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Protein

Probable glutathione S-transferase 7

Gene

gst-7

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection (PubMed:22216003).By similarity1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8GlutathioneBy similarity1
Binding sitei39GlutathioneBy similarity1
Binding sitei43GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-CEL-156590 Glutathione conjugation
R-CEL-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase 7 (EC:2.5.1.18)
Alternative name(s):
GST class-sigma
Gene namesi
Name:gst-7
ORF Names:F11G11.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF11G11.2 ; CE07055 ; WBGene00001755 ; gst-7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859301 – 206Probable glutathione S-transferase 7Add BLAST206

Proteomic databases

EPDiP91253
PaxDbiP91253
PeptideAtlasiP91253
PRIDEiP91253

Expressioni

Gene expression databases

BgeeiWBGene00001755

Interactioni

Protein-protein interaction databases

BioGridi39196, 1 interactor
DIPiDIP-24504N
IntActiP91253, 1 interactor
STRINGi6239.F11G11.2

Structurei

3D structure databases

ProteinModelPortaliP91253
SMRiP91253
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 79GST N-terminalAdd BLAST78
Domaini81 – 206GST C-terminalAdd BLAST126

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 51Glutathione bindingBy similarity3
Regioni63 – 64Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.Curated

Phylogenomic databases

eggNOGiKOG1695 Eukaryota
ENOG4111VAU LUCA
GeneTreeiENSGT00670000097856
HOGENOMiHOG000115733
InParanoidiP91253
KOiK00799
OMAiHYGFFAN
OrthoDBiEOG091G0MBB
PhylomeDBiP91253

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

P91253-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHYKVSYFP IRGAGEIARQ ILAYAGQDFE DNRIPKEEWP AVKPSTPFGQ
60 70 80 90 100
LPLLEVDGKV LAQSHAIARY LARQFGINGK CAWEEAQVNS VADQFKDYLN
110 120 130 140 150
EVRPYFMVKM GFAEGDLDAL AKDVFLPGFK KHYGFFANFL KSAGSGYLVG
160 170 180 190 200
DSLTFVDLLV AQHTADLLAA NAALLDEFPQ FKAHQEKVHS NANIKKWLET

RPVTPF
Length:206
Mass (Da):23,085
Last modified:May 1, 1997 - v1
Checksum:i0F72B5425295934E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081119 Genomic DNA Translation: CCD69255.1
PIRiT29985
RefSeqiNP_494883.1, NM_062482.4
UniGeneiCel.14874

Genome annotation databases

EnsemblMetazoaiF11G11.2; F11G11.2; WBGene00001755
GeneIDi173842
KEGGicel:CELE_F11G11.2
UCSCiF11G11.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiGST7_CAEEL
AccessioniPrimary (citable) accession number: P91253
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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