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Protein
Submitted name:

Transglutiminase

Gene
N/A
Organism
Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Note: Binds 1 calcium ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei348 – 3481UniRule annotation
Active sitei406 – 4061UniRule annotation
Active sitei429 – 4291UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: InterPro

GO - Biological processi

  1. peptide cross-linking Source: InterPro
Complete GO annotation...

Keywords - Ligandi

CalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
TransglutiminaseImported
OrganismiCiona intestinalis (Transparent sea squirt) (Ascidia intestinalis)Imported
Taxonomic identifieri7719 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataTunicataAscidiaceaEnterogonaPhlebobranchiaCionidaeCiona

Interactioni

Protein-protein interaction databases

STRINGi7719.ENSCINP00000000870.

Structurei

3D structure databases

ProteinModelPortaliP91590.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG80379.
HOGENOMiHOG000231695.
KOiK05625.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

P91590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRFRRRWFV IDAENAEEVN EFLDEHPRFL GEYIDRNPHL LDNYVIDNVD
60 70 80 90 100
EETIQKWLDK VSGPAPTEVL QILRVNYKKE TNCVDHHTDK YIHNSLVVRR
110 120 130 140 150
ATTFDLGLVF KNRNYRPAKD DIVLEFTIGS DPTIKNETKI RVPVGDSLQG
160 170 180 190 200
SKWTCMKINE DEVTKEVTLQ VNIPPDAIIG RYKLTVEVAT ELKDGRQKER
210 220 230 240 250
KVKPDIVVLF NPFKPADPVY MESSVEREEY VLNDTGRIYV GQWYRIGAKD
260 270 280 290 300
WLFGQFEEGI LDIALKLLRE HTNAQKNATK SLKKRASPAY CSRLLSAMVN
310 320 330 340 350
CNDDNGVLWG RWDGKYEEGV KPTTWSGSVA ILKQWNRTKM NPVKYGQCWV
360 370 380 390 400
FSGLLTTVLR ALGIPARSIT NFNSAHDTEY NMTIDKFLTE DGESAEGTGD
410 420 430 440 450
SIWNFHVWNE GFFRRPDLPK GYDGWQAVDA TPQEESSGVM QCGPAPIKAI
460 470 480 490 500
KNGEIYIGSD TNFVFAEVNA DRVFWEVNDE GEVTKMVKND KRHVGRNIST
510 520 530 540 550
KAVGSDERED VTLQYKFAEG SEEERVAFER AYAHGRKAPY HDKFVLEDEG
560 570 580 590 600
NIKIDINPVG DVINGSDVSI SVKVTNAKGV DCDATITTVI HTMLNNEERK
610 620 630 640 650
RLLKRSRGTR KIAAGKDDVE SFKFGFGDYG RHLSDENVIR VTTTVRVKET
660 670 680 690 700
NKLYVDQYDI QIESPQCLEL ICADELKVRE YQPIRFKITN PLKVAMTSAV
710 720 730 740 750
FSLQGSGISS GKSFEVPSPI EPGETYTSPE MEVRPYRSSR ATTILGDFDC
760
NEIWNIKARK RVAVNF
Length:766
Mass (Da):87,194
Last modified:November 1, 1998 - v2
Checksum:i7F90D921D87FDD1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10212 mRNA. Translation: CAA71263.1.
RefSeqiNP_001027712.1. NM_001032540.1.
UniGeneiCin.22973.

Genome annotation databases

GeneIDi445739.
KEGGicin:445739.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10212 mRNA. Translation: CAA71263.1.
RefSeqiNP_001027712.1. NM_001032540.1.
UniGeneiCin.22973.

3D structure databases

ProteinModelPortaliP91590.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7719.ENSCINP00000000870.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi445739.
KEGGicin:445739.

Organism-specific databases

CTDi7052.

Phylogenomic databases

eggNOGiNOG80379.
HOGENOMiHOG000231695.
KOiK05625.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "A new transglutaminase-like from the ascidian Ciona intestinalis."
    Cariello L., Ristoratore F., Zanetti L.
    FEBS Lett. 408:171-176(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cariello L.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiP91590_CIOIN
AccessioniPrimary (citable) accession number: P91590
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: November 1, 1998
Last modified: November 26, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.