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Protein

Protein lin-28

Gene

lin-28

Organism
Caenorhabditis remanei (Caenorhabditis vulgaris)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Heterochronic protein which controls the choice of stage specific cell fates. Regulates the timing of the second larval stage events (L2 events) in the hypodermis (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi140 – 1401Zinc 1By similarity
Metal bindingi143 – 1431Zinc 1By similarity
Metal bindingi149 – 1491Zinc 1By similarity
Metal bindingi154 – 1541Zinc 1By similarity
Metal bindingi164 – 1641Zinc 2By similarity
Metal bindingi167 – 1671Zinc 2By similarity
Metal bindingi172 – 1721Zinc 2By similarity
Metal bindingi177 – 1771Zinc 2By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri139 – 15618CCHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri162 – 17918CCHC-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-28
Alternative name(s):
Abnormal cell lineage protein 28
Gene namesi
Name:lin-28
OrganismiCaenorhabditis remanei (Caenorhabditis vulgaris)
Taxonomic identifieri31234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Protein lin-28PRO_0000253800Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi31234.CRE28214.

Structurei

3D structure databases

ProteinModelPortaliP91599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 11669CSDAdd
BLAST

Sequence similaritiesi

Belongs to the lin-28 family.Curated
Contains 2 CCHC-type zinc fingers.PROSITE-ProRule annotation
Contains 1 CSD (cold-shock) domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri139 – 15618CCHC-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri162 – 17918CCHC-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3070. Eukaryota.
COG1278. LUCA.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
PRINTSiPR00050. COLDSHOCK.
SMARTiSM00357. CSP. 1 hit.
SM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91599-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTVVSEGRN GGNERYSPQD ELPDLENLKL TDDMRVPSFD RLPSPTPRYY
60 70 80 90 100
GSCKWFNVSK GYGFVIDDIT REDLFVHQSN LNMQGFRSLD EGERVSYYIQ
110 120 130 140 150
ERSNGKGREA YAVSGEVEGQ GLKGSRIHPL GRKKAVSLRC FRCGKFATHK
160 170 180 190 200
AKSCPNVKTD AKVCYTCGSE EHVSSICPER RRKHRPEQVA AEEAEAARLA
210
AETAASSPRG DHDD
Length:214
Mass (Da):23,923
Last modified:May 1, 1997 - v1
Checksum:i04D049A9B654B509
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 3313ELPDL…KLTDD → DVSELIPNLNNIQLNET in AAC47478 (PubMed:9054503).CuratedAdd
BLAST
Sequence conflicti40 – 401D → E in AAC47478 (PubMed:9054503).Curated
Sequence conflicti50 – 501Y → F in AAC47478 (PubMed:9054503).Curated
Sequence conflicti187 – 1871E → D in AAC47478 (PubMed:9054503).Curated
Sequence conflicti196 – 21419AARLA…GDHDD → EAARRAAEESSSTSDEGSSG IKEEHHEHQVKNETSDDSEQ in AAC47478 (PubMed:9054503).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75913 mRNA. Translation: AAC47477.1.
U75914 mRNA. Translation: AAC47478.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75913 mRNA. Translation: AAC47477.1.
U75914 mRNA. Translation: AAC47478.1.

3D structure databases

ProteinModelPortaliP91599.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi31234.CRE28214.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3070. Eukaryota.
COG1278. LUCA.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
PRINTSiPR00050. COLDSHOCK.
SMARTiSM00357. CSP. 1 hit.
SM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA."
    Moss E.G., Lee R.C., Ambros V.
    Cell 88:637-646(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiLIN28_CAERE
AccessioniPrimary (citable) accession number: P91599
Secondary accession number(s): P91602
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: May 1, 1997
Last modified: May 11, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.