEKVTLCIS ILVALTIFFL 300
    LLTEIIPATS ITLPLIGKYL LFTMVMVTLS VVVTVISLNL HFRTPTTHLM 350
    PKWVKLVFLK WLPKVLFMRR PLDDGDESFR RVSSRKGIGP TTFDGKIPLN 400
    LHEHRVSRDI GKSLANAAID ERIQKLYYSP QVVKAFENIC FIAELLKKKD 450
    RDDKIDEDWK YVAMVLDRLF LLIFSFACFI GTVLILLQAP TLYDDRKPID 500
    LQYRPANLSA LF 512
    Length:512
    Mass (Da):59,540
    Last modified:May 1, 1997 - v1
    Checksum:iCABE7A264200DB03
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U72490 mRNA. Translation: AAB51667.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U72490 mRNA. Translation: AAB51667.1 .

    3D structure databases

    ProteinModelPortali P92039.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProi IPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Hoekstra R.R.
      Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Characterization of an acetylcholine receptor gene of Haemonchus contortus in relation to levamisole resistance."
      Hoekstra R., Visser A., Wiley L.J., Weiss A.S., Sangster N.C., Roos M.H.
      Mol. Biochem. Parasitol. 84:179-187(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiP92039_HAECO
    AccessioniPrimary (citable) accession number: P92039
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)