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P91254

- GST8_CAEEL

UniProt

P91254 - GST8_CAEEL

Protein

Probable glutathione S-transferase 8

Gene

gst-8

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei8 – 81GlutathioneBy similarity
    Binding sitei39 – 391GlutathioneBy similarity
    Binding sitei43 – 431GlutathioneBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glutathione S-transferase 8 (EC:2.5.1.18)
    Alternative name(s):
    GST class-sigma
    Gene namesi
    Name:gst-8
    ORF Names:F11G11.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiF11G11.1; CE07054; WBGene00001756; gst-8.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 206206Probable glutathione S-transferase 8PRO_0000185931Add
    BLAST

    Proteomic databases

    PaxDbiP91254.
    PRIDEiP91254.

    2D gel databases

    World-2DPAGE0020:P91254.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.F11G11.1.

    Structurei

    3D structure databases

    ProteinModelPortaliP91254.
    SMRiP91254. Positions 1-206.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 7978GST N-terminalAdd
    BLAST
    Domaini81 – 206126GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni50 – 512Glutathione bindingBy similarity
    Regioni63 – 642Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Sigma family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG265520.
    GeneTreeiENSGT00670000097856.
    HOGENOMiHOG000115733.
    InParanoidiP91254.
    KOiK00799.
    OMAiEDHRISI.
    OrthoDBiEOG78WKT1.
    PhylomeDBiP91254.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P91254-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVHYKLSYFP IRGAGEVIRQ IFVYAGQSFE DHRISIEEWA AVKPTTPFGQ    50
    LPLLEVDGKV LPQSHSIARF LARQFGINGK CAWEEAQVNS IADQFKDYRN 100
    EVRPYVMVKM GFAEGDLDAL SKDVFLPGFK KHYGFIYNFL KTAGSGYLVG 150
    DSLTFVDLLI AQHTADILST DPALLEEFPQ FKAHQEKVHS NANIKKWLET 200
    RPETQF 206
    Length:206
    Mass (Da):23,433
    Last modified:May 1, 1997 - v1
    Checksum:i53D50FE7794EA260
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081119 Genomic DNA. Translation: CCD69254.1.
    PIRiT29986.
    RefSeqiNP_494884.1. NM_062483.1.
    UniGeneiCel.14873.

    Genome annotation databases

    EnsemblMetazoaiF11G11.1; F11G11.1; WBGene00001756.
    GeneIDi184364.
    KEGGicel:CELE_F11G11.1.
    UCSCiF11G11.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081119 Genomic DNA. Translation: CCD69254.1 .
    PIRi T29986.
    RefSeqi NP_494884.1. NM_062483.1.
    UniGenei Cel.14873.

    3D structure databases

    ProteinModelPortali P91254.
    SMRi P91254. Positions 1-206.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.F11G11.1.

    2D gel databases

    World-2DPAGE 0020:P91254.

    Proteomic databases

    PaxDbi P91254.
    PRIDEi P91254.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F11G11.1 ; F11G11.1 ; WBGene00001756 .
    GeneIDi 184364.
    KEGGi cel:CELE_F11G11.1.
    UCSCi F11G11.1. c. elegans.

    Organism-specific databases

    CTDi 184364.
    WormBasei F11G11.1 ; CE07054 ; WBGene00001756 ; gst-8.

    Phylogenomic databases

    eggNOGi NOG265520.
    GeneTreei ENSGT00670000097856.
    HOGENOMi HOG000115733.
    InParanoidi P91254.
    KOi K00799.
    OMAi EDHRISI.
    OrthoDBi EOG78WKT1.
    PhylomeDBi P91254.

    Miscellaneous databases

    NextBioi 924486.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiGST8_CAEEL
    AccessioniPrimary (citable) accession number: P91254
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 28, 2003
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3