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P91929

- NDUAA_DROME

UniProt

P91929 - NDUAA_DROME

Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

Gene

ND42

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Cofactori

    Binds 1 FAD per subunit.By similarity

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. phosphotransferase activity, alcohol group as acceptor Source: InterPro

    GO - Biological processi

    1. nucleobase-containing compound metabolic process Source: InterPro
    2. oxidation-reduction process Source: UniProtKB-KW

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    FAD, Flavoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
    Alternative name(s):
    Complex I-42kD
    Short name:
    CI-42kD
    NADH-ubiquinone oxidoreductase 42 kDa subunit
    Gene namesi
    Name:ND42
    ORF Names:CG6343
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0019957. ND42.

    Subcellular locationi

    GO - Cellular componenti

    1. lipid particle Source: FlyBase
    2. mitochondrial matrix Source: UniProtKB-SubCell
    3. mitochondrion Source: FlyBase
    4. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 6060MitochondrionSequence AnalysisAdd
    BLAST
    Chaini61 – 407347NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialPRO_0000019990Add
    BLAST

    Proteomic databases

    PaxDbiP91929.

    Expressioni

    Gene expression databases

    BgeeiP91929.

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction By similarity.By similarity

    Protein-protein interaction databases

    BioGridi67552. 5 interactions.
    DIPiDIP-21667N.
    IntActiP91929. 1 interaction.
    MINTiMINT-811174.

    Structurei

    3D structure databases

    ProteinModelPortaliP91929.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I NDUFA10 subunit family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG279864.
    GeneTreeiENSGT00390000016151.
    InParanoidiP91929.
    KOiK03954.
    OMAiHAELLIY.
    OrthoDBiEOG741Z21.
    PhylomeDBiP91929.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR002624. DNK.
    IPR015828. NADH_UbQ_OxRdtase_42KD_su.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR10513. PTHR10513. 1 hit.
    PfamiPF01712. dNK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000543. NADH_UQ_42KD. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P91929-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAVFRVGLV RLVSRATQSP NLLQAQTNAL PAAFQQRCSI SGKTMRGGPR    50
    VPKAAPYPYK TKKYSVFNAI FDKTSKRFDE NSKVICVEGP IAAGKSKFAK 100
    ELAEELDMEY YPAVDLDLIY INSYGYDMRK LDPQLPPSCR SYDVRNFCLD 150
    PSHDLAAQFQ IRMYMLRYSQ YIDALQHVLS TGQGVVLERS PYSDFVFMEA 200
    MFRQGYLSRG ARSVYNELRQ NTIGELLKPH LVIYLDLPVD AVKKQIKARN 250
    VDYEVQSKVF SDAYLSDLEQ LYKQQYLKDI STHAELLIYD WTAGGETEVV 300
    VEDIERIDFN QFEADIHNKK MLDWRFPLEA EWCEARIKYC HEKPDLMNYF 350
    NVPRFDVPEL VRSADDGKVW RDVWFNAPGM KYRPGYNADM GDEGLLTKTK 400
    IGINQGI 407
    Length:407
    Mass (Da):46,898
    Last modified:December 1, 2000 - v2
    Checksum:i4B5F4EC7DED9B8D4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti177 – 1771H → R in CAA71852. (PubMed:10071211)Curated
    Sequence conflicti198 – 1981M → L in CAA71852. (PubMed:10071211)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014297 Genomic DNA. Translation: AAF55947.1.
    AY051764 mRNA. Translation: AAK93188.1.
    Y10911 mRNA. Translation: CAA71852.1.
    RefSeqiNP_001262821.1. NM_001275892.1.
    NP_524445.1. NM_079721.4.
    NP_732692.1. NM_169990.3.
    UniGeneiDm.1653.

    Genome annotation databases

    EnsemblMetazoaiFBtr0084172; FBpp0083570; FBgn0019957.
    FBtr0084173; FBpp0083571; FBgn0019957.
    GeneIDi42591.
    KEGGidme:Dmel_CG6343.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014297 Genomic DNA. Translation: AAF55947.1 .
    AY051764 mRNA. Translation: AAK93188.1 .
    Y10911 mRNA. Translation: CAA71852.1 .
    RefSeqi NP_001262821.1. NM_001275892.1.
    NP_524445.1. NM_079721.4.
    NP_732692.1. NM_169990.3.
    UniGenei Dm.1653.

    3D structure databases

    ProteinModelPortali P91929.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 67552. 5 interactions.
    DIPi DIP-21667N.
    IntActi P91929. 1 interaction.
    MINTi MINT-811174.

    Proteomic databases

    PaxDbi P91929.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0084172 ; FBpp0083570 ; FBgn0019957 .
    FBtr0084173 ; FBpp0083571 ; FBgn0019957 .
    GeneIDi 42591.
    KEGGi dme:Dmel_CG6343.

    Organism-specific databases

    CTDi 42591.
    FlyBasei FBgn0019957. ND42.

    Phylogenomic databases

    eggNOGi NOG279864.
    GeneTreei ENSGT00390000016151.
    InParanoidi P91929.
    KOi K03954.
    OMAi HAELLIY.
    OrthoDBi EOG741Z21.
    PhylomeDBi P91929.

    Miscellaneous databases

    GenomeRNAii 42591.
    NextBioi 829575.
    PROi P91929.

    Gene expression databases

    Bgeei P91929.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR002624. DNK.
    IPR015828. NADH_UbQ_OxRdtase_42KD_su.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR10513. PTHR10513. 1 hit.
    Pfami PF01712. dNK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000543. NADH_UQ_42KD. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.
    4. "Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database."
      Caggese C., Ragone G., Perrini B., Moschetti R., de Pinto V., Caizzi R., Barsanti P.
      Mol. Gen. Genet. 261:64-70(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-205.
      Tissue: Ovary.

    Entry informationi

    Entry nameiNDUAA_DROME
    AccessioniPrimary (citable) accession number: P91929
    Secondary accession number(s): Q9VD54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3