Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Ligand-Gated ion Channel

Gene

lgc-48

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotation
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Ligand-Gated ion ChannelImported
Gene namesi
Name:lgc-48Imported
ORF Names:C50B6.11Imported, CELE_C50B6.11Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC50B6.11 ; CE42944 ; WBGene00008223 ; lgc-48

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei237 – 259HelicalSequence analysisAdd BLAST23
Transmembranei271 – 288HelicalSequence analysisAdd BLAST18
Transmembranei300 – 323HelicalSequence analysisAdd BLAST24
Transmembranei344 – 363HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_501200011216 – 366Sequence analysisAdd BLAST351

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiP91985

Expressioni

Gene expression databases

BgeeiWBGene00008223

Interactioni

Protein-protein interaction databases

STRINGi6239.C50B6.11

Structurei

3D structure databases

ProteinModelPortaliP91985
SMRiP91985
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 236Neur_chan_LBDInterPro annotationAdd BLAST208
Domaini245 – 326Neur_chan_membInterPro annotationAdd BLAST82

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3644 Eukaryota
ENOG410XP43 LUCA
GeneTreeiENSGT00760000119010
HOGENOMiHOG000016259
InParanoidiP91985
OMAiITPRTMI
OrthoDBiEOG091G07NS
PhylomeDBiP91985

Family and domain databases

Gene3Di2.70.170.101 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

P91985-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFFHIFLGLL VAVLGEEVHE LRSECLNEAQ LMEKLLKGSG YSKHKIPREN
60 70 80 90 100
GITVSVEFWI QEINSISEMT NDFELELFIN EMWTDPSLRF PHLGACKANL
110 120 130 140 150
TLDQQTLTKL WTPNTCFVNS KFAEIYESSF QNVFLTLFDN GTVWVNYRVR
160 170 180 190 200
VKGACNMDLV DFPMDTQSCR LNYQSFTYNN EEVRLQWNSQ RSPVFALQEI
210 220 230 240 250
RIADFWLKDI TPAVIKRDYP AGLWDELVVT FVFERRYMWY FLQAYLPTFF
260 270 280 290 300
SIFISWIAFS LGPQAITPRT MIGVNALLSM IFHFGSIMKN LPRVSYIKAI
310 320 330 340 350
DVWMLSSMTF VFLSLIELAI VGYKLQIQRE KEHVIEKVDK IARFAFPAGF
360
SIFNIIYWAR YGFKVG
Length:366
Mass (Da):42,754
Last modified:September 23, 2008 - v3
Checksum:iFDDD0A2D22C43188
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAB02858.3
RefSeqiNP_506308.3, NM_073907.3
UniGeneiCel.26142

Genome annotation databases

EnsemblMetazoaiC50B6.11; C50B6.11; WBGene00008223
GeneIDi183638
KEGGicel:CELE_C50B6.11
UCSCiC50B6.11 c. elegans

Similar proteinsi

Entry informationi

Entry nameiP91985_CAEEL
AccessioniPrimary (citable) accession number: P91985
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: September 23, 2008
Last modified: February 28, 2018
This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported