Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanine nucleotide-binding protein alpha-15 subunit

Gene

gpa-15

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48MagnesiumBy similarity1
Metal bindingi183MagnesiumBy similarity1
Binding sitei328GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi41 – 48GTPBy similarity8
Nucleotide bindingi177 – 183GTPBy similarity7
Nucleotide bindingi202 – 206GTPBy similarity5
Nucleotide bindingi271 – 274GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein alpha-15 subunit
Gene namesi
Name:gpa-15
ORF Names:M04C7.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiM04C7.1; CE28623; WBGene00001677; gpa-15.

Subcellular locationi

GO - Cellular componenti

  • heterotrimeric G-protein complex Source: GO_Central
  • non-motile cilium Source: UniProtKB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002036552 – 356Guanine nucleotide-binding protein alpha-15 subunitAdd BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1
Lipidationi5S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Proteomic databases

EPDiP91907.
PaxDbiP91907.

Expressioni

Gene expression databases

BgeeiWBGene00001677.

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6239.M04C7.1.2.

Structurei

3D structure databases

ProteinModelPortaliP91907.
SMRiP91907.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family.Curated

Phylogenomic databases

eggNOGiKOG0082. Eukaryota.
ENOG410XNVQ. LUCA.
GeneTreeiENSGT00770000120503.
HOGENOMiHOG000038730.
InParanoidiP91907.
KOiK04534.
OMAiDMLRIRI.
OrthoDBiEOG091G0AD9.
PhylomeDBiP91907.

Family and domain databases

CDDicd00066. G-alpha. 1 hit.
Gene3Di1.10.400.10. 1 hit.
InterProiView protein in InterPro
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiView protein in Pfam
PF00503. G-alpha. 1 hit.
PRINTSiPR00318. GPROTEINA.
SMARTiView protein in SMART
SM00275. G_alpha. 1 hit.
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P91907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSTCSTPES KEQKRINSVI DKQIRKDEDD EIGNQKLLLL GTGECGKSTI
60 70 80 90 100
LKQINILHSS GFSKADLKNV AGTVYSNIIQ GVATLLKAKD HFYYELSTPE
110 120 130 140 150
LDADAQHILS LADSSKDAMP FIPLTFNAIK RLWHDPVVQK TFERRAEFQM
160 170 180 190 200
MDTLVYFMNE LDRINNADYI PTVDDMLRIR IPTMGVVQQT IEIKGTKFRI
210 220 230 240 250
YDVGGQRSER RKWIHLFDNV NATIFISAIN EFNQKLNEDG QTNRMKESIK
260 270 280 290 300
LFETICNSRW FVQAAMILFL NKRDLFEQKL KTTSINVLFS TYQGSNDYAE
310 320 330 340 350
CVAYIQMRFE RLNKYSDIKK IYTHVTCATD TNQIQLVIDS VVDMVIGRNL

RGTGME
Length:356
Mass (Da):40,862
Last modified:March 1, 2002 - v2
Checksum:i70F37C61031FA04E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008137 mRNA. Translation: AAG32090.1.
Z83117 Genomic DNA. Translation: CAB05570.2.
PIRiT23705.
RefSeqiNP_492312.1. NM_059911.1.
UniGeneiCel.18556.

Genome annotation databases

EnsemblMetazoaiM04C7.1.1; M04C7.1.1; WBGene00001677.
M04C7.1.2; M04C7.1.2; WBGene00001677.
GeneIDi172645.
KEGGicel:CELE_M04C7.1.
UCSCiM04C7.1. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGPA15_CAEEL
AccessioniPrimary (citable) accession number: P91907
Secondary accession number(s): Q9BIG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: June 7, 2017
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families