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Protein

Probable multidrug resistance-associated protein lethal(2)03659

Gene

l(2)03659

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Vital for development.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi534 – 541ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1153 – 1160ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-114608. Platelet degranulation.
R-DME-382556. ABC-family proteins mediated transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable multidrug resistance-associated protein lethal(2)03659
Alternative name(s):
Wunen region A protein
Gene namesi
ORF Names:CG8799
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0010549. l(2)03659.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei159 – 179HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei205 – 225HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei282 – 302HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei305 – 325HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei404 – 424HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei426 – 446HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei787 – 807HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei845 – 865HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei913 – 933HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei938 – 958HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1025 – 1045HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000934331 – 1374Probable multidrug resistance-associated protein lethal(2)03659Add BLAST1374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi561N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1254N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1353N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP91660.
PRIDEiP91660.

Expressioni

Tissue specificityi

Uniform expression in embryos.1 Publication

Gene expression databases

BgeeiFBgn0010549.
ExpressionAtlasiP91660. baseline.
GenevisibleiP91660. DM.

Interactioni

Protein-protein interaction databases

BioGridi71049. 1 interactor.
IntActiP91660. 3 interactors.
MINTiMINT-1698291.
STRINGi7227.FBpp0291666.

Structurei

3D structure databases

ProteinModelPortaliP91660.
SMRiP91660.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 449ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST282
Domaini499 – 722ABC transporter 1PROSITE-ProRule annotationAdd BLAST224
Domaini793 – 1079ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST287
Domaini1119 – 1352ABC transporter 2PROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133722.
InParanoidiP91660.
OrthoDBiEOG091G00IN.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91660-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKQPVLEPT FDSVSERENT SIEESSLLEN NGFDHRNKDE SLSVNTSPPL
60 70 80 90 100
VCRKCFELGH QTENCKQKLT VNSENNSAQN EKEKVLPENP RARSNFISSL
110 120 130 140 150
CFWYTIPIFR KGYRKTLDST DLYRPLEEQK SDILGNRLCA SWERELKNDG
160 170 180 190 200
RSPSLVRALL RVFGWQLGFP GLAIFVVELG LRTLQPIFLV KLISYFSGEP
210 220 230 240 250
DAANAGFYYA VAQIVISALT VMILTPTTFG IHHVCFKMRV AMGSMIFRKA
260 270 280 290 300
LRLTKGALGD TTSGHVVNLI SNDIPRLDSA PYTVHYLWVG PLQVLVITYL
310 320 330 340 350
MYQEIGISAV FGVLFMLLFM PIQMYLGTRT SAIQLKAAER TDNRIRMVNE
360 370 380 390 400
IISAIQVLKM YAWEQPFEQM VTHAREKEMN TIRQGQYIRG FDFARRIVLS
410 420 430 440 450
RVAIFLSLVG YVILGKVFTP EIAFMITAYY NVLLAAMSIY VPSAIIQTAQ
460 470 480 490 500
FLTSIRRVEQ FMQSEELGSS DKSEGPSKDT VPGNPPSNNN EADLLKSAIS
510 520 530 540 550
IRDLKAKWDP NSPDYTLSGI NLEIKPGSVV AVIGLTGSGK SSLIQAILGE
560 570 580 590 600
LKANSGQLQV NGSLSYTSQE SWLFSGTVRQ NILFGQPMDS QRYEEVVKKC
610 620 630 640 650
ALERDFDLLP LRDNTIVGER GATLSGGQKA RISLARSVYR KASIYLLDDP
660 670 680 690 700
LSAVDASVAR HLFDQCVRGH LRGSTVVLVT HQEQFLPHVD QIVILANGQI
710 720 730 740 750
KALGDYESLL KTGLITGLGS LSKTDKAKTE EQEPLNLNSP DNKNEVTPIK
760 770 780 790 800
ENSEQTVGGS SSGKEHVERQ ESGGISLALY RKYFQAGGGL VAFLVMLSSS
810 820 830 840 850
VLAQVAVTGG DYFLTYWVKK ESTAAGHGEM EDMESKSMDV YKYTLIIILS
860 870 880 890 900
VIMNLSSSFL LFNIAKKASI RLHNTIFNRV TRADMHFFSI NKHGSILNRF
910 920 930 940 950
TKDMSQVDEV LPVVLVDVMQ IALWLAGIII VIANVNPLLL VPTLMLSVIF
960 970 980 990 1000
YHLRNLYLKT SRDLKRVEAI NRSPVYSHLA ASLNGLTTIR ALDAQRVLEK
1010 1020 1030 1040 1050
EFDSYQDAHS SAFFMYISTS QAFGYCMNCI CVIYISIITL SFFAFPPGNG
1060 1070 1080 1090 1100
ADVGLVITQA MGLIDMVQWG VRQTAELENT MTAVERVVEY ESIEPEGMLE
1110 1120 1130 1140 1150
APDDKKPPKT WPEQGEIIFK ELNLRYTPNA KAENVLKSLS FVIQPREKVG
1160 1170 1180 1190 1200
IVGRTGAGKS SLINALFRLS YTDGSVLIDT RDTRQMGLHD LRRQISIIPQ
1210 1220 1230 1240 1250
EPVLFSGTMR YNLDPFDEYS DEKLWGCLEE VKLKEVVSDL PDGLASKISE
1260 1270 1280 1290 1300
GGTNFSVGQR QLVCLARAIL RENRILVMDE ATANVDPQTD GLIQATIRSK
1310 1320 1330 1340 1350
FRDCTVLTIA HRLHTIIDSD KVMVMDAGRV VEFGSPYELM TKSDSKVFHN
1360 1370
LVNQSGRASY EGLLKIAQET FESS
Length:1,374
Mass (Da):153,195
Last modified:March 16, 2016 - v4
Checksum:i0E1F4C0FC52CB155
GO

Sequence cautioni

The sequence AAC47448 differs from that shown. Reason: Erroneous translation. Wrong choice of frame. Uses complementary DNA strand, thus describing the wrong sequence.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58947.3.
U73821 Genomic DNA. Translation: AAC47448.1. Sequence problems.
RefSeqiNP_610482.3. NM_136638.4.
UniGeneiDm.14386.

Genome annotation databases

EnsemblMetazoaiFBtr0302504; FBpp0291666; FBgn0010549.
GeneIDi47905.
KEGGidme:Dmel_CG8799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58947.3.
U73821 Genomic DNA. Translation: AAC47448.1. Sequence problems.
RefSeqiNP_610482.3. NM_136638.4.
UniGeneiDm.14386.

3D structure databases

ProteinModelPortaliP91660.
SMRiP91660.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi71049. 1 interactor.
IntActiP91660. 3 interactors.
MINTiMINT-1698291.
STRINGi7227.FBpp0291666.

Proteomic databases

PaxDbiP91660.
PRIDEiP91660.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0302504; FBpp0291666; FBgn0010549.
GeneIDi47905.
KEGGidme:Dmel_CG8799.

Organism-specific databases

FlyBaseiFBgn0010549. l(2)03659.

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133722.
InParanoidiP91660.
OrthoDBiEOG091G00IN.

Enzyme and pathway databases

ReactomeiR-DME-114608. Platelet degranulation.
R-DME-382556. ABC-family proteins mediated transport.

Miscellaneous databases

GenomeRNAii47905.
PROiP91660.

Gene expression databases

BgeeiFBgn0010549.
ExpressionAtlasiP91660. baseline.
GenevisibleiP91660. DM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiL259_DROME
AccessioniPrimary (citable) accession number: P91660
Secondary accession number(s): Q9V571, Q9V572
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: March 16, 2016
Last modified: November 30, 2016
This is version 124 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.