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Protein

Adenine phosphoribosyltransferase

Gene

T19B4.3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.By similarity

Catalytic activityi

AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathwayi: AMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes AMP from adenine.
Proteins known to be involved in this subpathway in this organism are:
  1. Adenine phosphoribosyltransferase (T19B4.3)
This subpathway is part of the pathway AMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from adenine, the pathway AMP biosynthesis via salvage pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

ReactomeiR-CEL-74217. Purine salvage.
UniPathwayiUPA00588; UER00646.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenine phosphoribosyltransferase (EC:2.4.2.7)
Short name:
APRT
Gene namesi
ORF Names:T19B4.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiT19B4.3; CE13740; WBGene00020557.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Adenine phosphoribosyltransferasePRO_0000149511Add
BLAST

Proteomic databases

EPDiP91455.
PaxDbiP91455.

Interactioni

Protein-protein interaction databases

STRINGi6239.T19B4.3.1.

Structurei

3D structure databases

ProteinModelPortaliP91455.
SMRiP91455. Positions 17-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1712. Eukaryota.
COG0503. LUCA.
GeneTreeiENSGT00390000017259.
HOGENOMiHOG000036776.
InParanoidiP91455.
KOiK00759.
OMAiVHALCAF.
OrthoDBiEOG7FFMT9.
PhylomeDBiP91455.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_00004. Aden_phosphoribosyltr.
InterProiIPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01090. apt. 1 hit.

Sequencei

Sequence statusi: Complete.

P91455-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLPRFDQIR PKIEQHIREV KDFPKKGINF RDIMPLFTNP QLVNELCVVI
60 70 80 90 100
ADHVRHTVGH VDSVAGLEAR GFLFGPQVAI QLGVPFVPIR KKGKLPGATI
110 120 130 140 150
EASYVKEYGE DRVEIQEGAI KNGDIVFLID DLLATGGTLR AATDLVVKAG
160 170 180
GKVGEAFVLI ELAPLNGRSK LPDVNLTTLI SYDSA
Length:185
Mass (Da):20,210
Last modified:May 1, 1997 - v1
Checksum:i91A984C4F770F268
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080338 Genomic DNA. Translation: CCD62975.1.
AF303266 mRNA. Translation: AAG50224.1.
PIRiT25891.
RefSeqiNP_491663.1. NM_059262.7.
UniGeneiCel.35570.

Genome annotation databases

EnsemblMetazoaiT19B4.3; T19B4.3; WBGene00020557.
GeneIDi172232.
KEGGicel:CELE_T19B4.3.
UCSCiT19B4.3.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080338 Genomic DNA. Translation: CCD62975.1.
AF303266 mRNA. Translation: AAG50224.1.
PIRiT25891.
RefSeqiNP_491663.1. NM_059262.7.
UniGeneiCel.35570.

3D structure databases

ProteinModelPortaliP91455.
SMRiP91455. Positions 17-171.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T19B4.3.1.

Proteomic databases

EPDiP91455.
PaxDbiP91455.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT19B4.3; T19B4.3; WBGene00020557.
GeneIDi172232.
KEGGicel:CELE_T19B4.3.
UCSCiT19B4.3.1. c. elegans.

Organism-specific databases

CTDi172232.
WormBaseiT19B4.3; CE13740; WBGene00020557.

Phylogenomic databases

eggNOGiKOG1712. Eukaryota.
COG0503. LUCA.
GeneTreeiENSGT00390000017259.
HOGENOMiHOG000036776.
InParanoidiP91455.
KOiK00759.
OMAiVHALCAF.
OrthoDBiEOG7FFMT9.
PhylomeDBiP91455.

Enzyme and pathway databases

UniPathwayiUPA00588; UER00646.
ReactomeiR-CEL-74217. Purine salvage.

Miscellaneous databases

NextBioi874607.
PROiP91455.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_00004. Aden_phosphoribosyltr.
InterProiIPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01090. apt. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "The Caenorhabditis elegans transcriptome project, a complementary view of the genome."
    Kohara Y., Shin-i T., Suzuki Y., Sugano S., Potdevin M., Thierry-Mieg Y., Thierry-Mieg D., Thierry-Mieg J.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiAPT_CAEEL
AccessioniPrimary (citable) accession number: P91455
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 1, 1997
Last modified: March 16, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.