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P91254

- GST8_CAEEL

UniProt

P91254 - GST8_CAEEL

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Protein
Probable glutathione S-transferase 8
Gene
gst-8, F11G11.1
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81Glutathione By similarity
Binding sitei39 – 391Glutathione By similarity
Binding sitei43 – 431Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase 8 (EC:2.5.1.18)
Alternative name(s):
GST class-sigma
Gene namesi
Name:gst-8
ORF Names:F11G11.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiF11G11.1; CE07054; WBGene00001756; gst-8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Probable glutathione S-transferase 8
PRO_0000185931Add
BLAST

Proteomic databases

PaxDbiP91254.
PRIDEiP91254.

2D gel databases

World-2DPAGE0020:P91254.

Interactioni

Protein-protein interaction databases

STRINGi6239.F11G11.1.

Structurei

3D structure databases

ProteinModelPortaliP91254.
SMRiP91254. Positions 1-206.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7978GST N-terminal
Add
BLAST
Domaini81 – 206126GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 512Glutathione binding By similarity
Regioni63 – 642Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.By similarity

Phylogenomic databases

eggNOGiNOG265520.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiP91254.
KOiK00799.
OMAiEDHRISI.
OrthoDBiEOG78WKT1.
PhylomeDBiP91254.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91254-1 [UniParc]FASTAAdd to Basket

« Hide

MVHYKLSYFP IRGAGEVIRQ IFVYAGQSFE DHRISIEEWA AVKPTTPFGQ    50
LPLLEVDGKV LPQSHSIARF LARQFGINGK CAWEEAQVNS IADQFKDYRN 100
EVRPYVMVKM GFAEGDLDAL SKDVFLPGFK KHYGFIYNFL KTAGSGYLVG 150
DSLTFVDLLI AQHTADILST DPALLEEFPQ FKAHQEKVHS NANIKKWLET 200
RPETQF 206
Length:206
Mass (Da):23,433
Last modified:May 1, 1997 - v1
Checksum:i53D50FE7794EA260
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081119 Genomic DNA. Translation: CCD69254.1.
PIRiT29986.
RefSeqiNP_494884.1. NM_062483.1.
UniGeneiCel.14873.

Genome annotation databases

EnsemblMetazoaiF11G11.1; F11G11.1; WBGene00001756.
GeneIDi184364.
KEGGicel:CELE_F11G11.1.
UCSCiF11G11.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081119 Genomic DNA. Translation: CCD69254.1 .
PIRi T29986.
RefSeqi NP_494884.1. NM_062483.1.
UniGenei Cel.14873.

3D structure databases

ProteinModelPortali P91254.
SMRi P91254. Positions 1-206.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.F11G11.1.

2D gel databases

World-2DPAGE 0020:P91254.

Proteomic databases

PaxDbi P91254.
PRIDEi P91254.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F11G11.1 ; F11G11.1 ; WBGene00001756 .
GeneIDi 184364.
KEGGi cel:CELE_F11G11.1.
UCSCi F11G11.1. c. elegans.

Organism-specific databases

CTDi 184364.
WormBasei F11G11.1 ; CE07054 ; WBGene00001756 ; gst-8.

Phylogenomic databases

eggNOGi NOG265520.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115733.
InParanoidi P91254.
KOi K00799.
OMAi EDHRISI.
OrthoDBi EOG78WKT1.
PhylomeDBi P91254.

Miscellaneous databases

NextBioi 924486.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGST8_CAEEL
AccessioniPrimary (citable) accession number: P91254
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: May 1, 1997
Last modified: June 11, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi