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Protein

Protein max

Gene

Max

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: UniProtKB
  • protein heterodimerization activity Source: FlyBase

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: FlyBase
  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-DME-8953750 Transcriptional Regulation by E2F6

Names & Taxonomyi

Protein namesi
Recommended name:
Protein max
Short name:
dMax
Alternative name(s):
Myc-associated factor X
Gene namesi
Name:Max
ORF Names:CG9648
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0017578 Max

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272751 – 161Protein maxAdd BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei131Phosphoserine1 Publication1
Modified residuei137Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP91664
PRIDEiP91664

PTM databases

iPTMnetiP91664

Expressioni

Tissue specificityi

Embryo, especially in central nervous system.1 Publication

Developmental stagei

Highest expression in embryos.1 Publication

Gene expression databases

BgeeiFBgn0017578
ExpressionAtlasiP91664 baseline and differential
GenevisibleiP91664 DM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MYC or MAD.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MycQ9W4S73EBI-193577,EBI-120162

GO - Molecular functioni

  • protein heterodimerization activity Source: FlyBase

Protein-protein interaction databases

BioGridi65371, 3 interactors
DIPiDIP-60982N
IntActiP91664, 3 interactors
STRINGi7227.FBpp0074785

Structurei

3D structure databases

ProteinModelPortaliP91664
SMRiP91664
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 90bHLHPROSITE-ProRule annotationAdd BLAST52

Sequence similaritiesi

Belongs to the MAX family.Curated

Phylogenomic databases

eggNOGiKOG2483 Eukaryota
ENOG4111V1C LUCA
GeneTreeiENSGT00530000064011
InParanoidiP91664
KOiK04453
OMAiRHTSTAN
OrthoDBiEOG091G1312
PhylomeDBiP91664

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR037933 MAX
PANTHERiPTHR10328 PTHR10328, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P91664-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMSDDDRDI DIESDEDGDS DTGLGSSRHT NTANFTQAEK RAHHNALERR
60 70 80 90 100
RRDHIKESFT NLREAVPTLK GEKASRAQIL KKTTECIQTM RRKISENQKD
110 120 130 140 150
IEEIKRQNNI IAKQIQALES SNGDQFSEFL SDEEVGSEEA DDEDLDQDFS
160
RRNKKMKTFH A
Length:161
Mass (Da):18,530
Last modified:May 1, 1997 - v1
Checksum:iA217A22A7B514C77
GO

Sequence cautioni

The sequence AAL28562 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91R → G in AAL90428 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77369 mRNA Translation: AAB39841.1
AE014296 Genomic DNA Translation: AAF49179.1
AY061014 mRNA Translation: AAL28562.1 Sequence problems.
AY089690 mRNA Translation: AAL90428.1
BT025211 mRNA Translation: ABF17902.1
RefSeqiNP_001246833.1, NM_001259904.2
NP_001287114.1, NM_001300185.1
NP_649097.1, NM_140840.4
UniGeneiDm.3749

Genome annotation databases

EnsemblMetazoaiFBtr0075018; FBpp0074785; FBgn0017578
FBtr0310276; FBpp0301959; FBgn0017578
FBtr0345391; FBpp0311541; FBgn0017578
GeneIDi40095
KEGGidme:Dmel_CG9648
UCSCiCG9648-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiMAX_DROME
AccessioniPrimary (citable) accession number: P91664
Secondary accession number(s): Q1LZ15, Q8SXE2, Q95S07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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