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Protein

Macrophage migration inhibitory factor homolog

Gene

Bm1_28435

Organism
Brugia malayi (Filarial nematode worm)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Tautomerization of the methyl ester of L-dopachrome (By similarity). Inhibits migration of human peripheral blood mononuclear cells.By similarity1 Publication

Catalytic activityi

L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
Keto-phenylpyruvate = enol-phenylpyruvate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Proton acceptor; via imino nitrogenBy similarity
Binding sitei33 – 331SubstrateBy similarity
Binding sitei65 – 651Substrate; via amide nitrogenBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage migration inhibitory factor homolog (EC:5.3.2.1)
Short name:
Bm-MIF-1
Short name:
BmMIF
Short name:
MIF
Alternative name(s):
L-dopachrome isomerase
L-dopachrome tautomerase (EC:5.3.3.12)
Phenylpyruvate tautomerase
Gene namesi
ORF Names:Bm1_28435, BMBAC01P19.1
OrganismiBrugia malayi (Filarial nematode worm)
Taxonomic identifieri6279 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaFilarioideaOnchocercidaeBrugia
Proteomesi
  • UP000006672 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 115114Macrophage migration inhibitory factor homologPRO_0000158073Add
BLAST

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UZ7model-A/B/C2-115[»]
ProteinModelPortaliP91850.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MIF family.Curated

Phylogenomic databases

InParanoidiP91850.
KOiK07253.
OMAiMGKPAQY.
OrthoDBiEOG091G0ZNJ.

Family and domain databases

InterProiIPR001398. Macrophage_inhib_fac.
IPR019829. Macrophage_inhib_fac_CS.
IPR014347. Tautomerase/MIF_sf.
[Graphical view]
PANTHERiPTHR11954. PTHR11954. 1 hit.
PfamiPF01187. MIF. 1 hit.
[Graphical view]
ProDomiPD004816. Macrophage_inhib_fac. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55331. SSF55331. 1 hit.
PROSITEiPS01158. MIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P91850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYFTIDTNI PQNSISSAFL KKASNVVAKA LGKPESYVSI HVNGGQAMVF
60 70 80 90 100
GGSEDPCAVC VLKSIGCVGP KVNNSHAEKL YKLLADELKI PKNRCYIEFV
110
DIEASSMAFN GSTFG
Length:115
Mass (Da):12,320
Last modified:September 22, 2009 - v4
Checksum:iF4D2FE1B56630E73
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141F → L in AAB60943 (PubMed:9826378).Curated
Sequence conflicti114 – 1141F → L in AAC82502 (PubMed:9826378).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002699 Genomic DNA. Translation: AAB60943.1.
U88035 mRNA. Translation: AAC82502.1.
AL606837 Genomic DNA. Translation: CAC70155.1.
DS239369 Genomic DNA. Translation: EDP34019.1.
RefSeqiXP_001897136.1. XM_001897101.1.

Genome annotation databases

EnsemblMetazoaiBm6870a; Bm6870a; WBGene00227131.
GeneIDi6100584.
KEGGibmy:Bm1_28435.
WBParaSiteiBm6870a; Bm6870a; WBGene00227131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002699 Genomic DNA. Translation: AAB60943.1.
U88035 mRNA. Translation: AAC82502.1.
AL606837 Genomic DNA. Translation: CAC70155.1.
DS239369 Genomic DNA. Translation: EDP34019.1.
RefSeqiXP_001897136.1. XM_001897101.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UZ7model-A/B/C2-115[»]
ProteinModelPortaliP91850.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiBm6870a; Bm6870a; WBGene00227131.
GeneIDi6100584.
KEGGibmy:Bm1_28435.
WBParaSiteiBm6870a; Bm6870a; WBGene00227131.

Organism-specific databases

CTDi6100584.

Phylogenomic databases

InParanoidiP91850.
KOiK07253.
OMAiMGKPAQY.
OrthoDBiEOG091G0ZNJ.

Family and domain databases

InterProiIPR001398. Macrophage_inhib_fac.
IPR019829. Macrophage_inhib_fac_CS.
IPR014347. Tautomerase/MIF_sf.
[Graphical view]
PANTHERiPTHR11954. PTHR11954. 1 hit.
PfamiPF01187. MIF. 1 hit.
[Graphical view]
ProDomiPD004816. Macrophage_inhib_fac. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55331. SSF55331. 1 hit.
PROSITEiPS01158. MIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIFH_BRUMA
AccessioniPrimary (citable) accession number: P91850
Secondary accession number(s): A8PJU3, O02555, Q8IHI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 22, 2009
Last modified: September 7, 2016
This is version 75 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.