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Protein

Glutamate-gated chloride channel subunit beta

Gene
N/A
Organism
Haemonchus contortus (Barber pole worm)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Glutamate-gated chloride channel subunit; channel properties may be modulated by the formation of heteromeric channels. Glutamate binding triggers a rapidly reversible current, while the anti-helmintic drug ivermectin triggers a permanently open channel configuration.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei69GlutamateBy similarity1
Binding sitei88GlutamateBy similarity1
Binding sitei155GlutamateBy similarity1
Binding sitei184Glutamate; via carbonyl oxygenBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Protein family/group databases

TCDBi1.A.9.4.3. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-gated chloride channel subunit beta
Short name:
Glu-Cl subunit beta
Alternative name(s):
Avermectin-sensitive glutamate-gated chloride channel subunit
HG4
OrganismiHaemonchus contortus (Barber pole worm)
Taxonomic identifieri6289 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaStrongylidaTrichostrongyloideaHaemonchidaeHaemonchinaeHaemonchus

Subcellular locationi

  • Cell junctionsynapsepostsynaptic cell membrane By similarity; Multi-pass membrane protein By similarity
  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 249ExtracellularBy similarityAdd BLAST231
Transmembranei250 – 272Helical; Name=1By similarityAdd BLAST23
Topological domaini273 – 277CytoplasmicBy similarity5
Transmembranei278 – 299Helical; Name=2By similarityAdd BLAST22
Topological domaini300 – 306ExtracellularBy similarity7
Transmembranei307 – 327Helical; Name=3By similarityAdd BLAST21
Topological domaini328 – 402CytoplasmicBy similarityAdd BLAST75
Transmembranei403 – 426Helical; Name=4By similarityAdd BLAST24
Topological domaini427 – 432ExtracellularBy similarity6

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2363050.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000025571719 – 432Glutamate-gated chloride channel subunit betaAdd BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi164 ↔ 178By similarity
Glycosylationi219N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi226 ↔ 237By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed in motor neuron commissures at the anterior portion of the worms.1 Publication

Interactioni

Subunit structurei

Pentamer (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP91730.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR015680. Glu_Cl_Channel.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PTHR18945:SF504. PTHR18945:SF504. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P91730-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQYMMVAVA AVVAVAGSSQ ISRRSTGGTQ EQEILNELLS NYDMRVRPPP
60 70 80 90 100
SNYSDPMGPV TVRVNIMIRM LSKIDVVNME YSMQLTFREQ WLDSRLAYAH
110 120 130 140 150
LGYHNPPKFL TVPHIKSNLW IPDTFFPTEK AAHRHLIDTD NMFLRIHPDG
160 170 180 190 200
KVLYSSRISI TSSCHMQLQL YPLDLQFCDF DLVSYAHTMK DIVYEWDPLA
210 220 230 240 250
PVQLKPGVGS DLPNFQLTNI TTNDDCTSHT NTGSYACLRM QLTLKRQFSY
260 270 280 290 300
YLVQLYGPTT MIVIVSWVSF WIDMHSTAGR VALGVTTLLT MTTMQAAINA
310 320 330 340 350
KLPPVSYVKV VDVWLGACQT FVFGALLEYA FVSYQDSQRQ TEQAKSRAAR
360 370 380 390 400
KAQKRRAKME LVEREQYQPP CTCHLYQDYE PSFRDRLRRY FTKPDYLPAK
410 420 430
IDYYARFCVP LGFLAFNAIY WTSCLVMVSR LV
Length:432
Mass (Da):49,626
Last modified:May 1, 1997 - v1
Checksum:iAE6E7342FA8C883B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09796 mRNA. Translation: CAA70929.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09796 mRNA. Translation: CAA70929.1.

3D structure databases

ProteinModelPortaliP91730.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL2363050.

Protein family/group databases

TCDBi1.A.9.4.3. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR015680. Glu_Cl_Channel.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PTHR18945:SF504. PTHR18945:SF504. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLUCB_HAECO
AccessioniPrimary (citable) accession number: P91730
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 1, 1997
Last modified: November 11, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.