Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P91711

- XDH_DROSU

UniProt

P91711 - XDH_DROSU

Protein

Xanthine dehydrogenase

Gene

Xdh

Organism
Drosophila subobscura (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid By similarity.By similarity

    Catalytic activityi

    Xanthine + NAD+ + H2O = urate + NADH.
    Hypoxanthine + NAD+ + H2O = xanthine + NADH.

    Cofactori

    Binds 2 2Fe-2S clusters.By similarity
    FAD.By similarity
    Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi48 – 481Iron-sulfur 1By similarity
    Metal bindingi53 – 531Iron-sulfur 1By similarity
    Metal bindingi56 – 561Iron-sulfur 1By similarity
    Metal bindingi78 – 781Iron-sulfur 1By similarity
    Metal bindingi118 – 1181Iron-sulfur 2By similarity
    Metal bindingi121 – 1211Iron-sulfur 2By similarity
    Metal bindingi153 – 1531Iron-sulfur 2By similarity
    Metal bindingi155 – 1551Iron-sulfur 2By similarity
    Binding sitei344 – 3441FADBy similarity
    Binding sitei367 – 3671FADBy similarity
    Binding sitei415 – 4151FAD; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei433 – 4331FADBy similarity
    Metal bindingi781 – 7811MolybdenumBy similarity
    Metal bindingi812 – 8121Molybdenum; via carbonyl oxygenBy similarity
    Binding sitei816 – 8161SubstrateBy similarity
    Binding sitei894 – 8941SubstrateBy similarity
    Metal bindingi926 – 9261Molybdenum; via amide nitrogenBy similarity
    Binding sitei928 – 9281SubstrateBy similarity
    Metal bindingi1093 – 10931Molybdenum; via amide nitrogenBy similarity
    Active sitei1276 – 12761Proton acceptorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi264 – 2718FADBy similarity
    Nucleotide bindingi354 – 3585FADBy similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB
    2. electron carrier activity Source: InterPro
    3. flavin adenine dinucleotide binding Source: UniProtKB
    4. iron ion binding Source: InterPro
    5. molybdopterin cofactor binding Source: UniProtKB
    6. UDP-N-acetylmuramate dehydrogenase activity Source: InterPro
    7. xanthine dehydrogenase activity Source: UniProtKB
    8. xanthine oxidase activity Source: InterPro

    GO - Biological processi

    1. xanthine catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xanthine dehydrogenase (EC:1.17.1.4)
    Short name:
    XD
    Alternative name(s):
    Protein rosy locus
    Gene namesi
    Name:Xdh
    Synonyms:ry
    OrganismiDrosophila subobscura (Fruit fly)
    Taxonomic identifieri7241 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

    Organism-specific databases

    FlyBaseiFBgn0013892. Dsub\Xdh.

    Subcellular locationi

    Peroxisome By similarity

    GO - Cellular componenti

    1. peroxisome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13441344Xanthine dehydrogenasePRO_0000166081Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP91711.
    SMRiP91711. Positions 11-170.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 96882Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini236 – 425190FAD-binding PCMH-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the xanthine dehydrogenase family.Curated
    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 1 FAD-binding PCMH-type domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di1.10.150.120. 1 hit.
    3.10.20.30. 1 hit.
    3.30.365.10. 6 hits.
    3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    3.90.1170.50. 1 hit.
    InterProiIPR002888. 2Fe-2S-bd.
    IPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR000674. Ald_Oxase/Xan_DH_a/b.
    IPR016208. Ald_Oxase/xanthine_DH.
    IPR008274. AldOxase/xan_DH_Mopterin-bd.
    IPR012675. Beta-grasp_dom.
    IPR005107. CO_DH_flav_C.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR002346. Mopterin_DH_FAD-bd.
    IPR022407. OxRdtase_Mopterin_BS.
    IPR014307. Xanthine_DH_ssu.
    [Graphical view]
    PfamiPF01315. Ald_Xan_dh_C. 1 hit.
    PF02738. Ald_Xan_dh_C2. 1 hit.
    PF03450. CO_deh_flav_C. 1 hit.
    PF00941. FAD_binding_5. 1 hit.
    PF00111. Fer2. 1 hit.
    PF01799. Fer2_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000127. Xanthine_DH. 1 hit.
    SMARTiSM01008. Ald_Xan_dh_C. 1 hit.
    SM01092. CO_deh_flav_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47741. SSF47741. 1 hit.
    SSF54292. SSF54292. 1 hit.
    SSF54665. SSF54665. 1 hit.
    SSF55447. SSF55447. 1 hit.
    SSF56003. SSF56003. 1 hit.
    SSF56176. SSF56176. 1 hit.
    TIGRFAMsiTIGR02963. xanthine_xdhA. 1 hit.
    PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS51387. FAD_PCMH. 1 hit.
    PS00559. MOLYBDOPTERIN_EUK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P91711-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGQQQATSV LVFFVNGKKV TDTNPDPECT LLTYLRDKLR LCGTKLGCAE     50
    GGCGACTVMI SRMDRGQHKI RHLAVNACLT PVCAMHGCAV TTVEGIGSTR 100
    TRLHPVQERL AKAHGSQCGF CTPGIVMSMY ALLRNAEQPS MRDLEVAFQG 150
    NLCRCTGYRP ILEGYKTFTK EFLCGMGEKC CRVNGKGCGG GDDPESVTDD 200
    TLFERSKFQP LDASQEPIFP PELQLSNAYD SESLVFSSER VTWYRPTTLQ 250
    ELLQLKAAHP AAKLVVGNTE VGVEVKFKHF LYPHLINPTL VAELQEVRES 300
    EESIYFGAAV SLMEIDALLR QRIEELPEAQ TRLFQCTVDM LHYFAGKQIR 350
    NVACLGGNIM TGSPISDMNP VLTAAGARLE VASIVEGKIS QRTVHMGTGF 400
    FTGYRRNVIE PQEVLLGIHF QKTTPDQHVV AFKQARRRDD DIAIVNAAVN 450
    VRFEPKSNVV AEISMAFGGM APTTVLAPRT SQLMVKQPLD HQLLERVAES 500
    LCGELPLAAS APGGMIAYRR ALVVSLIFKA YLAISSKLSE AGIIAGDAIP 550
    PKERSGAELF HTPTLRSAQL FERVCSDQPV CDPIGRPEVH AAALKQATGE 600
    AIYTDDIPRM DGELYLGFVL STKPRAKITK LDASAALALE GVHAFFSHKD 650
    LTVHENEVGP VFHDEHVFAA GEVHCYGQIV GAVAADNKAL AQRASRLVRV 700
    EYEDLSPVIV TIEQAIEHGS YFPDYPRYVT KGNMAEAFAQ AEHTYEGSCR 750
    MGGQEHFYLE THAAVAVPRD SDELELFCST QHPSEVQKLV AHVTSLPAHR 800
    VVCRAKRLGG GFGGKESRGI SVALPVALAA YRLRRPVRCM LDRDEDMLIT 850
    GTRHPFLFKY KVAFSSDGLI TACDIECYNN AGWSMDLSFS VLERAMYHFE 900
    NCYHIPNVRV GGWVCKTNLP SNTAFRGFGG PQGMFAGEHI IRDVARIVGR 950
    DVLDVMRLNF YRTGDTTHYN QQLEHFPIER CLDDCLTQSR YHERRAEIAK 1000
    FNRENRWRKR GVAVIPTKYG IAFGVMHLNQ AGALLNVYGD GSVLLSHGGV 1050
    EIGQGLNTKM IQCAARALGI PSELIHISET ATDKVPNTSP TAASVGSDIN 1100
    GMAVLDACEK LNKRLAPIKE ALPQATWQEW INKAYFDRVS LSATGFYAMP 1150
    GIGYHPETNP NARTYSYYTN GVGISVVEID CLTGDHQVLS TDIVMDIGSS 1200
    INPAIDIGQI EGAFMQGYGL FTLEELMYSP QGMLYSRGPG MYKLPGFADI 1250
    PGEFNVSLLT GAPNPRAVYS SKAVGEPPLF IGASAFFAIK EAIAAARQEH 1300
    GLTGDFPLEA PSTSARIRMA CQDKFTNLLE VPEAGSFTPW NIVP 1344
    Length:1,344
    Mass (Da):147,254
    Last modified:May 1, 1997 - v1
    Checksum:i1DDB5BAC0E4C3175
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08237 Genomic DNA. Translation: CAA69405.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08237 Genomic DNA. Translation: CAA69405.1 .

    3D structure databases

    ProteinModelPortali P91711.
    SMRi P91711. Positions 11-170.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    FlyBasei FBgn0013892. Dsub\Xdh.

    Family and domain databases

    Gene3Di 1.10.150.120. 1 hit.
    3.10.20.30. 1 hit.
    3.30.365.10. 6 hits.
    3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    3.90.1170.50. 1 hit.
    InterProi IPR002888. 2Fe-2S-bd.
    IPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR000674. Ald_Oxase/Xan_DH_a/b.
    IPR016208. Ald_Oxase/xanthine_DH.
    IPR008274. AldOxase/xan_DH_Mopterin-bd.
    IPR012675. Beta-grasp_dom.
    IPR005107. CO_DH_flav_C.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR002346. Mopterin_DH_FAD-bd.
    IPR022407. OxRdtase_Mopterin_BS.
    IPR014307. Xanthine_DH_ssu.
    [Graphical view ]
    Pfami PF01315. Ald_Xan_dh_C. 1 hit.
    PF02738. Ald_Xan_dh_C2. 1 hit.
    PF03450. CO_deh_flav_C. 1 hit.
    PF00941. FAD_binding_5. 1 hit.
    PF00111. Fer2. 1 hit.
    PF01799. Fer2_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000127. Xanthine_DH. 1 hit.
    SMARTi SM01008. Ald_Xan_dh_C. 1 hit.
    SM01092. CO_deh_flav_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47741. SSF47741. 1 hit.
    SSF54292. SSF54292. 1 hit.
    SSF54665. SSF54665. 1 hit.
    SSF55447. SSF55447. 1 hit.
    SSF56003. SSF56003. 1 hit.
    SSF56176. SSF56176. 1 hit.
    TIGRFAMsi TIGR02963. xanthine_xdhA. 1 hit.
    PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS51387. FAD_PCMH. 1 hit.
    PS00559. MOLYBDOPTERIN_EUK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Synonymous substitutions in the Xdh gene of Drosophila: heterogeneous distribution along the coding region."
      Comeron J.M., Aguade M.
      Genetics 144:1053-1062(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiXDH_DROSU
    AccessioniPrimary (citable) accession number: P91711
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3