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Protein
Submitted name:

Fatty Acid SyNthase

Gene

fasn-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-CEL-163765. ChREBP activates metabolic gene expression.
R-CEL-199220. Vitamin B5 (pantothenate) metabolism.
R-CEL-2426168. Activation of gene expression by SREBF (SREBP).
R-CEL-75105. Fatty Acyl-CoA Biosynthesis.

Protein family/group databases

ESTHERicaeel-F32H2.5. Thioesterase.

Names & Taxonomyi

Protein namesi
Submitted name:
Fatty Acid SyNthaseImported
Gene namesi
Name:fasn-1Imported
ORF Names:CELE_F32H2.5Imported, F32H2.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF32H2.5; CE42777; WBGene00009342; fasn-1.

PTM / Processingi

Proteomic databases

EPDiP91871.
PaxDbiP91871.
PRIDEiP91871.

Interactioni

Protein-protein interaction databases

STRINGi6239.F32H2.5.

Structurei

3D structure databases

ProteinModelPortaliP91871.
SMRiP91871. Positions 38-888, 1332-1620, 1661-1949, 1970-2207, 2218-2288, 2330-2597.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2215 – 227157Acyl carrierInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1202. Eukaryota.
COG3321. LUCA.
GeneTreeiENSGT00530000063309.
HOGENOMiHOG000019642.
InParanoidiP91871.
KOiK00665.
OMAiIFTHINI.
OrthoDBiEOG71K623.
PhylomeDBiP91871.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
1.10.1470.20. 1 hit.
3.40.366.10. 2 hits.
3.40.47.10. 2 hits.
3.40.50.1820. 2 hits.
3.40.50.720. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013149. ADH_C.
IPR023102. Fatty_acid_synthase_dom_2.
IPR011032. GroES-like.
IPR032821. KAsynt_C_assoc.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR020843. PKS_ER.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
IPR001031. Thioesterase.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
PF16197. KAsynt_C_assoc. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF08659. KR. 1 hit.
PF00550. PP-binding. 1 hit.
PF14765. PS-DH. 1 hit.
PF00975. Thioesterase. 1 hit.
[Graphical view]
SMARTiSM00827. PKS_AT. 1 hit.
SM00826. PKS_DH. 1 hit.
SM00829. PKS_ER. 1 hit.
SM00825. PKS_KS. 1 hit.
SM00823. PKS_PP. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
SSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 2 hits.
SSF52151. SSF52151. 2 hits.
SSF53474. SSF53474. 1 hit.
SSF53901. SSF53901. 2 hits.
SSF55048. SSF55048. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91871-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNTGEGSSD SSGTWERISD NSQSSDNMDP TQWWQKQDDI VISGVSGRFP
60 70 80 90 100
RCDNVKMFGD MLLAGEDLVT EDSLRWTPGF CDLPKRHGKL KVLNKFDAGF
110 120 130 140 150
FQVTPKQANF MDPQVRLLLE ASWEAMVDAG INPTDLRGSK TGVFVGCSAS
160 170 180 190 200
ETSGMLTQDP DTVTGYTLTG CVRSMFSNRI SYTFDLQGPS FSVDTACSSS
210 220 230 240 250
LLALQLAVDS IRQGQCDAAI VAGAHLTLTP TAALQFLRLG MLTDKGSCRS
260 270 280 290 300
FDESGDGYCR TEGVAAIFIQ RKKKAQRLYA TVVHAKSNTD GHKEHGITFP
310 320 330 340 350
SGERQAQLLQ EVYSEAGIDP NSVYYVEAHG TGTKVGDPQE ANAICEVFCS
360 370 380 390 400
KRTDSLLIGS VKSNMGHAEP ASGVCSLTKI LLSIERQLIP PNLHYNTPNQ
410 420 430 440 450
YIPGLTDGRL KVVTEPTALP GGLIGINSFG FGGSNTHVIL KAADHIAPPI
460 470 480 490 500
TPHPFTKLVT YCGRTQEAVE NIFTEIESNK DDLYLQALLA NQANMPANLL
510 520 530 540 550
PFRGYMLLDR ENNVETLKSI TKVPITEARP IYFIYSGMGS QWPGMAIKLM
560 570 580 590 600
KIPMFDDSLR ASSKTLEEFG LDVYGMLCNP DPEQYSNNTM NCMLAITAIQ
610 620 630 640 650
IALTDVLTAL GVSPDGIIGH STGEMGCGYA DGGITREQTM RLAYHRGTTI
660 670 680 690 700
MKHTEIKGAM AAVGLTWEQV KEQAPPGVVA ACHNGADSVT ISGDAEGVAT
710 720 730 740 750
FCAQLKEKDI FAKVVDTSGI PFHSPAMLAV QDEMIECMRT AVPEPKPRSS
760 770 780 790 800
KWISTSIPED DWESDLAATC SAEYHVHNAC SPVLFYEAIQ KIPANAVTIE
810 820 830 840 850
MAPHSLMQAI LRRSLQKTVT NVGLMNRPKS ENDDELESFL GSLGKIYQAG
860 870 880 890 900
VNIQITELYP GGQYKGVVPK GTPMIGPMWK WDHTQDWLTI DGRQVLAGGS
910 920 930 940 950
GSVASSATYN IDPFATDSKE TYLLDHVIDG RVLYPFTGHM VLAWRTLCKL
960 970 980 990 1000
KGLDYTKTPV VFENINVFSA TILTKPIKLD VVLSPGNGYF EIISDDQVAA
1010 1020 1030 1040 1050
SGRIYIPEDN QPFYYGKLED IRTSEIADRI ELDTEDAYKE FLLRGYEYGQ
1060 1070 1080 1090 1100
AFRGIYKTCN SGERGFLYWT GNWVTFLDSL LQTALLAERS DTLRLPTRVR
1110 1120 1130 1140 1150
HLRIDPNKHL EHVVEKDGIQ VIELRNDHST NGCIAGGVEC CDLNAHSVAR
1160 1170 1180 1190 1200
RIQVSGQLYH EKIFFVPHFD HNCLSGHKKT STILKDYSAV IKQQLYTGFS
1210 1220 1230 1240 1250
KWQSAGLLKK LKNGAQIVKA LAVLKASQSD VVLDDTVTRF THDGKCTVLH
1260 1270 1280 1290 1300
HIADMFKIED CEDFEDRVAA KLKSVRGIFE LDRLWAGAVL NDRIVKSLQD
1310 1320 1330 1340 1350
ICIENSAGHH ATMAAVDLVS TDQIRHCIEA NSSHPLLETD YTCIGANVDH
1360 1370 1380 1390 1400
LDESTLEIIG GKKQKIDLEN NFTGHGEVKN LDYVLLDKVI SKKADPIAFI
1410 1420 1430 1440 1450
EACKHLIRET GFLLVVEVTS QYEIALAIEG LLGNEMVGDA SRKYNQFFTH
1460 1470 1480 1490 1500
EQLLDMFKST GFLICNFQSD PALMTTTYAV RRVSPIPRDP VFIDVDDVKE
1510 1520 1530 1540 1550
FNWIEPLQKV SEERLNEPDS KTIWLVSNKC RNNGIVGLGL CFVEENLKIN
1560 1570 1580 1590 1600
RFRSAFDMSA NKEIRDGPPV WNIGDEETKK IVELDLHAND YMDGQWGSMR
1610 1620 1630 1640 1650
HIVVKDEDVH VYKDCEHAFI NTLTRGDVSS LTWFESPNQY FDSMVKSKAT
1660 1670 1680 1690 1700
QELCSVYYAP INFRDIMLAY GRLPPDAIPG NFADRECLLG MEFSGRLKDG
1710 1720 1730 1740 1750
TRLMGILPAQ ALATTVMVDR DYAWEVPRDW TLAEASTVPV VYTTAYYALV
1760 1770 1780 1790 1800
RRGLMKKGDK ILIHGGAGGV GQAAIAIALA AGCEVFTTVG SAEKREFLKN
1810 1820 1830 1840 1850
LFPQLQEHHF ANSRSADFEL HIRQHTKGRG VNIVLNSLAN EMLQASLRCL
1860 1870 1880 1890 1900
ARHGRFLEIG KVDLSQNSSL GMAKLLDNVS VHGILLDSIM DPTVGDLDEW
1910 1920 1930 1940 1950
KEIARLLEQG IKSGVVKPLH SHSFPADKAE EAFRFMSAGK HIGKVIMEIR
1960 1970 1980 1990 2000
PDEGTKVCPP SKISVRAICR TLCHPQHTYL ITGGLGGFGL ELAQWLINRG
2010 2020 2030 2040 2050
ARKLVLTSRT GIRTGYQARC VHFWRRTGVS VLVSTLNIAK KSDAVELINQ
2060 2070 2080 2090 2100
CTAMGPIGGI FHLAMVLRDC LFENQNVQNF KDAAEAKYYG TINLDYASRE
2110 2120 2130 2140 2150
HCDKNILKWF VVFSSITSGR GNAGQTNYGW SNSCMERMID QRRADGFPGI
2160 2170 2180 2190 2200
AIQWGAIGDV GVILENMGDN NTVVGGTLPQ RMPSCLSSLD NFLSWNHPIV
2210 2220 2230 2240 2250
SSFIKAELGS KKNVGGGDLM ATIAHILGVN DISQLNADAN LSDLGLDSLM
2260 2270 2280 2290 2300
GVEIKQALER DHDIVLSMKE IRTLTLNKLQ QLADQGGTGR TALQVNELEM
2310 2320 2330 2340 2350
KKDGERDAEL NTAEMLEQQM NQLFKMRVDV NDLDPQDIIV KANKVEEGPI
2360 2370 2380 2390 2400
TFFVHSIEGI ATPLKKVMNK CEFPAYCFQS TKNVPQTSIE DVAKCYIREM
2410 2420 2430 2440 2450
KKIQPSGPYR LVGYSYGACI GFEMANMLQE SDGRDAVERL ILLDGSHLYM
2460 2470 2480 2490 2500
QTYRNVYRMA FGVTGDSLVN NPLFESEIMC AMTLRFANVD YKKFRFELLQ
2510 2520 2530 2540 2550
QPGFKARVQK VVDQVMLTGL FKSPETVAFA CEAMHSKFLM ADKYKPRRNF
2560 2570 2580 2590 2600
GGHITLIRAE QGAAREEDVG EDYGVAAVSE DCEVLKVKGD HDTFVQGKSS
2610
SVTVEHINRI ILQ
Length:2,613
Mass (Da):289,226
Last modified:September 2, 2008 - v2
Checksum:i4E30E9E645554522
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB04244.2.
RefSeqiNP_492417.2. NM_060016.5.
UniGeneiCel.18801.

Genome annotation databases

EnsemblMetazoaiF32H2.5; F32H2.5; WBGene00009342.
GeneIDi172715.
KEGGicel:CELE_F32H2.5.
UCSCiF32H2.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB04244.2.
RefSeqiNP_492417.2. NM_060016.5.
UniGeneiCel.18801.

3D structure databases

ProteinModelPortaliP91871.
SMRiP91871. Positions 38-888, 1332-1620, 1661-1949, 1970-2207, 2218-2288, 2330-2597.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F32H2.5.

Protein family/group databases

ESTHERicaeel-F32H2.5. Thioesterase.

Proteomic databases

EPDiP91871.
PaxDbiP91871.
PRIDEiP91871.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF32H2.5; F32H2.5; WBGene00009342.
GeneIDi172715.
KEGGicel:CELE_F32H2.5.
UCSCiF32H2.5. c. elegans.

Organism-specific databases

CTDi172715.
WormBaseiF32H2.5; CE42777; WBGene00009342; fasn-1.

Phylogenomic databases

eggNOGiKOG1202. Eukaryota.
COG3321. LUCA.
GeneTreeiENSGT00530000063309.
HOGENOMiHOG000019642.
InParanoidiP91871.
KOiK00665.
OMAiIFTHINI.
OrthoDBiEOG71K623.
PhylomeDBiP91871.

Enzyme and pathway databases

ReactomeiR-CEL-163765. ChREBP activates metabolic gene expression.
R-CEL-199220. Vitamin B5 (pantothenate) metabolism.
R-CEL-2426168. Activation of gene expression by SREBF (SREBP).
R-CEL-75105. Fatty Acyl-CoA Biosynthesis.

Miscellaneous databases

NextBioi876707.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
1.10.1470.20. 1 hit.
3.40.366.10. 2 hits.
3.40.47.10. 2 hits.
3.40.50.1820. 2 hits.
3.40.50.720. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013149. ADH_C.
IPR023102. Fatty_acid_synthase_dom_2.
IPR011032. GroES-like.
IPR032821. KAsynt_C_assoc.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR016040. NAD(P)-bd_dom.
IPR020801. PKS_acyl_transferase.
IPR020841. PKS_Beta-ketoAc_synthase_dom.
IPR020807. PKS_dehydratase.
IPR020843. PKS_ER.
IPR013968. PKS_KR.
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
IPR001031. Thioesterase.
IPR016039. Thiolase-like.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
PF16197. KAsynt_C_assoc. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF08659. KR. 1 hit.
PF00550. PP-binding. 1 hit.
PF14765. PS-DH. 1 hit.
PF00975. Thioesterase. 1 hit.
[Graphical view]
SMARTiSM00827. PKS_AT. 1 hit.
SM00826. PKS_DH. 1 hit.
SM00829. PKS_ER. 1 hit.
SM00825. PKS_KS. 1 hit.
SM00823. PKS_PP. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
SSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 2 hits.
SSF52151. SSF52151. 2 hits.
SSF53474. SSF53474. 1 hit.
SSF53901. SSF53901. 2 hits.
SSF55048. SSF55048. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiP91871_CAEEL
AccessioniPrimary (citable) accession number: P91871
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: September 2, 2008
Last modified: May 11, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.