P91254 (GST8_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable glutathione S-transferase 8
EC=2.5.1.18

Alternative name(s):
GST class-sigma

Gene names

Name:	gst-8
ORF Names:	F11G11.1

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity. UniProtKB P46436
Catalytic activity	RX + glutathione = HX + R-S-glutathione. UniProtKB P46436
Sequence similarities	Belongs to the GST superfamily. Sigma family. UniProtKB P46436 Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Probable glutathione S-transferase 8		PRO_0000185931
Regions
	Domain	2 – 79	78	GST N-terminal
	Domain	81 – 206	126	GST C-terminal
	Region	50 – 51	2	Glutathione binding By similarity
	Region	63 – 64	2	Glutathione binding By similarity
Sites
	Binding site	8	1	Glutathione By similarity
	Binding site	39	1	Glutathione By similarity
	Binding site	43	1	Glutathione By similarity

Sequences

	Sequence		Length	Mass (Da)
	P91254 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 53D50FE7794EA260	FASTA	206	23,433
	10 20 30 40 50 60 MVHYKLSYFP IRGAGEVIRQ IFVYAGQSFE DHRISIEEWA AVKPTTPFGQ LPLLEVDGKV 70 80 90 100 110 120 LPQSHSIARF LARQFGINGK CAWEEAQVNS IADQFKDYRN EVRPYVMVKM GFAEGDLDAL 130 140 150 160 170 180 SKDVFLPGFK KHYGFIYNFL KTAGSGYLVG DSLTFVDLLI AQHTADILST DPALLEEFPQ 190 200 FKAHQEKVHS NANIKKWLET RPETQF

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO081119 Genomic DNA. Translation: CCD69254.1.
PIR	T29986.
RefSeq	NP_494884.1. NM_062483.1.
UniGene	Cel.14873.
3D structure databases
ProteinModelPortal	P91254.
SMR	P91254. Positions 1-206.
ModBase	Search...
Protein-protein interaction databases
STRING	P91254.
2D gel databases
World-2DPAGE	0020:P91254.
Proteomic databases
PRIDE	P91254.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F11G11.1; F11G11.1; F11G11.1.
GeneID	184364.
KEGG	cel:F11G11.1.
NMPDR	fig|6239.3.peg.5316.
UCSC	F11G11.1. c. elegans.
Organism-specific databases
CTD	184364.
WormBase	F11G11.1; CE07054; WBGene00001756; gst-8.
Phylogenomic databases
eggNOG	meNOG14525.
GeneTree	EMGT00050000007317.
HOGENOM	HBG563238.
InParanoid	P91254.
OMA	SITIARF.
PhylomeDB	P91254.
Family and domain databases
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:1.20.1050.10. GST_C_like. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K00799.
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	924486.

Entry information

Entry name

GST8_CAEEL

Accession

Primary (citable) accession number: P91254

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	May 1, 1997
Last modified:	December 14, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project