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Protein

Mitochondrial proton/calcium exchanger protein

Gene

Letm1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi700 – 7111PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi783 – 7942PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium:sodium antiporter activity Source: FlyBase
  • calcium ion binding Source: InterPro
  • potassium:proton antiporter activity Source: FlyBase
  • ribosome binding Source: InterPro

GO - Biological processi

  • cellular metal ion homeostasis Source: GO_Central
  • cellular response to hypoxia Source: FlyBase
  • mitochondrial calcium ion transmembrane transport Source: FlyBase
  • mitochondrion morphogenesis Source: FlyBase
  • neurotransmitter secretion Source: FlyBase
  • potassium ion transmembrane transport Source: FlyBase
  • proton transmembrane transport Source: FlyBase

Keywordsi

Biological processAntiport, Calcium transport, Ion transport, Transport
LigandCalcium, Metal-binding

Protein family/group databases

TCDBi2.A.97.1.3 the mitochondrial inner membrane k(+)/h(+) and ca(2+)/h(+) exchanger (letm1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial proton/calcium exchanger proteinCurated
Alternative name(s):
Leucine zipper-EF-hand-containing transmembrane protein 1
Short name:
dLetm11 Publication
Gene namesi
Name:Letm1
Synonyms:anon-60Da
ORF Names:CG4589
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0284252 Letm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 60MitochondrionSequence analysisAdd BLAST60
ChainiPRO_000007386161 – 1013Mitochondrial proton/calcium exchanger proteinAdd BLAST953

Proteomic databases

PaxDbiP91927
PRIDEiP91927

Expressioni

Gene expression databases

BgeeiFBgn0019886
GenevisibleiP91927 DM

Interactioni

Protein-protein interaction databases

BioGridi63485, 5 interactors
DIPiDIP-23753N
IntActiP91927, 7 interactors
STRINGi7227.FBpp0072255

Structurei

3D structure databases

ProteinModelPortaliP91927
SMRiP91927
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini280 – 554Letm1 RBDPROSITE-ProRule annotationAdd BLAST275
Domaini687 – 722EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini770 – 805EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili104 – 131Sequence analysisAdd BLAST28
Coiled coili488 – 525Sequence analysisAdd BLAST38
Coiled coili573 – 653Sequence analysisAdd BLAST81
Coiled coili823 – 919Sequence analysisAdd BLAST97

Sequence similaritiesi

Belongs to the LETM1 family.Curated

Keywords - Domaini

Coiled coil, Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1043 Eukaryota
ENOG410XRSP LUCA
GeneTreeiENSGT00390000011225
InParanoidiP91927
KOiK17800
OMAiRVNKMIS
OrthoDBiEOG091G034T
PhylomeDBiP91927

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR011685 LETM1
IPR033122 LETM1_RBD
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF07766 LETM1, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS51758 LETM1_RBD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P91927-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNALLRHKGR NLRTSHLAQN VYKRFLKSNC CACSSVNVTD EPAKEDELPR
60 70 80 90 100
RSASTSVLEL SRSLGTYRRF QPHANYGYDY SGYGFRHLHT SRTLLETSSS
110 120 130 140 150
KIDATVKKLK NQQKEKVEEI MKEVANGQAA AVRASSAATA TASSEKGQNA
160 170 180 190 200
SATAGSTSAT ASTTSLAKTA DKSVAKPKKP LRTRIWDELV HYYHGFRLLF
210 220 230 240 250
IDVAICSKLL WRVLNGKTLT RRENKQLQRT TSDLFRLIPF SVFIIVPFME
260 270 280 290 300
LLLPLFIKFF PGMLPSTFQT STDRQEKLRQ SLSVRLEVAK FLQQTLDQMP
310 320 330 340 350
VQHKEHSSEE AKQFEAFFTK IRNPTEPVSN DEIIKFAKRF DDEITLDSLS
360 370 380 390 400
REQLAALCRV LELNTIGTTT LLRFQLRLKL RSLATDDRVI AREGVDSLDL
410 420 430 440 450
LELQQACKAR GMRAYGLTEE RLRFQLKEWI DLSLNEQVPP TLLLLSRTML
460 470 480 490 500
ISDDSITTDK LKETIRVLPD AVGAHTRHAI GESEGKVDNK TKIEIIKEEE
510 520 530 540 550
RKIREEREEE REETIAKRSA IKEEIPAPYV FAEKLSGSQD LLDHKEQSSV
560 570 580 590 600
SETDKGISST DVQLLSEALK TLSSDKQLVV EKETIKELKE ELADYKEDVE
610 620 630 640 650
ELREVRQVVK EPVRESRAAK LLYNRVNKMI SQLDNVLNDL EARQHQIKQA
660 670 680 690 700
ESSDYAASSP TVEPQQMVHI DELVATIRRM KEASDEERFK VVGDLLVKLD
710 720 730 740 750
ADKDGVISVN EITKAVQSID REATNIDKKQ LEEFTELLSK LASRRRHEEI
760 770 780 790 800
VHIDDLMNNI KVLKETSDEA RLKHIEAVLE KFDADKDGVV TVNDIRKVLE
810 820 830 840 850
SIGRDNIKLS DKAIEELISL LDKEQVLQAE QKIEKAIAKS MKEAEKLKSE
860 870 880 890 900
VDKADKDLSK LVNDIHDSAK EIQDIANEMR DKEETVPDKA KELKAEPAFK
910 920 930 940 950
DTAKTLKDNA KDLDDLAKDP KSDPKSPTKA STGSGPAGLS GGGPSSGSSG
960 970 980 990 1000
IATGSTTESA LREAAERQME KILPSTDIGL PPTIQTPSQP PTSKKATATA
1010
STLSTTITAK KLL
Length:1,013
Mass (Da):113,580
Last modified:February 21, 2001 - v2
Checksum:i8C710380263F262E
GO

Sequence cautioni

The sequence CAA71853 differs from that shown. Reason: Frameshift at positions 920 and 930.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti687E → Q in CAA71853 (PubMed:10071211).Curated1
Sequence conflicti690K → G in CAA71853 (PubMed:10071211).Curated1
Sequence conflicti717Q → H in CAA71853 (PubMed:10071211).Curated1
Sequence conflicti736E → D in CAA71853 (PubMed:10071211).Curated1
Sequence conflicti740K → R in CAA71853 (PubMed:10071211).Curated1
Sequence conflicti761K → E in CAA71853 (PubMed:10071211).Curated1
Sequence conflicti943G → S in CAA71853 (PubMed:10071211).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAM68316.1
AE013599 Genomic DNA Translation: AAM68317.1
AY047527 mRNA Translation: AAK77259.1
Y10912 mRNA Translation: CAA71853.1 Frameshift.
RefSeqiNP_611922.1, NM_138078.3
NP_726453.1, NM_166674.2
NP_726454.1, NM_166675.2
UniGeneiDm.7406

Genome annotation databases

EnsemblMetazoaiFBtr0072347; FBpp0072254; FBgn0284252
FBtr0072348; FBpp0072255; FBgn0284252
FBtr0072349; FBpp0072256; FBgn0284252
GeneIDi37912
KEGGidme:Dmel_CG4589
UCSCiCG4589-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiLETM1_DROME
AccessioniPrimary (citable) accession number: P91927
Secondary accession number(s): A4UZV1, Q0E8W7, Q9W160
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 21, 2001
Last modified: May 23, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health