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Protein

Protein max

Gene

Max

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: FlyBase
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DME-8953750. Transcriptional Regulation by E2F6.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein max
Short name:
dMax
Alternative name(s):
Myc-associated factor X
Gene namesi
Name:Max
ORF Names:CG9648
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0017578. Max.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272751 – 161Protein maxAdd BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei131Phosphoserine1 Publication1
Modified residuei137Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP91664.
PRIDEiP91664.

PTM databases

iPTMnetiP91664.

Expressioni

Tissue specificityi

Embryo, especially in central nervous system.1 Publication

Developmental stagei

Highest expression in embryos.1 Publication

Gene expression databases

BgeeiFBgn0017578.
ExpressionAtlasiP91664. differential.
GenevisibleiP91664. DM.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MYC or MAD.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
dmQ9W4S73EBI-193577,EBI-120162

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi65371. 3 interactors.
DIPiDIP-60982N.
IntActiP91664. 3 interactors.
MINTiMINT-977153.
STRINGi7227.FBpp0074785.

Structurei

3D structure databases

ProteinModelPortaliP91664.
SMRiP91664.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 90bHLHPROSITE-ProRule annotationAdd BLAST52

Sequence similaritiesi

Belongs to the MAX family.Curated

Phylogenomic databases

eggNOGiKOG2483. Eukaryota.
ENOG4111V1C. LUCA.
GeneTreeiENSGT00530000064011.
InParanoidiP91664.
KOiK04453.
OMAiRHTSTAN.
OrthoDBiEOG091G1312.
PhylomeDBiP91664.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR036638. HLH_DNA-bd_sf.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.

Sequencei

Sequence statusi: Complete.

P91664-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMSDDDRDI DIESDEDGDS DTGLGSSRHT NTANFTQAEK RAHHNALERR
60 70 80 90 100
RRDHIKESFT NLREAVPTLK GEKASRAQIL KKTTECIQTM RRKISENQKD
110 120 130 140 150
IEEIKRQNNI IAKQIQALES SNGDQFSEFL SDEEVGSEEA DDEDLDQDFS
160
RRNKKMKTFH A
Length:161
Mass (Da):18,530
Last modified:May 1, 1997 - v1
Checksum:iA217A22A7B514C77
GO

Sequence cautioni

The sequence AAL28562 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91R → G in AAL90428 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77369 mRNA. Translation: AAB39841.1.
AE014296 Genomic DNA. Translation: AAF49179.1.
AY061014 mRNA. Translation: AAL28562.1. Sequence problems.
AY089690 mRNA. Translation: AAL90428.1.
BT025211 mRNA. Translation: ABF17902.1.
RefSeqiNP_001246833.1. NM_001259904.2.
NP_001287114.1. NM_001300185.1.
NP_649097.1. NM_140840.4.
UniGeneiDm.3749.

Genome annotation databases

EnsemblMetazoaiFBtr0075018; FBpp0074785; FBgn0017578.
FBtr0310276; FBpp0301959; FBgn0017578.
FBtr0345391; FBpp0311541; FBgn0017578.
GeneIDi40095.
KEGGidme:Dmel_CG9648.
UCSCiCG9648-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiMAX_DROME
AccessioniPrimary (citable) accession number: P91664
Secondary accession number(s): Q1LZ15, Q8SXE2, Q95S07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 1, 1997
Last modified: November 22, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families