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Protein

Xanthine dehydrogenase

Gene

Xdh

Organism
Drosophila subobscura (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid (By similarity).By similarity

Catalytic activityi

Xanthine + NAD+ + H2O = urate + NADH.
Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactori

Protein has several cofactor binding sites:
  • [2Fe-2S] clusterBy similarityNote: Binds 2 [2Fe-2S] clusters.By similarity
  • FADBy similarity
  • Mo-molybdopterinBy similarityNote: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48Iron-sulfur 1By similarity1
Metal bindingi53Iron-sulfur 1By similarity1
Metal bindingi56Iron-sulfur 1By similarity1
Metal bindingi78Iron-sulfur 1By similarity1
Metal bindingi118Iron-sulfur 2By similarity1
Metal bindingi121Iron-sulfur 2By similarity1
Metal bindingi153Iron-sulfur 2By similarity1
Metal bindingi155Iron-sulfur 2By similarity1
Binding sitei344FADBy similarity1
Binding sitei367FADBy similarity1
Binding sitei415FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei433FADBy similarity1
Metal bindingi781MolybdenumBy similarity1
Metal bindingi812Molybdenum; via carbonyl oxygenBy similarity1
Binding sitei816SubstrateBy similarity1
Binding sitei894SubstrateBy similarity1
Metal bindingi926Molybdenum; via amide nitrogenBy similarity1
Binding sitei928SubstrateBy similarity1
Metal bindingi1093Molybdenum; via amide nitrogenBy similarity1
Active sitei1276Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi264 – 271FADBy similarity8
Nucleotide bindingi354 – 358FADBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Ligand2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine dehydrogenase (EC:1.17.1.4)
Short name:
XD
Alternative name(s):
Protein rosy locus
Gene namesi
Name:Xdh
Synonyms:ry
OrganismiDrosophila subobscura (Fruit fly)
Taxonomic identifieri7241 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

FlyBaseiFBgn0013892 Dsub\Xdh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001660811 – 1344Xanthine dehydrogenaseAdd BLAST1344

Proteomic databases

PRIDEiP91711

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP91711
SMRiP91711
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 962Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST88
Domaini236 – 425FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST190

Sequence similaritiesi

Belongs to the xanthine dehydrogenase family.Curated

Family and domain databases

CDDicd00207 fer2, 1 hit
InterProiView protein in InterPro
IPR002888 2Fe-2S-bd
IPR036884 2Fe-2S-bd_dom_sf
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR000674 Ald_Oxase/Xan_DH_a/b
IPR036856 Ald_Oxase/Xan_DH_a/b_sf
IPR016208 Ald_Oxase/xanthine_DH
IPR008274 AldOxase/xan_DH_Mopterin-bd
IPR037165 AldOxase/xan_DH_Mopterin-bd_sf
IPR005107 CO_DH_flav_C
IPR036683 CO_DH_flav_C_dom_sf
IPR016166 FAD-bd_2
IPR036318 FAD-bd_2-like_sf
IPR002346 Mopterin_DH_FAD-bd
IPR022407 OxRdtase_Mopterin_BS
IPR014307 Xanthine_DH_ssu
PfamiView protein in Pfam
PF01315 Ald_Xan_dh_C, 1 hit
PF02738 Ald_Xan_dh_C2, 1 hit
PF03450 CO_deh_flav_C, 1 hit
PF00941 FAD_binding_5, 1 hit
PF00111 Fer2, 1 hit
PF01799 Fer2_2, 1 hit
PIRSFiPIRSF000127 Xanthine_DH, 1 hit
SMARTiView protein in SMART
SM01008 Ald_Xan_dh_C, 1 hit
SM01092 CO_deh_flav_C, 1 hit
SUPFAMiSSF47741 SSF47741, 1 hit
SSF54292 SSF54292, 1 hit
SSF54665 SSF54665, 1 hit
SSF55447 SSF55447, 1 hit
SSF56003 SSF56003, 1 hit
SSF56176 SSF56176, 1 hit
TIGRFAMsiTIGR02963 xanthine_xdhA, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS51387 FAD_PCMH, 1 hit
PS00559 MOLYBDOPTERIN_EUK, 1 hit

Sequencei

Sequence statusi: Complete.

P91711-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGQQQATSV LVFFVNGKKV TDTNPDPECT LLTYLRDKLR LCGTKLGCAE
60 70 80 90 100
GGCGACTVMI SRMDRGQHKI RHLAVNACLT PVCAMHGCAV TTVEGIGSTR
110 120 130 140 150
TRLHPVQERL AKAHGSQCGF CTPGIVMSMY ALLRNAEQPS MRDLEVAFQG
160 170 180 190 200
NLCRCTGYRP ILEGYKTFTK EFLCGMGEKC CRVNGKGCGG GDDPESVTDD
210 220 230 240 250
TLFERSKFQP LDASQEPIFP PELQLSNAYD SESLVFSSER VTWYRPTTLQ
260 270 280 290 300
ELLQLKAAHP AAKLVVGNTE VGVEVKFKHF LYPHLINPTL VAELQEVRES
310 320 330 340 350
EESIYFGAAV SLMEIDALLR QRIEELPEAQ TRLFQCTVDM LHYFAGKQIR
360 370 380 390 400
NVACLGGNIM TGSPISDMNP VLTAAGARLE VASIVEGKIS QRTVHMGTGF
410 420 430 440 450
FTGYRRNVIE PQEVLLGIHF QKTTPDQHVV AFKQARRRDD DIAIVNAAVN
460 470 480 490 500
VRFEPKSNVV AEISMAFGGM APTTVLAPRT SQLMVKQPLD HQLLERVAES
510 520 530 540 550
LCGELPLAAS APGGMIAYRR ALVVSLIFKA YLAISSKLSE AGIIAGDAIP
560 570 580 590 600
PKERSGAELF HTPTLRSAQL FERVCSDQPV CDPIGRPEVH AAALKQATGE
610 620 630 640 650
AIYTDDIPRM DGELYLGFVL STKPRAKITK LDASAALALE GVHAFFSHKD
660 670 680 690 700
LTVHENEVGP VFHDEHVFAA GEVHCYGQIV GAVAADNKAL AQRASRLVRV
710 720 730 740 750
EYEDLSPVIV TIEQAIEHGS YFPDYPRYVT KGNMAEAFAQ AEHTYEGSCR
760 770 780 790 800
MGGQEHFYLE THAAVAVPRD SDELELFCST QHPSEVQKLV AHVTSLPAHR
810 820 830 840 850
VVCRAKRLGG GFGGKESRGI SVALPVALAA YRLRRPVRCM LDRDEDMLIT
860 870 880 890 900
GTRHPFLFKY KVAFSSDGLI TACDIECYNN AGWSMDLSFS VLERAMYHFE
910 920 930 940 950
NCYHIPNVRV GGWVCKTNLP SNTAFRGFGG PQGMFAGEHI IRDVARIVGR
960 970 980 990 1000
DVLDVMRLNF YRTGDTTHYN QQLEHFPIER CLDDCLTQSR YHERRAEIAK
1010 1020 1030 1040 1050
FNRENRWRKR GVAVIPTKYG IAFGVMHLNQ AGALLNVYGD GSVLLSHGGV
1060 1070 1080 1090 1100
EIGQGLNTKM IQCAARALGI PSELIHISET ATDKVPNTSP TAASVGSDIN
1110 1120 1130 1140 1150
GMAVLDACEK LNKRLAPIKE ALPQATWQEW INKAYFDRVS LSATGFYAMP
1160 1170 1180 1190 1200
GIGYHPETNP NARTYSYYTN GVGISVVEID CLTGDHQVLS TDIVMDIGSS
1210 1220 1230 1240 1250
INPAIDIGQI EGAFMQGYGL FTLEELMYSP QGMLYSRGPG MYKLPGFADI
1260 1270 1280 1290 1300
PGEFNVSLLT GAPNPRAVYS SKAVGEPPLF IGASAFFAIK EAIAAARQEH
1310 1320 1330 1340
GLTGDFPLEA PSTSARIRMA CQDKFTNLLE VPEAGSFTPW NIVP
Length:1,344
Mass (Da):147,254
Last modified:May 1, 1997 - v1
Checksum:i1DDB5BAC0E4C3175
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08237 Genomic DNA Translation: CAA69405.1

Similar proteinsi

Entry informationi

Entry nameiXDH_DROSU
AccessioniPrimary (citable) accession number: P91711
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

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