Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Warthog protein 6

Gene

wrt-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Intercellular signal essential for a variety of patterning events during development.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei460Involved in auto-cleavageBy similarity1
Sitei463Essential for auto-cleavageBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase, Protease

Protein family/group databases

MEROPSiC46.A04.

Names & Taxonomyi

Protein namesi
Recommended name:
Warthog protein 6
Cleaved into the following 2 chains:
Gene namesi
Name:wrt-6
ORF Names:ZK377.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiZK377.1; CE37175; WBGene00006952; wrt-6.

Subcellular locationi

Warthog protein 6 :
  • Secreted By similarity
  • Cell surface By similarity

  • Note: Also secreted in either cleaved or uncleaved form to mediate signaling to other cells.By similarity
Warthog protein 6 C-product :
  • Secretedextracellular space By similarity

  • Note: Also secreted in either cleaved or uncleaved form to mediate signaling to other cells.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000026864320 – 593Warthog protein 6Add BLAST574
ChainiPRO_000026864420 – 394Warthog protein 6 N-productBy similarityAdd BLAST375
ChainiPRO_0000268645395 – 593Warthog protein 6 C-productBy similarityAdd BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi95N-linked (GlcNAc...)1 Publication1

Post-translational modificationi

The C-terminal domain displays an autoproteolysis activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei394 – 395Cleavage; by autolysisBy similarity2

Keywords - PTMi

Autocatalytic cleavage, Glycoprotein

Proteomic databases

PaxDbiP91573.
PeptideAtlasiP91573.
PRIDEiP91573.

Expressioni

Tissue specificityi

Expressed in 4 to 7 sheath and socket cells of the anterior sensilla.1 Publication

Gene expression databases

BgeeiWBGene00006952.

Interactioni

Protein-protein interaction databases

IntActiP91573. 1 interactor.
STRINGi6239.ZK377.1.

Structurei

3D structure databases

ProteinModelPortaliP91573.
SMRiP91573.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi185 – 247Arg-richAdd BLAST63
Compositional biasi283 – 288Poly-Pro6

Sequence similaritiesi

Belongs to the hedgehog family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3638. Eukaryota.
ENOG410XQA3. LUCA.
GeneTreeiENSGT00530000065008.
HOGENOMiHOG000020214.
InParanoidiP91573.
OMAiNENALWP.
OrthoDBiEOG091G0N90.
PhylomeDBiP91573.

Family and domain databases

Gene3Di2.170.16.10. 1 hit.
InterProiIPR001657. Hedgehog.
IPR028992. Hedgehog/Intein_dom.
IPR001767. Hint_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR006141. Intein_N.
[Graphical view]
PfamiPF01079. Hint. 1 hit.
[Graphical view]
PRINTSiPR00632. SONICHHOG.
SMARTiSM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view]
SUPFAMiSSF51294. SSF51294. 1 hit.
PROSITEiPS50817. INTEIN_N_TER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P91573-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLLNLFYCF CLLFGAVLAD SIHDGGSCGT NSIPYKMEVD SEGKPVISCE
60 70 80 90 100
APSCLGVSSS AARRPRVLDV SCDPFKEIVC VKDLQWTSGL VEINNGTHRT
110 120 130 140 150
LKTECCSYEG MSDAKTIKSI FLGPGQSFVG GMVEKDGEQS GFDLIKEIRK
160 170 180 190 200
TVNADNQVQY IVGVYRMPCE ATSDSSEEAL PLLSRNRRKL RDRVGKYDDY
210 220 230 240 250
EEDRNYRSER RRPFAMRRRA LLQRLEDMYD DYDYEFRVVR RPFRKSRLPY
260 270 280 290 300
NENALWPLQY SSPQRSRTFA DNTYNKETVE SGPLPPPPSS NYIDNVAPAS
310 320 330 340 350
PVVQSPAYPQ TPAEMPLPPQ SGSYSGSYSG YPTADASQYN AYPAMQQPAY
360 370 380 390 400
QPAYQPAYQP AYQPAYQPAY QPAYSARGYS PNLNGLFGGT GMQCFSGDME
410 420 430 440 450
VETEDGIKMI KDLKIGDKVL SMDEAFVTYS PVIMFLHKRD EEIAEFNLIE
460 470 480 490 500
TANGHSIKLT DNHLIYVSDC RTRSDLKLVA AKEVKMDDCI HVTTDSNVVI
510 520 530 540 550
KKKVSKISKV IETGIYSPLT STGDIIVNRV LASCHSNLAL KSLQQTFFSL
560 570 580 590
YKRTSSVFHN LMFFKSSTEE GDLPVGVETL TSVMDLFIPQ SFV
Length:593
Mass (Da):66,416
Last modified:September 13, 2004 - v2
Checksum:i1E590B780E2F4A8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080516 Genomic DNA. Translation: CCD64326.1.
AF139521 mRNA. Translation: AAD33831.1.
PIRiT29550.
RefSeqiNP_508597.2. NM_076196.5.
UniGeneiCel.39255.

Genome annotation databases

EnsemblMetazoaiZK377.1; ZK377.1; WBGene00006952.
GeneIDi180638.
KEGGicel:CELE_ZK377.1.
UCSCiZK377.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080516 Genomic DNA. Translation: CCD64326.1.
AF139521 mRNA. Translation: AAD33831.1.
PIRiT29550.
RefSeqiNP_508597.2. NM_076196.5.
UniGeneiCel.39255.

3D structure databases

ProteinModelPortaliP91573.
SMRiP91573.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP91573. 1 interactor.
STRINGi6239.ZK377.1.

Protein family/group databases

MEROPSiC46.A04.

Proteomic databases

PaxDbiP91573.
PeptideAtlasiP91573.
PRIDEiP91573.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK377.1; ZK377.1; WBGene00006952.
GeneIDi180638.
KEGGicel:CELE_ZK377.1.
UCSCiZK377.1. c. elegans.

Organism-specific databases

CTDi180638.
WormBaseiZK377.1; CE37175; WBGene00006952; wrt-6.

Phylogenomic databases

eggNOGiKOG3638. Eukaryota.
ENOG410XQA3. LUCA.
GeneTreeiENSGT00530000065008.
HOGENOMiHOG000020214.
InParanoidiP91573.
OMAiNENALWP.
OrthoDBiEOG091G0N90.
PhylomeDBiP91573.

Miscellaneous databases

PROiP91573.

Gene expression databases

BgeeiWBGene00006952.

Family and domain databases

Gene3Di2.170.16.10. 1 hit.
InterProiIPR001657. Hedgehog.
IPR028992. Hedgehog/Intein_dom.
IPR001767. Hint_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR006141. Intein_N.
[Graphical view]
PfamiPF01079. Hint. 1 hit.
[Graphical view]
PRINTSiPR00632. SONICHHOG.
SMARTiSM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view]
SUPFAMiSSF51294. SSF51294. 1 hit.
PROSITEiPS50817. INTEIN_N_TER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWRT6_CAEEL
AccessioniPrimary (citable) accession number: P91573
Secondary accession number(s): Q9U7D2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: September 13, 2004
Last modified: November 2, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.