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Protein

Zinc metalloproteinase nas-5

Gene

nas-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable metalloprotease.By similarity

Catalytic activityi

Hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi165 – 1651Zinc; catalyticPROSITE-ProRule annotation
Active sitei166 – 1661PROSITE-ProRule annotation
Metal bindingi169 – 1691Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi175 – 1751Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • pharyngeal pumping Source: WormBase
  • pharynx development Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM12.A45.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase nas-5 (EC:3.4.24.21)
Alternative name(s):
Nematode astacin 5
Gene namesi
Name:nas-5
ORF Names:T23H4.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiT23H4.3; CE25126; WBGene00003524; nas-5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 360339Zinc metalloproteinase nas-5PRO_0000028910Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP91828.

Expressioni

Gene expression databases

BgeeiWBGene00003524.

Interactioni

Protein-protein interaction databases

STRINGi6239.T23H4.3.

Structurei

3D structure databases

ProteinModelPortaliP91828.
SMRiP91828. Positions 47-272.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini299 – 33638PLACPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M12A family.Curated
Contains 1 PLAC domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119227.
HOGENOMiHOG000017413.
InParanoidiP91828.
KOiK08076.
OMAiVIGLWHE.
OrthoDBiEOG091G0C21.
PhylomeDBiP91828.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
IPR010909. PLAC.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
[Graphical view]
PRINTSiPR00480. ASTACIN.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]
PROSITEiPS50900. PLAC. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P91828-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIKQLLLSI ILTVSVVNGR GRRINIYGAE NGKSDIVQLR GPAEQLVYSS
60 70 80 90 100
PIRERRPIFR NALLSNSPLR WSKMQDLDGN YLIPYVISGN YDTVERDTIK
110 120 130 140 150
TAMEKIANNT CIRLIPRTNQ PDYAEINNKK GQGCYASIGR FPGKNVVMLE
160 170 180 190 200
SNDDQSCIQE DTVIHELFHV IGLWHEHMRA DRDAFINVLY KNIEPAQYPQ
210 220 230 240 250
FEKLSSRDAT TYSVPYDYNS VMHYDENAFA KPGKISMMTK DSKFQKVIGH
260 270 280 290 300
PKDASSNDYK KVCAIYHCSK CMHQDFQQIV EQEHIELNNP IITNAPVQQG
310 320 330 340 350
DSCTDRLGIC PMLKSREMLN CKVMATFCCS SCSAPTSTTT TTSGTPSDGS
360
LWQRIKSIFQ
Length:360
Mass (Da):40,772
Last modified:May 1, 2000 - v2
Checksum:i31F91C70EC4832C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83240 Genomic DNA. Translation: CAB05814.2.
PIRiT25210.
RefSeqiNP_492616.1. NM_060215.1.
UniGeneiCel.16696.

Genome annotation databases

EnsemblMetazoaiT23H4.3; T23H4.3; WBGene00003524.
GeneIDi188819.
KEGGicel:CELE_T23H4.3.
UCSCiT23H4.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83240 Genomic DNA. Translation: CAB05814.2.
PIRiT25210.
RefSeqiNP_492616.1. NM_060215.1.
UniGeneiCel.16696.

3D structure databases

ProteinModelPortaliP91828.
SMRiP91828. Positions 47-272.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T23H4.3.

Protein family/group databases

MEROPSiM12.A45.

Proteomic databases

PaxDbiP91828.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT23H4.3; T23H4.3; WBGene00003524.
GeneIDi188819.
KEGGicel:CELE_T23H4.3.
UCSCiT23H4.3. c. elegans.

Organism-specific databases

CTDi188819.
WormBaseiT23H4.3; CE25126; WBGene00003524; nas-5.

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119227.
HOGENOMiHOG000017413.
InParanoidiP91828.
KOiK08076.
OMAiVIGLWHE.
OrthoDBiEOG091G0C21.
PhylomeDBiP91828.

Miscellaneous databases

PROiP91828.

Gene expression databases

BgeeiWBGene00003524.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
IPR010909. PLAC.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
[Graphical view]
PRINTSiPR00480. ASTACIN.
SMARTiSM00235. ZnMc. 1 hit.
[Graphical view]
PROSITEiPS50900. PLAC. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAS5_CAEEL
AccessioniPrimary (citable) accession number: P91828
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.