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P91253 (GST7_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glutathione S-transferase 7

EC=2.5.1.18
Alternative name(s):
GST class-sigma
Gene names
Name:gst-7
ORF Names:F11G11.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length206 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity. UniProtKB P46436

Catalytic activity

RX + glutathione = HX + R-S-glutathione. UniProtKB P46436

Sequence similarities

Belongs to the GST superfamily. Sigma family. UniProtKB P46436

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processinnate immune response

Inferred from expression pattern PubMed 16968778. Source: WormBase

   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 206206Probable glutathione S-transferase 7
PRO_0000185930

Regions

Domain2 – 7978GST N-terminal
Domain81 – 206126GST C-terminal
Region50 – 512Glutathione binding By similarity
Region63 – 642Glutathione binding By similarity

Sites

Binding site81Glutathione By similarity
Binding site391Glutathione By similarity
Binding site431Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
P91253 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 0F72B5425295934E

FASTA20623,085
        10         20         30         40         50         60 
MVHYKVSYFP IRGAGEIARQ ILAYAGQDFE DNRIPKEEWP AVKPSTPFGQ LPLLEVDGKV 

        70         80         90        100        110        120 
LAQSHAIARY LARQFGINGK CAWEEAQVNS VADQFKDYLN EVRPYFMVKM GFAEGDLDAL 

       130        140        150        160        170        180 
AKDVFLPGFK KHYGFFANFL KSAGSGYLVG DSLTFVDLLV AQHTADLLAA NAALLDEFPQ 

       190        200 
FKAHQEKVHS NANIKKWLET RPVTPF 

« Hide

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO081119 Genomic DNA. Translation: CCD69255.1.
PIRT29985.
RefSeqNP_494883.1. NM_062482.4.
UniGeneCel.14874.

3D structure databases

ProteinModelPortalP91253.
SMRP91253. Positions 1-206.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid39196. 1 interaction.
DIPDIP-24504N.
IntActP91253. 1 interaction.
MINTMINT-1086890.
STRING6239.F11G11.2.

Proteomic databases

PaxDbP91253.
PRIDEP91253.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF11G11.2; F11G11.2; WBGene00001755.
GeneID173842.
KEGGcel:CELE_F11G11.2.
UCSCF11G11.2. c. elegans.

Organism-specific databases

CTD173842.
WormBaseF11G11.2; CE07055; WBGene00001755; gst-7.

Phylogenomic databases

eggNOGNOG307242.
GeneTreeENSGT00670000097856.
HOGENOMHOG000115733.
InParanoidP91253.
KOK00799.
OMAEDNRIPK.
OrthoDBEOG78WKT1.
PhylomeDBP91253.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio881353.

Entry information

Entry nameGST7_CAEEL
AccessionPrimary (citable) accession number: P91253
Entry history
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: May 1, 1997
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase