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Protein

Probable phosphoglycerate kinase

Gene

pgk-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase 2 (gpd-2), Glyceraldehyde-3-phosphate dehydrogenase 4 (gpd-4), Glyceraldehyde-3-phosphate dehydrogenase 3 (gpd-3), Glyceraldehyde-3-phosphate dehydrogenase 1 (gpd-1)
  2. Probable phosphoglycerate kinase (pgk-1)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (ipgm-1)
  4. Enolase (enol-1)
  5. Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-2), Pyruvate kinase (pyk-2), Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-2), Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39SubstrateBy similarity1
Binding sitei122SubstrateBy similarity1
Binding sitei170SubstrateBy similarity1
Binding sitei219ATPBy similarity1
Binding sitei312ATP; via carbonyl oxygenBy similarity1
Binding sitei343ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi372 – 375ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-70171. Glycolysis.
R-CEL-70263. Gluconeogenesis.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk-1
ORF Names:T03F1.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiT03F1.3; CE13100; WBGene00020185; pgk-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001458441 – 417Probable phosphoglycerate kinaseAdd BLAST417

Proteomic databases

EPDiP91427.
PaxDbiP91427.
PeptideAtlasiP91427.
PRIDEiP91427.

2D gel databases

World-2DPAGE0020:P91427.

PTM databases

iPTMnetiP91427.

Expressioni

Gene expression databases

BgeeiWBGene00020185.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi37439. 1 interactor.
IntActiP91427. 1 interactor.
MINTiMINT-226425.
STRINGi6239.T03F1.3.1.

Structurei

3D structure databases

ProteinModelPortaliP91427.
SMRiP91427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingBy similarity3
Regioni63 – 66Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiKOG1367. Eukaryota.
COG0126. LUCA.
GeneTreeiENSGT00390000008820.
HOGENOMiHOG000227107.
InParanoidiP91427.
KOiK00927.
OMAiIKHCLDH.
OrthoDBiEOG091G08S6.
PhylomeDBiP91427.

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLNKLAID QLNLAGKRVL IRVDFNVPLK DGKITNNQRI AAAVPTIQHA
60 70 80 90 100
LSNGAKSVVL MSHLGRPDGR RQDKYTLKPV AEELKALLKK DVLFLDDCVG
110 120 130 140 150
SEVEAACADP APGSVILLEN LRYHLEEEGK GVDASGAKVK ADSAAVKKFR
160 170 180 190 200
ESLTKLGDIY VNDAFGTAHR AHSSMVGVEH SQRASGFLLK NELSYFSKAL
210 220 230 240 250
DNPARPFLAI LGGAKVADKI QLIKNLLDKV NEMIIGGGMA YTFLKVAQGV
260 270 280 290 300
KIGNSLYDEE GAKIVNELLE AAKAKGVQIH LPVDFVIADK FAEDATSKTV
310 320 330 340 350
TAEEGVPDGH MGLDVGPESS KIFAAAIQRA KTIVWNGPAG VFEFDKFATG
360 370 380 390 400
TKSLMDEVVK ATAAGAITII GGGDTATAAK KYNTEDKVSH VSTGGGASLE
410
LLEGKVLPGV DALSPAQ
Length:417
Mass (Da):44,113
Last modified:May 1, 1997 - v1
Checksum:iCB0369287AFE5AC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080917 Genomic DNA. Translation: CCD67788.1.
PIRiT29198.
RefSeqiNP_491245.1. NM_058844.4.

Genome annotation databases

EnsemblMetazoaiT03F1.3; T03F1.3; WBGene00020185.
GeneIDi171965.
KEGGicel:CELE_T03F1.3.
UCSCiT03F1.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080917 Genomic DNA. Translation: CCD67788.1.
PIRiT29198.
RefSeqiNP_491245.1. NM_058844.4.

3D structure databases

ProteinModelPortaliP91427.
SMRiP91427.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi37439. 1 interactor.
IntActiP91427. 1 interactor.
MINTiMINT-226425.
STRINGi6239.T03F1.3.1.

PTM databases

iPTMnetiP91427.

2D gel databases

World-2DPAGE0020:P91427.

Proteomic databases

EPDiP91427.
PaxDbiP91427.
PeptideAtlasiP91427.
PRIDEiP91427.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT03F1.3; T03F1.3; WBGene00020185.
GeneIDi171965.
KEGGicel:CELE_T03F1.3.
UCSCiT03F1.3. c. elegans.

Organism-specific databases

CTDi171965.
WormBaseiT03F1.3; CE13100; WBGene00020185; pgk-1.

Phylogenomic databases

eggNOGiKOG1367. Eukaryota.
COG0126. LUCA.
GeneTreeiENSGT00390000008820.
HOGENOMiHOG000227107.
InParanoidiP91427.
KOiK00927.
OMAiIKHCLDH.
OrthoDBiEOG091G08S6.
PhylomeDBiP91427.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.
ReactomeiR-CEL-70171. Glycolysis.
R-CEL-70263. Gluconeogenesis.

Miscellaneous databases

PROiP91427.

Gene expression databases

BgeeiWBGene00020185.

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGK_CAEEL
AccessioniPrimary (citable) accession number: P91427
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.