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Protein

Unconventional myosin heavy chain 6

Gene

hum-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi155 – 162ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

  • microtubule-based movement Source: InterPro
  • signal transduction Source: UniProtKB

Keywordsi

Molecular functionActin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-2453902 The canonical retinoid cycle in rods (twilight vision)

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin heavy chain 6
Gene namesi
Name:hum-61 Publication
ORF Names:T10H10.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiT10H10.1 ; CE13575 ; WBGene00002039 ; hum-6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003062471 – 2098Unconventional myosin heavy chain 6Add BLAST2098

Proteomic databases

EPDiP91443
PaxDbiP91443
PeptideAtlasiP91443
PRIDEiP91443

PTM databases

iPTMnetiP91443

Expressioni

Gene expression databases

BgeeiWBGene00002039

Interactioni

Subunit structurei

Interacts with unc-98.1 Publication

GO - Molecular functioni

  • actin filament binding Source: InterPro
  • microtubule binding Source: InterPro
  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi45484, 2 interactors
IntActiP91443, 1 interactor
MINTiP91443
STRINGi6239.T10H10.1

Structurei

3D structure databases

ProteinModelPortaliP91443
SMRiP91443
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 732Myosin motorPROSITE-ProRule annotationAdd BLAST671
Domaini735 – 757IQ 1PROSITE-ProRule annotationCuratedAdd BLAST23
Domaini758 – 787IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini804 – 833IQ 3PROSITE-ProRule annotationAdd BLAST30
Domaini929 – 1168MyTH4 1PROSITE-ProRule annotationAdd BLAST240
Domaini1171 – 1211Ras-associatingSequence analysisAdd BLAST41
Domaini1173 – 1481FERM 1PROSITE-ProRule annotationAdd BLAST309
Domaini1479 – 1547SH3PROSITE-ProRule annotationAdd BLAST69
Domaini1624 – 1772MyTH4 2PROSITE-ProRule annotationAdd BLAST149
Domaini1778 – 2086FERM 2PROSITE-ProRule annotationAdd BLAST309

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni609 – 631Actin-bindingBy similarityAdd BLAST23
Regioni711 – 725Actin-bindingBy similarityAdd BLAST15

Sequence similaritiesi

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG4229 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140810
HOGENOMiHOG000007836
InParanoidiP91443
KOiK10359
OMAiTPWHNPS
OrthoDBiEOG091G00BB
PhylomeDBiP91443

Family and domain databases

CDDicd14473 FERM_B-lobe, 2 hits
cd01381 MYSc_Myo7, 1 hit
Gene3Di1.20.80.10, 1 hit
1.25.40.530, 2 hits
2.30.29.30, 2 hits
2.30.30.360, 1 hit
3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR008989 Myosin_S1_N
IPR036106 MYSc_Myo7
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR001452 SH3_domain
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00373 FERM_M, 2 hits
PF00612 IQ, 3 hits
PF00063 Myosin_head, 1 hit
PF00784 MyTH4, 2 hits
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00295 B41, 2 hits
SM00015 IQ, 3 hits
SM00242 MYSc, 1 hit
SM00139 MyTH4, 2 hits
SUPFAMiSSF47031 SSF47031, 2 hits
SSF52540 SSF52540, 1 hit
SSF54236 SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS50057 FERM_3, 2 hits
PS50096 IQ, 3 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 2 hits
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

P91443-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLVSKGDFI WIEPGKTEGS IPIGARVIDQ DHGRLKVIDD LGNEQWLSAD
60 70 80 90 100
RRVRLMHPTS VQGVEDMCQL GDFHESAILR NLFIRYREKL IYAYTGSILI
110 120 130 140 150
AVNPYMDIAI YTADEIRMYK RKRIGELPPH IFAIADNAYT NMRREKKNQS
160 170 180 190 200
VIISGESGAG KTESTKLVLQ FLATISGQHS WIEQQVLEAN PVLEAFGNAK
210 220 230 240 250
TIRNDNSSRF GKYIDVHFNE SGSIEGAKIE QYLLEKSRIV TQSENERNYH
260 270 280 290 300
IFYCLLAGLS REEKSELELG TAADYYYLIQ GKTLTAEGRD DAADLAEIRS
310 320 330 340 350
AMRVLMINEQ EIGSIFKLLA SLLHIGNIRF RQNTNDNMES VDVADPSTLV
360 370 380 390 400
RIAKLLQLHE QNLLDAITTK SLVTREERVI SRLNGQQAVD ARDALAKAIY
410 420 430 440 450
GKLFIHIVRR VNDAIYKPSQ SRRTSIGILD IFGFENFESN SFEQLCINFA
460 470 480 490 500
NETLQQFFVH HVFKMEQKEY DEEHINWRHI KFVDNQATVD LIAQRPLNIL
510 520 530 540 550
SLIDEESIFP KGTDKTMLLK LHSTHGRNEL YLQPKSELQR AFGVTHFAGN
560 570 580 590 600
VFYNTRGFLE KNRDSFSADL SVLISSSKMP FLARLFDDIE YDTSSRKKVT
610 620 630 640 650
VGNQFRRSLE QLMSQLTQTH PFFIRCIKPN EMKRALVMDR DLVLRQLRYS
660 670 680 690 700
GMMETIKIRR SGYPIRHDYY PFVFRYRVLV SSIQGPVNRI DLHDAAKKIC
710 720 730 740 750
HMILGTNADY QLGKTKVFLK DKHDLVLEQE YYRILKDKAI VIQKNVRRWL
760 770 780 790 800
VRKDFEKQRQ AAVTIQTAWR GFDQRKRYRQ IISGFSRLQA VLRSRQLVSH
810 820 830 840 850
YQTLRKTIIQ FQAVCRGSLV RRQVGEKRKR GEKAPLTEVS STASVISDSH
860 870 880 890 900
EELVGHLFDF LPSDGKDSGN ENDSADSSRR GSYSRLHTSP VMPPANIPRV
910 920 930 940 950
DSYVDEDLSK YQFGKYAATF FQAQATATHV KKPLKTALLT HTEPSAQLAA
960 970 980 990 1000
LTAWTTILRF MGDLADVKPG STNGSEVYDK TPVMIKLYAT LGKKFSAHDL
1010 1020 1030 1040 1050
EEAMLSSEYG GAKTLKKGMG RKLISMTLKR KGKINGSDTS SISSDSVYSS
1060 1070 1080 1090 1100
FNAMLENKPM TSLDKLHYII GLGILREDLR DEIYCQLCKQ LSNNPSKLSA
1110 1120 1130 1140 1150
ARGWILLSLC VGCFAPSERF IKYLFCFIRE RGPAGTGYSK YIEDRLRRTQ
1160 1170 1180 1190 1200
VNGTRHQPPS YVELQANKSQ KPVVLAVTFM DGSVKTLCAD SATTAAELCK
1210 1220 1230 1240 1250
QLAEKVGLTN SFGFSLYIAL FDKVSSLGSG TDHVMDAISQ CEQYAKEQGR
1260 1270 1280 1290 1300
QERNAPWRLF FRKEIFSPWH DPRDDPVSTN LIYQQVIRGI KYGEYRCDKD
1310 1320 1330 1340 1350
EELAAICAQQ YYIDEGTMDV NKLENNLPSY LPDFEMSGKE MALEKWTQTI
1360 1370 1380 1390 1400
MHQYRKKFTG RLPSQIEVKE NVVSVAKTKW PLLFSRFYEA LKFAGPPLPK
1410 1420 1430 1440 1450
NEVIIAVNWT GVYVVDDREH VMLEFSFPEI STAYYGKGKR STTDTCTVRT
1460 1470 1480 1490 1500
VVGDEYTFQS PNADDITNLI VMFLEGLKKR SRYLVAIKSQ KGDEKNNFLE
1510 1520 1530 1540 1550
FEKGDLLILV NEFTGNTLLT ESVVKGENSR TCLFGLIRAE NVYVLPTLVK
1560 1570 1580 1590 1600
PSKNTLQIFP KDMDLSLDLF NNNKQVTVVD YNAEPYTLEN FAEDNFNSQV
1610 1620 1630 1640 1650
KRVGSQISLM TLRKKESQIE CWRFSREHID QPLLKKLNGR EDACRGAIEI
1660 1670 1680 1690 1700
FAAIMKYMGD EPSKRSRLGT HLTDHIFKLP ISMEALRDEL YCQLVKQLTL
1710 1720 1730 1740 1750
NPSIMSEERG WELLWMATGL FAPSAALAKE ISHFLKSRPH PIALDCQNRM
1760 1770 1780 1790 1800
QKLAKGGSRK YPPHLVEVEA IQHKTTQIFH KVFFPDNTDE AIEVDSATRA
1810 1820 1830 1840 1850
RDFCHKIGYR LGLKSSDGFS LFVKIKDKVL AVPESEFFFD YVRSLSDWVH
1860 1870 1880 1890 1900
TNHATQKDAT MIPINYQVYF MRKLWYNFVA GADPQADIIF HYHQESQKYL
1910 1920 1930 1940 1950
LGYHKTTKND VIELAALILR SMTKDGKNAP LAQIPQLLDE IIPKDSLKMY
1960 1970 1980 1990 2000
SASEWRKTIS NAYARIEHLK SDQAKIEFLN YICRWPTFGS AFFPVSQYSD
2010 2020 2030 2040 2050
LNLPDRLLLA INQTGVNIYH LDTKNLLVQY PFNVICNWTS GNTYFNMTVG
2060 2070 2080 2090
NMLKGNEGKK LLLDTTVGYK MDDLLTSYIS LLISNQNNHP SKTREVAL
Length:2,098
Mass (Da):239,785
Last modified:May 1, 1997 - v1
Checksum:iA972E51FC54B73BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080098 Genomic DNA Translation: CCD61190.1
PIRiT25888
RefSeqiNP_508420.1, NM_076019.3
UniGeneiCel.767

Genome annotation databases

EnsemblMetazoaiT10H10.1; T10H10.1; WBGene00002039
GeneIDi180539
KEGGicel:CELE_T10H10.1
UCSCiT10H10.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiHUM6_CAEEL
AccessioniPrimary (citable) accession number: P91443
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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