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P91943

- PANG1_DROME

UniProt

P91943 - PANG1_DROME

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Protein

Protein pangolin, isoforms A/H/I/S

Gene

pan

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi273 – 34169HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. beta-catenin binding Source: RefGenome
  2. kinase binding Source: FlyBase
  3. repressing transcription factor binding Source: FlyBase
  4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: FlyBase
  5. sequence-specific DNA binding Source: FlyBase
  6. transcription regulatory region DNA binding Source: RefGenome

GO - Biological processi

  1. canonical Wnt signaling pathway Source: RefGenome
  2. embryonic pattern specification Source: FlyBase
  3. heart development Source: FlyBase
  4. imaginal disc-derived wing morphogenesis Source: FlyBase
  5. mesodermal cell fate determination Source: FlyBase
  6. negative regulation of transcription, DNA-templated Source: UniProtKB
  7. negative regulation of Wnt signaling pathway Source: FlyBase
  8. positive regulation of gene expression Source: FlyBase
  9. positive regulation of transcription, DNA-templated Source: UniProtKB
  10. positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  11. regulation of hemocyte differentiation Source: FlyBase
  12. regulation of stem cell proliferation Source: FlyBase
  13. regulation of transcription, DNA-templated Source: UniProtKB
  14. regulation of Wnt signaling pathway Source: FlyBase
  15. salivary gland morphogenesis Source: FlyBase
  16. segment polarity determination Source: UniProtKB-KW
  17. spiracle morphogenesis, open tracheal system Source: FlyBase
  18. transcription from RNA polymerase II promoter Source: GOC
  19. Wnt signaling pathway Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein, Repressor, Segmentation polarity protein

Keywords - Biological processi

Transcription, Transcription regulation, Wnt signaling pathway

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_184321. Ca2+ pathway.
REACT_218447. formation of the beta-catenin:TCF transactivating complex.
REACT_236759. TCF7L2 mutants don't bind CTBP.
REACT_241983. repression of WNT target genes.
REACT_249265. deactivation of the beta-catenin transactivating complex.
SignaLinkiP91943.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein pangolin, isoforms A/H/I/S
Alternative name(s):
dTCF
Gene namesi
Name:pan
Synonyms:TCF
ORF Names:CG34403
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 4

Organism-specific databases

FlyBaseiFBgn0085432. pan.

Subcellular locationi

Nucleus 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. microtubule associated complex Source: FlyBase
  2. nucleus Source: FlyBase
  3. transcription factor complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Flies exhibit a segment polarity phenotype and altered expression of the wg target genes en and Ubx.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 751751Protein pangolin, isoforms A/H/I/SPRO_0000048601Add
BLAST

Proteomic databases

PaxDbiP91943.
PRIDEiP91943.

Expressioni

Gene expression databases

BgeeiP91943.
ExpressionAtlasiP91943. differential.

Interactioni

Subunit structurei

Binds to the beta-catenin homolog arm or to gro.

Binary interactionsi

WithEntry#Exp.IntActNotes
armP188242EBI-147301,EBI-216128
ebd1Q9W0N94EBI-147301,EBI-141287
groP163712EBI-147301,EBI-153866

Protein-protein interaction databases

BioGridi68607. 35 interactions.
DIPiDIP-19970N.
IntActiP91943. 24 interactions.
MINTiMINT-994044.

Structurei

3D structure databases

ProteinModelPortaliP91943.
SMRiP91943. Positions 272-347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5353Beta-catenin binding siteBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi351 – 3577Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi351 – 3577Poly-Lys

Sequence similaritiesi

Belongs to the TCF/LEF family.Curated
Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG252916.
GeneTreeiENSGT00390000009964.
OMAiKCIRYKE.
OrthoDBiEOG72VH6Z.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
4.10.900.10. 1 hit.
InterProiIPR027397. Catenin_binding_dom.
IPR013558. CTNNB1-bd_N.
IPR009071. HMG_box_dom.
IPR028782. Pangolin.
IPR024940. TCF/LEF.
[Graphical view]
PANTHERiPTHR10373. PTHR10373. 1 hit.
PTHR10373:SF36. PTHR10373:SF36. 1 hit.
PfamiPF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform A (identifier: P91943-3) [UniParc]FASTAAdd to Basket

Also known as: C, D, E, F, G

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPHTHSRHGS SGDDLCSTDE VKIFKDEGDR EDEKISSENL LVEEKSSLID
60 70 80 90 100
LTESEEKGHK ISRPDHSPVF NKLDTHAPSF NMGYLVSPYS YANGSPSGLP
110 120 130 140 150
VTMANKIGLP PFFCHNADPL STPPPAHCGI PPYQLDPKMG LTRPALYPFA
160 170 180 190 200
GGQYPYPMLS SDMSQVASWH TPSVYSASSF RTPYPSSLPI NTTLASDFPF
210 220 230 240 250
RFSPSLLPSV HATSHHVINA HSAIVGVSSK QECGVQDPTT NNRYPRNLEA
260 270 280 290 300
KHTSNAQSNE SKETTNDKKK PHIKKPLNAF MLYMKEMRAK VVAECTLKES
310 320 330 340 350
AAINQILGRR WHELSREEQS KYYEKARQER QLHMELYPGW SARDNYGYVS
360 370 380 390 400
KKKKRKKDRS TTDSGGNNMK KCRARFGLDQ QSQWCKPCRR KKKCIRYMEA
410 420 430 440 450
LNGNGPAEDG SCFDEHGSQL SDDDEDDYDD DKLGGSCGSA DETNKIEDED
460 470 480 490 500
SESLNQSMPS PGCLSGLSSL QSPSTTMSLA SPLNMNANSA TNVIFPASSN
510 520 530 540 550
ALLIVGADQP TAQQRPTLVS TSGSSSGSTS SISTTPNTSS TVSPVTCMTG
560 570 580 590 600
PCLGSSQERA MMLGNRFSHL GMGLSPPVVS TSTSKSEPFF KPHPTVCNNP
610 620 630 640 650
IFALPSIGNC SLNISSMPNT SRNPIGANPR DINNPLSINQ LTKRREYKNV
660 670 680 690 700
ELIEASESKT IVAHAATSII QHVAVNGYHA NHSLLNSNLG HLHHQLNNRT
710 720 730 740 750
ENPNRSEQTM LSVSNHSVNS SECHKESDSQ AIVSSNPPNA GSSDNGVISV

S
Length:751
Mass (Da):81,892
Last modified:May 1, 1997 - v1
Checksum:i1C6E5A0B36017143
GO
Isoform H (identifier: P91943-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     313-364: ELSREEQSKY...RKKDRSTTDS → ALGREEQAKY...KRKRKQDTND

Note: No experimental confirmation available.

Show »
Length:747
Mass (Da):81,391
Checksum:i227A1983477B38C8
GO
Isoform S (identifier: P91943-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     713-730: Missing.

Note: No experimental confirmation available.

Show »
Length:733
Mass (Da):79,936
Checksum:i2B90BC91E37D8FB1
GO
Isoform I (identifier: P91943-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     313-364: ELSREEQSKY...RKKDRSTTDS → ALGREEQAKY...KRKRKQDTND
     390-414: RKKKCIRYMEALNGNGPAEDGSCFD → YVLPLFLFTMLYILLQMDLQDSRKN
     415-751: Missing.

Note: No experimental confirmation available.

Show »
Length:410
Mass (Da):46,291
Checksum:iD80032389302FA84
GO
Isoform J (identifier: Q8IMA8-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry Q8IMA8.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: No experimental confirmation available.

Length:1,192
Mass (Da):132,080
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei313 – 36452ELSRE…STTDS → ALGREEQAKYYELARRERQL HMQMYPDWSSRTNASRGKKR KRKQDTND in isoform H and isoform I. 1 PublicationVSP_021967Add
BLAST
Alternative sequencei390 – 41425RKKKC…GSCFD → YVLPLFLFTMLYILLQMDLQ DSRKN in isoform I. 1 PublicationVSP_021968Add
BLAST
Alternative sequencei415 – 751337Missing in isoform I. 1 PublicationVSP_021969Add
BLAST
Alternative sequencei713 – 73018Missing in isoform S. CuratedVSP_047713Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09125 mRNA. Translation: CAA70343.1.
U88538 mRNA. Translation: AAC47464.1.
AE014135 Genomic DNA. Translation: AAF59371.2.
AE014135 Genomic DNA. Translation: AAN06545.1.
AE014135 Genomic DNA. Translation: AAN06548.2.
AE014135 Genomic DNA. Translation: AFH06766.1.
AE014135 Genomic DNA. Translation: AAX52517.1.
AE014135 Genomic DNA. Translation: ABC65830.1.
BT021431 mRNA. Translation: AAX33579.1.
BT029282 mRNA. Translation: ABK30919.1.
BT044547 mRNA. Translation: ACI03583.1.
BT053747 mRNA. Translation: ACK77665.1.
AY312729 Genomic DNA. Translation: AAQ67543.1.
AY312730 Genomic DNA. Translation: AAQ67544.1.
AY312731 Genomic DNA. Translation: AAQ67545.1.
AY312732 Genomic DNA. Translation: AAQ67546.1.
AY312733 Genomic DNA. Translation: AAQ67547.1.
AY312734 Genomic DNA. Translation: AAQ67548.1.
AY312735 Genomic DNA. Translation: AAQ67549.1.
AY312736 Genomic DNA. Translation: AAQ67550.1.
AY312737 Genomic DNA. Translation: AAQ67551.1.
AY312738 Genomic DNA. Translation: AAQ67552.1.
AY312739 Genomic DNA. Translation: AAQ67553.1.
AY312740 Genomic DNA. Translation: AAQ67554.1.
AY312741 Genomic DNA. Translation: AAQ67555.1.
AY312742 Genomic DNA. Translation: AAQ67556.1.
AY312743 Genomic DNA. Translation: AAQ67557.1.
AY312744 Genomic DNA. Translation: AAQ67558.1.
AY312745 Genomic DNA. Translation: AAQ67559.1.
AY312746 Genomic DNA. Translation: AAQ67560.1.
AY312747 Genomic DNA. Translation: AAQ67561.1.
AY312748 Genomic DNA. Translation: AAQ67562.1.
AY312749 Genomic DNA. Translation: AAQ67563.1.
AY312750 Genomic DNA. Translation: AAQ67564.1.
AY312751 Genomic DNA. Translation: AAQ67565.1.
AY312752 Genomic DNA. Translation: AAQ67566.1.
RefSeqiNP_001014685.1. NM_001014685.3. [P91943-4]
NP_001033798.1. NM_001038709.3. [P91943-5]
NP_001245406.1. NM_001258477.2. [P91943-3]
NP_524619.3. NM_079880.6. [P91943-3]
NP_726522.1. NM_166718.3. [P91943-3]
NP_726524.1. NM_166720.3. [P91943-3]
NP_726527.2. NM_166723.3. [P91943-6]
UniGeneiDm.17803.

Genome annotation databases

EnsemblMetazoaiFBtr0089156; FBpp0088223; FBgn0085432. [P91943-3]
FBtr0089157; FBpp0088224; FBgn0085432. [P91943-3]
FBtr0089158; FBpp0088225; FBgn0085432. [P91943-3]
FBtr0089159; FBpp0088226; FBgn0085432. [P91943-3]
FBtr0089160; FBpp0088227; FBgn0085432. [P91943-3]
FBtr0089161; FBpp0088228; FBgn0085432. [P91943-3]
FBtr0089162; FBpp0088229; FBgn0085432. [P91943-3]
FBtr0309803; FBpp0301556; FBgn0085432. [P91943-3]
GeneIDi43769.
KEGGidme:Dmel_CG34403.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09125 mRNA. Translation: CAA70343.1 .
U88538 mRNA. Translation: AAC47464.1 .
AE014135 Genomic DNA. Translation: AAF59371.2 .
AE014135 Genomic DNA. Translation: AAN06545.1 .
AE014135 Genomic DNA. Translation: AAN06548.2 .
AE014135 Genomic DNA. Translation: AFH06766.1 .
AE014135 Genomic DNA. Translation: AAX52517.1 .
AE014135 Genomic DNA. Translation: ABC65830.1 .
BT021431 mRNA. Translation: AAX33579.1 .
BT029282 mRNA. Translation: ABK30919.1 .
BT044547 mRNA. Translation: ACI03583.1 .
BT053747 mRNA. Translation: ACK77665.1 .
AY312729 Genomic DNA. Translation: AAQ67543.1 .
AY312730 Genomic DNA. Translation: AAQ67544.1 .
AY312731 Genomic DNA. Translation: AAQ67545.1 .
AY312732 Genomic DNA. Translation: AAQ67546.1 .
AY312733 Genomic DNA. Translation: AAQ67547.1 .
AY312734 Genomic DNA. Translation: AAQ67548.1 .
AY312735 Genomic DNA. Translation: AAQ67549.1 .
AY312736 Genomic DNA. Translation: AAQ67550.1 .
AY312737 Genomic DNA. Translation: AAQ67551.1 .
AY312738 Genomic DNA. Translation: AAQ67552.1 .
AY312739 Genomic DNA. Translation: AAQ67553.1 .
AY312740 Genomic DNA. Translation: AAQ67554.1 .
AY312741 Genomic DNA. Translation: AAQ67555.1 .
AY312742 Genomic DNA. Translation: AAQ67556.1 .
AY312743 Genomic DNA. Translation: AAQ67557.1 .
AY312744 Genomic DNA. Translation: AAQ67558.1 .
AY312745 Genomic DNA. Translation: AAQ67559.1 .
AY312746 Genomic DNA. Translation: AAQ67560.1 .
AY312747 Genomic DNA. Translation: AAQ67561.1 .
AY312748 Genomic DNA. Translation: AAQ67562.1 .
AY312749 Genomic DNA. Translation: AAQ67563.1 .
AY312750 Genomic DNA. Translation: AAQ67564.1 .
AY312751 Genomic DNA. Translation: AAQ67565.1 .
AY312752 Genomic DNA. Translation: AAQ67566.1 .
RefSeqi NP_001014685.1. NM_001014685.3. [P91943-4 ]
NP_001033798.1. NM_001038709.3. [P91943-5 ]
NP_001245406.1. NM_001258477.2. [P91943-3 ]
NP_524619.3. NM_079880.6. [P91943-3 ]
NP_726522.1. NM_166718.3. [P91943-3 ]
NP_726524.1. NM_166720.3. [P91943-3 ]
NP_726527.2. NM_166723.3. [P91943-6 ]
UniGenei Dm.17803.

3D structure databases

ProteinModelPortali P91943.
SMRi P91943. Positions 272-347.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 68607. 35 interactions.
DIPi DIP-19970N.
IntActi P91943. 24 interactions.
MINTi MINT-994044.

Proteomic databases

PaxDbi P91943.
PRIDEi P91943.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0089156 ; FBpp0088223 ; FBgn0085432 . [P91943-3 ]
FBtr0089157 ; FBpp0088224 ; FBgn0085432 . [P91943-3 ]
FBtr0089158 ; FBpp0088225 ; FBgn0085432 . [P91943-3 ]
FBtr0089159 ; FBpp0088226 ; FBgn0085432 . [P91943-3 ]
FBtr0089160 ; FBpp0088227 ; FBgn0085432 . [P91943-3 ]
FBtr0089161 ; FBpp0088228 ; FBgn0085432 . [P91943-3 ]
FBtr0089162 ; FBpp0088229 ; FBgn0085432 . [P91943-3 ]
FBtr0309803 ; FBpp0301556 ; FBgn0085432 . [P91943-3 ]
GeneIDi 43769.
KEGGi dme:Dmel_CG34403.

Organism-specific databases

CTDi 43769.
FlyBasei FBgn0085432. pan.

Phylogenomic databases

eggNOGi NOG252916.
GeneTreei ENSGT00390000009964.
OMAi KCIRYKE.
OrthoDBi EOG72VH6Z.

Enzyme and pathway databases

Reactomei REACT_184321. Ca2+ pathway.
REACT_218447. formation of the beta-catenin:TCF transactivating complex.
REACT_236759. TCF7L2 mutants don't bind CTBP.
REACT_241983. repression of WNT target genes.
REACT_249265. deactivation of the beta-catenin transactivating complex.
SignaLinki P91943.

Miscellaneous databases

ChiTaRSi pan. fly.
GenomeRNAii 43769.
NextBioi 835691.

Gene expression databases

Bgeei P91943.
ExpressionAtlasi P91943. differential.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
4.10.900.10. 1 hit.
InterProi IPR027397. Catenin_binding_dom.
IPR013558. CTNNB1-bd_N.
IPR009071. HMG_box_dom.
IPR028782. Pangolin.
IPR024940. TCF/LEF.
[Graphical view ]
PANTHERi PTHR10373. PTHR10373. 1 hit.
PTHR10373:SF36. PTHR10373:SF36. 1 hit.
Pfami PF08347. CTNNB1_binding. 1 hit.
PF00505. HMG_box. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF."
    van de Wetering M., Cavallo R.A., Dooijes D., van Beest M., van Es J., Loureiro J., Ypma A., Hursh D., Jones T., Bejsovec A., Peifer M., Mortin M., Clevers H.
    Cell 88:789-799(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, DISRUPTION PHENOTYPE.
  2. "Pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila."
    Brunner E., Peter O., Schweizer L., Basler K.
    Nature 385:829-833(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM I), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 363-751 (ISOFORM J).
    Strain: Berkeley.
    Tissue: Head.
  6. "Recombination, dominance and selection on amino acid polymorphism in the Drosophila genome: contrasting patterns on the X and fourth chromosomes."
    Sheldahl L.A., Weinreich D.M., Rand D.M.
    Genetics 165:1195-1208(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 390-751.
    Strain: Crete24, Crete26, Crete30, Crete31, Crete35, Crete40, Crete42, Crete43, Crete44, Crete8, FTF1, FTF105, FTF14, FTF2, FTF20, FTF23, FTF26, FTF28, FTF5, FTF6, Zim11, Zim2, Zim30 and Zim53.
  7. "Drosophila Tcf and Groucho interact to repress Wingless signalling activity."
    Cavallo R.A., Cox R.T., Moline M.M., Roose J., Polevoy G.A., Clevers H., Peifer M., Bejsovec A.
    Nature 395:604-608(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ARM AND GRO, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiPANG1_DROME
AccessioniPrimary (citable) accession number: P91943
Secondary accession number(s): A0AVW4
, A4V148, B5RJS3, O02548, Q0KIE9, Q59DP5, Q5BHZ3, Q6W492, Q6W493, Q6W494, Q6W495, Q6W4A6, Q6W4B4, Q9V4B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: November 26, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3