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P91929

- NDUAA_DROME

UniProt

P91929 - NDUAA_DROME

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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

Gene
ND42, CG6343
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Cofactori

Binds 1 FAD per subunit By similarity.

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. phosphotransferase activity, alcohol group as acceptor Source: InterPro

GO - Biological processi

  1. nucleobase-containing compound metabolic process Source: InterPro
  2. oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Alternative name(s):
Complex I-42kD
Short name:
CI-42kD
NADH-ubiquinone oxidoreductase 42 kDa subunit
Gene namesi
Name:ND42
ORF Names:CG6343
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0019957. ND42.

Subcellular locationi

GO - Cellular componenti

  1. lipid particle Source: FlyBase
  2. mitochondrial matrix Source: UniProtKB-SubCell
  3. mitochondrion Source: FlyBase
  4. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6060Mitochondrion Reviewed predictionAdd
BLAST
Chaini61 – 407347NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialPRO_0000019990Add
BLAST

Proteomic databases

PaxDbiP91929.

Expressioni

Gene expression databases

BgeeiP91929.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction By similarity.

Protein-protein interaction databases

BioGridi67552. 5 interactions.
DIPiDIP-21667N.
IntActiP91929. 1 interaction.
MINTiMINT-811174.

Structurei

3D structure databases

ProteinModelPortaliP91929.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG279864.
GeneTreeiENSGT00390000016151.
InParanoidiP91929.
KOiK03954.
OMAiHAELLIY.
OrthoDBiEOG741Z21.
PhylomeDBiP91929.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002624. DNK.
IPR015828. NADH_UbQ_OxRdtase_42KD_su.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10513. PTHR10513. 1 hit.
PfamiPF01712. dNK. 1 hit.
[Graphical view]
PIRSFiPIRSF000543. NADH_UQ_42KD. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P91929-1 [UniParc]FASTAAdd to Basket

« Hide

MTAVFRVGLV RLVSRATQSP NLLQAQTNAL PAAFQQRCSI SGKTMRGGPR    50
VPKAAPYPYK TKKYSVFNAI FDKTSKRFDE NSKVICVEGP IAAGKSKFAK 100
ELAEELDMEY YPAVDLDLIY INSYGYDMRK LDPQLPPSCR SYDVRNFCLD 150
PSHDLAAQFQ IRMYMLRYSQ YIDALQHVLS TGQGVVLERS PYSDFVFMEA 200
MFRQGYLSRG ARSVYNELRQ NTIGELLKPH LVIYLDLPVD AVKKQIKARN 250
VDYEVQSKVF SDAYLSDLEQ LYKQQYLKDI STHAELLIYD WTAGGETEVV 300
VEDIERIDFN QFEADIHNKK MLDWRFPLEA EWCEARIKYC HEKPDLMNYF 350
NVPRFDVPEL VRSADDGKVW RDVWFNAPGM KYRPGYNADM GDEGLLTKTK 400
IGINQGI 407
Length:407
Mass (Da):46,898
Last modified:December 1, 2000 - v2
Checksum:i4B5F4EC7DED9B8D4
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1771H → R in CAA71852. 1 Publication
Sequence conflicti198 – 1981M → L in CAA71852. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: AAF55947.1.
AY051764 mRNA. Translation: AAK93188.1.
Y10911 mRNA. Translation: CAA71852.1.
RefSeqiNP_001262821.1. NM_001275892.1.
NP_524445.1. NM_079721.4.
NP_732692.1. NM_169990.3.
UniGeneiDm.1653.

Genome annotation databases

EnsemblMetazoaiFBtr0084172; FBpp0083570; FBgn0019957.
FBtr0084173; FBpp0083571; FBgn0019957.
GeneIDi42591.
KEGGidme:Dmel_CG6343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014297 Genomic DNA. Translation: AAF55947.1 .
AY051764 mRNA. Translation: AAK93188.1 .
Y10911 mRNA. Translation: CAA71852.1 .
RefSeqi NP_001262821.1. NM_001275892.1.
NP_524445.1. NM_079721.4.
NP_732692.1. NM_169990.3.
UniGenei Dm.1653.

3D structure databases

ProteinModelPortali P91929.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 67552. 5 interactions.
DIPi DIP-21667N.
IntActi P91929. 1 interaction.
MINTi MINT-811174.

Proteomic databases

PaxDbi P91929.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0084172 ; FBpp0083570 ; FBgn0019957 .
FBtr0084173 ; FBpp0083571 ; FBgn0019957 .
GeneIDi 42591.
KEGGi dme:Dmel_CG6343.

Organism-specific databases

CTDi 42591.
FlyBasei FBgn0019957. ND42.

Phylogenomic databases

eggNOGi NOG279864.
GeneTreei ENSGT00390000016151.
InParanoidi P91929.
KOi K03954.
OMAi HAELLIY.
OrthoDBi EOG741Z21.
PhylomeDBi P91929.

Miscellaneous databases

GenomeRNAii 42591.
NextBioi 829575.
PROi P91929.

Gene expression databases

Bgeei P91929.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR002624. DNK.
IPR015828. NADH_UbQ_OxRdtase_42KD_su.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10513. PTHR10513. 1 hit.
Pfami PF01712. dNK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000543. NADH_UQ_42KD. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  4. "Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database."
    Caggese C., Ragone G., Perrini B., Moschetti R., de Pinto V., Caizzi R., Barsanti P.
    Mol. Gen. Genet. 261:64-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 45-205.
    Tissue: Ovary.

Entry informationi

Entry nameiNDUAA_DROME
AccessioniPrimary (citable) accession number: P91929
Secondary accession number(s): Q9VD54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: September 3, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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