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P91711 (XDH_DROSU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Xanthine dehydrogenase

Short name=XD
EC=1.17.1.4
Alternative name(s):
Protein rosy locus
Gene names
Name:Xdh
Synonyms:ry
OrganismDrosophila subobscura (Fruit fly)
Taxonomic identifier7241 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1344 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid By similarity.

Catalytic activity

Xanthine + NAD+ + H2O = urate + NADH.

Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactor

Binds 2 2Fe-2S clusters By similarity.

FAD By similarity.

Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the xanthine dehydrogenase family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 FAD-binding PCMH-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13441344Xanthine dehydrogenase
PRO_0000166081

Regions

Domain9 – 96882Fe-2S ferredoxin-type
Domain236 – 425190FAD-binding PCMH-type
Nucleotide binding264 – 2718FAD By similarity
Nucleotide binding354 – 3585FAD By similarity

Sites

Active site12761Proton acceptor By similarity
Metal binding481Iron-sulfur 1 By similarity
Metal binding531Iron-sulfur 1 By similarity
Metal binding561Iron-sulfur 1 By similarity
Metal binding781Iron-sulfur 1 By similarity
Metal binding1181Iron-sulfur 2 By similarity
Metal binding1211Iron-sulfur 2 By similarity
Metal binding1531Iron-sulfur 2 By similarity
Metal binding1551Iron-sulfur 2 By similarity
Metal binding7811Molybdenum By similarity
Metal binding8121Molybdenum; via carbonyl oxygen By similarity
Metal binding9261Molybdenum; via amide nitrogen By similarity
Metal binding10931Molybdenum; via amide nitrogen By similarity
Binding site3441FAD By similarity
Binding site3671FAD By similarity
Binding site4151FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding site4331FAD By similarity
Binding site8161Substrate By similarity
Binding site8941Substrate By similarity
Binding site9281Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P91711 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 1DDB5BAC0E4C3175

FASTA1,344147,254
        10         20         30         40         50         60 
MSGQQQATSV LVFFVNGKKV TDTNPDPECT LLTYLRDKLR LCGTKLGCAE GGCGACTVMI 

        70         80         90        100        110        120 
SRMDRGQHKI RHLAVNACLT PVCAMHGCAV TTVEGIGSTR TRLHPVQERL AKAHGSQCGF 

       130        140        150        160        170        180 
CTPGIVMSMY ALLRNAEQPS MRDLEVAFQG NLCRCTGYRP ILEGYKTFTK EFLCGMGEKC 

       190        200        210        220        230        240 
CRVNGKGCGG GDDPESVTDD TLFERSKFQP LDASQEPIFP PELQLSNAYD SESLVFSSER 

       250        260        270        280        290        300 
VTWYRPTTLQ ELLQLKAAHP AAKLVVGNTE VGVEVKFKHF LYPHLINPTL VAELQEVRES 

       310        320        330        340        350        360 
EESIYFGAAV SLMEIDALLR QRIEELPEAQ TRLFQCTVDM LHYFAGKQIR NVACLGGNIM 

       370        380        390        400        410        420 
TGSPISDMNP VLTAAGARLE VASIVEGKIS QRTVHMGTGF FTGYRRNVIE PQEVLLGIHF 

       430        440        450        460        470        480 
QKTTPDQHVV AFKQARRRDD DIAIVNAAVN VRFEPKSNVV AEISMAFGGM APTTVLAPRT 

       490        500        510        520        530        540 
SQLMVKQPLD HQLLERVAES LCGELPLAAS APGGMIAYRR ALVVSLIFKA YLAISSKLSE 

       550        560        570        580        590        600 
AGIIAGDAIP PKERSGAELF HTPTLRSAQL FERVCSDQPV CDPIGRPEVH AAALKQATGE 

       610        620        630        640        650        660 
AIYTDDIPRM DGELYLGFVL STKPRAKITK LDASAALALE GVHAFFSHKD LTVHENEVGP 

       670        680        690        700        710        720 
VFHDEHVFAA GEVHCYGQIV GAVAADNKAL AQRASRLVRV EYEDLSPVIV TIEQAIEHGS 

       730        740        750        760        770        780 
YFPDYPRYVT KGNMAEAFAQ AEHTYEGSCR MGGQEHFYLE THAAVAVPRD SDELELFCST 

       790        800        810        820        830        840 
QHPSEVQKLV AHVTSLPAHR VVCRAKRLGG GFGGKESRGI SVALPVALAA YRLRRPVRCM 

       850        860        870        880        890        900 
LDRDEDMLIT GTRHPFLFKY KVAFSSDGLI TACDIECYNN AGWSMDLSFS VLERAMYHFE 

       910        920        930        940        950        960 
NCYHIPNVRV GGWVCKTNLP SNTAFRGFGG PQGMFAGEHI IRDVARIVGR DVLDVMRLNF 

       970        980        990       1000       1010       1020 
YRTGDTTHYN QQLEHFPIER CLDDCLTQSR YHERRAEIAK FNRENRWRKR GVAVIPTKYG 

      1030       1040       1050       1060       1070       1080 
IAFGVMHLNQ AGALLNVYGD GSVLLSHGGV EIGQGLNTKM IQCAARALGI PSELIHISET 

      1090       1100       1110       1120       1130       1140 
ATDKVPNTSP TAASVGSDIN GMAVLDACEK LNKRLAPIKE ALPQATWQEW INKAYFDRVS 

      1150       1160       1170       1180       1190       1200 
LSATGFYAMP GIGYHPETNP NARTYSYYTN GVGISVVEID CLTGDHQVLS TDIVMDIGSS 

      1210       1220       1230       1240       1250       1260 
INPAIDIGQI EGAFMQGYGL FTLEELMYSP QGMLYSRGPG MYKLPGFADI PGEFNVSLLT 

      1270       1280       1290       1300       1310       1320 
GAPNPRAVYS SKAVGEPPLF IGASAFFAIK EAIAAARQEH GLTGDFPLEA PSTSARIRMA 

      1330       1340 
CQDKFTNLLE VPEAGSFTPW NIVP 

« Hide

References

[1]"Synonymous substitutions in the Xdh gene of Drosophila: heterogeneous distribution along the coding region."
Comeron J.M., Aguade M.
Genetics 144:1053-1062(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y08237 Genomic DNA. Translation: CAA69405.1.

3D structure databases

ProteinModelPortalP91711.
SMRP91711. Positions 11-170.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

FlyBaseFBgn0013892. Dsub\Xdh.

Family and domain databases

Gene3D1.10.150.120. 1 hit.
3.10.20.30. 1 hit.
3.30.365.10. 6 hits.
3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.1170.50. 1 hit.
InterProIPR002888. 2Fe-2S-bd.
IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR000674. Ald_Oxase/Xan_DH_a/b.
IPR016208. Ald_Oxase/xanthine_DH.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
IPR012675. Beta-grasp_dom.
IPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
IPR022407. OxRdtase_Mopterin_BS.
IPR014307. Xanthine_DH_ssu.
[Graphical view]
PfamPF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
PF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
PF00111. Fer2. 1 hit.
PF01799. Fer2_2. 1 hit.
[Graphical view]
PIRSFPIRSF000127. Xanthine_DH. 1 hit.
SMARTSM01008. Ald_Xan_dh_C. 1 hit.
SM01092. CO_deh_flav_C. 1 hit.
[Graphical view]
SUPFAMSSF47741. SSF47741. 1 hit.
SSF54292. SSF54292. 1 hit.
SSF54665. SSF54665. 1 hit.
SSF55447. SSF55447. 1 hit.
SSF56003. SSF56003. 1 hit.
SSF56176. SSF56176. 1 hit.
TIGRFAMsTIGR02963. xanthine_xdhA. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS51387. FAD_PCMH. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXDH_DROSU
AccessionPrimary (citable) accession number: P91711
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: October 16, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase