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Protein

Protein lin-28

Gene

lin-28

Organism
Caenorhabditis remanei (Caenorhabditis vulgaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Heterochronic protein which controls the choice of stage specific cell fates. Regulates the timing of the second larval stage events (L2 events) in the hypodermis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi140Zinc 1By similarity1
Metal bindingi143Zinc 1By similarity1
Metal bindingi149Zinc 1By similarity1
Metal bindingi154Zinc 1By similarity1
Metal bindingi164Zinc 2By similarity1
Metal bindingi167Zinc 2By similarity1
Metal bindingi172Zinc 2By similarity1
Metal bindingi177Zinc 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri139 – 156CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri162 – 179CCHC-type 2PROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-28
Alternative name(s):
Abnormal cell lineage protein 28
Gene namesi
Name:lin-28
OrganismiCaenorhabditis remanei (Caenorhabditis vulgaris)
Taxonomic identifieri31234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002538001 – 214Protein lin-28Add BLAST214

Structurei

3D structure databases

ProteinModelPortaliP91599
SMRiP91599
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 116CSDAdd BLAST69

Sequence similaritiesi

Belongs to the lin-28 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri139 – 156CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri162 – 179CCHC-type 2PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3070 Eukaryota
COG1278 LUCA

Family and domain databases

CDDicd04458 CSP_CDS, 1 hit
InterProiView protein in InterPro
IPR011129 CSD
IPR002059 CSP_DNA-bd
IPR012340 NA-bd_OB-fold
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00313 CSD, 1 hit
PF00098 zf-CCHC, 1 hit
PRINTSiPR00050 COLDSHOCK
SMARTiView protein in SMART
SM00357 CSP, 1 hit
SM00343 ZnF_C2HC, 2 hits
SUPFAMiSSF50249 SSF50249, 1 hit
SSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS51857 CSD_2, 1 hit
PS50158 ZF_CCHC, 1 hit

Sequencei

Sequence statusi: Complete.

P91599-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTVVSEGRN GGNERYSPQD ELPDLENLKL TDDMRVPSFD RLPSPTPRYY
60 70 80 90 100
GSCKWFNVSK GYGFVIDDIT REDLFVHQSN LNMQGFRSLD EGERVSYYIQ
110 120 130 140 150
ERSNGKGREA YAVSGEVEGQ GLKGSRIHPL GRKKAVSLRC FRCGKFATHK
160 170 180 190 200
AKSCPNVKTD AKVCYTCGSE EHVSSICPER RRKHRPEQVA AEEAEAARLA
210
AETAASSPRG DHDD
Length:214
Mass (Da):23,923
Last modified:May 1, 1997 - v1
Checksum:i04D049A9B654B509
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21 – 33ELPDL…KLTDD → DVSELIPNLNNIQLNET in AAC47478 (PubMed:9054503).CuratedAdd BLAST13
Sequence conflicti40D → E in AAC47478 (PubMed:9054503).Curated1
Sequence conflicti50Y → F in AAC47478 (PubMed:9054503).Curated1
Sequence conflicti187E → D in AAC47478 (PubMed:9054503).Curated1
Sequence conflicti196 – 214AARLA…GDHDD → EAARRAAEESSSTSDEGSSG IKEEHHEHQVKNETSDDSEQ in AAC47478 (PubMed:9054503).CuratedAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75913 mRNA Translation: AAC47477.1
U75914 mRNA Translation: AAC47478.1

Similar proteinsi

Entry informationi

Entry nameiLIN28_CAERE
AccessioniPrimary (citable) accession number: P91599
Secondary accession number(s): P91602
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: May 1, 1997
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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