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P91254

- GST8_CAEEL

UniProt

P91254 - GST8_CAEEL

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Protein

Probable glutathione S-transferase 8

Gene

gst-8

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81GlutathioneBy similarity
Binding sitei39 – 391GlutathioneBy similarity
Binding sitei43 – 431GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase 8 (EC:2.5.1.18)
Alternative name(s):
GST class-sigma
Gene namesi
Name:gst-8
ORF Names:F11G11.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiF11G11.1; CE07054; WBGene00001756; gst-8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Probable glutathione S-transferase 8PRO_0000185931Add
BLAST

Proteomic databases

PaxDbiP91254.
PRIDEiP91254.

2D gel databases

World-2DPAGE0020:P91254.

Interactioni

Protein-protein interaction databases

STRINGi6239.F11G11.1.

Structurei

3D structure databases

ProteinModelPortaliP91254.
SMRiP91254. Positions 1-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7978GST N-terminalAdd
BLAST
Domaini81 – 206126GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 512Glutathione bindingBy similarity
Regioni63 – 642Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG265520.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiP91254.
KOiK00799.
OMAiEDHRISI.
OrthoDBiEOG78WKT1.
PhylomeDBiP91254.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91254-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVHYKLSYFP IRGAGEVIRQ IFVYAGQSFE DHRISIEEWA AVKPTTPFGQ
60 70 80 90 100
LPLLEVDGKV LPQSHSIARF LARQFGINGK CAWEEAQVNS IADQFKDYRN
110 120 130 140 150
EVRPYVMVKM GFAEGDLDAL SKDVFLPGFK KHYGFIYNFL KTAGSGYLVG
160 170 180 190 200
DSLTFVDLLI AQHTADILST DPALLEEFPQ FKAHQEKVHS NANIKKWLET

RPETQF
Length:206
Mass (Da):23,433
Last modified:May 1, 1997 - v1
Checksum:i53D50FE7794EA260
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081119 Genomic DNA. Translation: CCD69254.1.
PIRiT29986.
RefSeqiNP_494884.1. NM_062483.1.
UniGeneiCel.14873.

Genome annotation databases

EnsemblMetazoaiF11G11.1; F11G11.1; WBGene00001756.
GeneIDi184364.
KEGGicel:CELE_F11G11.1.
UCSCiF11G11.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081119 Genomic DNA. Translation: CCD69254.1 .
PIRi T29986.
RefSeqi NP_494884.1. NM_062483.1.
UniGenei Cel.14873.

3D structure databases

ProteinModelPortali P91254.
SMRi P91254. Positions 1-206.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.F11G11.1.

2D gel databases

World-2DPAGE 0020:P91254.

Proteomic databases

PaxDbi P91254.
PRIDEi P91254.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F11G11.1 ; F11G11.1 ; WBGene00001756 .
GeneIDi 184364.
KEGGi cel:CELE_F11G11.1.
UCSCi F11G11.1. c. elegans.

Organism-specific databases

CTDi 184364.
WormBasei F11G11.1 ; CE07054 ; WBGene00001756 ; gst-8.

Phylogenomic databases

eggNOGi NOG265520.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115733.
InParanoidi P91254.
KOi K00799.
OMAi EDHRISI.
OrthoDBi EOG78WKT1.
PhylomeDBi P91254.

Miscellaneous databases

NextBioi 924486.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGST8_CAEEL
AccessioniPrimary (citable) accession number: P91254
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: May 1, 1997
Last modified: October 1, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3