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P91850

- MIFH_BRUMA

UniProt

P91850 - MIFH_BRUMA

Protein

Macrophage migration inhibitory factor homolog

Gene

Bm1_28435

Organism
Brugia malayi (Filarial nematode worm)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
  1. Functioni

    Tautomerization of the methyl ester of L-dopachrome By similarity. Inhibits migration of human peripheral blood mononuclear cells.By similarity1 Publication

    Catalytic activityi

    L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
    Keto-phenylpyruvate = enol-phenylpyruvate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Proton acceptor; via imino nitrogenBy similarity
    Binding sitei33 – 331SubstrateBy similarity
    Binding sitei65 – 651Substrate; via amide nitrogenBy similarity

    GO - Molecular functioni

    1. dopachrome isomerase activity Source: UniProtKB-EC
    2. phenylpyruvate tautomerase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Cytokine, Isomerase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Macrophage migration inhibitory factor homolog (EC:5.3.2.1)
    Short name:
    Bm-MIF-1
    Short name:
    BmMIF
    Short name:
    MIF
    Alternative name(s):
    L-dopachrome isomerase
    L-dopachrome tautomerase (EC:5.3.3.12)
    Phenylpyruvate tautomerase
    Gene namesi
    ORF Names:Bm1_28435, BMBAC01P19.1
    OrganismiBrugia malayi (Filarial nematode worm)
    Taxonomic identifieri6279 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaFilarioideaOnchocercidaeBrugia
    ProteomesiUP000006672: Unassembled WGS sequence

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 115114Macrophage migration inhibitory factor homologPRO_0000158073Add
    BLAST

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1UZ7model-A/B/C2-115[»]
    ProteinModelPortaliP91850.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MIF family.Curated

    Phylogenomic databases

    InParanoidiA8PJU3.
    KOiK07253.

    Family and domain databases

    InterProiIPR001398. Macrophage_inhib_fac.
    IPR019829. Macrophage_inhib_fac_CS.
    IPR014347. Tautomerase/MIF_sf.
    [Graphical view]
    PANTHERiPTHR11954. PTHR11954. 1 hit.
    PfamiPF01187. MIF. 1 hit.
    [Graphical view]
    ProDomiPD004816. Macrophage_inhib_fac. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF55331. SSF55331. 1 hit.
    PROSITEiPS01158. MIF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P91850-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPYFTIDTNI PQNSISSAFL KKASNVVAKA LGKPESYVSI HVNGGQAMVF    50
    GGSEDPCAVC VLKSIGCVGP KVNNSHAEKL YKLLADELKI PKNRCYIEFV 100
    DIEASSMAFN GSTFG 115
    Length:115
    Mass (Da):12,320
    Last modified:September 22, 2009 - v4
    Checksum:iF4D2FE1B56630E73
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti114 – 1141F → L in AAB60943. (PubMed:9826378)Curated
    Sequence conflicti114 – 1141F → L in AAC82502. (PubMed:9826378)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF002699 Genomic DNA. Translation: AAB60943.1.
    U88035 mRNA. Translation: AAC82502.1.
    AL606837 Genomic DNA. Translation: CAC70155.1.
    DS239369 Genomic DNA. Translation: EDP34019.1.
    RefSeqiXP_001897136.1. XM_001897101.1.

    Genome annotation databases

    EnsemblMetazoaiBm6870a; Bm6870a; Bm6870.
    GeneIDi6100584.
    KEGGibmy:Bm1_28435.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF002699 Genomic DNA. Translation: AAB60943.1 .
    U88035 mRNA. Translation: AAC82502.1 .
    AL606837 Genomic DNA. Translation: CAC70155.1 .
    DS239369 Genomic DNA. Translation: EDP34019.1 .
    RefSeqi XP_001897136.1. XM_001897101.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1UZ7 model - A/B/C 2-115 [» ]
    ProteinModelPortali P91850.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai Bm6870a ; Bm6870a ; Bm6870 .
    GeneIDi 6100584.
    KEGGi bmy:Bm1_28435.

    Organism-specific databases

    CTDi 6100584.

    Phylogenomic databases

    InParanoidi A8PJU3.
    KOi K07253.

    Family and domain databases

    InterProi IPR001398. Macrophage_inhib_fac.
    IPR019829. Macrophage_inhib_fac_CS.
    IPR014347. Tautomerase/MIF_sf.
    [Graphical view ]
    PANTHERi PTHR11954. PTHR11954. 1 hit.
    Pfami PF01187. MIF. 1 hit.
    [Graphical view ]
    ProDomi PD004816. Macrophage_inhib_fac. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF55331. SSF55331. 1 hit.
    PROSITEi PS01158. MIF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Filarial nematode parasites secrete a homologue of the human cytokine macrophage migration inhibitory factor."
      Pastrana D.V., Raghavan N., Fitzgerald P., Eisinger S.W., Metz C., Bucala R., Schleimer R.P., Bickel C., Scott A.L.
      Infect. Immun. 66:5955-5963(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, SUBCELLULAR LOCATION.
      Strain: TRW.
    2. "Conservation of long-range and micro-synteny between the genomes of two distantly related nematodes."
      Gulliano D.B., Hall N., Jones S.J.M., Clark L.N., Corton C.H., Barrell B.G., Blaxter M.L.
      Genome Biol. 3:RESEARCH0057.1-RESEARCH0057.14(2002)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Draft genome of the filarial nematode parasite Brugia malayi."
      Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E., Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T., Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.
      , Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M., Pop M., White O., Barton G.J., Carlow C.K.S., Crawford M.J., Daub J., Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F., Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.-W., Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M., McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J., Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E., Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G., Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B., Blaxter M.L., Scott A.L.
      Science 317:1756-1760(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiMIFH_BRUMA
    AccessioniPrimary (citable) accession number: P91850
    Secondary accession number(s): A8PJU3, O02555, Q8IHI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 65 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3