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P91309

- VIP1_CAEEL

UniProt

P91309 - VIP1_CAEEL

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Protein
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
Gene
F46F11.1
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 By similarity.

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei109 – 1091ATP By similarity
Binding sitei162 – 1621ATP By similarity
Binding sitei169 – 1691ATP By similarity
Binding sitei188 – 1881ATP By similarity
Binding sitei223 – 2231Substrate By similarity
Binding sitei237 – 2371Substrate By similarity
Binding sitei284 – 2841ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi212 – 2154ATP By similarity
Nucleotide bindingi221 – 2233ATP By similarity
Nucleotide bindingi296 – 2983ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. diphosphoinositol-pentakisphosphate kinase activity Source: UniProtKB
  3. inositol hexakisphosphate 1-kinase activity Source: UniProtKB-EC
  4. inositol hexakisphosphate 3-kinase activity Source: UniProtKB-EC
  5. inositol hexakisphosphate 5-kinase activity Source: UniProtKB
  6. inositol-1,3,4,5,6-pentakisphosphate kinase activity Source: UniProtKB

GO - Biological processi

  1. inositol metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_197741. Synthesis of pyrophosphates in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase (EC:2.7.4.21, EC:2.7.4.24)
Alternative name(s):
InsP6 and PP-IP5 kinase
Gene namesi
ORF Names:F46F11.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiF46F11.1a; CE41904; WBGene00018508.
F46F11.1b; CE30534; WBGene00018508.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytoplasm Source: WormBase
  2. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13231323Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
PRO_0000315696Add
BLAST

Proteomic databases

PaxDbiP91309.
PRIDEiP91309.

Interactioni

Protein-protein interaction databases

STRINGi6239.F46F11.1a.

Structurei

3D structure databases

ProteinModelPortaliP91309.
SMRiP91309. Positions 16-326.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 272Substrate binding By similarity
Regioni188 – 1892Substrate binding By similarity
Regioni301 – 3044Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG245915.
GeneTreeiENSGT00390000009048.
HOGENOMiHOG000177917.
InParanoidiP91309.
KOiK13024.
OMAiRTDMELY.
PhylomeDBiP91309.

Family and domain databases

Gene3Di3.40.50.1240. 4 hits.
InterProiIPR013651. ATP-grasp_RimK-type.
IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
PF08443. RimK. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 4 hits.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: P91309-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAHKGTESKE QIWPYKITIG ICAMNRKATS KPMRAIMKKI IDFYGQWVDS     50
FIFPEQVIIN EPVENWPLCH CLVSFHSTEF PLEKAIAYVK LRNPYVINNL 100
DRQYDLLDRR TVFKILSDNG IEHPRHGYVI RGRPNEPDTE LVEHPDHIEV 150
NGEVFNKPFV EKPISSEDHN VYIYYPSSVG GGSQRLFRKI NNRSSWYSPK 200
SEVRKEGSYI YEEFIPADGT DVKVYAVGPF YAHAEARKAP GLDGKVERDS 250
DGKEVRYPVI LSNKEKQIAK KIVLAFGQTV CGFDLLRANG KSYVCDVNGF 300
SFVKTSTKYY EDTAKILGNQ IVRHYAKSKN WRVPSDMPQP PILDLGLGDD 350
PPMITTPSGK LAELRCVVAV IRHGDRTPKQ KMKLIVTDQR FFALFEKYDG 400
YKKHEIKMKK PNQLMEVLEL ARALVIEKQR DRHQILEKLR EGTGEEEIHK 450
SEHDLEVCEE EMKKWEQMRT VLEMYGHFSG INRKVQMKYL KERETKTSDE 500
ELRREGPALL LILKWGGELT TAGNMQAEAL GRLFRTLYPG IRRTDGKSSP 550
EDTQGLGFLR LHSTYRHDLK IYASDEGRVQ TTAAAFAKGL LALEGELTPI 600
LMQMVKSANT DGLLDDDCQA RLYQTELKRY LHKALQADRD FTPQDYLELN 650
PNGLRAITAA MEFIKNPRKM CHEIAGYVEK MCGVIVEYSQ TRPTGSTLYL 700
QESMDLAQRR WNKELREFRR KNKHGEVEFD ISKIPDIYDN IKYDMEHNPD 750
LCINNEVEFE RMYVCVKNMA DIVVPQEYGI KTENKMVIAQ RVCTPLLRKI 800
RNDLHRCLEN KESEETQTRL DPRASQGIAT PFRHVRTRLY FTSESHIHTL 850
MNLIRYGNLC SVDDKKWQRA MNFLSGVTEF NYMTQVVLMV YEDSRKENDE 900
ADTGPRFHIE ILFSPGLYPC FLTEKERIYE TRFNLSTNPK PATSSRSSGR 950
ESRDTNDSAS SSTEGRRPSI EKVVTVVTPT QLSTPSVTND DLSISSNAES 1000
TAAESTGLVN TTTKTHNDSE DDLNDVESVN LVALDELNNT TKAMADDGKT 1050
AKRQRSVTGA EKSMEEGDKP HGEWKGNGVA KSGSQISVGS NEMESNNESM 1100
ETVGGGKGQW VKDLLDQTKR AMAMNSIREV EPPIVIPTPV PSTTTAVVED 1150
EASERQSRSR RYFPYRFKHH TAQLLTGMSG GGVHMQNRLI STDVLTGKFG 1200
DHDNKKNSRK DFGAGTAVLS TAVIARSSSA PRLMTYESED FSVGEIKRFW 1250
PPLRSLETLH DSINLSQFDG FLERLIKGAL TPLPSPPKTP LPSALSCDAI 1300
NKTPTQDEVE KVIGKLAPTS STD 1323
Length:1,323
Mass (Da):150,120
Last modified:April 8, 2008 - v3
Checksum:iB9D3A901879C8B0F
GO
Isoform b (identifier: P91309-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1044-1159: MADDGKTAKR...DEASERQSRS → SQRGSFHVTEPIQIDEKT

Note: No experimental confirmation available.

Show »
Length:1,225
Mass (Da):139,760
Checksum:iBF64E578B8E166AF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1044 – 1159116MADDG…RQSRS → SQRGSFHVTEPIQIDEKT in isoform b.
VSP_030639Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081396 Genomic DNA. Translation: CCD71324.1.
FO081396 Genomic DNA. Translation: CCD71335.1.
RefSeqiNP_740855.2. NM_170868.4. [P91309-1]
NP_740856.1. NM_171837.6. [P91309-2]
UniGeneiCel.5361.

Genome annotation databases

EnsemblMetazoaiF46F11.1a; F46F11.1a; WBGene00018508. [P91309-1]
GeneIDi172221.
KEGGicel:CELE_F46F11.1.
UCSCiF46F11.1b. c. elegans. [P91309-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081396 Genomic DNA. Translation: CCD71324.1 .
FO081396 Genomic DNA. Translation: CCD71335.1 .
RefSeqi NP_740855.2. NM_170868.4. [P91309-1 ]
NP_740856.1. NM_171837.6. [P91309-2 ]
UniGenei Cel.5361.

3D structure databases

ProteinModelPortali P91309.
SMRi P91309. Positions 16-326.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.F46F11.1a.

Proteomic databases

PaxDbi P91309.
PRIDEi P91309.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F46F11.1a ; F46F11.1a ; WBGene00018508 . [P91309-1 ]
GeneIDi 172221.
KEGGi cel:CELE_F46F11.1.
UCSCi F46F11.1b. c. elegans. [P91309-1 ]

Organism-specific databases

CTDi 172221.
WormBasei F46F11.1a ; CE41904 ; WBGene00018508 .
F46F11.1b ; CE30534 ; WBGene00018508 .

Phylogenomic databases

eggNOGi NOG245915.
GeneTreei ENSGT00390000009048.
HOGENOMi HOG000177917.
InParanoidi P91309.
KOi K13024.
OMAi RTDMELY.
PhylomeDBi P91309.

Enzyme and pathway databases

Reactomei REACT_197741. Synthesis of pyrophosphates in the cytosol.

Miscellaneous databases

NextBioi 874563.
PROi P91309.

Family and domain databases

Gene3Di 3.40.50.1240. 4 hits.
InterProi IPR013651. ATP-grasp_RimK-type.
IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
PF08443. RimK. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 4 hits.
PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiVIP1_CAEEL
AccessioniPrimary (citable) accession number: P91309
Secondary accession number(s): Q8T3B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 8, 2008
Last modified: September 3, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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