P91643 (P91643_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
KEK1 EMBL AAC47404.1

Gene names

Name:

kek1 EMBL AAC47404.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	880 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 LRRCT domain. SAAS SAAS000483

Ontologies

Keywords
Domain	Immunoglobulin domain SAAS SAAS000483 Leucine-rich repeat SAAS SAAS000483 Repeat SAAS SAAS000483 Signal EMBL AAC47404.1
PTM	Disulfide bond SAAS SAAS000483
Gene Ontology (GO)
Biological process	cytokinesis Inferred from mutant phenotype. Source: FlyBase negative regulation of epidermal growth factor-activated receptor activity Traceable author statement. Source: FlyBase oogenesis Inferred from mutant phenotype. Source: FlyBase
Cellular component	integral to membrane Traceable author statement. Source: FlyBase
Molecular function	epidermal growth factor binding Inferred from physical interaction. Source: FlyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential EMBL AAC47404.1
	Chain	21 – 880	860	KEK1 EMBL AAC47404.1		PRO_5000144810

Sequences

	Sequence		Length	Mass (Da)
	P91643 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 9C55A5418AF053EC	FASTA	880	94,542
	10 20 30 40 50 60 MHIREAVFLV LTLLPGMILG TRYNQLHLYA NGGASSSGPG GYRPAPSSQN EVYSIADSQP 70 80 90 100 110 120 MTEDGYMPPS QHFPPTHSDL DPPAQQQSTC QTVCACKWKG GKQTVECIDR HLIQIPEHID 130 140 150 160 170 180 PNTQVLDMSG NKLQTLSNEQ FIRANLLNLQ KLYLRNCKIG EIERETFKGL TNLVELDLSH 190 200 210 220 230 240 NLLVTVPSLA LGHIPSLREL TLASNHIHKI ESQAFGNTPS LHKLDLSHCD IQTISAQAFG 250 260 270 280 290 300 GLQGLTLLRL NGNKLSELLP KTIETLSRLH GIELHDNPWL CDCRLRDTKL WLMKRNIPYP 310 320 330 340 350 360 VAPVCSGGPE RIIDRSFADL HVDEFACRPE MLPISHYVEA AMGENASITC RARAVPAANI 370 380 390 400 410 420 NWYWNGRLLA NNSAFTAYQR IHMLEQVEGG FEKRSKLVLT NAQETDSSEF YCVAENRAGM 430 440 450 460 470 480 AEANFTLHVS MRAAGMASLG SGQIVGLSAA LVALIVFALG VIMCLLLRVK RQPYVDSKTP 490 500 510 520 530 540 NHMEVITSVN HQNSITNKTQ PATGNGSIGG VVIANGAVAN IIDGGVVQGG TLERKSSGRG 550 560 570 580 590 600 GVPHGVHDQR SANPVQKPPR LTDLPYSTQG YDNNGSVLST ASCFISPSGS TGNGGNNPDL 610 620 630 640 650 660 INDTKRFGSD EFADLKIPPI SGVGVGGSGE YSRANGCDSL YPSGLWEHGA PVGTTSADDL 670 680 690 700 710 720 FMKRYTDKTP IIDSTQLYDL HERTAATDYF SKTFPRSHLQ QGMMTGGGGG TSTASTVTTN 730 740 750 760 770 780 LSGGSSSGYP NDYGLPLVPG AEHQHNHQLQ MHPLQQLQQQ LTSTLNHQKQ EGSSTGSSPH 790 800 810 820 830 840 FSSRTLPRLH EGSGGGGSSR SSPTPAISGG HANQAANPST SSSSCSILPN GQPINAKTIR 850 860 870 880 VWQKGGVPVL PPVTALKRAL ISSSRNSPDE GYQEGCGTDV

References

[1]	"The Drosophila kekkon genes: novel members of both the leucine-rich repeat and immunoglobulin superfamilies expressed in the CNS." Musacchio M., Perrimon N. Dev. Biol. 178:63-76(1996) [PubMed: 8812109] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Oregon R EMBL AAC47404.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U42767 mRNA. Translation: AAC47404.1.
3D structure databases
HSSP	HSSP built from PDB template 1P9A based on UniProtKB P07359.
ProteinModelPortal	P91643.
SMR	P91643. Positions 90-431.
ModBase	Search...
Protein-protein interaction databases
STRING	P91643.
Proteomic databases
PRIDE	P91643.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
FlyBase	FBgn0015399. kek1.
Phylogenomic databases
eggNOG	inNOG06562.
InParanoid	P91643.
OrthoDB	EOG48932C.
Gene expression databases
ArrayExpress	P91643.
Bgee	P91643.
Family and domain databases
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003598. Ig_sub2. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
Pfam	PF07679. I-set. 1 hit. PF00560. LRR_1. 2 hits. [Graphical view]
SMART	SM00408. IGc2. 1 hit. SM00369. LRR_TYP. 1 hit. SM00082. LRRCT. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. PS51450. LRR. 6 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P91643_DROME

Accession

Primary (citable) accession number: P91643

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1997
Last sequence update:	May 1, 1997
Last modified:	January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)