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Protein

Peritrophin-48

Gene
N/A
Organism
Lucilia cuprina (Green bottle fly) (Australian sheep blowfly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May bind chitin or related oligosaccharide structures.1 Publication

GO - Molecular functioni

  1. chitin binding Source: UniProtKB

GO - Biological processi

  1. chitin metabolic process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Chitin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peritrophin-48
OrganismiLucilia cuprina (Green bottle fly) (Australian sheep blowfly)Imported
Taxonomic identifieri7375 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaOestroideaCalliphoridaeLuciliinaeLucilia

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20202 PublicationsAdd
BLAST
Chaini21 – 375355Peritrophin-48PRO_0000023615Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi60 ↔ 73PROSITE-ProRule annotation
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi120 ↔ 133PROSITE-ProRule annotation
Disulfide bondi187 ↔ 200PROSITE-ProRule annotation
Disulfide bondi265 ↔ 278PROSITE-ProRule annotation
Disulfide bondi330 ↔ 343PROSITE-ProRule annotation
Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Cardia and midgut peritrophic membrane.1 Publication

Developmental stagei

Expressed in all 3 larval instars and adults, but not pupae or eggs.

Structurei

3D structure databases

ProteinModelPortaliP91745.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 8359Chitin-binding type-2 1PROSITE-ProRule annotationAdd
BLAST
Domaini86 – 14358Chitin-binding type-2 2PROSITE-ProRule annotationAdd
BLAST
Domaini153 – 21058Chitin-binding type-2 3PROSITE-ProRule annotationAdd
BLAST
Domaini224 – 29269Chitin-binding type-2 4PROSITE-ProRule annotationAdd
BLAST
Domaini294 – 36067Chitin-binding type-2 5PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 chitin-binding type-2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.170.140.10. 4 hits.
InterProiIPR002557. Chitin-bd_dom.
[Graphical view]
PfamiPF01607. CBM_14. 5 hits.
[Graphical view]
SMARTiSM00494. ChtBD2. 5 hits.
[Graphical view]
SUPFAMiSSF57625. SSF57625. 4 hits.
PROSITEiPS50940. CHIT_BIND_II. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P91745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIKTLLASV AIMLIATVNA EYNVAKYCEL VKIGTLMPSM ISCQDYYICR
60 70 80 90 100
LNNQPIPVKC GANTVFDKDT QGCVPEAQAN CILSLDNPCE NKDRTFAPSS
110 120 130 140 150
KACNEWHYCL NGNIVANGSC QPGQIFDASK NSCIYGACNS DDDDSNSDFT
160 170 180 190 200
PVLNICDIMQ NGQFFGDFEN CQNWQKCNNG RLQKGICLGN LVYDTKNGMC
210 220 230 240 250
LQNDGTMCER TNGMVSEDGG APDETLCTSS NDGPLPDKLT CSVYYICEQD
260 270 280 290 300
TTSTPTTYKW IKTSCPNGQY FDVFGDGCLD RAKRRVYTGC NRCEYTTGST
310 320 330 340 350
TYWVNAVSND CTKFSTCRNG RKITNEDGSC NSGYYFNEAD QYCNMGDFTN
360 370
YAETNGACQN YSCNGYDCTT KPSAT
Length:375
Mass (Da):41,318
Last modified:May 1, 1997 - v1
Checksum:i459082BF0AF6C7AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79715 mRNA. Translation: AAB38414.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79715 mRNA. Translation: AAB38414.1.

3D structure databases

ProteinModelPortaliP91745.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.170.140.10. 4 hits.
InterProiIPR002557. Chitin-bd_dom.
[Graphical view]
PfamiPF01607. CBM_14. 5 hits.
[Graphical view]
SMARTiSM00494. ChtBD2. 5 hits.
[Graphical view]
SUPFAMiSSF57625. SSF57625. 4 hits.
PROSITEiPS50940. CHIT_BIND_II. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA and deduced amino acid sequences of a peritrophic membrane glycoprotein, 'peritrophin-48', from the larvae of Lucilia cuprina."
    Schorderet S., Pearson R.D., Vuocolo T., Eisemann C.H., Riding G.A., Tellam R.L.
    Insect Biochem. Mol. Biol. 28:99-111(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 21-47; 60-68; 93-101; 185-196 AND 239-256, TISSUE SPECIFICITY.
    Tissue: Larval peritrophic membrane.
  2. "Characterization of a major peritrophic membrane protein, peritrophin-44, from the larvae of Lucilia cuprina. cDNA and deduced amino acid sequences."
    Elvin C.M., Vuocolo T., Pearson R.D., East I.J., Riding G.A., Eisemann C.H., Tellam R.L.
    J. Biol. Chem. 271:8925-8935(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-49.
    Tissue: Larval peritrophic membrane.

Entry informationi

Entry nameiPE48A_LUCCU
AccessioniPrimary (citable) accession number: P91745
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: May 1, 1997
Last modified: October 1, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.