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P91309 (VIP1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

EC=2.7.4.21
EC=2.7.4.24
Alternative name(s):
InsP6 and PP-IP5 kinase
Gene names
ORF Names:F46F11.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length1323 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 By similarity.

Catalytic activity

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.

ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate.

Subcellular location

Cytoplasmcytosol By similarity.

Sequence similarities

Belongs to the histidine acid phosphatase family. VIP1 subfamily.

Caution

Although related to histidine acid phosphatases, it lacks the conserved active sites, suggesting that it has no phosphatase activity.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform a (identifier: P91309-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform b (identifier: P91309-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1044-1159: MADDGKTAKR...DEASERQSRS → SQRGSFHVTEPIQIDEKT
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13231323Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
PRO_0000315696

Regions

Nucleotide binding212 – 2154ATP By similarity
Nucleotide binding221 – 2233ATP By similarity
Nucleotide binding296 – 2983ATP By similarity
Region26 – 272Substrate binding By similarity
Region188 – 1892Substrate binding By similarity
Region301 – 3044Substrate binding By similarity

Sites

Binding site1091ATP By similarity
Binding site1621ATP By similarity
Binding site1691ATP By similarity
Binding site1881ATP By similarity
Binding site2231Substrate By similarity
Binding site2371Substrate By similarity
Binding site2841ATP By similarity

Natural variations

Alternative sequence1044 – 1159116MADDG…RQSRS → SQRGSFHVTEPIQIDEKT in isoform b.
VSP_030639

Sequences

Sequence LengthMass (Da)Tools
Isoform a [UniParc].

Last modified April 8, 2008. Version 3.
Checksum: B9D3A901879C8B0F

FASTA1,323150,120
        10         20         30         40         50         60 
MAHKGTESKE QIWPYKITIG ICAMNRKATS KPMRAIMKKI IDFYGQWVDS FIFPEQVIIN 

        70         80         90        100        110        120 
EPVENWPLCH CLVSFHSTEF PLEKAIAYVK LRNPYVINNL DRQYDLLDRR TVFKILSDNG 

       130        140        150        160        170        180 
IEHPRHGYVI RGRPNEPDTE LVEHPDHIEV NGEVFNKPFV EKPISSEDHN VYIYYPSSVG 

       190        200        210        220        230        240 
GGSQRLFRKI NNRSSWYSPK SEVRKEGSYI YEEFIPADGT DVKVYAVGPF YAHAEARKAP 

       250        260        270        280        290        300 
GLDGKVERDS DGKEVRYPVI LSNKEKQIAK KIVLAFGQTV CGFDLLRANG KSYVCDVNGF 

       310        320        330        340        350        360 
SFVKTSTKYY EDTAKILGNQ IVRHYAKSKN WRVPSDMPQP PILDLGLGDD PPMITTPSGK 

       370        380        390        400        410        420 
LAELRCVVAV IRHGDRTPKQ KMKLIVTDQR FFALFEKYDG YKKHEIKMKK PNQLMEVLEL 

       430        440        450        460        470        480 
ARALVIEKQR DRHQILEKLR EGTGEEEIHK SEHDLEVCEE EMKKWEQMRT VLEMYGHFSG 

       490        500        510        520        530        540 
INRKVQMKYL KERETKTSDE ELRREGPALL LILKWGGELT TAGNMQAEAL GRLFRTLYPG 

       550        560        570        580        590        600 
IRRTDGKSSP EDTQGLGFLR LHSTYRHDLK IYASDEGRVQ TTAAAFAKGL LALEGELTPI 

       610        620        630        640        650        660 
LMQMVKSANT DGLLDDDCQA RLYQTELKRY LHKALQADRD FTPQDYLELN PNGLRAITAA 

       670        680        690        700        710        720 
MEFIKNPRKM CHEIAGYVEK MCGVIVEYSQ TRPTGSTLYL QESMDLAQRR WNKELREFRR 

       730        740        750        760        770        780 
KNKHGEVEFD ISKIPDIYDN IKYDMEHNPD LCINNEVEFE RMYVCVKNMA DIVVPQEYGI 

       790        800        810        820        830        840 
KTENKMVIAQ RVCTPLLRKI RNDLHRCLEN KESEETQTRL DPRASQGIAT PFRHVRTRLY 

       850        860        870        880        890        900 
FTSESHIHTL MNLIRYGNLC SVDDKKWQRA MNFLSGVTEF NYMTQVVLMV YEDSRKENDE 

       910        920        930        940        950        960 
ADTGPRFHIE ILFSPGLYPC FLTEKERIYE TRFNLSTNPK PATSSRSSGR ESRDTNDSAS 

       970        980        990       1000       1010       1020 
SSTEGRRPSI EKVVTVVTPT QLSTPSVTND DLSISSNAES TAAESTGLVN TTTKTHNDSE 

      1030       1040       1050       1060       1070       1080 
DDLNDVESVN LVALDELNNT TKAMADDGKT AKRQRSVTGA EKSMEEGDKP HGEWKGNGVA 

      1090       1100       1110       1120       1130       1140 
KSGSQISVGS NEMESNNESM ETVGGGKGQW VKDLLDQTKR AMAMNSIREV EPPIVIPTPV 

      1150       1160       1170       1180       1190       1200 
PSTTTAVVED EASERQSRSR RYFPYRFKHH TAQLLTGMSG GGVHMQNRLI STDVLTGKFG 

      1210       1220       1230       1240       1250       1260 
DHDNKKNSRK DFGAGTAVLS TAVIARSSSA PRLMTYESED FSVGEIKRFW PPLRSLETLH 

      1270       1280       1290       1300       1310       1320 
DSINLSQFDG FLERLIKGAL TPLPSPPKTP LPSALSCDAI NKTPTQDEVE KVIGKLAPTS 


STD 

« Hide

Isoform b [UniParc].

Checksum: BF64E578B8E166AF
Show »

FASTA1,225139,760

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO081396 Genomic DNA. Translation: CCD71324.1.
FO081396 Genomic DNA. Translation: CCD71335.1.
RefSeqNP_740855.2. NM_170868.4.
NP_740856.1. NM_171837.6.
UniGeneCel.5361.

3D structure databases

ProteinModelPortalP91309.
SMRP91309. Positions 16-326, 515-592.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.F46F11.1a.

Proteomic databases

PaxDbP91309.
PRIDEP91309.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF46F11.1a.1; F46F11.1a.1; F46F11.1. [P91309-1]
F46F11.1a.2; F46F11.1a.2; F46F11.1. [P91309-1]
GeneID172221.
KEGGcel:CELE_F46F11.1.
UCSCF46F11.1b. c. elegans. [P91309-1]

Organism-specific databases

CTD172221.
WormBaseF46F11.1a; CE41904; WBGene00018508.
F46F11.1b; CE30534; WBGene00018508.

Phylogenomic databases

eggNOGNOG245915.
HOGENOMHOG000177917.
InParanoidP91309.
KOK13024.
OMAGICCMMK.
PhylomeDBP91309.

Family and domain databases

InterProIPR013651. ATP-grasp_RimK-type.
IPR000560. His_Pase_superF_clade-2.
[Graphical view]
PfamPF00328. His_Phos_2. 1 hit.
PF08443. RimK. 1 hit.
[Graphical view]
PROSITEPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio874563.
PROP91309.

Entry information

Entry nameVIP1_CAEEL
AccessionPrimary (citable) accession number: P91309
Secondary accession number(s): Q8T3B4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 8, 2008
Last modified: April 16, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase