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Protein

Nuclear hormone receptor family member nhr-69

Gene

nhr-69

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Orphan nuclear receptor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi3 – 78Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri6 – 26NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri42 – 66NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription from RNA polymerase II promoter Source: WormBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear hormone receptor family member nhr-69
Gene namesi
Name:nhr-69
ORF Names:T23H4.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiT23H4.2; CE32501; WBGene00003659; nhr-69.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537951 – 373Nuclear hormone receptor family member nhr-69Add BLAST373

Proteomic databases

EPDiP91829.
PaxDbiP91829.
PeptideAtlasiP91829.

Expressioni

Gene expression databases

BgeeiWBGene00003659.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
tag-260P920043EBI-322112,EBI-316398

GO - Molecular functioni

  • SMAD binding Source: WormBase

Protein-protein interaction databases

BioGridi38263. 6 interactors.
DIPiDIP-24463N.
IntActiP91829. 5 interactors.
MINTiMINT-117310.
STRINGi6239.T23H4.2.

Structurei

3D structure databases

ProteinModelPortaliP91829.
SMRiP91829.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.Curated
Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri6 – 26NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri42 – 66NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4215. Eukaryota.
ENOG410XQT8. LUCA.
GeneTreeiENSGT00760000118948.
HOGENOMiHOG000260822.
InParanoidiP91829.
KOiK07295.
OMAiMIEQLQF.
OrthoDBiEOG091G0A89.
PhylomeDBiP91829.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91829-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEEICHICN DKSTGKHYGA ISCDGCKGFF RRSIRKRYHY QCRFEQNCDV
60 70 80 90 100
TKNKRNACRA CRLQKCVKAG MKSNAIQNER DAIGKRKKTT GAEKEDLIDQ
110 120 130 140 150
LVAAETLCQQ LRSSVIKNTS SLAPYDCGKV KWNYEDARAA TLDDIGKSIH
160 170 180 190 200
QQLVLFIEWA KSLPQFSFLA QADQAALLKG GAASIIVLGV AYRSICLTVE
210 220 230 240 250
NTICLANDTL LPKEHATQVG DINCVVGRII DEIVNPMRRL NMDLIEYVAL
260 270 280 290 300
KAILFFNPVV REINDQSPVE NARYAFLRSL QRRCTDKALE NMEDESMDCR
310 320 330 340 350
SGKLLLLLPS LQAIAQQLVE DVQLARLFGL VNVDSLMEEL ILNDMKPSDP
360 370
QILQTSLASP VNSSVKAEVE LEE
Length:373
Mass (Da):41,778
Last modified:March 1, 2003 - v2
Checksum:i469B4471C8FB30F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY204178 mRNA. Translation: AAO39182.1.
Z83240 Genomic DNA. Translation: CAB05815.2.
PIRiT25211.
RefSeqiNP_492615.2. NM_060214.4.
UniGeneiCel.18404.

Genome annotation databases

EnsemblMetazoaiT23H4.2; T23H4.2; WBGene00003659.
GeneIDi172840.
KEGGicel:CELE_T23H4.2.
UCSCiT23H4.2.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY204178 mRNA. Translation: AAO39182.1.
Z83240 Genomic DNA. Translation: CAB05815.2.
PIRiT25211.
RefSeqiNP_492615.2. NM_060214.4.
UniGeneiCel.18404.

3D structure databases

ProteinModelPortaliP91829.
SMRiP91829.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi38263. 6 interactors.
DIPiDIP-24463N.
IntActiP91829. 5 interactors.
MINTiMINT-117310.
STRINGi6239.T23H4.2.

Proteomic databases

EPDiP91829.
PaxDbiP91829.
PeptideAtlasiP91829.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT23H4.2; T23H4.2; WBGene00003659.
GeneIDi172840.
KEGGicel:CELE_T23H4.2.
UCSCiT23H4.2.1. c. elegans.

Organism-specific databases

CTDi172840.
WormBaseiT23H4.2; CE32501; WBGene00003659; nhr-69.

Phylogenomic databases

eggNOGiKOG4215. Eukaryota.
ENOG410XQT8. LUCA.
GeneTreeiENSGT00760000118948.
HOGENOMiHOG000260822.
InParanoidiP91829.
KOiK07295.
OMAiMIEQLQF.
OrthoDBiEOG091G0A89.
PhylomeDBiP91829.

Miscellaneous databases

PROiP91829.

Gene expression databases

BgeeiWBGene00003659.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNHR69_CAEEL
AccessioniPrimary (citable) accession number: P91829
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.