Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanine nucleotide-binding protein alpha-15 subunit

Gene

gpa-15

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi48 – 481MagnesiumBy similarity
Metal bindingi183 – 1831MagnesiumBy similarity
Binding sitei328 – 3281GTP; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi41 – 488GTPBy similarity
Nucleotide bindingi177 – 1837GTPBy similarity
Nucleotide bindingi202 – 2065GTPBy similarity
Nucleotide bindingi271 – 2744GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein alpha-15 subunit
Gene namesi
Name:gpa-15
ORF Names:M04C7.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiM04C7.1; CE28623; WBGene00001677; gpa-15.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedSequence analysis
Chaini2 – 356355Guanine nucleotide-binding protein alpha-15 subunitPRO_0000203655Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence analysis
Lipidationi5 – 51S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Proteomic databases

EPDiP91907.
PaxDbiP91907.

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Protein-protein interaction databases

STRINGi6239.M04C7.1.2.

Structurei

3D structure databases

ProteinModelPortaliP91907.
SMRiP91907. Positions 7-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family.Curated

Phylogenomic databases

eggNOGiKOG0082. Eukaryota.
ENOG410XNVQ. LUCA.
GeneTreeiENSGT00760000118851.
HOGENOMiHOG000038730.
InParanoidiP91907.
KOiK04534.
OMAiDMLRIRI.
PhylomeDBiP91907.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P91907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSTCSTPES KEQKRINSVI DKQIRKDEDD EIGNQKLLLL GTGECGKSTI
60 70 80 90 100
LKQINILHSS GFSKADLKNV AGTVYSNIIQ GVATLLKAKD HFYYELSTPE
110 120 130 140 150
LDADAQHILS LADSSKDAMP FIPLTFNAIK RLWHDPVVQK TFERRAEFQM
160 170 180 190 200
MDTLVYFMNE LDRINNADYI PTVDDMLRIR IPTMGVVQQT IEIKGTKFRI
210 220 230 240 250
YDVGGQRSER RKWIHLFDNV NATIFISAIN EFNQKLNEDG QTNRMKESIK
260 270 280 290 300
LFETICNSRW FVQAAMILFL NKRDLFEQKL KTTSINVLFS TYQGSNDYAE
310 320 330 340 350
CVAYIQMRFE RLNKYSDIKK IYTHVTCATD TNQIQLVIDS VVDMVIGRNL

RGTGME
Length:356
Mass (Da):40,862
Last modified:March 1, 2002 - v2
Checksum:i70F37C61031FA04E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008137 mRNA. Translation: AAG32090.1.
Z83117 Genomic DNA. Translation: CAB05570.2.
PIRiT23705.
RefSeqiNP_492312.1. NM_059911.1.
UniGeneiCel.18556.

Genome annotation databases

EnsemblMetazoaiM04C7.1.1; M04C7.1.1; WBGene00001677.
M04C7.1.2; M04C7.1.2; WBGene00001677.
GeneIDi172645.
KEGGicel:CELE_M04C7.1.
UCSCiM04C7.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008137 mRNA. Translation: AAG32090.1.
Z83117 Genomic DNA. Translation: CAB05570.2.
PIRiT23705.
RefSeqiNP_492312.1. NM_059911.1.
UniGeneiCel.18556.

3D structure databases

ProteinModelPortaliP91907.
SMRiP91907. Positions 7-350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.M04C7.1.2.

Proteomic databases

EPDiP91907.
PaxDbiP91907.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiM04C7.1.1; M04C7.1.1; WBGene00001677.
M04C7.1.2; M04C7.1.2; WBGene00001677.
GeneIDi172645.
KEGGicel:CELE_M04C7.1.
UCSCiM04C7.1. c. elegans.

Organism-specific databases

CTDi172645.
WormBaseiM04C7.1; CE28623; WBGene00001677; gpa-15.

Phylogenomic databases

eggNOGiKOG0082. Eukaryota.
ENOG410XNVQ. LUCA.
GeneTreeiENSGT00760000118851.
HOGENOMiHOG000038730.
InParanoidiP91907.
KOiK04534.
OMAiDMLRIRI.
PhylomeDBiP91907.

Miscellaneous databases

NextBioi876399.
PROiP91907.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Interaction analysis of the complete G-alpha subfamily of heterotrimeric G proteins from Caenorhabditis elegans."
    Cuppen E., Jansen G., Plasterk R.H.A.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "The complete family of genes encoding G proteins of Caenorhabditis elegans."
    Jansen G., Thijssen K.L., Werner P., van der Horst M., Hazendonk E., Plasterk R.H.A.
    Nat. Genet. 21:414-419(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiGPA15_CAEEL
AccessioniPrimary (citable) accession number: P91907
Secondary accession number(s): Q9BIG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.