Reviewed,
UniProtKB/Swiss-Prot P91929 (NDUAA_DROME)
Last modified
December 15, 2009.
Version 81.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial Alternative name(s): NADH-ubiquinone oxidoreductase 42 kDa subunit Complex I-42kD Short name=CI-42kD | ||||
| Gene names |
| ||||
| Organism | Drosophila melanogaster (Fruit fly) [Complete proteome] | ||||
| Taxonomic identifier | 7227 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 407 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. |
| Cofactor | Binds 1 FAD per subunit By similarity. |
| Subunit structure | Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the complex I NDUFA10 subunit family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Electron transport Respiratory chain Transport |
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | FAD Flavoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW nucleobase, nucleoside, nucleotide and nucleic acid metabolic processInferred from electronic annotation. Source: InterPro transportInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chainInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: InterPro phosphotransferase activity, alcohol group as acceptorInferred from electronic annotation. Source: InterPro protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 60 | 60 | Mitochondrion Potential | ||||||
| Chain | 61 – 407 | 347 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | PRO_0000019990 | |||||
Experimental info | |||||||||
| Sequence conflict | 177 | 1 | H → R in CAA71852. Ref.4 | ||||||
| Sequence conflict | 198 | 1 | M → L in CAA71852. Ref.4 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| AE014297 Genomic DNA. Translation: AAF55947.1. AY051764 mRNA. Translation: AAK93188.1. Y10911 mRNA. Translation: CAA71852.1. | |
| RefSeq | NP_524445.1. NP_732692.1. |
| UniGene | Dm.1653 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-21667N. |
| IntAct | P91929. 5 interactions. |
| STRING | P91929. |
Genome annotation databases | |
| Ensembl | FBtr0084172; FBpp0083570; FBgn0019957; Drosophila melanogaster. [Genome view] FBtr0084173; FBpp0083571; FBgn0019957; Drosophila melanogaster. [Genome view] |
| GeneID | 42591. |
| KEGG | dme:Dmel_CG6343. |
Organism-specific databases | |
| CTD | 42591. |
| FlyBase | FBgn0019957. ND42. |
Phylogenomic databases | |
| InParanoid | P91929. |
| OMA | HAELLIY. |
| OrthoDB | EOG9FJ8GW. |
Enzyme and pathway databases | |
| BioCyc | DMEL-XXX-02:DMEL-XXX-02-012754-MON. DMEL-XXX-02:DMEL-XXX-02-012755-MON. |
Gene expression databases | |
| ArrayExpress | P91929. |
| GermOnline | CG6343. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR002624. Deoxynucleoside_kinase. IPR015828. NADH_UbQ_OxRdtase_42KD_su. [Graphical view] |
| PANTHER | PTHR10513. dNK. 1 hit. |
| Pfam | PF01712. dNK. 1 hit. [Graphical view] |
| PIRSF | PIRSF000543. NADH_UQ_42KD. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 829575. |
Entry information
| Entry name | NDUAA_DROME | ||||||||
| Accession | Primary (citable) accession number: P91929 Secondary accession number(s): Q9VD54 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with


