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Protein

Probable glutathione S-transferase 8

Gene

gst-8

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8GlutathioneBy similarity1
Binding sitei39GlutathioneBy similarity1
Binding sitei43GlutathioneBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-CEL-156590 Glutathione conjugation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase 8 (EC:2.5.1.18)
Alternative name(s):
GST class-sigma
Gene namesi
Name:gst-8
ORF Names:F11G11.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF11G11.1 ; CE07054 ; WBGene00001756 ; gst-8

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859311 – 206Probable glutathione S-transferase 8Add BLAST206

Proteomic databases

PaxDbiP91254
PeptideAtlasiP91254

2D gel databases

World-2DPAGEi0020:P91254

Expressioni

Gene expression databases

BgeeiWBGene00001756

Interactioni

Protein-protein interaction databases

STRINGi6239.F11G11.1

Structurei

3D structure databases

ProteinModelPortaliP91254
SMRiP91254
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 79GST N-terminalAdd BLAST78
Domaini81 – 206GST C-terminalAdd BLAST126

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 51Glutathione bindingBy similarity3
Regioni63 – 64Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.Curated

Phylogenomic databases

eggNOGiKOG1695 Eukaryota
ENOG4111VAU LUCA
GeneTreeiENSGT00670000097856
HOGENOMiHOG000115733
InParanoidiP91254
KOiK00799
OMAiEDHRISI
OrthoDBiEOG091G0MBB
PhylomeDBiP91254

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

P91254-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHYKLSYFP IRGAGEVIRQ IFVYAGQSFE DHRISIEEWA AVKPTTPFGQ
60 70 80 90 100
LPLLEVDGKV LPQSHSIARF LARQFGINGK CAWEEAQVNS IADQFKDYRN
110 120 130 140 150
EVRPYVMVKM GFAEGDLDAL SKDVFLPGFK KHYGFIYNFL KTAGSGYLVG
160 170 180 190 200
DSLTFVDLLI AQHTADILST DPALLEEFPQ FKAHQEKVHS NANIKKWLET

RPETQF
Length:206
Mass (Da):23,433
Last modified:May 1, 1997 - v1
Checksum:i53D50FE7794EA260
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081119 Genomic DNA Translation: CCD69254.1
PIRiT29986
RefSeqiNP_494884.1, NM_062483.1
UniGeneiCel.14873

Genome annotation databases

EnsemblMetazoaiF11G11.1; F11G11.1; WBGene00001756
GeneIDi184364
KEGGicel:CELE_F11G11.1
UCSCiF11G11.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiGST8_CAEEL
AccessioniPrimary (citable) accession number: P91254
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: May 1, 1997
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health