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P91477 (PSB2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteasome subunit beta type-2

EC=3.4.25.1
Alternative name(s):
Proteasome subunit beta 4
Gene names
Name:pbs-4
ORF Names:T20F5.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1B family.

Sequence caution

The sequence CCD67779.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 199199Proteasome subunit beta type-2
PRO_0000148046

Sequences

Sequence LengthMass (Da)Tools
P91477 [UniParc].

Last modified October 18, 2001. Version 2.
Checksum: 27510AF7CBA8DEBF

FASTA19922,549
        10         20         30         40         50         60 
MHFLVGISTE NYVILAADKA TFAYGAILAD SENDKEYRLG KKLTMMCIGE EGDVAQFGDW 

        70         80         90        100        110        120 
TKRNLQLYSV RNGYEVSPSC AHHFVRRSIA EGLRSQDHYT VDVLIGGYDD KEDKAFLGSV 

       130        140        150        160        170        180 
DYLANGLGQQ PYLFRGFCGR FCYAIMDREY KKDMTEAEGL ALMNKCIGEA KRRFVANIPG 

       190 
YKVVIIDKKG YRKLDDVLF 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO080916 Genomic DNA. Translation: CCD67779.1. Different initiation.
PIRT29206.
RefSeqNP_491261.1. NM_058860.6.
UniGeneCel.20577.

3D structure databases

ProteinModelPortalP91477.
SMRP91477. Positions 1-196.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.T20F5.2.

Protein family/group databases

MEROPST01.984.

Proteomic databases

PaxDbP91477.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID171975.
KEGGcel:CELE_T20F5.2.
UCSCT20F5.2. c. elegans.

Organism-specific databases

CTD171975.
WormBaseT20F5.2; CE13818; WBGene00003950; pbs-4.

Phylogenomic databases

eggNOGCOG0638.
HOGENOMHOG000188743.
InParanoidP91477.
KOK02734.
PhylomeDBP91477.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio873489.
PROP91477.

Entry information

Entry namePSB2_CAEEL
AccessionPrimary (citable) accession number: P91477
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: June 11, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase