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Protein

Glutamate-gated chloride channel subunit beta

Gene
N/A
Organism
Haemonchus contortus (Barber pole worm)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Glutamate-gated chloride channel subunit; channel properties may be modulated by the formation of heteromeric channels. Glutamate binding triggers a rapidly reversible current, while the anti-helmintic drug ivermectin triggers a permanently open channel configuration.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei69 – 691GlutamateBy similarity
Binding sitei88 – 881GlutamateBy similarity
Binding sitei155 – 1551GlutamateBy similarity
Binding sitei184 – 1841Glutamate; via carbonyl oxygenBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Protein family/group databases

TCDBi1.A.9.4.3. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-gated chloride channel subunit beta
Short name:
Glu-Cl subunit beta
Alternative name(s):
Avermectin-sensitive glutamate-gated chloride channel subunit
HG4
OrganismiHaemonchus contortus (Barber pole worm)
Taxonomic identifieri6289 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaStrongylidaTrichostrongyloideaHaemonchidaeHaemonchinaeHaemonchus

Subcellular locationi

  • Cell junctionsynapsepostsynaptic cell membrane By similarity; Multi-pass membrane protein By similarity
  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 249231ExtracellularBy similarityAdd
BLAST
Transmembranei250 – 27223Helical; Name=1By similarityAdd
BLAST
Topological domaini273 – 2775CytoplasmicBy similarity
Transmembranei278 – 29922Helical; Name=2By similarityAdd
BLAST
Topological domaini300 – 3067ExtracellularBy similarity
Transmembranei307 – 32721Helical; Name=3By similarityAdd
BLAST
Topological domaini328 – 40275CytoplasmicBy similarityAdd
BLAST
Transmembranei403 – 42624Helical; Name=4By similarityAdd
BLAST
Topological domaini427 – 4326ExtracellularBy similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2363050.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 432414Glutamate-gated chloride channel subunit betaPRO_0000255717Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence analysis
Disulfide bondi164 ↔ 178By similarity
Glycosylationi219 – 2191N-linked (GlcNAc...)Sequence analysis
Disulfide bondi226 ↔ 237By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed in motor neuron commissures at the anterior portion of the worms.1 Publication

Interactioni

Subunit structurei

Pentamer (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP91730.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR015680. Glu_Cl_Channel.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PTHR18945:SF504. PTHR18945:SF504. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P91730-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQYMMVAVA AVVAVAGSSQ ISRRSTGGTQ EQEILNELLS NYDMRVRPPP
60 70 80 90 100
SNYSDPMGPV TVRVNIMIRM LSKIDVVNME YSMQLTFREQ WLDSRLAYAH
110 120 130 140 150
LGYHNPPKFL TVPHIKSNLW IPDTFFPTEK AAHRHLIDTD NMFLRIHPDG
160 170 180 190 200
KVLYSSRISI TSSCHMQLQL YPLDLQFCDF DLVSYAHTMK DIVYEWDPLA
210 220 230 240 250
PVQLKPGVGS DLPNFQLTNI TTNDDCTSHT NTGSYACLRM QLTLKRQFSY
260 270 280 290 300
YLVQLYGPTT MIVIVSWVSF WIDMHSTAGR VALGVTTLLT MTTMQAAINA
310 320 330 340 350
KLPPVSYVKV VDVWLGACQT FVFGALLEYA FVSYQDSQRQ TEQAKSRAAR
360 370 380 390 400
KAQKRRAKME LVEREQYQPP CTCHLYQDYE PSFRDRLRRY FTKPDYLPAK
410 420 430
IDYYARFCVP LGFLAFNAIY WTSCLVMVSR LV
Length:432
Mass (Da):49,626
Last modified:May 1, 1997 - v1
Checksum:iAE6E7342FA8C883B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09796 mRNA. Translation: CAA70929.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09796 mRNA. Translation: CAA70929.1.

3D structure databases

ProteinModelPortaliP91730.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

ChEMBLiCHEMBL2363050.

Protein family/group databases

TCDBi1.A.9.4.3. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR015680. Glu_Cl_Channel.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PTHR18945:SF504. PTHR18945:SF504. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLUCB_HAECO
AccessioniPrimary (citable) accession number: P91730
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 1, 1997
Last modified: November 11, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.