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P91745 (PE48A_LUCCU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May bind chitin or related oligosaccharide structures. Ref.1

Tissue specificity

Cardia and midgut peritrophic membrane. Ref.1

Developmental stage

Expressed in all 3 larval instars and adults, but not pupae or eggs.

Post-translational modification

Glycosylated. Ref.1

Sequence similarities

Contains 5 chitin-binding type-2 domains.

Ontologies

Keywords
   DomainRepeat
Signal
   LigandChitin-binding
   PTMDisulfide bond
Glycoprotein
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processchitin metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: InterPro

   Molecular_functionchitin binding

Inferred from direct assay Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Ref.1 Ref.2
Chain21 – 375355Peritrophin-48 Ref.1
PRO_0000023615

Regions

Domain25 – 8359Chitin-binding type-2 1
Domain86 – 14358Chitin-binding type-2 2
Domain153 – 21058Chitin-binding type-2 3
Domain224 – 29269Chitin-binding type-2 4
Domain294 – 36067Chitin-binding type-2 5

Amino acid modifications

Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation3601N-linked (GlcNAc...) Potential
Disulfide bond60 ↔ 73 By similarity
Disulfide bond120 ↔ 133 By similarity
Disulfide bond187 ↔ 200 By similarity
Disulfide bond265 ↔ 278 By similarity
Disulfide bond330 ↔ 343 By similarity

Sequences

Sequence LengthMass (Da)Tools
P91745 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 459082BF0AF6C7AF

FASTA37541,318
        10         20         30         40         50         60 
MIIKTLLASV AIMLIATVNA EYNVAKYCEL VKIGTLMPSM ISCQDYYICR LNNQPIPVKC 

        70         80         90        100        110        120 
GANTVFDKDT QGCVPEAQAN CILSLDNPCE NKDRTFAPSS KACNEWHYCL NGNIVANGSC 

       130        140        150        160        170        180 
QPGQIFDASK NSCIYGACNS DDDDSNSDFT PVLNICDIMQ NGQFFGDFEN CQNWQKCNNG 

       190        200        210        220        230        240 
RLQKGICLGN LVYDTKNGMC LQNDGTMCER TNGMVSEDGG APDETLCTSS NDGPLPDKLT 

       250        260        270        280        290        300 
CSVYYICEQD TTSTPTTYKW IKTSCPNGQY FDVFGDGCLD RAKRRVYTGC NRCEYTTGST 

       310        320        330        340        350        360 
TYWVNAVSND CTKFSTCRNG RKITNEDGSC NSGYYFNEAD QYCNMGDFTN YAETNGACQN 

       370 
YSCNGYDCTT KPSAT 

« Hide

References

[1]"cDNA and deduced amino acid sequences of a peritrophic membrane glycoprotein, 'peritrophin-48', from the larvae of Lucilia cuprina."
Schorderet S., Pearson R.D., Vuocolo T., Eisemann C.H., Riding G.A., Tellam R.L.
Insect Biochem. Mol. Biol. 28:99-111(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 21-47; 60-68; 93-101; 185-196 AND 239-256, TISSUE SPECIFICITY.
Tissue: Larval peritrophic membrane.
[2]"Characterization of a major peritrophic membrane protein, peritrophin-44, from the larvae of Lucilia cuprina. cDNA and deduced amino acid sequences."
Elvin C.M., Vuocolo T., Pearson R.D., East I.J., Riding G.A., Eisemann C.H., Tellam R.L.
J. Biol. Chem. 271:8925-8935(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 21-49.
Tissue: Larval peritrophic membrane.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U79715 mRNA. Translation: AAB38414.1.

3D structure databases

ProteinModelPortalP91745.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.170.140.10. 4 hits.
InterProIPR002557. Chitin-bd_dom.
[Graphical view]
PfamPF01607. CBM_14. 5 hits.
[Graphical view]
SMARTSM00494. ChtBD2. 5 hits.
[Graphical view]
SUPFAMSSF57625. SSF57625. 4 hits.
PROSITEPS50940. CHIT_BIND_II. 5 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePE48A_LUCCU
AccessionPrimary (citable) accession number: P91745
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: May 1, 1997
Last modified: October 16, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families