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Protein
Submitted name:

RAB family

Gene

rab-5

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • GTPase activating protein binding Source: WormBase
  • GTPase activity Source: WormBase
  • GTP binding Source: InterPro

GO - Biological processi

  • apical protein localization Source: WormBase
  • asymmetric protein localization Source: WormBase
  • embryo development ending in birth or egg hatching Source: WormBase
  • intracellular protein transport Source: InterPro
  • nucleocytoplasmic transport Source: InterPro
  • phagosome maturation involved in apoptotic cell clearance Source: WormBase
  • protein secretion Source: WormBase
  • receptor-mediated endocytosis Source: WormBase
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-CEL-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Submitted name:
RAB familyImported
Gene namesi
Name:rab-5Imported
ORF Names:CELE_F26H9.6Imported, F26H9.6Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF26H9.6; CE09711; WBGene00004268; rab-5.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: WormBase
  • early endosome Source: WormBase
  • endosome Source: WormBase
  • periciliary membrane compartment Source: WormBase
  • phagocytic vesicle Source: WormBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiP91857.
PaxDbiP91857.

Expressioni

Gene expression databases

ExpressionAtlasiP91857. baseline.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
rabx-5Q8I1002EBI-2655330,EBI-2655296
rme-6Q9GYH72EBI-2655330,EBI-320814

GO - Molecular functioni

  • GTPase activating protein binding Source: WormBase

Protein-protein interaction databases

IntActiP91857. 5 interactions.
STRINGi6239.F26H9.6.1.

Structurei

3D structure databases

ProteinModelPortaliP91857.
SMRiP91857. Positions 18-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0092. Eukaryota.
ENOG410YCCP. LUCA.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
InParanoidiP91857.
KOiK07888.
OMAiTREATGY.
OrthoDBiEOG77DJ7M.
PhylomeDBiP91857.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.

Sequencei

Sequence statusi: Complete.

P91857-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARNAGTAR PGGPNRTCQF KLVLLGESAV GKSSLVLRFV KGQFHEYQES
60 70 80 90 100
TIGAAFLTQT VCLDDATIKF EIWDTAGQER YHSLAPMYYR GAQAAIVVYD
110 120 130 140 150
ITNQESFQKA KNWVKELQRQ ASPNIVMALA GNKADVANKR TVEYEEANAY
160 170 180 190 200
AEDNALLFME TSAKTSMNVN DIFMAIAKKL PIGPAQGEPT GTVDMNQPQQ

QQKGSCCK
Length:208
Mass (Da):22,836
Last modified:May 1, 1997 - v1
Checksum:i3DCD9DA1716AB992
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB04205.1.
PIRiT21442.
RefSeqiNP_492481.1. NM_060080.3.
UniGeneiCel.17365.

Genome annotation databases

EnsemblMetazoaiF26H9.6; F26H9.6; WBGene00004268.
GeneIDi172755.
KEGGicel:CELE_F26H9.6.
UCSCiF26H9.6.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB04205.1.
PIRiT21442.
RefSeqiNP_492481.1. NM_060080.3.
UniGeneiCel.17365.

3D structure databases

ProteinModelPortaliP91857.
SMRiP91857. Positions 18-180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP91857. 5 interactions.
STRINGi6239.F26H9.6.1.

Proteomic databases

EPDiP91857.
PaxDbiP91857.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF26H9.6; F26H9.6; WBGene00004268.
GeneIDi172755.
KEGGicel:CELE_F26H9.6.
UCSCiF26H9.6.1. c. elegans.

Organism-specific databases

CTDi172755.
WormBaseiF26H9.6; CE09711; WBGene00004268; rab-5.

Phylogenomic databases

eggNOGiKOG0092. Eukaryota.
ENOG410YCCP. LUCA.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
InParanoidiP91857.
KOiK07888.
OMAiTREATGY.
OrthoDBiEOG77DJ7M.
PhylomeDBiP91857.

Enzyme and pathway databases

ReactomeiR-CEL-983231. Factors involved in megakaryocyte development and platelet production.

Gene expression databases

ExpressionAtlasiP91857. baseline.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiP91857_CAEEL
AccessioniPrimary (citable) accession number: P91857
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: June 8, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.