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Protein
Submitted name:

Elongation factor 1 alpha-like factor

Gene

Elf

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • GTPase activity Source: FlyBase
  • GTP binding Source: FlyBase
  • translation elongation factor activity Source: UniProtKB-KW
  • translation release factor activity Source: FlyBase
  • translation termination factor activity Source: FlyBase

GO - Biological processi

  • translational termination Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Elongation factorImported

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-DME-72764. Eukaryotic Translation Termination.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Submitted name:
Elongation factor 1 alpha-like factorImported
Gene namesi
Name:ElfImported
Synonyms:Dsup35Imported
ORF Names:CG6382Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0020443. Elf.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: FlyBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiP91944.
PeptideAtlasiP91944.
PRIDEiP91944.

Expressioni

Gene expression databases

BgeeiFBgn0020443.
ExpressionAtlasiP91944. differential.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0305302.

Structurei

3D structure databases

ProteinModelPortaliP91944.
SMRiP91944. Positions 187-619.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini193 – 419227Tr-type G (guanine nucleotide-binding)InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0459. Eukaryota.
COG5256. LUCA.
OrthoDBiEOG091G0637.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR009818. Ataxin-2_C.
IPR004161. EFTu-like_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
PF07145. PAM2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQENTEIS TKFSTLNVNA VEFVPSFSYN SVVNVAEEAA AVVVAAAAAE
60 70 80 90 100
ETADPGPASG SATPATTPDS VGSGGSTAGA APPPPTAQGA GAAAPSAQPP
110 120 130 140 150
TSSSNSASPA PGSPATTPSA GAAAADPTPI DGLNPSDKIA NNETDPADSW
160 170 180 190 200
DVDDAVITPE DEEVEDAEFT EGEATPKVSK KKVVKVEENR SKREHVNVVF
210 220 230 240 250
IGHVDAGKST IGGQIMSLTG MVHKRTLEKY EREAREKSRE SWYLSWGLDT
260 270 280 290 300
NQEERDKGKT VGVGRAFFET DRKHFTILDA PGHKSFVPNM IGGAAQADLA
310 320 330 340 350
VLVISARKGE FETGFDRGGQ TREHAMLAKT AGVKHLVVLV NKMDDPTVNW
360 370 380 390 400
DQTRYNECKD KILPYLKKLG FNPAKDLTFM PCSGLSGTGL KDQIPETLCP
410 420 430 440 450
WYRGPAFIPF IDELPSLNRK SDGPFIMPIV DKYKDMGTVV MGKVESGTAR
460 470 480 490 500
KGQNLLVMPN RTQVAVDQLF SDDFEVTSVG PGENVKIKLK GIEEEDVSPG
510 520 530 540 550
FVLCDAANPI KTGKIFDAQV VILEHKSIIC AGYSAVMHIH CAAEEVTVKA
560 570 580 590 600
LICLVDKKSG DKSKTRPRFV KQDQVAIMRI ECSGMICLEQ FKLFPQMGRF
610
TLRDENKTIA IGKVLKVVE
Length:619
Mass (Da):66,326
Last modified:May 1, 1997 - v1
Checksum:i729FB24640EF010A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88868 mRNA. Translation: AAC24943.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88868 mRNA. Translation: AAC24943.1.

3D structure databases

ProteinModelPortaliP91944.
SMRiP91944. Positions 187-619.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0305302.

Proteomic databases

PaxDbiP91944.
PeptideAtlasiP91944.
PRIDEiP91944.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0020443. Elf.

Phylogenomic databases

eggNOGiKOG0459. Eukaryota.
COG5256. LUCA.
OrthoDBiEOG091G0637.

Enzyme and pathway databases

ReactomeiR-DME-72764. Eukaryotic Translation Termination.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Gene expression databases

BgeeiFBgn0020443.
ExpressionAtlasiP91944. differential.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR009818. Ataxin-2_C.
IPR004161. EFTu-like_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
PF07145. PAM2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP91944_DROME
AccessioniPrimary (citable) accession number: P91944
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.