P91667 (P91667_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Adenomatous polyposis coli EMBL AAB41404.1

Gene names

Name:	Apc FlyBase FBgn0015589
Synonyms:	D-APC EMBL AAB41404.1
ORF Names:	CG1451 FlyBase FBgn0015589

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	2416 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: InterPro axon guidance Inferred from genetic interaction. Source: FlyBase cell-cell adhesion Inferred from genetic interaction. Source: FlyBase chitin-based larval cuticle pattern formation Inferred from genetic interaction. Source: FlyBase establishment or maintenance of microtubule cytoskeleton polarity Inferred from mutant phenotype. Source: FlyBase head involution Inferred from genetic interaction. Source: FlyBase imaginal disc pattern formation Inferred from genetic interaction. Source: FlyBase medulla oblongata development Inferred from genetic interaction. Source: FlyBase negative regulation of Wnt receptor signaling pathway Inferred from genetic interaction. Source: FlyBase negative regulation of compound eye retinal cell programmed cell death Inferred from mutant phenotype. Source: FlyBase neuroblast proliferation Inferred from genetic interaction. Source: FlyBase oocyte localization involved in germarium-derived egg chamber formation Inferred from genetic interaction. Source: FlyBase
Cellular component	apical part of cell Inferred from direct assay. Source: FlyBase axon Inferred from direct assay. Source: FlyBase cytoplasm Inferred from direct assay. Source: FlyBase
Molecular function	beta-catenin binding Inferred from direct assay Ref.1. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	P91667 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 4DE3A10BE10E42A9	FASTA	2,416	261,408
	10 20 30 40 50 60 MLEPTLTPDL EEGIAELSLE DVDVDSVPER KPHFLDYDAV PPPDYEEGFG ASSGEQLKMD 70 80 90 100 110 120 KKYERDGEVS DYELAASGYT KKEFTQDDNT LHFTQSAVGL GSGAVGKKPA AKHFLDENPI 130 140 150 160 170 180 PPDYMLAQEL REMREHRSLD RNFERQSAQQ QQLDELPPRN GGGSPASAGR PSRSKEPSYT 190 200 210 220 230 240 LSRFLDGDAP APAPRLPKGA AWTTSFDERY TSSAVEATLG SKVECVYSLL SMLGSNDPLE 250 260 270 280 290 300 MAKKFLELSG NAQSCATLRR SGCMPLLVQM MHAPDNDQEV RKCAEQALHN VVHSHPDEKA 310 320 330 340 350 360 GRREAKVLRL LDQIVDYCSF LKTLLQSGGE AIADDSDRHP LAAISSLMKV SFDEEHRHAM 370 380 390 400 410 420 CELGALHAIP NLVHLDHAVH GPKPEDQCCN SLRRYALMAL TNLTFGDENN KALLCGQKQF 430 440 450 460 470 480 MEALVAQLDS APDDLLQVTA SVLRNLSWRA DSNMKAVLNE IGTVTALALA AMRNRSENTL 490 500 510 520 530 540 KAILSALWNL SAHCSTNKAE FCAVDGALAF LVGMLSYEGP SKTLKIIENA GGILRNVSSH 550 560 570 580 590 600 IAVCEPYRQI LRQHNCLAIL LQQLKSESLT VVSNSCGTLW NLSARSAEDQ KFLWDNGAVP 610 620 630 640 650 660 MLRSLIHSKH AMISEGSSSA LKNLLNFRPA VQNHHQLDPI ARSMGLKALP TLEARKAKAL 670 680 690 700 710 720 QQELGERHTA ETCDNLDTGG KLDKERASSS SRRHPAPRLT RSAMLTKSES RDSVYSAKSD 730 740 750 760 770 780 CAYDHLIRSA SASDAHRKVK PKITDFDLEM EQDTEATEEQ PIDYSVKYSE NATKTSTYQE 790 800 810 820 830 840 TDLDQPTDFS LRYAENQIES DLDISGPAGG QKSTITPPAE TVPEKSEGQE ILLILDDSVK 850 860 870 880 890 900 CYQTEDTPYV ISNAASVTDL RVAAKADREA EVKPEVREVT SKEGAPKKLP KLSQCGSGSY 910 920 930 940 950 960 TPEKPINYCE EGTPGYFSRY DSLSSLDESG KANQAIVGTD ADIKPKLEKQ EEQESQPAEQ 970 980 990 1000 1010 1020 VLTKPPTQAN SALETPLMFS RRSSMDSLVH DPDVDVANCD DKSSVVSDFS RLASGVISPS 1030 1040 1050 1060 1070 1080 EIPDSPTQSM PQSPRRNSVA GSGQNVDSPP VVIPASLQPL RSVFEDDLSS FNVEHTPAQF 1090 1100 1110 1120 1130 1140 STATSLSNLS IVDDEKAPAV WTEDNEDELL LANCINMGMQ RKPTEAVKST VVNSEVDVAE 1150 1160 1170 1180 1190 1200 ETIRSYCTED TPALLSKVPS NTNLSVISMS STDPKDATAG QAQMYAHQLS DDVSSNASDC 1210 1220 1230 1240 1250 1260 GGASGHLLQQ CIRDGMKKPL GEATSDPIAM LRRGGNELPG YLPSADEMNK FLVEDSPCNF 1270 1280 1290 1300 1310 1320 SVVSGLSNLT VGSSLVGPAV QLKETEPSSA DQNPEMKRSL ANRSKSRRPP HWQDDSLSSL 1330 1340 1350 1360 1370 1380 SIDSEDDTNL LSQAIAAGCN RPKSNLGFSS NGKRSSSLSS SQPIAINAAT SASSLNSAMT 1390 1400 1410 1420 1430 1440 VRKSQQQESY SSVDSSDSND NQSKSLFELC ILKGMYKTKE PGARAQQMQE QPIVGSSSVQ 1450 1460 1470 1480 1490 1500 SNPSLKQFDS LPVQLPSSGQ VKRQRHHHHH HHHRERERER KDEKLLQECI NTGISKKINA 1510 1520 1530 1540 1550 1560 VPKNVLATSA AALEPCHPMA ATTSASALST AAPDVEQKAH ATSNPQQQSS THPSSHILPN 1570 1580 1590 1600 1610 1620 PIDAIATVTD TARSPAAPNQ GNGNASQNGL ETATGSKDLD SEDRSSDESN QSFIMETMVR 1630 1640 1650 1660 1670 1680 LDSALNETCI SGASEKHKDP DLMLKSVERL TMEFVTSAEQ LRSSSHNHSS SNSHKNNSSN 1690 1700 1710 1720 1730 1740 NTWNESTCPN DVSFPSVSQT APVLASLSLD EDATEARSLH ELIEITPTNE QQPESLEGET 1750 1760 1770 1780 1790 1800 DTLVNGHADS YSGSSGGLNF QLGGQVQNAG VRLEPQRLLF NGTSASIMTN STMIAFEARA 1810 1820 1830 1840 1850 1860 LAENLLQPAA TDDDTTEMTF SLNSLDLDNI RPPSGMESLN SCYQDHSQPS SLRQAMPSKS 1870 1880 1890 1900 1910 1920 PRFARKMFPA NLVARRALGH LAGSAESVNS SCNLLDNIKP PSLMDELLDS MISVDSIQSE 1930 1940 1950 1960 1970 1980 VADGEQDCSM ATTISVSNYE TAACDDQTMT VLQSCFDEDE DATMNDYSSA ESTPKHGSTP 1990 2000 2010 2020 2030 2040 SPNRRSLTPK DKRRLTKDRF KTYTIATSCE MEAPEANETL QIEIVEAAVP VATPSPRANG 2050 2060 2070 2080 2090 2100 RRRGSAERYK TQLIECPLAL IQPQPDDCPS EQLSSIRAMM QQFTFITDIN IGHSQETCES 2110 2120 2130 2140 2150 2160 TDHPEDAGES PECDQNSETE SCDGQEPDHL PPPPSIVDLR TSVVKPTTLE PATAVKLVRG 2170 2180 2190 2200 2210 2220 RKKPAYVSPY SMQSQRNSNN AAPSKKKTLS PTIAKRSLVP GGSGVRLPAK KKPTPPPEPA 2230 2240 2250 2260 2270 2280 PARLERQGTF VKDEPTNSNV QVPVVETKPA QTSPTHRASK LPTKKGTASG GSPSKAGSPK 2290 2300 2310 2320 2330 2340 RIPLAPARRM TPQRANTSLR LAAGKSPAAS RVVSGRVSST TPPSRSNSNL NGSSAAAAAA 2350 2360 2370 2380 2390 2400 AKINQAQSRI ANIWKRVDEA KTKQSSSNLR TQKTKSSNML NANGTKPTLL RSSTFDNTPS 2410 TAGGVKSKLP VVGARK

References

[1]	"A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo." Hayashi S., Rubinfeld B., Souza B., Polakis P., Wieschaus E., Levine A.J. Proc. Natl. Acad. Sci. U.S.A. 94:242-247(1997) [PubMed: 8990193] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U77947 mRNA. Translation: AAB41404.1.
PIR	T13825.
3D structure databases
ProteinModelPortal	P91667.
SMR	P91667. Positions 342-630.
ModBase	Search...
Protein-protein interaction databases
STRING	P91667.
Proteomic databases
PRIDE	P91667.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0015589. Apc.
Phylogenomic databases
eggNOG	meNOG11256.
InParanoid	P91667.
OrthoDB	EOG40K6DN.
Gene expression databases
ArrayExpress	P91667.
Bgee	P91667.
Family and domain databases
InterPro	IPR009240. APC_15aa_rpt. IPR009223. APC_Cys-rich_rpt. IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR000225. Armadillo. [Graphical view]
Gene3D	G3DSA:1.25.10.10. ARM-like. 2 hits.
Pfam	PF05972. APC_15aa. 2 hits. PF05923. APC_crr. 6 hits. PF00514. Arm. 2 hits. [Graphical view]
SMART	SM00185. ARM. 7 hits. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50176. ARM_REPEAT. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P91667_DROME

Accession

Primary (citable) accession number: P91667

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1997
Last sequence update:	May 1, 1997
Last modified:	November 16, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)