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Protein

LETM1 and EF-hand domain-containing protein anon-60Da, mitochondrial

Gene

Letm1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi700 – 711121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi783 – 794122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • calcium:sodium antiporter activity Source: FlyBase
  • calcium ion binding Source: FlyBase
  • potassium:proton antiporter activity Source: FlyBase
  • ribosome binding Source: InterPro

GO - Biological processi

  • cellular response to hypoxia Source: FlyBase
  • mitochondrial calcium ion transport Source: FlyBase
  • mitochondrion morphogenesis Source: FlyBase
  • neurotransmitter secretion Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

TCDBi2.A.97.1.3. the mitochondrial inner membrane k(+)/h(+) and ca(2+)/h(+) exchanger (letm1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
LETM1 and EF-hand domain-containing protein anon-60Da, mitochondrial
Alternative name(s):
Leucine zipper-EF-hand-containing transmembrane protein 1
Gene namesi
Name:Letm1
Synonyms:anon-60Da
ORF Names:CG4589
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0019886. Letm1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei237 – 25721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial membrane Source: FlyBase
  • mitochondrion Source: FlyBase
  • presynapse Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6060MitochondrionSequence analysisAdd
BLAST
Chaini61 – 1013953LETM1 and EF-hand domain-containing protein anon-60Da, mitochondrialPRO_0000073861Add
BLAST

Proteomic databases

PaxDbiP91927.

Expressioni

Gene expression databases

BgeeiFBgn0019886.
GenevisibleiP91927. DM.

Interactioni

Protein-protein interaction databases

BioGridi63485. 4 interactions.
DIPiDIP-23753N.
IntActiP91927. 7 interactions.
MINTiMINT-1017214.
STRINGi7227.FBpp0072255.

Structurei

3D structure databases

ProteinModelPortaliP91927.
SMRiP91927. Positions 282-448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini280 – 554275Letm1 RBDPROSITE-ProRule annotationAdd
BLAST
Domaini687 – 72236EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini770 – 80536EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili104 – 13128Sequence analysisAdd
BLAST
Coiled coili488 – 52538Sequence analysisAdd
BLAST
Coiled coili573 – 65381Sequence analysisAdd
BLAST
Coiled coili823 – 91997Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 1 Letm1 RBD (ribosome-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1043. Eukaryota.
ENOG410XRSP. LUCA.
GeneTreeiENSGT00390000011225.
InParanoidiP91927.
KOiK17800.
OMAiRVNKMIS.
OrthoDBiEOG091G034T.
PhylomeDBiP91927.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR011685. LETM1.
IPR033122. LETM1_RBD.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF07766. LETM1. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS51758. LETM1_RBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P91927-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNALLRHKGR NLRTSHLAQN VYKRFLKSNC CACSSVNVTD EPAKEDELPR
60 70 80 90 100
RSASTSVLEL SRSLGTYRRF QPHANYGYDY SGYGFRHLHT SRTLLETSSS
110 120 130 140 150
KIDATVKKLK NQQKEKVEEI MKEVANGQAA AVRASSAATA TASSEKGQNA
160 170 180 190 200
SATAGSTSAT ASTTSLAKTA DKSVAKPKKP LRTRIWDELV HYYHGFRLLF
210 220 230 240 250
IDVAICSKLL WRVLNGKTLT RRENKQLQRT TSDLFRLIPF SVFIIVPFME
260 270 280 290 300
LLLPLFIKFF PGMLPSTFQT STDRQEKLRQ SLSVRLEVAK FLQQTLDQMP
310 320 330 340 350
VQHKEHSSEE AKQFEAFFTK IRNPTEPVSN DEIIKFAKRF DDEITLDSLS
360 370 380 390 400
REQLAALCRV LELNTIGTTT LLRFQLRLKL RSLATDDRVI AREGVDSLDL
410 420 430 440 450
LELQQACKAR GMRAYGLTEE RLRFQLKEWI DLSLNEQVPP TLLLLSRTML
460 470 480 490 500
ISDDSITTDK LKETIRVLPD AVGAHTRHAI GESEGKVDNK TKIEIIKEEE
510 520 530 540 550
RKIREEREEE REETIAKRSA IKEEIPAPYV FAEKLSGSQD LLDHKEQSSV
560 570 580 590 600
SETDKGISST DVQLLSEALK TLSSDKQLVV EKETIKELKE ELADYKEDVE
610 620 630 640 650
ELREVRQVVK EPVRESRAAK LLYNRVNKMI SQLDNVLNDL EARQHQIKQA
660 670 680 690 700
ESSDYAASSP TVEPQQMVHI DELVATIRRM KEASDEERFK VVGDLLVKLD
710 720 730 740 750
ADKDGVISVN EITKAVQSID REATNIDKKQ LEEFTELLSK LASRRRHEEI
760 770 780 790 800
VHIDDLMNNI KVLKETSDEA RLKHIEAVLE KFDADKDGVV TVNDIRKVLE
810 820 830 840 850
SIGRDNIKLS DKAIEELISL LDKEQVLQAE QKIEKAIAKS MKEAEKLKSE
860 870 880 890 900
VDKADKDLSK LVNDIHDSAK EIQDIANEMR DKEETVPDKA KELKAEPAFK
910 920 930 940 950
DTAKTLKDNA KDLDDLAKDP KSDPKSPTKA STGSGPAGLS GGGPSSGSSG
960 970 980 990 1000
IATGSTTESA LREAAERQME KILPSTDIGL PPTIQTPSQP PTSKKATATA
1010
STLSTTITAK KLL
Length:1,013
Mass (Da):113,580
Last modified:February 21, 2001 - v2
Checksum:i8C710380263F262E
GO

Sequence cautioni

The sequence CAA71853 differs from that shown. Reason: Frameshift at positions 920 and 930. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti687 – 6871E → Q in CAA71853 (PubMed:10071211).Curated
Sequence conflicti690 – 6901K → G in CAA71853 (PubMed:10071211).Curated
Sequence conflicti717 – 7171Q → H in CAA71853 (PubMed:10071211).Curated
Sequence conflicti736 – 7361E → D in CAA71853 (PubMed:10071211).Curated
Sequence conflicti740 – 7401K → R in CAA71853 (PubMed:10071211).Curated
Sequence conflicti761 – 7611K → E in CAA71853 (PubMed:10071211).Curated
Sequence conflicti943 – 9431G → S in CAA71853 (PubMed:10071211).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAM68316.1.
AE013599 Genomic DNA. Translation: AAM68317.1.
AY047527 mRNA. Translation: AAK77259.1.
Y10912 mRNA. Translation: CAA71853.1. Frameshift.
RefSeqiNP_611922.1. NM_138078.3.
NP_726453.1. NM_166674.2.
NP_726454.1. NM_166675.2.
UniGeneiDm.7406.

Genome annotation databases

EnsemblMetazoaiFBtr0072347; FBpp0072254; FBgn0019886.
FBtr0072348; FBpp0072255; FBgn0019886.
FBtr0072349; FBpp0072256; FBgn0019886.
GeneIDi37912.
KEGGidme:Dmel_CG4589.
UCSCiCG4589-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAM68316.1.
AE013599 Genomic DNA. Translation: AAM68317.1.
AY047527 mRNA. Translation: AAK77259.1.
Y10912 mRNA. Translation: CAA71853.1. Frameshift.
RefSeqiNP_611922.1. NM_138078.3.
NP_726453.1. NM_166674.2.
NP_726454.1. NM_166675.2.
UniGeneiDm.7406.

3D structure databases

ProteinModelPortaliP91927.
SMRiP91927. Positions 282-448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi63485. 4 interactions.
DIPiDIP-23753N.
IntActiP91927. 7 interactions.
MINTiMINT-1017214.
STRINGi7227.FBpp0072255.

Protein family/group databases

TCDBi2.A.97.1.3. the mitochondrial inner membrane k(+)/h(+) and ca(2+)/h(+) exchanger (letm1) family.

Proteomic databases

PaxDbiP91927.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0072347; FBpp0072254; FBgn0019886.
FBtr0072348; FBpp0072255; FBgn0019886.
FBtr0072349; FBpp0072256; FBgn0019886.
GeneIDi37912.
KEGGidme:Dmel_CG4589.
UCSCiCG4589-RA. d. melanogaster.

Organism-specific databases

CTDi3954.
FlyBaseiFBgn0019886. Letm1.

Phylogenomic databases

eggNOGiKOG1043. Eukaryota.
ENOG410XRSP. LUCA.
GeneTreeiENSGT00390000011225.
InParanoidiP91927.
KOiK17800.
OMAiRVNKMIS.
OrthoDBiEOG091G034T.
PhylomeDBiP91927.

Miscellaneous databases

GenomeRNAii37912.
PROiP91927.

Gene expression databases

BgeeiFBgn0019886.
GenevisibleiP91927. DM.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR011685. LETM1.
IPR033122. LETM1_RBD.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF07766. LETM1. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS51758. LETM1_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA60DA_DROME
AccessioniPrimary (citable) accession number: P91927
Secondary accession number(s): A4UZV1, Q0E8W7, Q9W160
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 21, 2001
Last modified: September 7, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.