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P91254 (GST8_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glutathione S-transferase 8

EC=2.5.1.18
Alternative name(s):
GST class-sigma
Gene names
Name:gst-8
ORF Names:F11G11.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length206 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity. UniProtKB P46436

Catalytic activity

RX + glutathione = HX + R-S-glutathione. UniProtKB P46436

Sequence similarities

Belongs to the GST superfamily. Sigma family. UniProtKB P46436

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 206206Probable glutathione S-transferase 8
PRO_0000185931

Regions

Domain2 – 7978GST N-terminal
Domain81 – 206126GST C-terminal
Region50 – 512Glutathione binding By similarity
Region63 – 642Glutathione binding By similarity

Sites

Binding site81Glutathione By similarity
Binding site391Glutathione By similarity
Binding site431Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
P91254 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 53D50FE7794EA260

FASTA20623,433
        10         20         30         40         50         60 
MVHYKLSYFP IRGAGEVIRQ IFVYAGQSFE DHRISIEEWA AVKPTTPFGQ LPLLEVDGKV 

        70         80         90        100        110        120 
LPQSHSIARF LARQFGINGK CAWEEAQVNS IADQFKDYRN EVRPYVMVKM GFAEGDLDAL 

       130        140        150        160        170        180 
SKDVFLPGFK KHYGFIYNFL KTAGSGYLVG DSLTFVDLLI AQHTADILST DPALLEEFPQ 

       190        200 
FKAHQEKVHS NANIKKWLET RPETQF 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO081119 Genomic DNA. Translation: CCD69254.1.
PIRT29986.
RefSeqNP_494884.1. NM_062483.1.
UniGeneCel.14873.

3D structure databases

ProteinModelPortalP91254.
SMRP91254. Positions 1-206.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.F11G11.1.

2D gel databases

World-2DPAGE0020:P91254.

Proteomic databases

PaxDbP91254.
PRIDEP91254.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF11G11.1; F11G11.1; F11G11.1.
GeneID184364.
KEGGcel:CELE_F11G11.1.
UCSCF11G11.1. c. elegans.

Organism-specific databases

CTD184364.
WormBaseF11G11.1; CE07054; WBGene00001756; gst-8.

Phylogenomic databases

eggNOGNOG265520.
HOGENOMHOG000115733.
InParanoidP91254.
KOK00799.
OMAHRISIEE.
OrthoDBEOG78WKT1.
PhylomeDBP91254.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio924486.

Entry information

Entry nameGST8_CAEEL
AccessionPrimary (citable) accession number: P91254
Entry history
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: May 1, 1997
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase