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P91309

- VIP1_CAEEL

UniProt

P91309 - VIP1_CAEEL

Protein

Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

Gene

F46F11.1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 By similarity.By similarity

    Catalytic activityi

    ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
    ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
    ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
    ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei109 – 1091ATPBy similarity
    Binding sitei162 – 1621ATPBy similarity
    Binding sitei169 – 1691ATPBy similarity
    Binding sitei188 – 1881ATPBy similarity
    Binding sitei223 – 2231SubstrateBy similarity
    Binding sitei237 – 2371SubstrateBy similarity
    Binding sitei284 – 2841ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi212 – 2154ATPBy similarity
    Nucleotide bindingi221 – 2233ATPBy similarity
    Nucleotide bindingi296 – 2983ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. diphosphoinositol-pentakisphosphate kinase activity Source: UniProtKB
    3. inositol-1,3,4,5,6-pentakisphosphate kinase activity Source: UniProtKB
    4. inositol hexakisphosphate 1-kinase activity Source: UniProtKB-EC
    5. inositol hexakisphosphate 3-kinase activity Source: UniProtKB-EC
    6. inositol hexakisphosphate 5-kinase activity Source: UniProtKB

    GO - Biological processi

    1. inositol metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_197741. Synthesis of pyrophosphates in the cytosol.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase (EC:2.7.4.21, EC:2.7.4.24)
    Alternative name(s):
    InsP6 and PP-IP5 kinase
    Gene namesi
    ORF Names:F46F11.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiF46F11.1a; CE41904; WBGene00018508.
    F46F11.1b; CE30534; WBGene00018508.

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytoplasm Source: WormBase
    2. cytosol Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13231323Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinasePRO_0000315696Add
    BLAST

    Proteomic databases

    PaxDbiP91309.
    PRIDEiP91309.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.F46F11.1a.

    Structurei

    3D structure databases

    ProteinModelPortaliP91309.
    SMRiP91309. Positions 16-326.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni26 – 272Substrate bindingBy similarity
    Regioni188 – 1892Substrate bindingBy similarity
    Regioni301 – 3044Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG245915.
    GeneTreeiENSGT00390000009048.
    HOGENOMiHOG000177917.
    InParanoidiP91309.
    KOiK13024.
    OMAiRTDMELY.
    PhylomeDBiP91309.

    Family and domain databases

    Gene3Di3.40.50.1240. 4 hits.
    InterProiIPR013651. ATP-grasp_RimK-type.
    IPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00328. His_Phos_2. 1 hit.
    PF08443. RimK. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 4 hits.
    PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform a (identifier: P91309-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAHKGTESKE QIWPYKITIG ICAMNRKATS KPMRAIMKKI IDFYGQWVDS     50
    FIFPEQVIIN EPVENWPLCH CLVSFHSTEF PLEKAIAYVK LRNPYVINNL 100
    DRQYDLLDRR TVFKILSDNG IEHPRHGYVI RGRPNEPDTE LVEHPDHIEV 150
    NGEVFNKPFV EKPISSEDHN VYIYYPSSVG GGSQRLFRKI NNRSSWYSPK 200
    SEVRKEGSYI YEEFIPADGT DVKVYAVGPF YAHAEARKAP GLDGKVERDS 250
    DGKEVRYPVI LSNKEKQIAK KIVLAFGQTV CGFDLLRANG KSYVCDVNGF 300
    SFVKTSTKYY EDTAKILGNQ IVRHYAKSKN WRVPSDMPQP PILDLGLGDD 350
    PPMITTPSGK LAELRCVVAV IRHGDRTPKQ KMKLIVTDQR FFALFEKYDG 400
    YKKHEIKMKK PNQLMEVLEL ARALVIEKQR DRHQILEKLR EGTGEEEIHK 450
    SEHDLEVCEE EMKKWEQMRT VLEMYGHFSG INRKVQMKYL KERETKTSDE 500
    ELRREGPALL LILKWGGELT TAGNMQAEAL GRLFRTLYPG IRRTDGKSSP 550
    EDTQGLGFLR LHSTYRHDLK IYASDEGRVQ TTAAAFAKGL LALEGELTPI 600
    LMQMVKSANT DGLLDDDCQA RLYQTELKRY LHKALQADRD FTPQDYLELN 650
    PNGLRAITAA MEFIKNPRKM CHEIAGYVEK MCGVIVEYSQ TRPTGSTLYL 700
    QESMDLAQRR WNKELREFRR KNKHGEVEFD ISKIPDIYDN IKYDMEHNPD 750
    LCINNEVEFE RMYVCVKNMA DIVVPQEYGI KTENKMVIAQ RVCTPLLRKI 800
    RNDLHRCLEN KESEETQTRL DPRASQGIAT PFRHVRTRLY FTSESHIHTL 850
    MNLIRYGNLC SVDDKKWQRA MNFLSGVTEF NYMTQVVLMV YEDSRKENDE 900
    ADTGPRFHIE ILFSPGLYPC FLTEKERIYE TRFNLSTNPK PATSSRSSGR 950
    ESRDTNDSAS SSTEGRRPSI EKVVTVVTPT QLSTPSVTND DLSISSNAES 1000
    TAAESTGLVN TTTKTHNDSE DDLNDVESVN LVALDELNNT TKAMADDGKT 1050
    AKRQRSVTGA EKSMEEGDKP HGEWKGNGVA KSGSQISVGS NEMESNNESM 1100
    ETVGGGKGQW VKDLLDQTKR AMAMNSIREV EPPIVIPTPV PSTTTAVVED 1150
    EASERQSRSR RYFPYRFKHH TAQLLTGMSG GGVHMQNRLI STDVLTGKFG 1200
    DHDNKKNSRK DFGAGTAVLS TAVIARSSSA PRLMTYESED FSVGEIKRFW 1250
    PPLRSLETLH DSINLSQFDG FLERLIKGAL TPLPSPPKTP LPSALSCDAI 1300
    NKTPTQDEVE KVIGKLAPTS STD 1323
    Length:1,323
    Mass (Da):150,120
    Last modified:April 8, 2008 - v3
    Checksum:iB9D3A901879C8B0F
    GO
    Isoform b (identifier: P91309-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1044-1159: MADDGKTAKR...DEASERQSRS → SQRGSFHVTEPIQIDEKT

    Note: No experimental confirmation available.

    Show »
    Length:1,225
    Mass (Da):139,760
    Checksum:iBF64E578B8E166AF
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1044 – 1159116MADDG…RQSRS → SQRGSFHVTEPIQIDEKT in isoform b. CuratedVSP_030639Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081396 Genomic DNA. Translation: CCD71324.1.
    FO081396 Genomic DNA. Translation: CCD71335.1.
    RefSeqiNP_740855.2. NM_170868.4. [P91309-1]
    NP_740856.1. NM_171837.6. [P91309-2]
    UniGeneiCel.5361.

    Genome annotation databases

    EnsemblMetazoaiF46F11.1a; F46F11.1a; WBGene00018508. [P91309-1]
    GeneIDi172221.
    KEGGicel:CELE_F46F11.1.
    UCSCiF46F11.1b. c. elegans. [P91309-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081396 Genomic DNA. Translation: CCD71324.1 .
    FO081396 Genomic DNA. Translation: CCD71335.1 .
    RefSeqi NP_740855.2. NM_170868.4. [P91309-1 ]
    NP_740856.1. NM_171837.6. [P91309-2 ]
    UniGenei Cel.5361.

    3D structure databases

    ProteinModelPortali P91309.
    SMRi P91309. Positions 16-326.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.F46F11.1a.

    Proteomic databases

    PaxDbi P91309.
    PRIDEi P91309.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F46F11.1a ; F46F11.1a ; WBGene00018508 . [P91309-1 ]
    GeneIDi 172221.
    KEGGi cel:CELE_F46F11.1.
    UCSCi F46F11.1b. c. elegans. [P91309-1 ]

    Organism-specific databases

    CTDi 172221.
    WormBasei F46F11.1a ; CE41904 ; WBGene00018508 .
    F46F11.1b ; CE30534 ; WBGene00018508 .

    Phylogenomic databases

    eggNOGi NOG245915.
    GeneTreei ENSGT00390000009048.
    HOGENOMi HOG000177917.
    InParanoidi P91309.
    KOi K13024.
    OMAi RTDMELY.
    PhylomeDBi P91309.

    Enzyme and pathway databases

    Reactomei REACT_197741. Synthesis of pyrophosphates in the cytosol.

    Miscellaneous databases

    NextBioi 874563.
    PROi P91309.

    Family and domain databases

    Gene3Di 3.40.50.1240. 4 hits.
    InterProi IPR013651. ATP-grasp_RimK-type.
    IPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00328. His_Phos_2. 1 hit.
    PF08443. RimK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 4 hits.
    PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.

    Entry informationi

    Entry nameiVIP1_CAEEL
    AccessioniPrimary (citable) accession number: P91309
    Secondary accession number(s): Q8T3B4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3