Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P91309

- VIP1_CAEEL

UniProt

P91309 - VIP1_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

Gene

F46F11.1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (By similarity).By similarity

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei109 – 1091ATPBy similarity
Binding sitei162 – 1621ATPBy similarity
Binding sitei169 – 1691ATPBy similarity
Binding sitei188 – 1881ATPBy similarity
Binding sitei223 – 2231SubstrateBy similarity
Binding sitei237 – 2371SubstrateBy similarity
Binding sitei284 – 2841ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi212 – 2154ATPBy similarity
Nucleotide bindingi221 – 2233ATPBy similarity
Nucleotide bindingi296 – 2983ATPBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. diphosphoinositol-pentakisphosphate kinase activity Source: UniProtKB
  4. inositol-1,3,4,5,6-pentakisphosphate kinase activity Source: UniProtKB
  5. inositol hexakisphosphate 1-kinase activity Source: UniProtKB-EC
  6. inositol hexakisphosphate 3-kinase activity Source: UniProtKB-EC
  7. inositol hexakisphosphate 5-kinase activity Source: UniProtKB

GO - Biological processi

  1. inositol metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_197741. Synthesis of pyrophosphates in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase (EC:2.7.4.21, EC:2.7.4.24)
Alternative name(s):
InsP6 and PP-IP5 kinase
Gene namesi
ORF Names:F46F11.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiF46F11.1a; CE41904; WBGene00018508.
F46F11.1b; CE30534; WBGene00018508.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytoplasm Source: WormBase
  2. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13231323Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinasePRO_0000315696Add
BLAST

Proteomic databases

PaxDbiP91309.
PRIDEiP91309.

Interactioni

Protein-protein interaction databases

STRINGi6239.F46F11.1a.

Structurei

3D structure databases

ProteinModelPortaliP91309.
SMRiP91309. Positions 16-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 272Substrate bindingBy similarity
Regioni188 – 1892Substrate bindingBy similarity
Regioni301 – 3044Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG245915.
GeneTreeiENSGT00390000009048.
HOGENOMiHOG000177917.
InParanoidiP91309.
KOiK13024.
OMAiRTDMELY.
PhylomeDBiP91309.

Family and domain databases

Gene3Di3.40.50.1240. 4 hits.
InterProiIPR013651. ATP-grasp_RimK-type.
IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
PF08443. RimK. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 4 hits.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: P91309-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHKGTESKE QIWPYKITIG ICAMNRKATS KPMRAIMKKI IDFYGQWVDS
60 70 80 90 100
FIFPEQVIIN EPVENWPLCH CLVSFHSTEF PLEKAIAYVK LRNPYVINNL
110 120 130 140 150
DRQYDLLDRR TVFKILSDNG IEHPRHGYVI RGRPNEPDTE LVEHPDHIEV
160 170 180 190 200
NGEVFNKPFV EKPISSEDHN VYIYYPSSVG GGSQRLFRKI NNRSSWYSPK
210 220 230 240 250
SEVRKEGSYI YEEFIPADGT DVKVYAVGPF YAHAEARKAP GLDGKVERDS
260 270 280 290 300
DGKEVRYPVI LSNKEKQIAK KIVLAFGQTV CGFDLLRANG KSYVCDVNGF
310 320 330 340 350
SFVKTSTKYY EDTAKILGNQ IVRHYAKSKN WRVPSDMPQP PILDLGLGDD
360 370 380 390 400
PPMITTPSGK LAELRCVVAV IRHGDRTPKQ KMKLIVTDQR FFALFEKYDG
410 420 430 440 450
YKKHEIKMKK PNQLMEVLEL ARALVIEKQR DRHQILEKLR EGTGEEEIHK
460 470 480 490 500
SEHDLEVCEE EMKKWEQMRT VLEMYGHFSG INRKVQMKYL KERETKTSDE
510 520 530 540 550
ELRREGPALL LILKWGGELT TAGNMQAEAL GRLFRTLYPG IRRTDGKSSP
560 570 580 590 600
EDTQGLGFLR LHSTYRHDLK IYASDEGRVQ TTAAAFAKGL LALEGELTPI
610 620 630 640 650
LMQMVKSANT DGLLDDDCQA RLYQTELKRY LHKALQADRD FTPQDYLELN
660 670 680 690 700
PNGLRAITAA MEFIKNPRKM CHEIAGYVEK MCGVIVEYSQ TRPTGSTLYL
710 720 730 740 750
QESMDLAQRR WNKELREFRR KNKHGEVEFD ISKIPDIYDN IKYDMEHNPD
760 770 780 790 800
LCINNEVEFE RMYVCVKNMA DIVVPQEYGI KTENKMVIAQ RVCTPLLRKI
810 820 830 840 850
RNDLHRCLEN KESEETQTRL DPRASQGIAT PFRHVRTRLY FTSESHIHTL
860 870 880 890 900
MNLIRYGNLC SVDDKKWQRA MNFLSGVTEF NYMTQVVLMV YEDSRKENDE
910 920 930 940 950
ADTGPRFHIE ILFSPGLYPC FLTEKERIYE TRFNLSTNPK PATSSRSSGR
960 970 980 990 1000
ESRDTNDSAS SSTEGRRPSI EKVVTVVTPT QLSTPSVTND DLSISSNAES
1010 1020 1030 1040 1050
TAAESTGLVN TTTKTHNDSE DDLNDVESVN LVALDELNNT TKAMADDGKT
1060 1070 1080 1090 1100
AKRQRSVTGA EKSMEEGDKP HGEWKGNGVA KSGSQISVGS NEMESNNESM
1110 1120 1130 1140 1150
ETVGGGKGQW VKDLLDQTKR AMAMNSIREV EPPIVIPTPV PSTTTAVVED
1160 1170 1180 1190 1200
EASERQSRSR RYFPYRFKHH TAQLLTGMSG GGVHMQNRLI STDVLTGKFG
1210 1220 1230 1240 1250
DHDNKKNSRK DFGAGTAVLS TAVIARSSSA PRLMTYESED FSVGEIKRFW
1260 1270 1280 1290 1300
PPLRSLETLH DSINLSQFDG FLERLIKGAL TPLPSPPKTP LPSALSCDAI
1310 1320
NKTPTQDEVE KVIGKLAPTS STD
Length:1,323
Mass (Da):150,120
Last modified:April 8, 2008 - v3
Checksum:iB9D3A901879C8B0F
GO
Isoform b (identifier: P91309-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1044-1159: MADDGKTAKR...DEASERQSRS → SQRGSFHVTEPIQIDEKT

Note: No experimental confirmation available.

Show »
Length:1,225
Mass (Da):139,760
Checksum:iBF64E578B8E166AF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1044 – 1159116MADDG…RQSRS → SQRGSFHVTEPIQIDEKT in isoform b. CuratedVSP_030639Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081396 Genomic DNA. Translation: CCD71324.1.
FO081396 Genomic DNA. Translation: CCD71335.1.
RefSeqiNP_740855.2. NM_170868.4. [P91309-1]
NP_740856.1. NM_171837.6. [P91309-2]
UniGeneiCel.5361.

Genome annotation databases

EnsemblMetazoaiF46F11.1a; F46F11.1a; WBGene00018508. [P91309-1]
GeneIDi172221.
KEGGicel:CELE_F46F11.1.
UCSCiF46F11.1b. c. elegans. [P91309-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081396 Genomic DNA. Translation: CCD71324.1 .
FO081396 Genomic DNA. Translation: CCD71335.1 .
RefSeqi NP_740855.2. NM_170868.4. [P91309-1 ]
NP_740856.1. NM_171837.6. [P91309-2 ]
UniGenei Cel.5361.

3D structure databases

ProteinModelPortali P91309.
SMRi P91309. Positions 16-326.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.F46F11.1a.

Proteomic databases

PaxDbi P91309.
PRIDEi P91309.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F46F11.1a ; F46F11.1a ; WBGene00018508 . [P91309-1 ]
GeneIDi 172221.
KEGGi cel:CELE_F46F11.1.
UCSCi F46F11.1b. c. elegans. [P91309-1 ]

Organism-specific databases

CTDi 172221.
WormBasei F46F11.1a ; CE41904 ; WBGene00018508 .
F46F11.1b ; CE30534 ; WBGene00018508 .

Phylogenomic databases

eggNOGi NOG245915.
GeneTreei ENSGT00390000009048.
HOGENOMi HOG000177917.
InParanoidi P91309.
KOi K13024.
OMAi RTDMELY.
PhylomeDBi P91309.

Enzyme and pathway databases

Reactomei REACT_197741. Synthesis of pyrophosphates in the cytosol.

Miscellaneous databases

NextBioi 874563.
PROi P91309.

Family and domain databases

Gene3Di 3.40.50.1240. 4 hits.
InterProi IPR013651. ATP-grasp_RimK-type.
IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
PF08443. RimK. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 4 hits.
PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiVIP1_CAEEL
AccessioniPrimary (citable) accession number: P91309
Secondary accession number(s): Q8T3B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3