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Protein

Probable glutathione S-transferase 8

Gene

gst-8

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81GlutathioneBy similarity
Binding sitei39 – 391GlutathioneBy similarity
Binding sitei43 – 431GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase 8 (EC:2.5.1.18)
Alternative name(s):
GST class-sigma
Gene namesi
Name:gst-8
ORF Names:F11G11.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF11G11.1; CE07054; WBGene00001756; gst-8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Probable glutathione S-transferase 8PRO_0000185931Add
BLAST

Proteomic databases

PaxDbiP91254.
PRIDEiP91254.

2D gel databases

World-2DPAGE0020:P91254.

Interactioni

Protein-protein interaction databases

STRINGi6239.F11G11.1.

Structurei

3D structure databases

ProteinModelPortaliP91254.
SMRiP91254. Positions 1-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7978GST N-terminalAdd
BLAST
Domaini81 – 206126GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 512Glutathione bindingBy similarity
Regioni63 – 642Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG265520.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiP91254.
KOiK00799.
OMAiEDHRISI.
OrthoDBiEOG78WKT1.
PhylomeDBiP91254.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91254-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHYKLSYFP IRGAGEVIRQ IFVYAGQSFE DHRISIEEWA AVKPTTPFGQ
60 70 80 90 100
LPLLEVDGKV LPQSHSIARF LARQFGINGK CAWEEAQVNS IADQFKDYRN
110 120 130 140 150
EVRPYVMVKM GFAEGDLDAL SKDVFLPGFK KHYGFIYNFL KTAGSGYLVG
160 170 180 190 200
DSLTFVDLLI AQHTADILST DPALLEEFPQ FKAHQEKVHS NANIKKWLET

RPETQF
Length:206
Mass (Da):23,433
Last modified:May 1, 1997 - v1
Checksum:i53D50FE7794EA260
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081119 Genomic DNA. Translation: CCD69254.1.
PIRiT29986.
RefSeqiNP_494884.1. NM_062483.1.
UniGeneiCel.14873.

Genome annotation databases

EnsemblMetazoaiF11G11.1; F11G11.1; WBGene00001756.
GeneIDi184364.
KEGGicel:CELE_F11G11.1.
UCSCiF11G11.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081119 Genomic DNA. Translation: CCD69254.1.
PIRiT29986.
RefSeqiNP_494884.1. NM_062483.1.
UniGeneiCel.14873.

3D structure databases

ProteinModelPortaliP91254.
SMRiP91254. Positions 1-206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F11G11.1.

2D gel databases

World-2DPAGE0020:P91254.

Proteomic databases

PaxDbiP91254.
PRIDEiP91254.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF11G11.1; F11G11.1; WBGene00001756.
GeneIDi184364.
KEGGicel:CELE_F11G11.1.
UCSCiF11G11.1. c. elegans.

Organism-specific databases

CTDi184364.
WormBaseiF11G11.1; CE07054; WBGene00001756; gst-8.

Phylogenomic databases

eggNOGiNOG265520.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiP91254.
KOiK00799.
OMAiEDHRISI.
OrthoDBiEOG78WKT1.
PhylomeDBiP91254.

Miscellaneous databases

NextBioi924486.
PROiP91254.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGST8_CAEEL
AccessioniPrimary (citable) accession number: P91254
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: May 1, 1997
Last modified: April 29, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.