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Protein

[Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial

Gene

Pdk

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.

Catalytic activityi

ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei294ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi253 – 260ATPBy similarity8
Nucleotide bindingi313 – 314ATPBy similarity2
Nucleotide bindingi330 – 335ATPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-204174 Regulation of pyruvate dehydrogenase (PDH) complex
R-DME-5362517 Signaling by Retinoic Acid

Names & Taxonomyi

Protein namesi
Recommended name:
[Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial (EC:2.7.11.2)
Short name:
DmPDK
Short name:
Pyruvate dehydrogenase kinase
Gene namesi
Name:Pdk
ORF Names:CG8808
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0017558 Pdk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000023451? – 413[Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiP91622
PRIDEiP91622

Expressioni

Developmental stagei

Expressed both maternally and zygotically.1 Publication

Gene expression databases

BgeeiFBgn0017558
ExpressionAtlasiP91622 baseline and differential
GenevisibleiP91622 DM

Interactioni

Protein-protein interaction databases

BioGridi61801, 5 interactors
STRINGi7227.FBpp0111805

Structurei

3D structure databases

ProteinModelPortaliP91622
SMRiP91622
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini137 – 369Histidine kinasePROSITE-ProRule annotationAdd BLAST233

Sequence similaritiesi

Belongs to the PDK/BCKDK protein kinase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0787 Eukaryota
COG0642 LUCA
GeneTreeiENSGT00550000074574
InParanoidiP91622
KOiK00898
OMAiQMVQFGE
OrthoDBiEOG091G07DJ
PhylomeDBiP91622

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.140.20, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR036784 AK/P_DHK_N_sf
IPR018955 BCDHK/PDK_N
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
PfamiView protein in Pfam
PF10436 BCDHK_Adom3, 1 hit
PF02518 HATPase_c, 1 hit
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
SSF69012 SSF69012, 1 hit
PROSITEiView protein in PROSITE
PS50109 HIS_KIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P91622-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLFPVRFSA ASSSMASLAK MLDFYSGFNP SPLSIKQFMD FGQNACEKKS
60 70 80 90 100
YIFLRKELPV RLANIMKEIA LLPDNLLHTR SVSEVSSWYV KSFEDVLVYE
110 120 130 140 150
KAEPTHDNLQ KFVADLDLIR NRHNDVVQTM AQGVIEMKEN EGGQVDAPTE
160 170 180 190 200
SSIQYFLDRL YMSRISIRML INQHTLLFGG NPHAGGRHIG CLDPACDLSD
210 220 230 240 250
VVRDAYENAR FLCDQYYLTS PALEIQQHSS EPGDNLPIRT VYVPSHLYYM
260 270 280 290 300
LFELFKNSMR AVVEHHGHDN NDTLPPLKVA ICKGKEDICV KISDQGGGIP
310 320 330 340 350
RSQTDQLFKY MYSTAPQPSK SDLHTVPLAG YGYGLPISRL YARYFHGDIV
360 370 380 390 400
LLSCEGFGTD AIIYLKALSD EANELLPIFN KTSSKFYRAT VPTGDWSNQV
410
KYAKKKKTSA VNQ
Length:413
Mass (Da):46,626
Last modified:August 16, 2005 - v2
Checksum:iAB8F1A5A61047D81
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13S → L in BAA13724 (PubMed:9115642).Curated1
Sequence conflicti412N → S in BAA13724 (PubMed:9115642).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88814 mRNA Translation: BAA13724.1
AE013599 Genomic DNA Translation: AAF58938.1
AY075385 mRNA Translation: AAL68223.1
RefSeqiNP_001246224.1, NM_001259295.2
NP_477215.1, NM_057867.4
UniGeneiDm.7142

Genome annotation databases

EnsemblMetazoaiFBtr0088508; FBpp0087592; FBgn0017558
FBtr0306807; FBpp0297719; FBgn0017558
GeneIDi35970
KEGGidme:Dmel_CG8808

Similar proteinsi

Entry informationi

Entry nameiPDK_DROME
AccessioniPrimary (citable) accession number: P91622
Secondary accession number(s): Q9V580
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: August 16, 2005
Last modified: May 23, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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