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Protein

Probable phosphoserine aminotransferase

Gene

F26H9.5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.By similarity

Catalytic activityi

O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.
4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.

Cofactori

pyridoxal 5'-phosphateBy similarityNote: Binds 1 pyridoxal phosphate per subunit.By similarity

Pathwayi: L-serine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-serine from 3-phospho-D-glycerate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable phosphoserine aminotransferase (F26H9.5)
  3. no protein annotated in this organism
This subpathway is part of the pathway L-serine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-serine from 3-phospho-D-glycerate, the pathway L-serine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: pyridoxine 5'-phosphate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Probable phosphoserine aminotransferase (F26H9.5)
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway pyridoxine 5'-phosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate, the pathway pyridoxine 5'-phosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45L-glutamateBy similarity1
Binding sitei105Pyridoxal phosphateBy similarity1
Binding sitei154Pyridoxal phosphateBy similarity1
Binding sitei175Pyridoxal phosphateBy similarity1
Binding sitei198Pyridoxal phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Serine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-CEL-977347. Serine biosynthesis.
UniPathwayiUPA00135; UER00197.
UPA00244; UER00311.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphoserine aminotransferase (EC:2.6.1.52)
Short name:
PSAT
Alternative name(s):
Phosphohydroxythreonine aminotransferase
Gene namesi
ORF Names:F26H9.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF26H9.5; CE09710; WBGene00009177.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001501381 – 370Probable phosphoserine aminotransferaseAdd BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei199N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

EPDiP91856.
PaxDbiP91856.
PeptideAtlasiP91856.
PRIDEiP91856.

Expressioni

Gene expression databases

BgeeiWBGene00009177.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi6239.F26H9.5.

Structurei

3D structure databases

ProteinModelPortaliP91856.
SMRiP91856.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni79 – 80Pyridoxal phosphate bindingBy similarity2
Regioni240 – 241Pyridoxal phosphate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2790. Eukaryota.
COG1932. LUCA.
GeneTreeiENSGT00390000015177.
HOGENOMiHOG000088965.
InParanoidiP91856.
KOiK00831.
OMAiGAQKNMG.
OrthoDBiEOG091G0964.
PhylomeDBiP91856.

Family and domain databases

CDDicd00611. PSAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00160. SerC_aminotrans_5. 1 hit.
InterProiView protein in InterPro
IPR000192. Aminotrans_V_dom.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR022278. Pser_aminoTfrase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00266. Aminotran_5. 1 hit.
PIRSFiPIRSF000525. SerC. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01364. serC_1. 1 hit.
PROSITEiView protein in PROSITE
PS00595. AA_TRANSFER_CLASS_5. 1 hit.

Sequencei

Sequence statusi: Complete.

P91856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPGRKINF AAGPAKLPEE VLLKMQEEQL NFNNLGVSVI EMSHRSKEFG
60 70 80 90 100
ALLNETISLI RELMNVPDNF EILFMQGGGT GQFAAIPLNL KGDHEHADYI
110 120 130 140 150
VTGAWSSKAA DEAGKYINVK KVFQPSKPYV TVPDQENWVH DEKAAYLYYC
160 170 180 190 200
ANETVHGIEF TPTAPESHNV PLVADVSSNF MARPFDFKDH GVVFGGAQKN
210 220 230 240 250
LGAAGLTIVI VRKDLIGKQQ AITPSVFSYK EMIANNSLYN TPPTGGIYTT
260 270 280 290 300
NLVLKWIKSK GGLQAIYELN LQKSGMIYDI IDNSNGFYHC AVDKRYRSIM
310 320 330 340 350
NVCFRIGGPS GNDELEEKFL KGSIERNMIS LKGHRSVGGI RASLYNAISV
360 370
EETQVLATWM NEFQKLHNTN
Length:370
Mass (Da):41,002
Last modified:May 1, 1997 - v1
Checksum:i676735A56AEEAFC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81516 Genomic DNA. Translation: CAB04204.1.
PIRiT21441.
RefSeqiNP_492483.1. NM_060082.4.
UniGeneiCel.18863.

Genome annotation databases

EnsemblMetazoaiF26H9.5; F26H9.5; WBGene00009177.
GeneIDi172756.
KEGGicel:CELE_F26H9.5.
UCSCiF26H9.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81516 Genomic DNA. Translation: CAB04204.1.
PIRiT21441.
RefSeqiNP_492483.1. NM_060082.4.
UniGeneiCel.18863.

3D structure databases

ProteinModelPortaliP91856.
SMRiP91856.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F26H9.5.

Proteomic databases

EPDiP91856.
PaxDbiP91856.
PeptideAtlasiP91856.
PRIDEiP91856.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF26H9.5; F26H9.5; WBGene00009177.
GeneIDi172756.
KEGGicel:CELE_F26H9.5.
UCSCiF26H9.5. c. elegans.

Organism-specific databases

CTDi172756.
WormBaseiF26H9.5; CE09710; WBGene00009177.

Phylogenomic databases

eggNOGiKOG2790. Eukaryota.
COG1932. LUCA.
GeneTreeiENSGT00390000015177.
HOGENOMiHOG000088965.
InParanoidiP91856.
KOiK00831.
OMAiGAQKNMG.
OrthoDBiEOG091G0964.
PhylomeDBiP91856.

Enzyme and pathway databases

UniPathwayiUPA00135; UER00197.
UPA00244; UER00311.
ReactomeiR-CEL-977347. Serine biosynthesis.

Miscellaneous databases

PROiPR:P91856.

Gene expression databases

BgeeiWBGene00009177.

Family and domain databases

CDDicd00611. PSAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00160. SerC_aminotrans_5. 1 hit.
InterProiView protein in InterPro
IPR000192. Aminotrans_V_dom.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR022278. Pser_aminoTfrase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00266. Aminotran_5. 1 hit.
PIRSFiPIRSF000525. SerC. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01364. serC_1. 1 hit.
PROSITEiView protein in PROSITE
PS00595. AA_TRANSFER_CLASS_5. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSERC_CAEEL
AccessioniPrimary (citable) accession number: P91856
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: April 12, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.