Reviewed,
UniProtKB/Swiss-Prot P91711 (XDH_DROSU)
Last modified
June 16, 2009.
Version 62.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (2) |
 Third-party data |
 Customize display | text xml rdf/xml gff fasta |
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Xanthine dehydrogenase Short name=XD EC=1.17.1.4 Alternative name(s): Protein rosy locus | ||||
| Gene names |
| ||||
| Organism | Drosophila subobscura (Fruit fly) | ||||
| Taxonomic identifier | 7241 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 1344 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | Xanthine + NAD+ + H2O = urate + NADH. Hypoxanthine + NAD+ + H2O = xanthine + NADH. |
| Cofactor | Binds 2 2Fe-2S clusters. FAD. Molybdopterin. |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the xanthine dehydrogenase family. Contains 1 2Fe-2S ferredoxin-type domain. Contains 1 FAD-binding PCMH-type domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Peroxisome |
| Ligand | 2Fe-2S FAD Flavoprotein Iron Iron-sulfur Metal-binding Molybdenum NAD |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW FAD bindingInferred from electronic annotation. Source: InterPro electron carrier activityInferred from electronic annotation. Source: InterPro iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW molybdenum ion bindingInferred from electronic annotation. Source: UniProtKB-KW xanthine dehydrogenase activityInferred from electronic annotation. Source: EC xanthine oxidase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1344 | 1344 | Xanthine dehydrogenase | PRO_0000166081 | |||||
Regions | |||||||||
| Domain | 9 – 96 | 88 | 2Fe-2S ferredoxin-type | ||||||
| Domain | 236 – 425 | 190 | FAD-binding PCMH-type | ||||||
Sites | |||||||||
| Metal binding | 42 | 1 | Iron-sulfur (2Fe-2S) By similarity | ||||||
| Metal binding | 48 | 1 | Iron-sulfur (2Fe-2S) By similarity | ||||||
| Metal binding | 53 | 1 | Iron-sulfur (2Fe-2S) By similarity | ||||||
| Metal binding | 56 | 1 | Iron-sulfur (2Fe-2S) By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Synonymous substitutions in the Xdh gene of Drosophila: heterogeneous distribution along the coding region." Comeron J.M., Aguade M. Genetics 144:1053-1062(1996) [PubMed: 8913749] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| Y08237 Genomic DNA. Translation: CAA69405.1. | |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FO4 based on UniProtKB P80457. |
| ModBase | Search... |
Organism-specific databases | |
| FlyBase | FBgn0013892. Dsub\Xdh. |
Enzyme and pathway databases | |
| BRENDA | 1.17.1.4. 270690. |
Family and domain databases | |
| InterPro | IPR002888. 2Fe-2S_bd. IPR006058. 2Fe2S_fd_BS. IPR000674. Ald_Oxase/Xan_DH_a/b. IPR016208. Ald_Oxase/xanthine_DH. IPR008274. AldOxase/xan_DH_Mopterin-bd. IPR012675. b-grasp_ferredoxin-like. IPR005107. CO_DH_flav_C. IPR016169. CO_DH_flavot_FAD-bd_sub2. IPR016166. FAD-bd_2. IPR016167. FAD-bd_2_sub1. IPR001041. Ferredoxin. IPR002346. Mopterin_DH_FAD-bd. IPR000572. OxRdtase_Mopterin-bd. IPR014307. Xanthine_DH_ssu. [Graphical view] |
| Gene3D | G3DSA:3.30.365.10. Ald_xan_DH_mo_bd. 2 hits. G3DSA:3.90.1170.50. Aldxan_DH_hamm. 1 hit. G3DSA:3.30.390.50. CO_DH_flav_C. 1 hit. G3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit. G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit. G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit. |
| Pfam | PF01315. Ald_Xan_dh_C. 1 hit. PF02738. Ald_Xan_dh_C2. 1 hit. PF03450. CO_deh_flav_C. 1 hit. PF00941. FAD_binding_5. 1 hit. PF00111. Fer2. 1 hit. PF01799. Fer2_2. 1 hit. [Graphical view] |
| PIRSF | PIRSF000127. Xanthine_DH. 1 hit. |
| ProDom | PD186071. 2Fe-2S_bind. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR02963. xanthine_xdhA. 1 hit. |
| PROSITE | PS00197. 2FE2S_FER_1. 1 hit. PS51085. 2FE2S_FER_2. 1 hit. PS51387. FAD_PCMH. 1 hit. PS00559. MOLYBDOPTERIN_EUK. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | XDH_DROSU | ||||||||
| Accession | Primary (citable) accession number: P91711 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |
