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P91745

- PE48A_LUCCU

UniProt

P91745 - PE48A_LUCCU

Protein

Peritrophin-48

Gene
N/A
Organism
Lucilia cuprina (Green bottle fly) (Australian sheep blowfly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    May bind chitin or related oligosaccharide structures.1 Publication

    GO - Molecular functioni

    1. chitin binding Source: UniProtKB

    GO - Biological processi

    1. chitin metabolic process Source: InterPro

    Keywords - Ligandi

    Chitin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peritrophin-48
    OrganismiLucilia cuprina (Green bottle fly) (Australian sheep blowfly)Imported
    Taxonomic identifieri7375 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaOestroideaCalliphoridaeLuciliinaeLucilia

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 20202 PublicationsAdd
    BLAST
    Chaini21 – 375355Peritrophin-48PRO_0000023615Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi60 ↔ 73PROSITE-ProRule annotation
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi120 ↔ 133PROSITE-ProRule annotation
    Disulfide bondi187 ↔ 200PROSITE-ProRule annotation
    Disulfide bondi265 ↔ 278PROSITE-ProRule annotation
    Disulfide bondi330 ↔ 343PROSITE-ProRule annotation
    Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Cardia and midgut peritrophic membrane.1 Publication

    Developmental stagei

    Expressed in all 3 larval instars and adults, but not pupae or eggs.

    Structurei

    3D structure databases

    ProteinModelPortaliP91745.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 8359Chitin-binding type-2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini86 – 14358Chitin-binding type-2 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini153 – 21058Chitin-binding type-2 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini224 – 29269Chitin-binding type-2 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini294 – 36067Chitin-binding type-2 5PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 5 chitin-binding type-2 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    Gene3Di2.170.140.10. 4 hits.
    InterProiIPR002557. Chitin-bd_dom.
    [Graphical view]
    PfamiPF01607. CBM_14. 5 hits.
    [Graphical view]
    SMARTiSM00494. ChtBD2. 5 hits.
    [Graphical view]
    SUPFAMiSSF57625. SSF57625. 4 hits.
    PROSITEiPS50940. CHIT_BIND_II. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P91745-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIIKTLLASV AIMLIATVNA EYNVAKYCEL VKIGTLMPSM ISCQDYYICR    50
    LNNQPIPVKC GANTVFDKDT QGCVPEAQAN CILSLDNPCE NKDRTFAPSS 100
    KACNEWHYCL NGNIVANGSC QPGQIFDASK NSCIYGACNS DDDDSNSDFT 150
    PVLNICDIMQ NGQFFGDFEN CQNWQKCNNG RLQKGICLGN LVYDTKNGMC 200
    LQNDGTMCER TNGMVSEDGG APDETLCTSS NDGPLPDKLT CSVYYICEQD 250
    TTSTPTTYKW IKTSCPNGQY FDVFGDGCLD RAKRRVYTGC NRCEYTTGST 300
    TYWVNAVSND CTKFSTCRNG RKITNEDGSC NSGYYFNEAD QYCNMGDFTN 350
    YAETNGACQN YSCNGYDCTT KPSAT 375
    Length:375
    Mass (Da):41,318
    Last modified:May 1, 1997 - v1
    Checksum:i459082BF0AF6C7AF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U79715 mRNA. Translation: AAB38414.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U79715 mRNA. Translation: AAB38414.1 .

    3D structure databases

    ProteinModelPortali P91745.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.170.140.10. 4 hits.
    InterProi IPR002557. Chitin-bd_dom.
    [Graphical view ]
    Pfami PF01607. CBM_14. 5 hits.
    [Graphical view ]
    SMARTi SM00494. ChtBD2. 5 hits.
    [Graphical view ]
    SUPFAMi SSF57625. SSF57625. 4 hits.
    PROSITEi PS50940. CHIT_BIND_II. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA and deduced amino acid sequences of a peritrophic membrane glycoprotein, 'peritrophin-48', from the larvae of Lucilia cuprina."
      Schorderet S., Pearson R.D., Vuocolo T., Eisemann C.H., Riding G.A., Tellam R.L.
      Insect Biochem. Mol. Biol. 28:99-111(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 21-47; 60-68; 93-101; 185-196 AND 239-256, TISSUE SPECIFICITY.
      Tissue: Larval peritrophic membrane.
    2. "Characterization of a major peritrophic membrane protein, peritrophin-44, from the larvae of Lucilia cuprina. cDNA and deduced amino acid sequences."
      Elvin C.M., Vuocolo T., Pearson R.D., East I.J., Riding G.A., Eisemann C.H., Tellam R.L.
      J. Biol. Chem. 271:8925-8935(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-49.
      Tissue: Larval peritrophic membrane.

    Entry informationi

    Entry nameiPE48A_LUCCU
    AccessioniPrimary (citable) accession number: P91745
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3