P91309 (VIP1_CAEEL) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 29, 2013.
Version 86.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase EC=2.7.4.21 EC=2.7.4.24 Alternative name(s): InsP6 and PP-IP5 kinase | ||
| Gene names |
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| Organism | Caenorhabditis elegans [Reference proteome] | ||
| Taxonomic identifier | 6239 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 1323 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 By similarity. |
| Catalytic activity | ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate. ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol diphosphate tetrakisphosphate (isomeric configuration unknown). ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate (isomeric configuration unknown). |
| Subcellular location | |
| Sequence similarities | Belongs to the histidine acid phosphatase family. VIP1 subfamily. |
| Caution | Although related to histidine acid phosphatases, it lacks the conserved active sites, suggesting that it has no phosphatase activity. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform a (identifier: P91309-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform b (identifier: P91309-2) The sequence of this isoform differs from the canonical sequence as follows: 1044-1159: MADDGKTAKR...DEASERQSRS → SQRGSFHVTEPIQIDEKT | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1323 | 1323 | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase | PRO_0000315696 | |||||
Regions | |||||||||
| Nucleotide binding | 212 – 215 | 4 | ATP By similarity | ||||||
| Nucleotide binding | 221 – 223 | 3 | ATP By similarity | ||||||
| Nucleotide binding | 296 – 298 | 3 | ATP By similarity | ||||||
| Region | 26 – 27 | 2 | Substrate binding By similarity | ||||||
| Region | 188 – 189 | 2 | Substrate binding By similarity | ||||||
| Region | 301 – 304 | 4 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Binding site | 109 | 1 | ATP By similarity | ||||||
| Binding site | 162 | 1 | ATP By similarity | ||||||
| Binding site | 169 | 1 | ATP By similarity | ||||||
| Binding site | 188 | 1 | ATP By similarity | ||||||
| Binding site | 223 | 1 | Substrate By similarity | ||||||
| Binding site | 237 | 1 | Substrate By similarity | ||||||
| Binding site | 284 | 1 | ATP By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 1044 – 1159 | 116 | MADDG…RQSRS → SQRGSFHVTEPIQIDEKT in isoform b. | VSP_030639 | |||||
Sequences
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References
| [1] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Bristol N2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | FO081396 Genomic DNA. Translation: CCD71324.1. FO081396 Genomic DNA. Translation: CCD71335.1. |
| RefSeq | NP_740855.2. NM_170868.4. NP_740856.1. NM_171837.6. |
| UniGene | Cel.5361. |
3D structure databases | |
| ProteinModelPortal | P91309. |
| SMR | P91309. Positions 16-326. |
| ModBase | Search... |
Proteomic databases | |
| PaxDb | P91309. |
| PRIDE | P91309. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | F46F11.1a.1; F46F11.1a.1; F46F11.1. F46F11.1a.2; F46F11.1a.2; F46F11.1. |
| GeneID | 172221. |
| KEGG | cel:CELE_F46F11.1. |
| UCSC | F46F11.1b. c. elegans. |
Organism-specific databases | |
| CTD | 172221. |
| WormBase | F46F11.1a; CE41904; WBGene00018508. F46F11.1b; CE30534; WBGene00018508. |
Phylogenomic databases | |
| eggNOG | NOG245915. |
| GeneTree | ENSGT00390000009048. |
| HOGENOM | HOG000177917. |
| InParanoid | P91309. |
| KO | K13024. |
| OMA | LTDCQQK. |
Family and domain databases | |
| InterPro | IPR013651. ATP-grasp_RimK-type. IPR000560. His_Pase_superF_clade-2. [Graphical view] |
| Pfam | PF00328. His_Phos_2. 1 hit. PF08443. RimK. 1 hit. [Graphical view] |
| PROSITE | PS00616. HIS_ACID_PHOSPHAT_1. 1 hit. PS00778. HIS_ACID_PHOSPHAT_2. False negative. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 874563. |
Entry information
| Entry name | VIP1_CAEEL | ||||||||
| Accession | Primary (citable) accession number: P91309 Secondary accession number(s): Q8T3B4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormBase |
| SIMILARITY comments Index of protein domains and families |