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Protein

Probable glutathione S-transferase 7

Gene

gst-7

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection (PubMed:22216003).By similarity1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8GlutathioneBy similarity1
Binding sitei39GlutathioneBy similarity1
Binding sitei43GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

  • innate immune response Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiR-CEL-156590. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase 7 (EC:2.5.1.18)
Alternative name(s):
GST class-sigma
Gene namesi
Name:gst-7
ORF Names:F11G11.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF11G11.2; CE07055; WBGene00001755; gst-7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859301 – 206Probable glutathione S-transferase 7Add BLAST206

Proteomic databases

EPDiP91253.
PaxDbiP91253.
PeptideAtlasiP91253.
PRIDEiP91253.

Expressioni

Gene expression databases

BgeeiWBGene00001755.

Interactioni

Protein-protein interaction databases

BioGridi39196. 1 interactor.
DIPiDIP-24504N.
IntActiP91253. 1 interactor.
MINTiMINT-1086890.
STRINGi6239.F11G11.2.

Structurei

3D structure databases

ProteinModelPortaliP91253.
SMRiP91253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 79GST N-terminalAdd BLAST78
Domaini81 – 206GST C-terminalAdd BLAST126

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 51Glutathione bindingBy similarity3
Regioni63 – 64Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG1695. Eukaryota.
ENOG4111VAU. LUCA.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiP91253.
KOiK00799.
OMAiEDNRIPK.
OrthoDBiEOG091G0MBB.
PhylomeDBiP91253.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P91253-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHYKVSYFP IRGAGEIARQ ILAYAGQDFE DNRIPKEEWP AVKPSTPFGQ
60 70 80 90 100
LPLLEVDGKV LAQSHAIARY LARQFGINGK CAWEEAQVNS VADQFKDYLN
110 120 130 140 150
EVRPYFMVKM GFAEGDLDAL AKDVFLPGFK KHYGFFANFL KSAGSGYLVG
160 170 180 190 200
DSLTFVDLLV AQHTADLLAA NAALLDEFPQ FKAHQEKVHS NANIKKWLET

RPVTPF
Length:206
Mass (Da):23,085
Last modified:May 1, 1997 - v1
Checksum:i0F72B5425295934E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081119 Genomic DNA. Translation: CCD69255.1.
PIRiT29985.
RefSeqiNP_494883.1. NM_062482.4.
UniGeneiCel.14874.

Genome annotation databases

EnsemblMetazoaiF11G11.2; F11G11.2; WBGene00001755.
GeneIDi173842.
KEGGicel:CELE_F11G11.2.
UCSCiF11G11.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081119 Genomic DNA. Translation: CCD69255.1.
PIRiT29985.
RefSeqiNP_494883.1. NM_062482.4.
UniGeneiCel.14874.

3D structure databases

ProteinModelPortaliP91253.
SMRiP91253.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi39196. 1 interactor.
DIPiDIP-24504N.
IntActiP91253. 1 interactor.
MINTiMINT-1086890.
STRINGi6239.F11G11.2.

Proteomic databases

EPDiP91253.
PaxDbiP91253.
PeptideAtlasiP91253.
PRIDEiP91253.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF11G11.2; F11G11.2; WBGene00001755.
GeneIDi173842.
KEGGicel:CELE_F11G11.2.
UCSCiF11G11.2. c. elegans.

Organism-specific databases

CTDi173842.
WormBaseiF11G11.2; CE07055; WBGene00001755; gst-7.

Phylogenomic databases

eggNOGiKOG1695. Eukaryota.
ENOG4111VAU. LUCA.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115733.
InParanoidiP91253.
KOiK00799.
OMAiEDNRIPK.
OrthoDBiEOG091G0MBB.
PhylomeDBiP91253.

Enzyme and pathway databases

ReactomeiR-CEL-156590. Glutathione conjugation.

Miscellaneous databases

PROiP91253.

Gene expression databases

BgeeiWBGene00001755.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGST7_CAEEL
AccessioniPrimary (citable) accession number: P91253
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: May 1, 1997
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.