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Protein

Unconventional myosin heavy chain 6

Gene

hum-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi155 – 162ATPBy similarity8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • motor activity Source: InterPro
  • transcription factor binding Source: UniProtKB

GO - Biological processi

  • signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-2453902. The canonical retinoid cycle in rods (twilight vision).

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin heavy chain 6
Gene namesi
Name:hum-61 Publication
ORF Names:T10H10.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT10H10.1; CE13575; WBGene00002039; hum-6.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • myosin VI complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003062471 – 2098Unconventional myosin heavy chain 6Add BLAST2098

Proteomic databases

EPDiP91443.
PaxDbiP91443.
PeptideAtlasiP91443.
PRIDEiP91443.

PTM databases

iPTMnetiP91443.

Expressioni

Gene expression databases

BgeeiWBGene00002039.

Interactioni

Subunit structurei

Interacts with unc-98.1 Publication

GO - Molecular functioni

  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi45484. 2 interactors.
IntActiP91443. 1 interactor.
MINTiMINT-227760.
STRINGi6239.T10H10.1.

Structurei

3D structure databases

ProteinModelPortaliP91443.
SMRiP91443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 732Myosin motorAdd BLAST671
Domaini735 – 757IQ 1PROSITE-ProRule annotationCuratedAdd BLAST23
Domaini758 – 787IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini804 – 833IQ 3PROSITE-ProRule annotationAdd BLAST30
Domaini929 – 1168MyTH4 1PROSITE-ProRule annotationAdd BLAST240
Domaini1171 – 1211Ras-associatingSequence analysisAdd BLAST41
Domaini1173 – 1481FERM 1PROSITE-ProRule annotationAdd BLAST309
Domaini1624 – 1772MyTH4 2PROSITE-ProRule annotationAdd BLAST149
Domaini1778 – 2086FERM 2PROSITE-ProRule annotationAdd BLAST309

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni609 – 631Actin-bindingBy similarityAdd BLAST23
Regioni711 – 725Actin-bindingBy similarityAdd BLAST15

Sequence similaritiesi

Contains 2 FERM domains.PROSITE-ProRule annotation
Contains 3 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 2 MyTH4 domains.PROSITE-ProRule annotation
Contains 1 Ras-associating domain.Sequence analysis

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4229. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129687.
HOGENOMiHOG000007836.
InParanoidiP91443.
KOiK10359.
OMAiTPWHNPS.
OrthoDBiEOG091G00BB.
PhylomeDBiP91443.

Family and domain databases

Gene3Di1.20.80.10. 2 hits.
2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR000857. MyTH4_dom.
IPR027417. P-loop_NTPase.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00373. FERM_M. 2 hits.
PF00612. IQ. 3 hits.
PF00063. Myosin_head. 1 hit.
PF00784. MyTH4. 2 hits.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00295. B41. 2 hits.
SM00015. IQ. 3 hits.
SM00242. MYSc. 1 hit.
SM00139. MyTH4. 2 hits.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 2 hits.
SSF50729. SSF50729. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54236. SSF54236. 2 hits.
PROSITEiPS50057. FERM_3. 2 hits.
PS50096. IQ. 3 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51016. MYTH4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91443-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLVSKGDFI WIEPGKTEGS IPIGARVIDQ DHGRLKVIDD LGNEQWLSAD
60 70 80 90 100
RRVRLMHPTS VQGVEDMCQL GDFHESAILR NLFIRYREKL IYAYTGSILI
110 120 130 140 150
AVNPYMDIAI YTADEIRMYK RKRIGELPPH IFAIADNAYT NMRREKKNQS
160 170 180 190 200
VIISGESGAG KTESTKLVLQ FLATISGQHS WIEQQVLEAN PVLEAFGNAK
210 220 230 240 250
TIRNDNSSRF GKYIDVHFNE SGSIEGAKIE QYLLEKSRIV TQSENERNYH
260 270 280 290 300
IFYCLLAGLS REEKSELELG TAADYYYLIQ GKTLTAEGRD DAADLAEIRS
310 320 330 340 350
AMRVLMINEQ EIGSIFKLLA SLLHIGNIRF RQNTNDNMES VDVADPSTLV
360 370 380 390 400
RIAKLLQLHE QNLLDAITTK SLVTREERVI SRLNGQQAVD ARDALAKAIY
410 420 430 440 450
GKLFIHIVRR VNDAIYKPSQ SRRTSIGILD IFGFENFESN SFEQLCINFA
460 470 480 490 500
NETLQQFFVH HVFKMEQKEY DEEHINWRHI KFVDNQATVD LIAQRPLNIL
510 520 530 540 550
SLIDEESIFP KGTDKTMLLK LHSTHGRNEL YLQPKSELQR AFGVTHFAGN
560 570 580 590 600
VFYNTRGFLE KNRDSFSADL SVLISSSKMP FLARLFDDIE YDTSSRKKVT
610 620 630 640 650
VGNQFRRSLE QLMSQLTQTH PFFIRCIKPN EMKRALVMDR DLVLRQLRYS
660 670 680 690 700
GMMETIKIRR SGYPIRHDYY PFVFRYRVLV SSIQGPVNRI DLHDAAKKIC
710 720 730 740 750
HMILGTNADY QLGKTKVFLK DKHDLVLEQE YYRILKDKAI VIQKNVRRWL
760 770 780 790 800
VRKDFEKQRQ AAVTIQTAWR GFDQRKRYRQ IISGFSRLQA VLRSRQLVSH
810 820 830 840 850
YQTLRKTIIQ FQAVCRGSLV RRQVGEKRKR GEKAPLTEVS STASVISDSH
860 870 880 890 900
EELVGHLFDF LPSDGKDSGN ENDSADSSRR GSYSRLHTSP VMPPANIPRV
910 920 930 940 950
DSYVDEDLSK YQFGKYAATF FQAQATATHV KKPLKTALLT HTEPSAQLAA
960 970 980 990 1000
LTAWTTILRF MGDLADVKPG STNGSEVYDK TPVMIKLYAT LGKKFSAHDL
1010 1020 1030 1040 1050
EEAMLSSEYG GAKTLKKGMG RKLISMTLKR KGKINGSDTS SISSDSVYSS
1060 1070 1080 1090 1100
FNAMLENKPM TSLDKLHYII GLGILREDLR DEIYCQLCKQ LSNNPSKLSA
1110 1120 1130 1140 1150
ARGWILLSLC VGCFAPSERF IKYLFCFIRE RGPAGTGYSK YIEDRLRRTQ
1160 1170 1180 1190 1200
VNGTRHQPPS YVELQANKSQ KPVVLAVTFM DGSVKTLCAD SATTAAELCK
1210 1220 1230 1240 1250
QLAEKVGLTN SFGFSLYIAL FDKVSSLGSG TDHVMDAISQ CEQYAKEQGR
1260 1270 1280 1290 1300
QERNAPWRLF FRKEIFSPWH DPRDDPVSTN LIYQQVIRGI KYGEYRCDKD
1310 1320 1330 1340 1350
EELAAICAQQ YYIDEGTMDV NKLENNLPSY LPDFEMSGKE MALEKWTQTI
1360 1370 1380 1390 1400
MHQYRKKFTG RLPSQIEVKE NVVSVAKTKW PLLFSRFYEA LKFAGPPLPK
1410 1420 1430 1440 1450
NEVIIAVNWT GVYVVDDREH VMLEFSFPEI STAYYGKGKR STTDTCTVRT
1460 1470 1480 1490 1500
VVGDEYTFQS PNADDITNLI VMFLEGLKKR SRYLVAIKSQ KGDEKNNFLE
1510 1520 1530 1540 1550
FEKGDLLILV NEFTGNTLLT ESVVKGENSR TCLFGLIRAE NVYVLPTLVK
1560 1570 1580 1590 1600
PSKNTLQIFP KDMDLSLDLF NNNKQVTVVD YNAEPYTLEN FAEDNFNSQV
1610 1620 1630 1640 1650
KRVGSQISLM TLRKKESQIE CWRFSREHID QPLLKKLNGR EDACRGAIEI
1660 1670 1680 1690 1700
FAAIMKYMGD EPSKRSRLGT HLTDHIFKLP ISMEALRDEL YCQLVKQLTL
1710 1720 1730 1740 1750
NPSIMSEERG WELLWMATGL FAPSAALAKE ISHFLKSRPH PIALDCQNRM
1760 1770 1780 1790 1800
QKLAKGGSRK YPPHLVEVEA IQHKTTQIFH KVFFPDNTDE AIEVDSATRA
1810 1820 1830 1840 1850
RDFCHKIGYR LGLKSSDGFS LFVKIKDKVL AVPESEFFFD YVRSLSDWVH
1860 1870 1880 1890 1900
TNHATQKDAT MIPINYQVYF MRKLWYNFVA GADPQADIIF HYHQESQKYL
1910 1920 1930 1940 1950
LGYHKTTKND VIELAALILR SMTKDGKNAP LAQIPQLLDE IIPKDSLKMY
1960 1970 1980 1990 2000
SASEWRKTIS NAYARIEHLK SDQAKIEFLN YICRWPTFGS AFFPVSQYSD
2010 2020 2030 2040 2050
LNLPDRLLLA INQTGVNIYH LDTKNLLVQY PFNVICNWTS GNTYFNMTVG
2060 2070 2080 2090
NMLKGNEGKK LLLDTTVGYK MDDLLTSYIS LLISNQNNHP SKTREVAL
Length:2,098
Mass (Da):239,785
Last modified:May 1, 1997 - v1
Checksum:iA972E51FC54B73BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080098 Genomic DNA. Translation: CCD61190.1.
PIRiT25888.
RefSeqiNP_508420.1. NM_076019.3.
UniGeneiCel.767.

Genome annotation databases

EnsemblMetazoaiT10H10.1; T10H10.1; WBGene00002039.
GeneIDi180539.
KEGGicel:CELE_T10H10.1.
UCSCiT10H10.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080098 Genomic DNA. Translation: CCD61190.1.
PIRiT25888.
RefSeqiNP_508420.1. NM_076019.3.
UniGeneiCel.767.

3D structure databases

ProteinModelPortaliP91443.
SMRiP91443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi45484. 2 interactors.
IntActiP91443. 1 interactor.
MINTiMINT-227760.
STRINGi6239.T10H10.1.

PTM databases

iPTMnetiP91443.

Proteomic databases

EPDiP91443.
PaxDbiP91443.
PeptideAtlasiP91443.
PRIDEiP91443.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT10H10.1; T10H10.1; WBGene00002039.
GeneIDi180539.
KEGGicel:CELE_T10H10.1.
UCSCiT10H10.1. c. elegans.

Organism-specific databases

CTDi180539.
WormBaseiT10H10.1; CE13575; WBGene00002039; hum-6.

Phylogenomic databases

eggNOGiKOG4229. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129687.
HOGENOMiHOG000007836.
InParanoidiP91443.
KOiK10359.
OMAiTPWHNPS.
OrthoDBiEOG091G00BB.
PhylomeDBiP91443.

Enzyme and pathway databases

ReactomeiR-CEL-2453902. The canonical retinoid cycle in rods (twilight vision).

Miscellaneous databases

PROiP91443.

Gene expression databases

BgeeiWBGene00002039.

Family and domain databases

Gene3Di1.20.80.10. 2 hits.
2.30.29.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR000857. MyTH4_dom.
IPR027417. P-loop_NTPase.
IPR011993. PH_dom-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00373. FERM_M. 2 hits.
PF00612. IQ. 3 hits.
PF00063. Myosin_head. 1 hit.
PF00784. MyTH4. 2 hits.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00295. B41. 2 hits.
SM00015. IQ. 3 hits.
SM00242. MYSc. 1 hit.
SM00139. MyTH4. 2 hits.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 2 hits.
SSF50729. SSF50729. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54236. SSF54236. 2 hits.
PROSITEiPS50057. FERM_3. 2 hits.
PS50096. IQ. 3 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51016. MYTH4. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHUM6_CAEEL
AccessioniPrimary (citable) accession number: P91443
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.