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Protein
Submitted name:

Acetylcholine receptor alpha subunit

Gene

AChR

Organism
Haemonchus contortus (Barber pole worm)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. acetylcholine-activated cation-selective channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Acetylcholine receptor alpha subunitImported
Gene namesi
Name:AChRImported
OrganismiHaemonchus contortus (Barber pole worm)Imported
Taxonomic identifieri6289 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaStrongylidaTrichostrongyloideaHaemonchidaeHaemonchinaeHaemonchus

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 PotentialImportedAdd
BLAST
Chaini20 – 512493acetylcholine receptor alpha subunitImportedPRO_5000145150Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliP92039.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotation

Keywords - Domaini

SignalImported, Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P92039-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRHLLSFVIS FVSFYYIYAN EDAKRLYDDL MVNYNRHRRP ASGPHEPLTI
60 70 80 90 100
KLKLRLSQII DVHEIDQIMT CSVWLKQVWI DKKLSWDPES YGGVSVLYVP
110 120 130 140 150
YEMIWVPDIV LYNNADSNYN ITISTKATLH YSGEVTWEPP AIFKSMCQID
160 170 180 190 200
VRWFPFDEQQ CHLKFGSWTN SENLLNLELL ENNVRYEEEV NEQGIVDNIT
210 220 230 240 250
IADDGIDLSD YYPSVEWDIM SRVARRRSKN YPSCCPQSAY IDIMYYLELR
260 270 280 290 300
RKPLFYTVNL VFPCVGISFL TILVFYLPSD SGEKVTLCIS ILVALTIFFL
310 320 330 340 350
LLTEIIPATS ITLPLIGKYL LFTMVMVTLS VVVTVISLNL HFRTPTTHLM
360 370 380 390 400
PKWVKLVFLK WLPKVLFMRR PLDDGDESFR RVSSRKGIGP TTFDGKIPLN
410 420 430 440 450
LHEHRVSRDI GKSLANAAID ERIQKLYYSP QVVKAFENIC FIAELLKKKD
460 470 480 490 500
RDDKIDEDWK YVAMVLDRLF LLIFSFACFI GTVLILLQAP TLYDDRKPID
510
LQYRPANLSA LF
Length:512
Mass (Da):59,540
Last modified:May 1, 1997 - v1
Checksum:iCABE7A264200DB03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72490 mRNA. Translation: AAB51667.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72490 mRNA. Translation: AAB51667.1.

3D structure databases

ProteinModelPortaliP92039.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Hoekstra R.R.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Characterization of an acetylcholine receptor gene of Haemonchus contortus in relation to levamisole resistance."
    Hoekstra R., Visser A., Wiley L.J., Weiss A.S., Sangster N.C., Roos M.H.
    Mol. Biochem. Parasitol. 84:179-187(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiP92039_HAECO
AccessioniPrimary (citable) accession number: P92039
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: February 4, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.