Reviewed, UniProtKB/Swiss-Prot P91895 (TPIS_ANOME)

Names and origin

Protein names

Recommended name:
    Triosephosphate isomerase
      Short name=TIM
    EC=5.3.1.1
Alternative name(s):
    Triose-phosphate isomerase

Gene names

Name:

Tpi

Organism

Anopheles merus (Mosquito)

Taxonomic identifier

30066 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Anophelinae › Anopheles

Protein attributes

Sequence length	206 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glyceraldehyde 3-phosphate = glycerone phosphate.
Pathway	Carbohydrate biosynthesis; gluconeogenesis. Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the triosephosphate isomerase family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Gluconeogenesis Glycolysis Lipid synthesis Pentose shunt
Molecular function	Isomerase
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	triose-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›206	›206	Triosephosphate isomerase		PRO_0000090125
Sites
	Active site	76	1	Electrophile By similarity
	Active site	146	1	Proton acceptor By similarity
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	206	1

Sequences

	Sequence		Length	Mass (Da)
	P91895-1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 049162C164094385	FASTA	206	21,878
	10 20 30 40 50 60 SITELCKTLS AGPLDPNTEV VVGCPAPYLS LARSLLPETI GVAAQNCYKV AKGAFTGEIS 70 80 90 100 110 120 PAMLKDLGLG WVILGHSERR AIFGETDELI AEKVAHALGE GLKVIACIGE TLQEREAGQT 130 140 150 160 170 180 EAVCFRQTKA IAAQVKDWSN VVIAYEPVWA IGTGKTATPE QAQEVHAALR KWFTENVSAD 190 200 VSNAIRIQYG GSVTAANCRE LAGKPD

References

[1]	"Towards a reconciliation of the introns early or late views: triosephosphate isomerase genes from insects." Tyshenko M.G., Walker V.K. Biochim. Biophys. Acta 1353:131-136(1997) [PubMed: 9294007] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U82707 Genomic DNA. Translation: AAB48448.1.
3D structure databases
SMR	P91895. Positions 2-206.
ModBase	Search...
Enzyme and pathway databases
BRENDA	5.3.1.1. 290879.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR000652. Triosephosphate_isomerase. IPR020861. Triosephosphate_isomerase_AS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR21139. Triophos_ismrse. 1 hit.
Pfam	PF00121. TIM. 1 hit. [Graphical view]
TIGRFAMs	TIGR00419. tim. 1 hit.
PROSITE	PS00171. TIM_1. 1 hit. PS51440. TIM_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPIS_ANOME

Accession

Primary (citable) accession number: P91895

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	February 9, 2010
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)