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Protein
Submitted name:

Ligand-Gated ion Channel

Gene

lgc-48

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Ligand-Gated ion ChannelImported
Gene namesi
Name:lgc-48Imported
ORF Names:C50B6.11Imported, CELE_C50B6.11Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC50B6.11; CE42944; WBGene00008223; lgc-48.

Subcellular locationi

  • Cell junctionsynapse SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei237 – 25923HelicalSequence analysisAdd
BLAST
Transmembranei271 – 28818HelicalSequence analysisAdd
BLAST
Transmembranei300 – 32324HelicalSequence analysisAdd
BLAST
Transmembranei344 – 36320HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, SynapseSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiP91985.

Expressioni

Gene expression databases

BgeeiWBGene00008223.

Interactioni

Protein-protein interaction databases

STRINGi6239.C50B6.11.

Structurei

3D structure databases

ProteinModelPortaliP91985.
SMRiP91985. Positions 29-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 236208Neur_chan_LBDInterPro annotationAdd
BLAST
Domaini245 – 32682Neur_chan_membInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3644. Eukaryota.
ENOG410XP43. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000016259.
InParanoidiP91985.
OMAiITPRTMI.
OrthoDBiEOG091G07NS.
PhylomeDBiP91985.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91985-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFHIFLGLL VAVLGEEVHE LRSECLNEAQ LMEKLLKGSG YSKHKIPREN
60 70 80 90 100
GITVSVEFWI QEINSISEMT NDFELELFIN EMWTDPSLRF PHLGACKANL
110 120 130 140 150
TLDQQTLTKL WTPNTCFVNS KFAEIYESSF QNVFLTLFDN GTVWVNYRVR
160 170 180 190 200
VKGACNMDLV DFPMDTQSCR LNYQSFTYNN EEVRLQWNSQ RSPVFALQEI
210 220 230 240 250
RIADFWLKDI TPAVIKRDYP AGLWDELVVT FVFERRYMWY FLQAYLPTFF
260 270 280 290 300
SIFISWIAFS LGPQAITPRT MIGVNALLSM IFHFGSIMKN LPRVSYIKAI
310 320 330 340 350
DVWMLSSMTF VFLSLIELAI VGYKLQIQRE KEHVIEKVDK IARFAFPAGF
360
SIFNIIYWAR YGFKVG
Length:366
Mass (Da):42,754
Last modified:September 23, 2008 - v3
Checksum:iFDDD0A2D22C43188
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB02858.3.
RefSeqiNP_506308.3. NM_073907.3.
UniGeneiCel.26142.

Genome annotation databases

EnsemblMetazoaiC50B6.11; C50B6.11; WBGene00008223.
GeneIDi183638.
KEGGicel:CELE_C50B6.11.
UCSCiC50B6.11. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA. Translation: CAB02858.3.
RefSeqiNP_506308.3. NM_073907.3.
UniGeneiCel.26142.

3D structure databases

ProteinModelPortaliP91985.
SMRiP91985. Positions 29-361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C50B6.11.

Proteomic databases

PaxDbiP91985.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC50B6.11; C50B6.11; WBGene00008223.
GeneIDi183638.
KEGGicel:CELE_C50B6.11.
UCSCiC50B6.11. c. elegans.

Organism-specific databases

CTDi183638.
WormBaseiC50B6.11; CE42944; WBGene00008223; lgc-48.

Phylogenomic databases

eggNOGiKOG3644. Eukaryota.
ENOG410XP43. LUCA.
GeneTreeiENSGT00760000119010.
HOGENOMiHOG000016259.
InParanoidiP91985.
OMAiITPRTMI.
OrthoDBiEOG091G07NS.
PhylomeDBiP91985.

Gene expression databases

BgeeiWBGene00008223.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP91985_CAEEL
AccessioniPrimary (citable) accession number: P91985
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: September 23, 2008
Last modified: September 7, 2016
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.