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P91427

- PGK_CAEEL

UniProt

P91427 - PGK_CAEEL

Protein

Probable phosphoglycerate kinase

Gene

pgk-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391SubstrateBy similarity
    Binding sitei122 – 1221SubstrateBy similarity
    Binding sitei170 – 1701SubstrateBy similarity
    Binding sitei219 – 2191ATPBy similarity
    Binding sitei312 – 3121ATP; via carbonyl oxygenBy similarity
    Binding sitei343 – 3431ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi372 – 3754ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. phosphoglycerate kinase activity Source: UniProtKB

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway
    2. phosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable phosphoglycerate kinase (EC:2.7.2.3)
    Gene namesi
    Name:pgk-1
    ORF Names:T03F1.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiT03F1.3; CE13100; WBGene00020185; pgk-1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 417417Probable phosphoglycerate kinasePRO_0000145844Add
    BLAST

    Proteomic databases

    PaxDbiP91427.
    PRIDEiP91427.

    2D gel databases

    World-2DPAGE0020:P91427.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    BioGridi37439. 1 interaction.
    IntActiP91427. 1 interaction.
    MINTiMINT-226425.
    STRINGi6239.T03F1.3.

    Structurei

    3D structure databases

    ProteinModelPortaliP91427.
    SMRiP91427. Positions 5-414.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 263Substrate bindingBy similarity
    Regioni63 – 664Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0126.
    GeneTreeiENSGT00390000008820.
    HOGENOMiHOG000227107.
    InParanoidiP91427.
    KOiK00927.
    OMAiFPVDYVT.
    PhylomeDBiP91427.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P91427-1 [UniParc]FASTAAdd to Basket

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    MSSLNKLAID QLNLAGKRVL IRVDFNVPLK DGKITNNQRI AAAVPTIQHA    50
    LSNGAKSVVL MSHLGRPDGR RQDKYTLKPV AEELKALLKK DVLFLDDCVG 100
    SEVEAACADP APGSVILLEN LRYHLEEEGK GVDASGAKVK ADSAAVKKFR 150
    ESLTKLGDIY VNDAFGTAHR AHSSMVGVEH SQRASGFLLK NELSYFSKAL 200
    DNPARPFLAI LGGAKVADKI QLIKNLLDKV NEMIIGGGMA YTFLKVAQGV 250
    KIGNSLYDEE GAKIVNELLE AAKAKGVQIH LPVDFVIADK FAEDATSKTV 300
    TAEEGVPDGH MGLDVGPESS KIFAAAIQRA KTIVWNGPAG VFEFDKFATG 350
    TKSLMDEVVK ATAAGAITII GGGDTATAAK KYNTEDKVSH VSTGGGASLE 400
    LLEGKVLPGV DALSPAQ 417
    Length:417
    Mass (Da):44,113
    Last modified:May 1, 1997 - v1
    Checksum:iCB0369287AFE5AC4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080917 Genomic DNA. Translation: CCD67788.1.
    PIRiT29198.
    RefSeqiNP_491245.1. NM_058844.4.

    Genome annotation databases

    EnsemblMetazoaiT03F1.3; T03F1.3; WBGene00020185.
    GeneIDi171965.
    KEGGicel:CELE_T03F1.3.
    UCSCiT03F1.3. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO080917 Genomic DNA. Translation: CCD67788.1 .
    PIRi T29198.
    RefSeqi NP_491245.1. NM_058844.4.

    3D structure databases

    ProteinModelPortali P91427.
    SMRi P91427. Positions 5-414.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 37439. 1 interaction.
    IntActi P91427. 1 interaction.
    MINTi MINT-226425.
    STRINGi 6239.T03F1.3.

    2D gel databases

    World-2DPAGE 0020:P91427.

    Proteomic databases

    PaxDbi P91427.
    PRIDEi P91427.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai T03F1.3 ; T03F1.3 ; WBGene00020185 .
    GeneIDi 171965.
    KEGGi cel:CELE_T03F1.3.
    UCSCi T03F1.3. c. elegans.

    Organism-specific databases

    CTDi 171965.
    WormBasei T03F1.3 ; CE13100 ; WBGene00020185 ; pgk-1.

    Phylogenomic databases

    eggNOGi COG0126.
    GeneTreei ENSGT00390000008820.
    HOGENOMi HOG000227107.
    InParanoidi P91427.
    KOi K00927.
    OMAi FPVDYVT.
    PhylomeDBi P91427.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .

    Miscellaneous databases

    NextBioi 873451.
    PROi P91427.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPGK_CAEEL
    AccessioniPrimary (citable) accession number: P91427
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3