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Protein

Probable multidrug resistance-associated protein lethal(2)03659

Gene

l(2)03659

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Vital for development.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi534 – 5418ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1153 – 11608ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-382556. ABC-family proteins mediated transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable multidrug resistance-associated protein lethal(2)03659
Alternative name(s):
Wunen region A protein
Gene namesi
Name:l(2)03659
ORF Names:CG8799
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0010549. l(2)03659.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei159 – 17921HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei205 – 22521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei282 – 30221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei305 – 32521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei404 – 42421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei426 – 44621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei787 – 80721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei845 – 86521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei913 – 93321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei938 – 95821HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei1025 – 104521HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13741374Probable multidrug resistance-associated protein lethal(2)03659PRO_0000093433Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi561 – 5611N-linked (GlcNAc...)Sequence analysis
Glycosylationi1254 – 12541N-linked (GlcNAc...)Sequence analysis
Glycosylationi1353 – 13531N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP91660.
PRIDEiP91660.

Expressioni

Tissue specificityi

Uniform expression in embryos.1 Publication

Gene expression databases

BgeeiP91660.
ExpressionAtlasiP91660. differential.
GenevisibleiP91660. DM.

Interactioni

Protein-protein interaction databases

BioGridi71049. 1 interaction.
IntActiP91660. 3 interactions.
MINTiMINT-1698291.
STRINGi7227.FBpp0291666.

Structurei

3D structure databases

ProteinModelPortaliP91660.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini168 – 449282ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini499 – 722224ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini793 – 1079287ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1119 – 1352234ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
InParanoidiP91660.
OrthoDBiEOG7MWGW0.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91660-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKQPVLEPT FDSVSERENT SIEESSLLEN NGFDHRNKDE SLSVNTSPPL
60 70 80 90 100
VCRKCFELGH QTENCKQKLT VNSENNSAQN EKEKVLPENP RARSNFISSL
110 120 130 140 150
CFWYTIPIFR KGYRKTLDST DLYRPLEEQK SDILGNRLCA SWERELKNDG
160 170 180 190 200
RSPSLVRALL RVFGWQLGFP GLAIFVVELG LRTLQPIFLV KLISYFSGEP
210 220 230 240 250
DAANAGFYYA VAQIVISALT VMILTPTTFG IHHVCFKMRV AMGSMIFRKA
260 270 280 290 300
LRLTKGALGD TTSGHVVNLI SNDIPRLDSA PYTVHYLWVG PLQVLVITYL
310 320 330 340 350
MYQEIGISAV FGVLFMLLFM PIQMYLGTRT SAIQLKAAER TDNRIRMVNE
360 370 380 390 400
IISAIQVLKM YAWEQPFEQM VTHAREKEMN TIRQGQYIRG FDFARRIVLS
410 420 430 440 450
RVAIFLSLVG YVILGKVFTP EIAFMITAYY NVLLAAMSIY VPSAIIQTAQ
460 470 480 490 500
FLTSIRRVEQ FMQSEELGSS DKSEGPSKDT VPGNPPSNNN EADLLKSAIS
510 520 530 540 550
IRDLKAKWDP NSPDYTLSGI NLEIKPGSVV AVIGLTGSGK SSLIQAILGE
560 570 580 590 600
LKANSGQLQV NGSLSYTSQE SWLFSGTVRQ NILFGQPMDS QRYEEVVKKC
610 620 630 640 650
ALERDFDLLP LRDNTIVGER GATLSGGQKA RISLARSVYR KASIYLLDDP
660 670 680 690 700
LSAVDASVAR HLFDQCVRGH LRGSTVVLVT HQEQFLPHVD QIVILANGQI
710 720 730 740 750
KALGDYESLL KTGLITGLGS LSKTDKAKTE EQEPLNLNSP DNKNEVTPIK
760 770 780 790 800
ENSEQTVGGS SSGKEHVERQ ESGGISLALY RKYFQAGGGL VAFLVMLSSS
810 820 830 840 850
VLAQVAVTGG DYFLTYWVKK ESTAAGHGEM EDMESKSMDV YKYTLIIILS
860 870 880 890 900
VIMNLSSSFL LFNIAKKASI RLHNTIFNRV TRADMHFFSI NKHGSILNRF
910 920 930 940 950
TKDMSQVDEV LPVVLVDVMQ IALWLAGIII VIANVNPLLL VPTLMLSVIF
960 970 980 990 1000
YHLRNLYLKT SRDLKRVEAI NRSPVYSHLA ASLNGLTTIR ALDAQRVLEK
1010 1020 1030 1040 1050
EFDSYQDAHS SAFFMYISTS QAFGYCMNCI CVIYISIITL SFFAFPPGNG
1060 1070 1080 1090 1100
ADVGLVITQA MGLIDMVQWG VRQTAELENT MTAVERVVEY ESIEPEGMLE
1110 1120 1130 1140 1150
APDDKKPPKT WPEQGEIIFK ELNLRYTPNA KAENVLKSLS FVIQPREKVG
1160 1170 1180 1190 1200
IVGRTGAGKS SLINALFRLS YTDGSVLIDT RDTRQMGLHD LRRQISIIPQ
1210 1220 1230 1240 1250
EPVLFSGTMR YNLDPFDEYS DEKLWGCLEE VKLKEVVSDL PDGLASKISE
1260 1270 1280 1290 1300
GGTNFSVGQR QLVCLARAIL RENRILVMDE ATANVDPQTD GLIQATIRSK
1310 1320 1330 1340 1350
FRDCTVLTIA HRLHTIIDSD KVMVMDAGRV VEFGSPYELM TKSDSKVFHN
1360 1370
LVNQSGRASY EGLLKIAQET FESS
Length:1,374
Mass (Da):153,195
Last modified:March 16, 2016 - v4
Checksum:i0E1F4C0FC52CB155
GO

Sequence cautioni

The sequence AAC47448.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame. Uses complementary DNA strand, thus describing the wrong sequence.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58947.3.
U73821 Genomic DNA. Translation: AAC47448.1. Sequence problems.
RefSeqiNP_610482.3. NM_136638.4.
UniGeneiDm.14386.

Genome annotation databases

GeneIDi47905.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA. Translation: AAF58947.3.
U73821 Genomic DNA. Translation: AAC47448.1. Sequence problems.
RefSeqiNP_610482.3. NM_136638.4.
UniGeneiDm.14386.

3D structure databases

ProteinModelPortaliP91660.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi71049. 1 interaction.
IntActiP91660. 3 interactions.
MINTiMINT-1698291.
STRINGi7227.FBpp0291666.

Proteomic databases

PaxDbiP91660.
PRIDEiP91660.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi47905.

Organism-specific databases

FlyBaseiFBgn0010549. l(2)03659.

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
InParanoidiP91660.
OrthoDBiEOG7MWGW0.

Enzyme and pathway databases

ReactomeiR-DME-382556. ABC-family proteins mediated transport.

Miscellaneous databases

GenomeRNAii47905.
NextBioi839225.
PROiP91660.

Gene expression databases

BgeeiP91660.
ExpressionAtlasiP91660. differential.
GenevisibleiP91660. DM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. "The Drosophila protein Wunen repels migrating germ cells."
    Zhang N., Zhang J.P., Purcell K.J., Chen Y., Howard K.
    Nature 385:64-67(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 891-1004, FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiL259_DROME
AccessioniPrimary (citable) accession number: P91660
Secondary accession number(s): Q9V571, Q9V572
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: March 16, 2016
Last modified: May 11, 2016
This is version 120 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.