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P91253

- GST7_CAEEL

UniProt

P91253 - GST7_CAEEL

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Protein

Probable glutathione S-transferase 7

Gene
gst-7, F11G11.2
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81Glutathione By similarity
Binding sitei39 – 391Glutathione By similarity
Binding sitei43 – 431Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. innate immune response Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase 7 (EC:2.5.1.18)
Alternative name(s):
GST class-sigma
Gene namesi
Name:gst-7
ORF Names:F11G11.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiF11G11.2; CE07055; WBGene00001755; gst-7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Probable glutathione S-transferase 7PRO_0000185930Add
BLAST

Proteomic databases

PaxDbiP91253.
PRIDEiP91253.

Interactioni

Protein-protein interaction databases

BioGridi39196. 1 interaction.
DIPiDIP-24504N.
IntActiP91253. 1 interaction.
MINTiMINT-1086890.
STRINGi6239.F11G11.2.

Structurei

3D structure databases

ProteinModelPortaliP91253.
SMRiP91253. Positions 1-206.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7978GST N-terminalAdd
BLAST
Domaini81 – 206126GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 512Glutathione binding By similarity
Regioni63 – 642Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.By similarity

Phylogenomic databases

eggNOGiNOG307242.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiP91253.
KOiK00799.
OMAiEDNRIPK.
OrthoDBiEOG78WKT1.
PhylomeDBiP91253.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91253-1 [UniParc]FASTAAdd to Basket

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MVHYKVSYFP IRGAGEIARQ ILAYAGQDFE DNRIPKEEWP AVKPSTPFGQ    50
LPLLEVDGKV LAQSHAIARY LARQFGINGK CAWEEAQVNS VADQFKDYLN 100
EVRPYFMVKM GFAEGDLDAL AKDVFLPGFK KHYGFFANFL KSAGSGYLVG 150
DSLTFVDLLV AQHTADLLAA NAALLDEFPQ FKAHQEKVHS NANIKKWLET 200
RPVTPF 206
Length:206
Mass (Da):23,085
Last modified:May 1, 1997 - v1
Checksum:i0F72B5425295934E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081119 Genomic DNA. Translation: CCD69255.1.
PIRiT29985.
RefSeqiNP_494883.1. NM_062482.4.
UniGeneiCel.14874.

Genome annotation databases

EnsemblMetazoaiF11G11.2; F11G11.2; WBGene00001755.
GeneIDi173842.
KEGGicel:CELE_F11G11.2.
UCSCiF11G11.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081119 Genomic DNA. Translation: CCD69255.1 .
PIRi T29985.
RefSeqi NP_494883.1. NM_062482.4.
UniGenei Cel.14874.

3D structure databases

ProteinModelPortali P91253.
SMRi P91253. Positions 1-206.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 39196. 1 interaction.
DIPi DIP-24504N.
IntActi P91253. 1 interaction.
MINTi MINT-1086890.
STRINGi 6239.F11G11.2.

Proteomic databases

PaxDbi P91253.
PRIDEi P91253.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F11G11.2 ; F11G11.2 ; WBGene00001755 .
GeneIDi 173842.
KEGGi cel:CELE_F11G11.2.
UCSCi F11G11.2. c. elegans.

Organism-specific databases

CTDi 173842.
WormBasei F11G11.2 ; CE07055 ; WBGene00001755 ; gst-7.

Phylogenomic databases

eggNOGi NOG307242.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115733.
InParanoidi P91253.
KOi K00799.
OMAi EDNRIPK.
OrthoDBi EOG78WKT1.
PhylomeDBi P91253.

Miscellaneous databases

NextBioi 881353.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiGST7_CAEEL
AccessioniPrimary (citable) accession number: P91253
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: May 1, 1997
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi