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P91711

- XDH_DROSU

UniProt

P91711 - XDH_DROSU

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Protein
Xanthine dehydrogenase
Gene
Xdh, ry
Organism
Drosophila subobscura (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid By similarity.

Catalytic activityi

Xanthine + NAD+ + H2O = urate + NADH.
Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactori

Binds 2 2Fe-2S clusters By similarity.
FAD By similarity.
Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi48 – 481Iron-sulfur 1 By similarity
Metal bindingi53 – 531Iron-sulfur 1 By similarity
Metal bindingi56 – 561Iron-sulfur 1 By similarity
Metal bindingi78 – 781Iron-sulfur 1 By similarity
Metal bindingi118 – 1181Iron-sulfur 2 By similarity
Metal bindingi121 – 1211Iron-sulfur 2 By similarity
Metal bindingi153 – 1531Iron-sulfur 2 By similarity
Metal bindingi155 – 1551Iron-sulfur 2 By similarity
Binding sitei344 – 3441FAD By similarity
Binding sitei367 – 3671FAD By similarity
Binding sitei415 – 4151FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei433 – 4331FAD By similarity
Metal bindingi781 – 7811Molybdenum By similarity
Metal bindingi812 – 8121Molybdenum; via carbonyl oxygen By similarity
Binding sitei816 – 8161Substrate By similarity
Binding sitei894 – 8941Substrate By similarity
Metal bindingi926 – 9261Molybdenum; via amide nitrogen By similarity
Binding sitei928 – 9281Substrate By similarity
Metal bindingi1093 – 10931Molybdenum; via amide nitrogen By similarity
Active sitei1276 – 12761Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi264 – 2718FAD By similarity
Nucleotide bindingi354 – 3585FAD By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB
  2. UDP-N-acetylmuramate dehydrogenase activity Source: InterPro
  3. electron carrier activity Source: InterPro
  4. flavin adenine dinucleotide binding Source: UniProtKB
  5. iron ion binding Source: InterPro
  6. molybdopterin cofactor binding Source: UniProtKB
  7. xanthine dehydrogenase activity Source: UniProtKB
  8. xanthine oxidase activity Source: InterPro

GO - Biological processi

  1. xanthine catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine dehydrogenase (EC:1.17.1.4)
Short name:
XD
Alternative name(s):
Protein rosy locus
Gene namesi
Name:Xdh
Synonyms:ry
OrganismiDrosophila subobscura (Fruit fly)
Taxonomic identifieri7241 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0013892. Dsub\Xdh.

Subcellular locationi

Peroxisome By similarity

GO - Cellular componenti

  1. peroxisome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13441344Xanthine dehydrogenase
PRO_0000166081Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP91711.
SMRiP91711. Positions 11-170.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 96882Fe-2S ferredoxin-type
Add
BLAST
Domaini236 – 425190FAD-binding PCMH-type
Add
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.150.120. 1 hit.
3.10.20.30. 1 hit.
3.30.365.10. 6 hits.
3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.1170.50. 1 hit.
InterProiIPR002888. 2Fe-2S-bd.
IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR000674. Ald_Oxase/Xan_DH_a/b.
IPR016208. Ald_Oxase/xanthine_DH.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
IPR012675. Beta-grasp_dom.
IPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
IPR022407. OxRdtase_Mopterin_BS.
IPR014307. Xanthine_DH_ssu.
[Graphical view]
PfamiPF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
PF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
PF00111. Fer2. 1 hit.
PF01799. Fer2_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000127. Xanthine_DH. 1 hit.
SMARTiSM01008. Ald_Xan_dh_C. 1 hit.
SM01092. CO_deh_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF47741. SSF47741. 1 hit.
SSF54292. SSF54292. 1 hit.
SSF54665. SSF54665. 1 hit.
SSF55447. SSF55447. 1 hit.
SSF56003. SSF56003. 1 hit.
SSF56176. SSF56176. 1 hit.
TIGRFAMsiTIGR02963. xanthine_xdhA. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS51387. FAD_PCMH. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91711-1 [UniParc]FASTAAdd to Basket

« Hide

MSGQQQATSV LVFFVNGKKV TDTNPDPECT LLTYLRDKLR LCGTKLGCAE     50
GGCGACTVMI SRMDRGQHKI RHLAVNACLT PVCAMHGCAV TTVEGIGSTR 100
TRLHPVQERL AKAHGSQCGF CTPGIVMSMY ALLRNAEQPS MRDLEVAFQG 150
NLCRCTGYRP ILEGYKTFTK EFLCGMGEKC CRVNGKGCGG GDDPESVTDD 200
TLFERSKFQP LDASQEPIFP PELQLSNAYD SESLVFSSER VTWYRPTTLQ 250
ELLQLKAAHP AAKLVVGNTE VGVEVKFKHF LYPHLINPTL VAELQEVRES 300
EESIYFGAAV SLMEIDALLR QRIEELPEAQ TRLFQCTVDM LHYFAGKQIR 350
NVACLGGNIM TGSPISDMNP VLTAAGARLE VASIVEGKIS QRTVHMGTGF 400
FTGYRRNVIE PQEVLLGIHF QKTTPDQHVV AFKQARRRDD DIAIVNAAVN 450
VRFEPKSNVV AEISMAFGGM APTTVLAPRT SQLMVKQPLD HQLLERVAES 500
LCGELPLAAS APGGMIAYRR ALVVSLIFKA YLAISSKLSE AGIIAGDAIP 550
PKERSGAELF HTPTLRSAQL FERVCSDQPV CDPIGRPEVH AAALKQATGE 600
AIYTDDIPRM DGELYLGFVL STKPRAKITK LDASAALALE GVHAFFSHKD 650
LTVHENEVGP VFHDEHVFAA GEVHCYGQIV GAVAADNKAL AQRASRLVRV 700
EYEDLSPVIV TIEQAIEHGS YFPDYPRYVT KGNMAEAFAQ AEHTYEGSCR 750
MGGQEHFYLE THAAVAVPRD SDELELFCST QHPSEVQKLV AHVTSLPAHR 800
VVCRAKRLGG GFGGKESRGI SVALPVALAA YRLRRPVRCM LDRDEDMLIT 850
GTRHPFLFKY KVAFSSDGLI TACDIECYNN AGWSMDLSFS VLERAMYHFE 900
NCYHIPNVRV GGWVCKTNLP SNTAFRGFGG PQGMFAGEHI IRDVARIVGR 950
DVLDVMRLNF YRTGDTTHYN QQLEHFPIER CLDDCLTQSR YHERRAEIAK 1000
FNRENRWRKR GVAVIPTKYG IAFGVMHLNQ AGALLNVYGD GSVLLSHGGV 1050
EIGQGLNTKM IQCAARALGI PSELIHISET ATDKVPNTSP TAASVGSDIN 1100
GMAVLDACEK LNKRLAPIKE ALPQATWQEW INKAYFDRVS LSATGFYAMP 1150
GIGYHPETNP NARTYSYYTN GVGISVVEID CLTGDHQVLS TDIVMDIGSS 1200
INPAIDIGQI EGAFMQGYGL FTLEELMYSP QGMLYSRGPG MYKLPGFADI 1250
PGEFNVSLLT GAPNPRAVYS SKAVGEPPLF IGASAFFAIK EAIAAARQEH 1300
GLTGDFPLEA PSTSARIRMA CQDKFTNLLE VPEAGSFTPW NIVP 1344
Length:1,344
Mass (Da):147,254
Last modified:May 1, 1997 - v1
Checksum:i1DDB5BAC0E4C3175
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08237 Genomic DNA. Translation: CAA69405.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08237 Genomic DNA. Translation: CAA69405.1 .

3D structure databases

ProteinModelPortali P91711.
SMRi P91711. Positions 11-170.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

FlyBasei FBgn0013892. Dsub\Xdh.

Family and domain databases

Gene3Di 1.10.150.120. 1 hit.
3.10.20.30. 1 hit.
3.30.365.10. 6 hits.
3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.1170.50. 1 hit.
InterProi IPR002888. 2Fe-2S-bd.
IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR000674. Ald_Oxase/Xan_DH_a/b.
IPR016208. Ald_Oxase/xanthine_DH.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
IPR012675. Beta-grasp_dom.
IPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
IPR022407. OxRdtase_Mopterin_BS.
IPR014307. Xanthine_DH_ssu.
[Graphical view ]
Pfami PF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
PF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
PF00111. Fer2. 1 hit.
PF01799. Fer2_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000127. Xanthine_DH. 1 hit.
SMARTi SM01008. Ald_Xan_dh_C. 1 hit.
SM01092. CO_deh_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47741. SSF47741. 1 hit.
SSF54292. SSF54292. 1 hit.
SSF54665. SSF54665. 1 hit.
SSF55447. SSF55447. 1 hit.
SSF56003. SSF56003. 1 hit.
SSF56176. SSF56176. 1 hit.
TIGRFAMsi TIGR02963. xanthine_xdhA. 1 hit.
PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS51387. FAD_PCMH. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Synonymous substitutions in the Xdh gene of Drosophila: heterogeneous distribution along the coding region."
    Comeron J.M., Aguade M.
    Genetics 144:1053-1062(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiXDH_DROSU
AccessioniPrimary (citable) accession number: P91711
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: October 16, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi