P91455 (APT_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine phosphoribosyltransferase
Short name=APRT
EC=2.4.2.7

Gene names

ORF Names:

T19B4.3

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity.
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	adenine salvage Inferred from electronic annotation. Source: InterPro purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Adenine phosphoribosyltransferase		PRO_0000149511

Sequences

	Sequence		Length	Mass (Da)
	P91455 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 91A984C4F770F268	FASTA	185	20,210
	10 20 30 40 50 60 MTLPRFDQIR PKIEQHIREV KDFPKKGINF RDIMPLFTNP QLVNELCVVI ADHVRHTVGH 70 80 90 100 110 120 VDSVAGLEAR GFLFGPQVAI QLGVPFVPIR KKGKLPGATI EASYVKEYGE DRVEIQEGAI 130 140 150 160 170 180 KNGDIVFLID DLLATGGTLR AATDLVVKAG GKVGEAFVLI ELAPLNGRSK LPDVNLTTLI SYDSA

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"The Caenorhabditis elegans transcriptome project, a complementary view of the genome." Kohara Y., Shin-i T., Suzuki Y., Sugano S., Potdevin M., Thierry-Mieg Y., Thierry-Mieg D., Thierry-Mieg J. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO080338 Genomic DNA. Translation: CCD62975.1. AF303266 mRNA. Translation: AAG50224.1.
PIR	T25891.
RefSeq	NP_491663.1. NM_059262.6.
UniGene	Cel.35570.
3D structure databases
ProteinModelPortal	P91455.
SMR	P91455. Positions 7-183.
ModBase	Search...
Protein-protein interaction databases
STRING	P91455.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	T19B4.3.1; T19B4.3.1; T19B4.3. T19B4.3.2; T19B4.3.2; T19B4.3.
GeneID	172232.
KEGG	cel:T19B4.3.
UCSC	T19B4.3.1. c. elegans.
Organism-specific databases
CTD	172232.
WormBase	T19B4.3; CE13740; WBGene00020557.
Phylogenomic databases
eggNOG	meNOG17119.
GeneTree	EMGT00050000016639.
HOGENOM	HBG703830.
InParanoid	P91455.
OMA	MNAACEL.
PhylomeDB	P91455.
Gene expression databases
ArrayExpress	P91455.
Family and domain databases
InterPro	IPR005764. Ade_phspho_trans. IPR000836. PRibTrfase. [Graphical view]
KO	K00759.
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01090. Apt. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	874607.

Entry information

Entry name

APT_CAEEL

Accession

Primary (citable) accession number: P91455

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	May 1, 1997
Last modified:	December 14, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project