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Protein
Submitted name:

Ryanodine receptor

Gene

ryr-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation, ReceptorImported

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi1.A.3.1.6. the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family.

Names & Taxonomyi

Protein namesi
Submitted name:
Ryanodine receptorImported
Gene namesi
Name:ryr-1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4436 – 445924HelicalSequence analysisAdd
BLAST
Transmembranei4622 – 463918HelicalSequence analysisAdd
BLAST
Transmembranei4685 – 470723HelicalSequence analysisAdd
BLAST
Transmembranei4823 – 484523HelicalSequence analysisAdd
BLAST
Transmembranei4865 – 489026HelicalSequence analysisAdd
BLAST
Transmembranei4950 – 496920HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiP91905.
PaxDbiP91905.

Interactioni

Protein-protein interaction databases

STRINGi6239.K11C4.5b.

Structurei

3D structure databases

ProteinModelPortaliP91905.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini104 – 15855MIRInterPro annotationAdd
BLAST
Domaini165 – 20945MIRInterPro annotationAdd
BLAST
Domaini218 – 27356MIRInterPro annotationAdd
BLAST
Domaini279 – 33658MIRInterPro annotationAdd
BLAST
Domaini344 – 40259MIRInterPro annotationAdd
BLAST
Domaini582 – 803222B30.2/SPRYInterPro annotationAdd
BLAST
Domaini1006 – 1214209B30.2/SPRYInterPro annotationAdd
BLAST
Domaini1477 – 1696220B30.2/SPRYInterPro annotationAdd
BLAST
Domaini4182 – 421736EF-handInterPro annotationAdd
BLAST
Domaini4220 – 425233EF-handInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili4469 – 449123Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2243. Eukaryota.
ENOG410YCNW. LUCA.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.25.10.30. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR003877. SPRY_dom.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 7 hits.
PfamiPF13499. EF-hand_7. 1 hit.
PF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view]
PRINTSiPR00795. RYANODINER.
SMARTiSM00054. EFh. 2 hits.
SM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 1 hit.
SSF47473. SSF47473. 1 hit.
SSF49899. SSF49899. 2 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50188. B302_SPRY. 3 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50919. MIR. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91905-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKEEQGGG EQDDVSFLRT GDIVCLSCVA SHNRDGVLGS ERVCLCTEGF
60 70 80 90 100
GNRMCTLENV SDKDIPPDIA MCMLYIDNAL SMRALQEMMS ADSDHKSASG
110 120 130 140 150
AGGHKTLLYG HAVQLKHVQS EMYLACLSSC SSNDKLAFDV GVQETNEGEA
160 170 180 190 200
CWWTIHPASK QRSEGEKVRV GDDVILVSVA TERYLHMAYS KGYMVIASFH
210 220 230 240 250
QTLWNIQSVS SGSMRTRNMG FLFGNDVLRL FHGNDECLTI PENWSEHPQH
260 270 280 290 300
NMVIYEGGAA VTQARSLWRV ELIRMKWHGA LVGWEQVFRI KHITSGRYLG
310 320 330 340 350
VLDNSVQLYH KEKADFDLTA FVMCQNKDPK KQMLDEKEEE GMGNATIRYG
360 370 380 390 400
ETNAFIQHVK TQLWLSYQTT EVTKKGLGKV EEKKAVALKD GHMDDCYTFF
410 420 430 440 450
MALEEESKSA RVIRKCSSVL NKFLKGIDAL QLEGNQSTDW TRVDLNEVLK
460 470 480 490 500
LMEDLIEYFA QPNDEQDFEE KQNHLRALRS RQDLFQEEGV LNMILDTIDK
510 520 530 540 550
FSQMEALPDF AGLIGEETHV KWEQISTYLY LLVAAMIKGN HYNCAQFASA
560 570 580 590 600
QRLDWLFGRL SNPQSAEGIL DVLYCVLTES PEALNMINEG HIRSVISLLE
610 620 630 640 650
KVGRDPKVLD VLSSLCEGNG MAVRSSQNLI TQYLLPGKDL LLQTSMRDHV
660 670 680 690 700
SSMMPNVMLG VVEGSALFRK WYFEAEVEHI ETMTKQTPYL RIGWANSVGF
710 720 730 740 750
KPFPGSGDKM GCNGVGDDFY SYGFDGKSMY FGGKSRRVGH KLLEKGDVIG
760 770 780 790 800
CSIDLTIPEI KFSVNGTYMS GSFKKFNIDG YFFPVMSLSA KVSCRFILGG
810 820 830 840 850
NQGRLRYGPP TGFSAVVEAV NGELQITDCL SFGDLGKNIF SGPQTIFNNL
860 870 880 890 900
EPFIPTPIDV SATQLNHHAT EMHQKYAENL HELWAMRKIE LGWSYGETRS
910 920 930 940 950
ETSRKHPCLT KFEYLPETEK KYNILLALTT MKTIEALGYH LITEDPPCRL
960 970 980 990 1000
RAVRLGPNFQ QQNGYKPGPL DTHEIQLPAE LQPLTEALAR NTHNIWAKEK
1010 1020 1030 1040 1050
IKRGWTFGLS EHVDATQKRS PHLVPYEQVD ERIKQANRES AAENIRALQL
1060 1070 1080 1090 1100
FGIFLEPPAH EHDEVAEKEL RARKDNTRTY RAEATYAVCG GKWYFEFEIL
1110 1120 1130 1140 1150
TAGYMKIGWM DIGSTPEIQL GADDRSYAFD GYLGRKWHQG AETYGKEWKI
1160 1170 1180 1190 1200
GDVVGCFLDL NDRTISFSLN GELLLDPSGS EMAFDNVVCG DGLVPAMTLG
1210 1220 1230 1240 1250
SGQRGRLNFG QQSNSLKFFT TCGLQEGYEP FCVNMYRTMP MWFAKHFPRF
1260 1270 1280 1290 1300
EDISTLKSGS ILEVSRIPAT GNSPPCLKIL QKVTISEGGP SEKAKMEYIK
1310 1320 1330 1340 1350
LSLPVKCNDT FVKNKDKETI RRQLQEYKPR SQSVVSQIRA PGIPKEFDDN
1360 1370 1380 1390 1400
KEKKGFLRSM LGSKDSHESD DDRRSRTNSK QPSVDGDEPP AVRRSLLELP
1410 1420 1430 1440 1450
HDERQIAEDS MRDLNDRHSE KPKKGGLLSR LRDSSNTRKN FRDSDRRKEE
1460 1470 1480 1490 1500
KAAQLRQMKA NSRSFDAGSL DTSTLPTGQK DVLASSEMPL SGPGRQLTIK
1510 1520 1530 1540 1550
RSSIKKNKKG KKAEIALEKM EREKKGSIIP MDAQLDVLQE GDAHALVHHK
1560 1570 1580 1590 1600
DKVDEYYYGI RIFPGQDPSQ VWVGWVTTQY HYYNVNFDGS QGVRKCRFSE
1610 1620 1630 1640 1650
ADHHGTTVDS VQSQNCYMVN VSELLATTPD VANTKVSGTL IGCIIDTSIG
1660 1670 1680 1690 1700
ELSFQVGSTD TGIKFKLEPG AMLFPAAFVT PTATEILQFE LGRIKYTFPL
1710 1720 1730 1740 1750
SAAMFKSCEK SLVPFCPPRL TVEQIESVYW ARVPNETLRT TALKLSEVRG
1760 1770 1780 1790 1800
WSVLCNDPVR IMSVYIPEKD QSLDILEMIE MPDMLEFHRQ TLNLYCKLAS
1810 1820 1830 1840 1850
HGNHKVAHTL CQHIDEDQIM YAIKSHYLSG PMRQGFHDLL IGLHLMSHTA
1860 1870 1880 1890 1900
ARNSMAKEYV IPLVPQLQIK NVLDPDSESR YPQITGESVS MLSQMASEPV
1910 1920 1930 1940 1950
KKHVSREDEM KLLPPSVDFE ALKKHVMESL QSATHHAVMN CRDLIGGDNT
1960 1970 1980 1990 2000
NHFEPLFKLF DQLLVIGLIN DEELECLLRL IHPQAFDENY ETGTTQKGLT
2010 2020 2030 2040 2050
QLELAEPVKI QLVSILDHLC DIQLRYRIES LVAFTEGFVG ELQSDQCKRY
2060 2070 2080 2090 2100
MEIKQTDMPP AEAAKKTKEF RCPPKEQMFR LLMCKVKEER DPELMEEDAD
2110 2120 2130 2140 2150
VDQCPMAEGL QQQLRDFCEL LVGKIGNVKE GDSDDQLALI ESEEGSWVDS
2160 2170 2180 2190 2200
FARIVVKVPP PVLEEGMEMQ KKGTQNFREI IVTMLREWAQ ADFIESKSLI
2210 2220 2230 2240 2250
RNMFRLLLRQ YSGIREIRDA MSQTYVFHER NEKDVTDFLV YLIQIRELLT
2260 2270 2280 2290 2300
VQFEHTEEAI LKRGLWKLMN NRIFFQHPDL MRLLSVHENV MSIMMNILTA
2310 2320 2330 2340 2350
QQGTVEHEGD ELKEKAPIKD ASEMVVACSR FLCYFCRTSR QNQKAMFEHL
2360 2370 2380 2390 2400
SFLLDNATML LARPSLRGSV PLDVAYSSFM DNNELALALK EEELDKVAVY
2410 2420 2430 2440 2450
LSRCGLQPNS ELITKGYPDI GWDPVEGERY IDFLRFCVWI NGENVEENAN
2460 2470 2480 2490 2500
LVIRLLIRRP ECLGVALKGE GQGLFSAFKE AIALSEDIRL LENDSHPSLL
2510 2520 2530 2540 2550
SSGLLGENPT YPSKDAEGED YIDLGAATLD FYSSLVDLLA KCAPDPMAIQ
2560 2570 2580 2590 2600
AGKGDSLRAR AILRSLISLD DLGQILALRF TIPNLAAPSI EDTGPLPGLL
2610 2620 2630 2640 2650
PNHKGSVLLF LDRVYGIDQQ DMLFHVLEQS FLPDLRAATM MDSPRALESD
2660 2670 2680 2690 2700
TALALNRYLC NSVLPLLTNH SHFFADAEHH SALLDATLHT VYRMNRLKSL
2710 2720 2730 2740 2750
TKNQRDAVSD FLVAITRELP PAMMIKLLKK VITDILTMND MNVLVPLRLI
2760 2770 2780 2790 2800
TLHYERCGKY YGSGNHYGVA SEQEKRLSML LFDAIFDTLG SRPYDPELFG
2810 2820 2830 2840 2850
KALPCMTAIG SAISPDYTLT SGLEDVRNKR REEEGAWIPR TVDVSRCEIN
2860 2870 2880 2890 2900
RDLEKMTELF AEHFHDSWAS RKLEKGWVHG DLYSRANFTH PRLKPFALLK
2910 2920 2930 2940 2950
DFEKSFYKER CSECLKALMA WNYSFEMMDR DANDRASAAR TLSGTSISNF
2960 2970 2980 2990 3000
APKPIDLSSM TLEKDMVNAA EKMAEHSHLI WAKKVMNDLN TKGGFMPIPL
3010 3020 3030 3040 3050
VPWDLLTDFE RRKDRFRASE ILKFLQYHGY HVNCPKDEQS QNDRLKSEGE
3060 3070 3080 3090 3100
RTSVEKRFAY NLLEKLITYL EQASLKMKSV KPSQELTRRN SFKKEGQDVK
3110 3120 3130 3140 3150
FFEKVVLPLM HAYFNAHKNY FLEGSSIVQT GTASNKEKEM VANLFCRLAA
3160 3170 3180 3190 3200
LLRIKNRAFG SVAKITVKCL QGLTQALDLR TLVKVNSDIV RTSLLTFFNN
3210 3220 3230 3240 3250
CADDLYASVN ELKDGGQYSL IRGQALKSWN SFEFANQMIV PVLTTMFAHL
3260 3270 3280 3290 3300
ARNHFGTDLL LDDIQAACYK ILDSLYMVTG LSSSISHRKS ISGESEKHRP
3310 3320 3330 3340 3350
GLGQCLAAFA SCFPVAFLEP EFNKSNKFSV LAKSQDQSVQ VQEMLQNLST
3360 3370 3380 3390 3400
HIPHLEKLLT DLETVANNNT MYSDVPNVYD VDLPLMCSYM AHWFSVGPDG
3410 3420 3430 3440 3450
KRDKEDQRAS VVQTTSVSCD HINRIFNALL KMIRNHVGIE NAPWLCRVNF
3460 3470 3480 3490 3500
FAVQIIQNVT SDPVREFVLP IAERLRRMSE KAYKEEEHMR THPDDADEGT
3510 3520 3530 3540 3550
VAEDNARLVR DTYAFFPILM KYTDLHRAQW LKTPTWETDG VYENVAVIFR
3560 3570 3580 3590 3600
IWSQSQHFKR EELNYVAQFE EDAAATGGGD MKTGKAAIAE RKKKRREGQI
3610 3620 3630 3640 3650
KKDKHAASIV IACLKRLLPV GLNVFGGREL DIVQQSKEKF IQKETEEKIR
3660 3670 3680 3690 3700
EFIKGLLEIP VKTDPTDKNA WQLSLYRKIG KSQMRGKDEM SQDAVIEKIF
3710 3720 3730 3740 3750
NMGQVSAILH TMTSRMEKED IWKKVLTLQR KRMAISLITA SHLYKTELHR
3760 3770 3780 3790 3800
GINFFLPAFS RLWMEEEDAG QDQLIADICS GVEEEEGPRI EIIMEEGVPI
3810 3820 3830 3840 3850
VASSEDTKEK ETNPDPLKQL IRCFQRAATS EETAASAIHE DSLYIRFADV
3860 3870 3880 3890 3900
MAKSIHIEEE DGEDGEEGEI DQAAKEEQSQ ALRGEQAVLA SRGAAIMCLM
3910 3920 3930 3940 3950
YLSASGGEPN EMVAQTLQLG IHLLSGGNVE IQKMLIEYLQ LKKDVRFFTS
3960 3970 3980 3990 4000
MAGLMNKCSV LNLEMFERQI KAEGLGMGAE LASGDNQNLN DADFTCSLFR
4010 4020 4030 4040 4050
FLQLTCEGHN LEFQNYLRTQ PGHTTSVNLI NCTVDYLLRL QESVMDFYWH
4060 4070 4080 4090 4100
YSSKEVIDEG GKEYFLRAIQ VCSQVFNTLT ESIQGPCVGN QMTLANSRLW
4110 4120 4130 4140 4150
DAINGFFFLF AHMMEKLYKN STQLELLREF LNLQKDMIVL MLSMLEGNVL
4160 4170 4180 4190 4200
NGSIGKQMVD ALVESQPSVE KILKFSDMFL KLKDLTTSQA FQDFDTNQDG
4210 4220 4230 4240 4250
WISPKEFQRA MESQKMYTVE DITYLMMCTD VNNDGKVDYM EFTERFHNPA
4260 4270 4280 4290 4300
RDIGFNLAVL LVNLKEHITN DPRLEKIIEK AQTLLEYFDP FLGRIEIMGS
4310 4320 4330 4340 4350
SKRVEKIYFE IQESWLEQWG KQQIRDSKNS FLFNVLQDDG GDQGKLEAFI
4360 4370 4380 4390 4400
NFCEDTIFEM QHAAAISSGD SDTKMERAIK QRDYFLQQTS ADHISETFKS
4410 4420 4430 4440 4450
GYNYGISAAS ALSPQNISTT MRNVSSSVRQ MSWTQLLYAV IILFIRAGLA
4460 4470 4480 4490 4500
IGWAGYLLLM TIFRFGYFLT TSSEEEEAAR QEKEQAKMNN EHPSFNPPII
4510 4520 4530 4540 4550
QEFHHSHVGV TAFGVGMNAD HLNVNSLPDF VPPERPETPE TVLEEEKPLN
4560 4570 4580 4590 4600
QETSPPTSPT SPASKAPSIY ESIGAPQMVQ LQSEADFQQG QYEPKIAESN
4610 4620 4630 4640 4650
STKSRGSILN MLARNFKTIE KITLYLAFFI NVILLFHRVD ISHAENAEAA
4660 4670 4680 4690 4700
SEGDDDEDAL ESIFITGMQF PYVEYEITGW MLAQILYWIS VLHLSTSFAL
4710 4720 4730 4740 4750
LVSFYQLKIP LITFKREKEI ARKLMFDGCW ITEEDSEELG IVDTFMWYLD
4760 4770 4780 4790 4800
RIVVSAKSFP MMYWDKFVRR KTRSKFKDQV DEETLTSILG EEKMSTDSSY
4810 4820 4830 4840 4850
DYRYSCWLWI GVILTNGQFL YRVGYLLCSA CGVFLSPFFY AFHLIDVVLS
4860 4870 4880 4890 4900
FPMLKAILQS VTHNLQQLIL TIMMTLVVVY LYTVIAFNFF RKFYVQEGEE
4910 4920 4930 4940 4950
GEEPDRKCHN MLTCFIYHFY AGVRAGGGIG DELESPYGDD LEYPRMFYDI
4960 4970 4980 4990 5000
SFFFFVIIIL LAIMQGLIID AFGELRDQQE SATEKLESSC FICDIGKETF
5010 5020 5030 5040 5050
DRMPRGFEIH TTKEHNFANY LFFLQHLVNK DETEYTGQET YVREKYDNRD
5060 5070
WDFFPVGECF VKQYEDQLLQ S
Length:5,071
Mass (Da):576,362
Last modified:May 1, 1997 - v1
Checksum:i145EF32288613324
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45899 Genomic DNA. Translation: BAA08309.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45899 Genomic DNA. Translation: BAA08309.1.

3D structure databases

ProteinModelPortaliP91905.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.K11C4.5b.

Protein family/group databases

TCDBi1.A.3.1.6. the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family.

Proteomic databases

EPDiP91905.
PaxDbiP91905.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG2243. Eukaryota.
ENOG410YCNW. LUCA.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.25.10.30. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR003877. SPRY_dom.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 7 hits.
PfamiPF13499. EF-hand_7. 1 hit.
PF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view]
PRINTSiPR00795. RYANODINER.
SMARTiSM00054. EFh. 2 hits.
SM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 1 hit.
SSF47473. SSF47473. 1 hit.
SSF49899. SSF49899. 2 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50188. B302_SPRY. 3 hits.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50919. MIR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "An abnormal ketamine response in mutants defective in the ryanodine receptor gene ryr-1 (unc-68) of Caenorhabditis elegans."
    Sakube Y., Ando H., Kagawa H.
    J. Mol. Biol. 267:849-864(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiP91905_CAEEL
AccessioniPrimary (citable) accession number: P91905
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.