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Protein

Macrophage migration inhibitory factor homolog

Gene

Bm1_28435

Organism
Brugia malayi (Filarial nematode worm)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Tautomerization of the methyl ester of L-dopachrome (By similarity). Inhibits migration of human peripheral blood mononuclear cells.By similarity1 Publication

Catalytic activityi

L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
Keto-phenylpyruvate = enol-phenylpyruvate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Proton acceptor; via imino nitrogenBy similarity1
Binding sitei33SubstrateBy similarity1
Binding sitei65Substrate; via amide nitrogenBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionCytokine, Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage migration inhibitory factor homolog (EC:5.3.2.1)
Short name:
Bm-MIF-1
Short name:
BmMIF
Short name:
MIF
Alternative name(s):
L-dopachrome isomerase
L-dopachrome tautomerase (EC:5.3.3.12)
Phenylpyruvate tautomerase
Gene namesi
ORF Names:Bm1_28435, BMBAC01P19.1
OrganismiBrugia malayi (Filarial nematode worm)
Taxonomic identifieri6279 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaSpiruridaSpiruromorphaFilarioideaOnchocercidaeBrugia
Proteomesi
  • UP000006672 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001580732 – 115Macrophage migration inhibitory factor homologAdd BLAST114

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UZ7model-A/B/C2-115[»]
ProteinModelPortaliP91850
SMRiP91850
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MIF family.Curated

Phylogenomic databases

InParanoidiP91850
KOiK07253
OMAiPDRIYIN
OrthoDBiEOG091G0ZNJ

Family and domain databases

Gene3Di3.30.429.101 hit
InterProiView protein in InterPro
IPR001398 Macrophage_inhib_fac
IPR019829 Macrophage_inhib_fac_CS
IPR014347 Tautomerase/MIF_sf
PANTHERiPTHR11954 PTHR11954, 1 hit
PfamiView protein in Pfam
PF01187 MIF, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004816 Macrophage_inhib_fac, 1 hit
SUPFAMiSSF55331 SSF55331, 1 hit
PROSITEiView protein in PROSITE
PS01158 MIF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P91850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYFTIDTNI PQNSISSAFL KKASNVVAKA LGKPESYVSI HVNGGQAMVF
60 70 80 90 100
GGSEDPCAVC VLKSIGCVGP KVNNSHAEKL YKLLADELKI PKNRCYIEFV
110
DIEASSMAFN GSTFG
Length:115
Mass (Da):12,320
Last modified:September 22, 2009 - v4
Checksum:iF4D2FE1B56630E73
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114F → L in AAB60943 (PubMed:9826378).Curated1
Sequence conflicti114F → L in AAC82502 (PubMed:9826378).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002699 Genomic DNA Translation: AAB60943.1
U88035 mRNA Translation: AAC82502.1
AL606837 Genomic DNA Translation: CAC70155.1
DS239369 Genomic DNA Translation: EDP34019.1
RefSeqiXP_001897136.1, XM_001897101.1

Genome annotation databases

EnsemblMetazoaiBm6870; Bm6870; WBGene00227131
GeneIDi6100584
KEGGibmy:Bm1_28435
WBParaSiteiBm6870; Bm6870; WBGene00227131

Similar proteinsi

Entry informationi

Entry nameiMIFH_BRUMA
AccessioniPrimary (citable) accession number: P91850
Secondary accession number(s): A8PJU3, O02555, Q8IHI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 22, 2009
Last modified: February 28, 2018
This is version 82 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome