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P91427

- PGK_CAEEL

UniProt

P91427 - PGK_CAEEL

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Protein

Probable phosphoglycerate kinase

Gene

pgk-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391SubstrateBy similarity
Binding sitei122 – 1221SubstrateBy similarity
Binding sitei170 – 1701SubstrateBy similarity
Binding sitei219 – 2191ATPBy similarity
Binding sitei312 – 3121ATP; via carbonyl oxygenBy similarity
Binding sitei343 – 3431ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi372 – 3754ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. phosphoglycerate kinase activity Source: UniProtKB

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
  2. phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk-1
ORF Names:T03F1.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiT03F1.3; CE13100; WBGene00020185; pgk-1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Probable phosphoglycerate kinasePRO_0000145844Add
BLAST

Proteomic databases

PaxDbiP91427.
PRIDEiP91427.

2D gel databases

World-2DPAGE0020:P91427.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi37439. 1 interaction.
IntActiP91427. 1 interaction.
MINTiMINT-226425.
STRINGi6239.T03F1.3.

Structurei

3D structure databases

ProteinModelPortaliP91427.
SMRiP91427. Positions 5-414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 263Substrate bindingBy similarity
Regioni63 – 664Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0126.
GeneTreeiENSGT00390000008820.
HOGENOMiHOG000227107.
InParanoidiP91427.
KOiK00927.
OMAiFPVDYVT.
PhylomeDBiP91427.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91427-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSLNKLAID QLNLAGKRVL IRVDFNVPLK DGKITNNQRI AAAVPTIQHA
60 70 80 90 100
LSNGAKSVVL MSHLGRPDGR RQDKYTLKPV AEELKALLKK DVLFLDDCVG
110 120 130 140 150
SEVEAACADP APGSVILLEN LRYHLEEEGK GVDASGAKVK ADSAAVKKFR
160 170 180 190 200
ESLTKLGDIY VNDAFGTAHR AHSSMVGVEH SQRASGFLLK NELSYFSKAL
210 220 230 240 250
DNPARPFLAI LGGAKVADKI QLIKNLLDKV NEMIIGGGMA YTFLKVAQGV
260 270 280 290 300
KIGNSLYDEE GAKIVNELLE AAKAKGVQIH LPVDFVIADK FAEDATSKTV
310 320 330 340 350
TAEEGVPDGH MGLDVGPESS KIFAAAIQRA KTIVWNGPAG VFEFDKFATG
360 370 380 390 400
TKSLMDEVVK ATAAGAITII GGGDTATAAK KYNTEDKVSH VSTGGGASLE
410
LLEGKVLPGV DALSPAQ
Length:417
Mass (Da):44,113
Last modified:May 1, 1997 - v1
Checksum:iCB0369287AFE5AC4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080917 Genomic DNA. Translation: CCD67788.1.
PIRiT29198.
RefSeqiNP_491245.1. NM_058844.4.

Genome annotation databases

EnsemblMetazoaiT03F1.3; T03F1.3; WBGene00020185.
GeneIDi171965.
KEGGicel:CELE_T03F1.3.
UCSCiT03F1.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO080917 Genomic DNA. Translation: CCD67788.1 .
PIRi T29198.
RefSeqi NP_491245.1. NM_058844.4.

3D structure databases

ProteinModelPortali P91427.
SMRi P91427. Positions 5-414.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 37439. 1 interaction.
IntActi P91427. 1 interaction.
MINTi MINT-226425.
STRINGi 6239.T03F1.3.

2D gel databases

World-2DPAGE 0020:P91427.

Proteomic databases

PaxDbi P91427.
PRIDEi P91427.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai T03F1.3 ; T03F1.3 ; WBGene00020185 .
GeneIDi 171965.
KEGGi cel:CELE_T03F1.3.
UCSCi T03F1.3. c. elegans.

Organism-specific databases

CTDi 171965.
WormBasei T03F1.3 ; CE13100 ; WBGene00020185 ; pgk-1.

Phylogenomic databases

eggNOGi COG0126.
GeneTreei ENSGT00390000008820.
HOGENOMi HOG000227107.
InParanoidi P91427.
KOi K00927.
OMAi FPVDYVT.
PhylomeDBi P91427.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .

Miscellaneous databases

NextBioi 873451.
PROi P91427.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPGK_CAEEL
AccessioniPrimary (citable) accession number: P91427
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3