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P91477

- PSB2_CAEEL

UniProt

P91477 - PSB2_CAEEL

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Protein
Proteasome subunit beta type-2
Gene
pbs-4, T20F5.2
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. proteolysis involved in cellular protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiREACT_101459. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_183279. ER-Phagosome pathway.
REACT_183284. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_184635. Orc1 removal from chromatin.
REACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
REACT_215136. Asymmetric localization of PCP proteins.

Protein family/group databases

MEROPSiT01.984.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-2 (EC:3.4.25.1)
Alternative name(s):
Proteasome subunit beta 4
Gene namesi
Name:pbs-4
ORF Names:T20F5.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiT20F5.2; CE13818; WBGene00003950; pbs-4.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
  3. proteasome core complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Proteasome subunit beta type-2
PRO_0000148046Add
BLAST

Proteomic databases

PaxDbiP91477.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Protein-protein interaction databases

STRINGi6239.T20F5.2.

Structurei

3D structure databases

ProteinModelPortaliP91477.
SMRiP91477. Positions 1-196.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.

Phylogenomic databases

eggNOGiCOG0638.
HOGENOMiHOG000188743.
InParanoidiP91477.
KOiK02734.
PhylomeDBiP91477.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91477-1 [UniParc]FASTAAdd to Basket

« Hide

MHFLVGISTE NYVILAADKA TFAYGAILAD SENDKEYRLG KKLTMMCIGE    50
EGDVAQFGDW TKRNLQLYSV RNGYEVSPSC AHHFVRRSIA EGLRSQDHYT 100
VDVLIGGYDD KEDKAFLGSV DYLANGLGQQ PYLFRGFCGR FCYAIMDREY 150
KKDMTEAEGL ALMNKCIGEA KRRFVANIPG YKVVIIDKKG YRKLDDVLF 199
Length:199
Mass (Da):22,549
Last modified:October 18, 2001 - v2
Checksum:i27510AF7CBA8DEBF
GO

Sequence cautioni

The sequence CCD67779.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080916 Genomic DNA. Translation: CCD67779.1. Different initiation.
PIRiT29206.
RefSeqiNP_491261.1. NM_058860.6.
UniGeneiCel.20577.

Genome annotation databases

GeneIDi171975.
KEGGicel:CELE_T20F5.2.
UCSCiT20F5.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080916 Genomic DNA. Translation: CCD67779.1 . Different initiation.
PIRi T29206.
RefSeqi NP_491261.1. NM_058860.6.
UniGenei Cel.20577.

3D structure databases

ProteinModelPortali P91477.
SMRi P91477. Positions 1-196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.T20F5.2.

Protein family/group databases

MEROPSi T01.984.

Proteomic databases

PaxDbi P91477.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 171975.
KEGGi cel:CELE_T20F5.2.
UCSCi T20F5.2. c. elegans.

Organism-specific databases

CTDi 171975.
WormBasei T20F5.2 ; CE13818 ; WBGene00003950 ; pbs-4.

Phylogenomic databases

eggNOGi COG0638.
HOGENOMi HOG000188743.
InParanoidi P91477.
KOi K02734.
PhylomeDBi P91477.

Enzyme and pathway databases

Reactomei REACT_101459. Regulation of activated PAK-2p34 by proteasome mediated degradation.
REACT_183279. ER-Phagosome pathway.
REACT_183284. Cross-presentation of soluble exogenous antigens (endosomes).
REACT_183296. Antigen processing: Ubiquitination & Proteasome degradation.
REACT_184635. Orc1 removal from chromatin.
REACT_205379. SCF-beta-TrCP mediated degradation of Emi1.
REACT_215136. Asymmetric localization of PCP proteins.

Miscellaneous databases

NextBioi 873489.
PROi P91477.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPSB2_CAEEL
AccessioniPrimary (citable) accession number: P91477
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: September 3, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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