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Protein

Protein lin-28

Gene

lin-28

Organism
Caenorhabditis remanei (Caenorhabditis vulgaris)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Heterochronic protein which controls the choice of stage specific cell fates. Regulates the timing of the second larval stage events (L2 events) in the hypodermis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi140Zinc 1By similarity1
Metal bindingi143Zinc 1By similarity1
Metal bindingi149Zinc 1By similarity1
Metal bindingi154Zinc 1By similarity1
Metal bindingi164Zinc 2By similarity1
Metal bindingi167Zinc 2By similarity1
Metal bindingi172Zinc 2By similarity1
Metal bindingi177Zinc 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri139 – 156CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri162 – 179CCHC-type 2PROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-28
Alternative name(s):
Abnormal cell lineage protein 28
Gene namesi
Name:lin-28
OrganismiCaenorhabditis remanei (Caenorhabditis vulgaris)
Taxonomic identifieri31234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002538001 – 214Protein lin-28Add BLAST214

Interactioni

Protein-protein interaction databases

STRINGi31234.CRE28214.

Structurei

3D structure databases

ProteinModelPortaliP91599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 116CSDAdd BLAST69

Sequence similaritiesi

Belongs to the lin-28 family.Curated
Contains 2 CCHC-type zinc fingers.PROSITE-ProRule annotation
Contains 1 CSD (cold-shock) domain.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri139 – 156CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri162 – 179CCHC-type 2PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3070. Eukaryota.
COG1278. LUCA.

Family and domain databases

CDDicd04458. CSP_CDS. 1 hit.
Gene3Di4.10.60.10. 1 hit.
InterProiIPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
PRINTSiPR00050. COLDSHOCK.
SMARTiSM00357. CSP. 1 hit.
SM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91599-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTVVSEGRN GGNERYSPQD ELPDLENLKL TDDMRVPSFD RLPSPTPRYY
60 70 80 90 100
GSCKWFNVSK GYGFVIDDIT REDLFVHQSN LNMQGFRSLD EGERVSYYIQ
110 120 130 140 150
ERSNGKGREA YAVSGEVEGQ GLKGSRIHPL GRKKAVSLRC FRCGKFATHK
160 170 180 190 200
AKSCPNVKTD AKVCYTCGSE EHVSSICPER RRKHRPEQVA AEEAEAARLA
210
AETAASSPRG DHDD
Length:214
Mass (Da):23,923
Last modified:May 1, 1997 - v1
Checksum:i04D049A9B654B509
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21 – 33ELPDL…KLTDD → DVSELIPNLNNIQLNET in AAC47478 (PubMed:9054503).CuratedAdd BLAST13
Sequence conflicti40D → E in AAC47478 (PubMed:9054503).Curated1
Sequence conflicti50Y → F in AAC47478 (PubMed:9054503).Curated1
Sequence conflicti187E → D in AAC47478 (PubMed:9054503).Curated1
Sequence conflicti196 – 214AARLA…GDHDD → EAARRAAEESSSTSDEGSSG IKEEHHEHQVKNETSDDSEQ in AAC47478 (PubMed:9054503).CuratedAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75913 mRNA. Translation: AAC47477.1.
U75914 mRNA. Translation: AAC47478.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75913 mRNA. Translation: AAC47477.1.
U75914 mRNA. Translation: AAC47478.1.

3D structure databases

ProteinModelPortaliP91599.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi31234.CRE28214.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3070. Eukaryota.
COG1278. LUCA.

Family and domain databases

CDDicd04458. CSP_CDS. 1 hit.
Gene3Di4.10.60.10. 1 hit.
InterProiIPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
PF00098. zf-CCHC. 1 hit.
[Graphical view]
PRINTSiPR00050. COLDSHOCK.
SMARTiSM00357. CSP. 1 hit.
SM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIN28_CAERE
AccessioniPrimary (citable) accession number: P91599
Secondary accession number(s): P91602
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: May 1, 1997
Last modified: October 5, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.